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McManus, Linda M

Graduate School of Biomedical Sciences
Pathology
(210) 567-4071
mcmanus@uthscsa.edu

Appointments Education Expertise Teaching Publications Grants

6/2012 - Present	Director	Office of Postdoctoral Affairs, UTHSCSA, San Antonio, TX
1/2010 - Present	Distinguished Teaching Professor	The University of Texas Health Science Center, Department of Pathology, Periodontics, San Antonio, TX
1/2004 - Present	Faculty Member	Sam and Ann Barshop Institute for Longevity and Aging, UTHSCSA, Pathology, San Antonio, TX
1/1992 - Present	Scientist (Adjunct)	Southwest Foundation for Biomedical Research, San Antonio, TX

Date	Description	Institution	# Students
1/2012 - Present	Membership on Supervising Committee	University of Texas Health Science Center San Antonio

1/2011 - Present	Membership on Supervising Committee	University of Texas Health Science Center San Antonio

9/2010 - Present	Director, F-Troop: Fellowship (F) Grant Writing	Institute for the Integration of Medicine and Science, University of Texas Health Science Center San

6/2010 - Present	Topics in Translational Science (MEDI 6101)
Course Director
1/2010 - Present	Membership on Supervising Committee	University of Texas Health Science Center San Antonio

1/2010 - Present	Membership on Supervising Committee	University of Texas Health Science Center San Antonio

1/2010 - Present	Member, Evaluation Sub-Committee of the Research Education/Training/Career Development Key Function	NCATS, NIH
Clinical and Translational Science Awards (CTSA)
1/2009 - Present	Organizer and Speaker, Grants and Career Development Workshop	University of Texas Health Science Center San Antonio
Institute for the Integration of Medicine and Science
1/2009 - Present	Co-Director, Translational Science Training (TST) Across Disciplines	University of Texas Health Science Center San Antonio
Graduate School of Biomedical Sciences and Institute for the Integration of Medicine and Science, San Antonio, Texas
1/2009 - Present	Practium in Translational Science (MEDI 5077)
Course Director
1/2009 - Present	Member, Council for Innovative Research Education (CIRE)	University of Texas Health Science Center San Antonio
Institute for the Integration of Medicine and Science
1/2008 - Present	Undergraduate Student Supervision	University of Texas Health Science Center San Antonio

1/2008 - Present	Co-Director, Office of Research Education and Mentoring (OREM)	University of Texas Health Science Center San Antonio
Intitute for Integration of Medicine and Science, San Antonio, Texas
1/2006 - Present	Associate Director, Masters of Science in Clinical Investigation	University of Texas Health Science Center San Antonio
Institute for Integration of Medicine and Science
1/2004 - Present	Grantsmanship and Peer Review (MEDI 6064)
Course Director - Hours: 16 class/0 lab
1/2004 - Present	Introduction to Clinical Investigation
Hours: 2 class
1/2001 - Present	Responsible Conduct of Patient Oriented Clinical Research (MEDI5070)
Hours: 2 class/0 lab
1/1986 - Present	Clinical Pathology (OT) (OT5025)
Hours: 5 class/0 lab
1/1986 - Present	General Pathology (Dental) (PATH6019)
Hours: 5 class/0 lab

Journal Article

McHale MJ, Sarwar ZU, Cardenas DP, Porter L, Salinas AS, Michalek JE, McManus LM, Shireman PK. Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones. PMCID: PMC3289262 Am J Physiol Regul Integr Comp Physiol 2012 Jan;302:R331-339.

Burns S, Dodd GD, McManus LM, Cardan RA, Ping Q, Orsi MD, Head HW, Blakemore DL, Blume JD, Fullerton GD, Green TJ. 3T-Magnetic resonance imaging accurately depicts radiofrequency ablation zones in a blood-perfused bovine liver model J Vascular Intervention Radiol 2012 Jan;23:801-808.

Lee LS, Pusek SN, McCormack WT, Helitzer DL, Martina CA, Dozier A, Ahluwalia JS, Schwartz L, McManus LM, Reynolds B, Haynes E, Rubio DM. Clinical and translational scientist career success: metrics for evaluation. PMCID: PMC3476049 Clin Translational Sci 2012 Jan;5:400-407.

Chen Y, Melton D, Gelfond J, McManus LM, Shireman PK. MiR-351 Transiently increases during muscle regeneration and promotes progenitor cell proliferation and survival upon differentiation. PMCID: PMC3524771 Physiol Genomics 2012 Jan;44:1042-1051.

Soundararajan A, Bao A, Phillips WT, McManus LM, Goins BA. Chemoradionuclide therapy with 186re-labeled liposomal doxorubicin: toxicity, dosimetry, and therapeutic response. PMCID: PMC3189008 Cancer Biother Radiopharm 2011 Oct;26(5):603-614.

Chen Y, Gelfond J, McManus LM, Shireman PK. Temporal microRNA expression during in vitro myogenic progenitor cell proliferation and differentiation: regulation of proliferation by miR-682. PMCID: PMC3110887 Physiol Genomics 2011 May;43(10):621-630.

Soundararajan A, Dodd GD, Bao A, Phillips WT, McManus LM, Prihoda TJ, Goins BA. Chemoradionuclide therapy with 186Re-labeled liposomal doxorubicin in combination with radiofrequency ablation for effective treatment of head and neck cancer in a nude rat tumor xenograft model. PMCID: PMC3219911 Radiol 2011 Jan;261:813-823.

Martinez CO, McHale MJ, Wells JT, Ochoa O, Michalek JE, McManus LM, Shireman PK. Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment. PMCID: PMC2944434 Am J Physiol Regul Integr Comp Physiol 2010 Sep;299(3):R832-R842.

Prajapati SI, Martinez CO, Abraham J, McCleish AT, Michalek JE, McManus LM, Rubin B, Shireman PK, Keller C. Crimson carrier, a long-acting contrast agent for in vivo near-infrared imaging of injured and diseased muscle. PMCID: PMC2910161 Muscle and Nerve 2010 Aug;42(2):245-251.

Head HW, Dodd GD 3rd, Bao A, Soundararajan A, Garcia-Rojas X, Prihoda TJ, McManus LM, Goins BA, Santoyo CA, Phillips WT. Combination radiofrequency ablation and intravenous radiolabeled liposomal doxorubicin: imaging and quantification of increased drug delivery to tumors. PMCID: PMC2858812 Radiology 2010 May;255(2):405-414.

Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. PMCID: PMC2793066 Am J Physiol Cell Physiol 2009 Dec;297(6):C1520-C1532.

Prajapati SI, Martinez CO, Bahadur AN, Wu IQ, Zheng W, Lechleiter JD, McManus LM, Chisholm GB, Michalek JA, Shireman PK, Keller C. Near-infrared Imaging of Injured Tissue in Living Subjects Using IR-820. [Cover Article] PMCID: PMC2793066 Mol Imaging 2009 Sep;8:45-54.

Sun D, Martinez C, Ochoa O, Ruiz-Willhite L, Bonilla JR, Centonze VE, Waite LL, Michalek JE, McManus LM, Shireman PK. Bone marrow-derived cell regulation of skeletal muscle regeneration. PMCID: PMC2630778 FASEB J 2009 Feb;23(2):382-395.

Chen Y, Gelfond JA, McManus LM, Shireman PK. Reproducibility of quantitative RT-PCR array in miRNA expression profiling and comparison with microarray analysis. PMCID: PMC2753550 BMC Genomics 2009 Jan;10:407-417.

Zavaleta CL, Goins BA, Bao A, McManus LM, McMahan CA, Phillips WT. Imaging of 186Re-liposome therapy in ovarian cancer xenograft model of peritoneal carcinomatosis J Drug Target 2008 Aug;16(7):626-637.

Pierce A, deWaal E, McManus LM, Shireman PK, Chaudhuri A. oxidative damage and structural perturbation in redox-sensitive metabolic enzymes in injured skeletal muscle. PMID: 18037124 Free Radicals Biol Med 2007 Sep;43:1584-1593.

Ochoa O, Sun D, Reyes-Reyna SM, Waite LL, Michalek JE, McManus LM, Shireman PK. Delayed angiogenesis and VEGF production in CCR2-/- mice during impaired skeletal muscle regeneration. PMID: 17522124 Am J Physiol Regul Integr Comp Physiol 2007 Aug;293(2):651-661.

Abstract

Fearing CM, Hancock HM, McHale MJ, Porter L, Sarwar ZU, McManus LM, Shireman PK. Increased adipocyte deposition in injured muscle with aging and impaired remodeling in females; 2013 Feb. (Academic Surgical Congress, New Orleans, LA).

Wang H, Porter L, Sarwar ZU, McManus LM, Shireman PK. Proinflammatory macrophage ablation in CD11b-diphtheria toxin receptor (DTR) transgenic mice impairs skeletal muscle regeneration; 2012 Apr. (Experimental Biology, San Diego, CA).

Melton DW, Gelfond JAL, Chen Y, McManus LM, Shireman PK. Unique microRNA epression patterns associated with macrophage infiltration following skeletal muscle injury; 2012 Apr. (Experimental Biology, San Diego, CA).

Chen Y, Gelfond S, McManus LM, Shireman PK. MiR-682 antisense inhibits skeletal muscle regeneration. Washington, DC; 2011 Apr. (Experimental Biology).

Wang H, Porter L, Sarwar ZU, Wells JT, McManus LM, Shireman PK. Macrophage ablation in CD11b-diptheria toxin receptor (DTR) transgenic mice impairs skeletal muscle regeneration. Washington, DC; 2011 Apr. (Experimental Biology).

Wells JT, McManus LM, Shireman PK. Skeletal muscle regeneration in dependent upon CCR2 expression on bone marrow (BM)-derived cells. Washington, DC; 2011 Apr. (Experimental Biology).

Chen Y, Gelfond JA, McManus LM, Shireman PK. Comparative Study of MicroRNA Expression during in vitro myogenic progenitor cell proliferation/differentiation and in vivo muscle regeneration (Dr. Chen received recognition as the best junior faculty in this presentation.) San Antonio, TX; 2011 Jan. (2nd Annual Frontiers of Translational Science Research Day).

Hancock HM, McHale M, Porter L, Sawar Z, McManus LM, Shireman PK. Despite sarcopenia, aging does not affect myofiber regenerative capacity in mice; 2011 Jan. (Academic Surgical Congress).

Chen Y, Gelfond JA, McManus LM, Shireman PK. Comparative Study of MicroRNA Expression during in vitro myogenic progenitor cell proliferation/differentiation and in vivo muscle regeneration Carefree, AZ; 2010 Jun. (2010 FASEB Summer Research Conferences).

Chen Y, Gelfond JA, McManus LM, Shireman PK. MiRNA expression patterns during skeletal muscle regeneration San Antonio, TX; 2010 May. (Annual Terry M. Mikiten Graduate Student Research).

Chen Y, Gelfond JA, McManus LM, Shireman PK. MiRNA expression patterns during skeletal muscle regeneration. Anaheim, CA; 2010 Apr. (Experimental Biology).

McHale MJ, Schlechter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Gender-specific differences in skeletal muscle regeneration, presented at the Academic Surgical Congress, Association for Academic Surgery,; 2010 Feb. (J Surg Res; vol. 158, no. 2).

McHale M, Schlecter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Increased fat accumulation in regenerating skeletal muscle in females; 2009 Aug. (Annual Meeting of the San Antonio Vascular Surgery Society).

Martinez CO, McManus LM, Shireman PK. CCR2 influence in skeletal muscle recovery from injury San Antonio, TX; 2009 Jun. (Aust Surgical Society).

Chen Y, Gelfond JA, McManus LM, Shireman PK. Differential microRNA expression during myogenic progenitor cell proliferation and differentiation. Proceedings of the Joint Meeting; 2009 May. (Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells, New York, NY).

Martinez CO, McHale MJ, Ochoa O, McManus LM, Shireman PK. Early macrophage recruitment is directly related to regenerated skeletal muscle fiber size; 2009 May. (Making Muscle in the Embryo and Adult).

Chen Y, Gelfond JA, McManus LM, Shireman PK. Differential microRNA expression during myogenic progenitor cell proliferation and differentiation New York, NY; 2009 May. (Meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells).

Martinez CO, McManus LM, Shireman PK. Kinetics of myogenic progenitor cell (MPC) expansion and bone marrow-derived cell recruitment in skeletal muscle regeneration; 2009 Apr. (Experimental Biology).

Chen Y, Gelfond JA, McManus LM, Shireman PK. Reproducibility of miRNA expression by proliferating C2C12 cells using RT-PCR array; 2009 Apr. (Platform Presentation at Experimental Biology).

Chen Y, Gelfond JA, McManus LM, Shireman PK. Reproducibility of miRNA expression by proliferating C2C12 cells using RT-PCR Array New Orleans, LA; 2009 Apr. (2009 Experimental Biology).

Martinez CO, McManus LM, Shireman PK. Myogenic progenitor cell and bone marrow-derived cell kinetics in skeletal muscle regeneration; 2009 Mar. (Proceedings of the American College of Surgery).

Chen Y, Gelfond JA, McManus LM, Shireman PK. MicroRNA profiling in murine myoblasts using quantitative RT-PCR array; 2009 Mar. (UTHSCSA Graduate Student Association sponsored Research Day).

Chen Y, Gelfond JA, McManus LM, Shireman PK. microRNA profiling in murine myoblasts using quantitative RE-PCR array San Antonio, TX; 2009 Mar. (Annual Terry M. Mikiten, PHD Graduate Student Research Forum).

McHale M, Schlecter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Gender-dependent fat accumulation in regenerating skeletal muscle; 2009 Jan. (Aust Surgical Society).

Martinez CO, Sun D, Waite LL, Michalek JE, McManus LM, Shireman PK. Differential regulation of skeletal muscle regeneration by CCR2-activating chemokines and in vivo characteristics of myogenic progenitor cells; 2008 Oct. (Annual Meeting of the San Antonio Vascular Surgery Society).

Schlechter AK, Torres FM, McManus LM, Shireman PK. Altered muscle regeneration in the absence of CC chemokine receptor 2; 2008 Sep. (8th Annual Medical Student Research Day, UTHSCSA).

Sun, D, MD Wetzel, LL Waite, JE Michalek, LM McManus, and PK Shireman. Environmental factors determine in vivo myogenic progenitor cell proliferation and differentiation. Chicago, IL; 2008 Jan. (Academic Surgical Congress).

Ochoa, O, CO Martinez, FM Torres, L Ruiz-Willhite, JE Michalek, LM McManus, and PK Shireman. Differential regulation of skeletal muscle regeneration and angiogenesis by CCR2-activating chemokines. Chicago, IL; 2008 Jan. (American College of Surgery).

Kelley S, Boykin R, Peng Q, Orsi, Head HW, Fullerton GD, McManus LM, Dodd III GD. Validation of optimized T1W-3T MRI to characterize the dimensions of RF ablation lesions in a perfused bovine liver model; 2008 Jan. (RSNA Annual Meeting).

Shireman PK, Sun D, Ochoa O, Bonilla JR, Waite LL, Michalek JE, McManus LM. Increased myogenic progenitor cell accumulation in CCR2 -/- mice despite bone marrow-dependent impairments in muscle regeneration and macrophage recruitment; 2007 Jul. (Skeletal Muscle Satellite & Stem Cells, FASEB Summer Meeting).

Editorial

McManus LM. Mission, Leadership, and Scientific Discovery. Looking to the Future Am J Pathol 2008 Jan;173.

Kant JA, McManus LM. The Journal of Molecular Diagnostics - Emulsifying Professional Societies J Mol Diag 2008 Jan;10:478-479.

Federal
Funding Agency	NIH/NHLBI (T32)
Title	Pathobiology of Occlusive Vascular Disease
Status	Active
Period	1/2012 - 1/2017
Role	Principal Investigator
Grant Detail	Program Director
Funding Agency	NIH/NHLBI (F30)
Title	Improved Muscle Regeneration by Anti-mRNA Alteration in Macrophage Polarization
Status	Active
Period	1/2011 - 1/2016
Role	Consultant
Grant Detail	Co-Mentor
Funding Agency	NIH/NIGMS (R01)
Title	Mechanisms Enhancing Scholarly Achievement (MESA)
Status	Active
Period	1/2010 - 1/2014
Role	Co-Investigator
Grant Detail
Funding Agency	NIH/NHLBI
Title	Chemokines and Immune Cells in Hind Limb Ischemia
Status	Active
Period	7/2008 - 6/2013
Role	Consultant
Grant Detail	Competitive renewal application studying the effect of macrophages on angiogenesis and tissue regeneration after ischemic injury. (Co-Mentor)
Funding Agency	NIH / NCRR
Title	Institute for Integration of Medicine & Science: A Partnership to Improve Health
Status	Active
Period	5/2008 - 4/2013
Role	Contributor
Grant Detail	This Clinical and Translational Science Award (CTSA) provides a broad range of infrastructure support across the institution and its CTSA partners.
Funding Agency	NIH / NHLBI
Title	Pathobiology of Occlusive Vascular Disease
Status	Complete
Period	9/2007 - 8/2012
Role	Principal Investigator
Grant Detail	This NIH training grant supports postdoctoral training in the area of occlusive cardiovascular disease, inflammation, and degenerative disorders of cardiovascular tissues.
State
Funding Agency	UT System Graduate Education Initiative
Title	Translational Science Training Across Disciplines
Status	Active
Period	1/2009 - 12/2014
Role	Co-Principal Investigator
Grant Detail	This project provides translational science training for graduate students and lead to development of a certificate program in Translational Science (2012). The Translational Science Training (TST) Across Disciplines Program develops scientists with skills in translational research through individualized combinations of innovative coursework, novel training, and successful mentoring. Through these activities, the TST Program enhances graduate research training at the University of Texas (UT) Health Science Center at San Antonio and adds value to the research environment of all its PhD programs. Since receipt of UT System funding in January 2009, the TST Program has been fully implemented within the Institute for Integration of Medicine and Science (IIMS) and the Graduate School of Biomedical Sciences (GSBS) at the UT Health Science Center at San Antonio. To date, three cohorts of TST Scholars have completed the program - five (5) TST Scholars completed the program in August 2010, six (6) Scholars completed the program in August 2011, and six (6) Scholars completed the program in August 2012. Six (6) new TST Scholars were selected in June 2012. As a result of TST Program success, in 2012 a 12 semester-credit-hour Graduate Certificate in Translational Science was approved to provide graduate students and others with a formal introduction to the essential components of translational science.

Year	Degree	Discipline	Institution
1980	Postdoctoral Fellowship	Pathology	The University of Texas Health Science Center San Antonio , TX
1978	PhD	Experimental Pathology	The University of Colorado Medical School Denver , CO
1973	MS	Microbiology	The University of Houston Houston , TX
1970	BA	Microbiology	The University of Texas Austin , TX
1969	AA		Blinn College Brenham , TX

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McManus, Linda M

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