Journal Article |
| Nair AS, Nair HB, Lucidi RS, Kirchner AJ, Schenken RS, Tekmal RR, and Witz CA. Modeling of early endometriotic Lesion: Mesothelium-endometrial cell co-culture increases endometrial cell invasion and alters mesothelial and endometrial gene transcription Fertil. Steril 2008 Jan;.
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| Rajhans R, Nair H, Kirma NB, Kijima I, Chen S, Tekmal RR, and Vadlamudi RK. PELP-1/MNAR deregulation promotes local estrogen synthesis in breast cancer cells Mol. Endocrinol 2008 Jan;.
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| Nagpal JK, Nair SS, Chakravarty D, Rajhans R, Saikumar P, Brann DW, Tekmal RR, and Vadlamudi RK. Growth Factor Regulation of ER-coregulator PELP1 Functions via PKA Pathway Molecular Cancer Research 2008 Jan;6(5):851-861.
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| Rajhans R, Nair SS, Holden AH, Kumar R, Tekmal RR, Vadlamudi RK. Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor Cancer Research 2007 Jun;67(11):5505-5512.
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| Tekmal RR, Nair HB, Perla RP, Kirma NB. HER-2/neu x aromatase double transgenic mice model: The effects of aromatase overexpression on mammary tumorigenesis J steroid Biochem Mol Biol 2007 Jan;106:111-118.
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| Nair SS, Guo Z, Mueller JM, Koochekpour S, Qiu Y, Tekmal RR, Schule R, Kung HJ, Kumar R, Vadlamudi RK. PELP1/MNAR enhances androgen receptor functions through LIM-only coactivator FHL2 Mol Endocrinol 2007 Jan;21:613-624.
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| Sidell N, Kirma N, Morgan ET, Nair H, Tekmal RR. Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate Cancer Lett 2007 Jan;251(2):302-310.
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| Silva JM, Lin Y, Nielsen A, Friedrichs WE, Beeram M, Tekmal RR, and DeGraffenried LA. Akt-induced suppression of the ASK/JNK pathway in resistant breast cancer cells Ann. Oncol 2007 Jan;18:1323-1328.
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| Kirma N, Hammes LS, Liu YG, Nair HB, Valente PT, Kumar S, Flowers L, and Tekmal RR. Elevated expression of the oncogene c-fms and its ligand the macrophage colony stimulating factor-1, in cervical cancer and the role of transforming growth factor-β1in inducing c-fms expression Cancer Res 2007 Jan;67:1918-1926.
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| Hammes LS, Korte JE, Tekmal RR, Naud P, Edelweiss MI, Valente PT, Longatto-Filho A, Kirma N, Cunha-Filho JS. Computer-assisted immunohistochemical analysis of cervical cancer biomarkers using low-cost and simple software Appl. Immunohistochem. Mol. Morphol 2007 Jan;15:456-462.
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| Hammes LS, Tekmal RR, Naud P, Edelweiss MI, Kirma N, Valente PT, Syrjnen KJ, Cunha-Filho JS, Kirma NB. Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression-Clinicopathological correlation Gynecol Oncol 2007 Jan;105(1):157-165.
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| Liu G, Liu Wu Y, Brenin D, Yue W, Aiyar S, Anne Gompel A, Wang J, Tekmal RR, Santen RJ. Development of a high sensitivity, nested Q-PCR assay for mouse and human aromatase Breast Cancer Res. Treat 2007 Jan;.
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| Tekmal RR, Zhou J, Liu M, Luthra R, Jones J, Aneja R, Chandra R and Joshi HC. EM102, a microtuble-interfering agent, inhibits the progression of multidrug-resistant human ovarian cancer both in cultured cells and in athymic nude mice Cancer Chemo. Pharmacol. (Online: 10.1007/s00280-004-0903-1) 2005 Feb;55:461-465.
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| Tekmal RR, Liu Y-, Jones J, Lubahn DB, Korach KS and Kirma NB. Estrogen receptor alpha is required for the mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice J. Steroid Biochem. Mol. Biol 2005 Jan;95:9-15.
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| Nair HB, Luthra R, Kirma N, Liu Y-G, Flowers L, Evans D and Tekmal RR. Induction of aromatase expression in cervical carcinomas: Effects of endogenous estrogen on cervical cancer cell proliferation Cancer Research 2005 Jan;65:11164-11173.
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| Kirma N, Luthra R, JOnes, J, Liu YG, Mandava U, and Tekmal RR. Overexpression of the CSF-1 and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation Cancer Res 2004 Jan;64(12):4162-4170.
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Book Chapter |
| Tekmal RR, Kirma N and Luthra R. Aromatase overexpression: Biochemical and phenotypic characteristics. In: J. Li, S.A. Li and Llombart-Bosh (Eds). IN: Hormonal Carcinogenesis IV. Springer-Verlag, NY; 2005. p. 130-140.
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Abstract |
| Chakravarty D, Nair S, Nair CB, Wang L, Bandyopadhyay AM, Agyin JK, Francis L, Sun L, Yeh I, Tekmal RR, Vadlamudi RK. Therapeutic potential of blocking ER non-genomic actions on ER-positive metastasis; 2009 Apr. (American Association for Cancer Research Annual Meeting: Proceedings: April 18-22, Denver, CO, AACR; vol. 2009, no. 2387).
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| Nair Hareesh B, Tamirisa Nina, Santhamma Bindu, Agyin K Joseph, Perla P Rao, Kirma Nameer B, Liu Ya-Guang, Markandeswar Panda, Tekmal RR. Therapeutic modulation of estrogen rceptor in ovarian cancer cells by ER- agonist nanoparticles; 2008 Apr. (Proc. Am. Assn. Cancer Res; vol. 1223).
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| Nair Binoj Chandrasekharan, Nair Sujit S, Chakravarty Dimple, Rajhans Rajib, Cortez Valerie, Tekmal RR, Vadlamudi Ratna K. PELP1/MNAR: A novel CDKs substrate and regulator of pRb/E2F pathway; 2008 Apr. (Proc. Am. Assn. Cancer Res; vol. 4222).
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| Kirma Nameer B, Nair Hareesh B, Liu Ya-Guang, Tekmal RR,. Transforming growth factor beta induces the expression and promoter 1 activity of the oncogene c-fms in cervical and ovarian cancer cells and immortalized endometrial cells; 2008 Apr. (Proc. Am. Assn. Cancer Res; vol. 5202).
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| Chakravarty Dimple, Santhamma Bindu, Nair Binoj Chandrasekharan, Rajhans Rajib, Nair Sujit, Agyin Joseph, Tekmal RR, Vadlamudi Ratna K. PELP1/MNAR couples estrogen signaling to cytoskeleton through ILK axis; 2008 Apr. (Proc. Am. Assn. Cancer Res; vol. 5451).
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| Agyin Joseph K, Santhamma Bindu, Nair Hareesh B, Tekmal RR. BU-32: A novel proteasome inhibitor for breast cancer; 2008 Apr. (Proc. Am. Assn. Cancer Res; vol. 3254).
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| Kirma NB, Nair HB, Liu YG, Tekmal RR. Transforming growth factor beta induces the expression and promoter 1 activity of the oncogene c-fms in cervical and ovarian cancer cells and immortalized endometrial cells; 2008 Jan. (Proc. Am. Assn. Cancer. Res).
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| Kirma N, Nair HB, Perla RP, and Tekmal RR. Conjugated linoleic acid in combination with a synthetic derivative of rhapontigenin synergistically inhibit the growth of Her2/neu positive breast cancer. Poster#36. Abstr. #36; 2007 Nov. (World Cancer research Fund/American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer Launch Conference).
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| Kirma NB, Nair HB, Liu Y-G, Tekmal RR. Conjugated linoleic acid synergies the CYP1B1 inhibitor 2,3,4,5-tetramethoxystilbene in suppressing breast cancer cell growth. 106(suppl.1):S184(Abstr.#4053); 2007 Jan. (Breast Cancer Res. Treat).
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| Nair HB, Santhamma B, Agyin JK, Perla RP, Rossini G, Kirma NB, Liu Y-G, Evans DB, Tekmal RR. Increased efficiency and combination therapy: targeted letrozole/estrogen receptor- specific ligand nanoparticles homing to mammary tumors in HER-2/aromatase double transgenic mice. 106(suppl.1):S110 (Abstr. #2075); 2007 Jan. (Breast Cancer Res. Treat).
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| Nair CB, Nair SS, Chakravarty D, Rajhans R, Cortez V, Yew RP, Tekmal RR, Vadlamudi RK. Identification of proline, glutamic acid-leucine, rich protein (PELP-1) as a novel CDK4 substrate and characterizing its role in breast cancer cell proliferation. 106(suppl.1):S124 (Abstr.#2119); 2007 Jan. (Breast Cancer Res. Treat).
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| Chakravarty D, Nair CB, Rajhans R, Cortez V, Nair SS, Tekmal RR, DeGraffenried LA, Sun LZ, Vadlamudi RK. Significance of PELP-1/MNAR-mediated ER-Nongenomic action in cytoskeleton signaling. 106(suppl.1):S29 (Abstr.# 209); 2007 Jan. (Breast Cancer Res. Treat).
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| Jensen, JR, Perla Rao P, Tekmal RR, Schenken RS, Witz CA. An in vivo model suggests that colony stimulating factor-1 plays a critical role in the genesis of early endometriotic lesion. 88(suppl.1):S205; 2007 Jan. (Fertil. Steril).
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| Chakravarty D, Nair S, Balasenthil S, Liu J, Tekmal RR, Auersperg N, Burow M, Broaddus R, and Vadlamudi RK. PELP-1/MNAR in ovarian cancer:implications in tumorigenesis. 48:Abstr. 4345; 2007 Jan. (Proc. Am. Assn. Cancer Res).
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| Kirma NB, Hammes LS, Ya-Guang Liu, Nair HB, Valente PT, Hall K, and Tekmal RR. Elevated transforming growth factor beta response in invasive cervical carcinoma and induction of colony stimulating factor receptor by this growth factor. 48:Abstr. 3786; 2007 Jan. (Proc. Am. Assn. Cancer Res).
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| Rajhans R, Nair H, Kirma NB, Kijima I, Chen S, Tekmal RR and Vadlamudi RK. PELP-1/MNAR deregulation promotes local estrogen synthesis in breast cancer cells. Abstr. 2520; 2007 Jan. (Proc. Am. Assn. Cancer Res).
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| Nair HB, Rao P Perla, Ya-Guang Liu, Rajhans R, Nair SS, Kirma NB, Pothana S, Vadlamudi RK, and Tekmal RR. Estrogen receptor overexpression leads to decreased mammary tumorigenesis in aromatase x HER-2/neu double transgenic mice. 48:Abstr. 4332; 2007 Jan. (Proc. Am. Assn. Cancer Res).
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| Griffith JS, Binkley PA, Kirma NB, Schenken RS, Tekmal RR, and Witz CA. Imatinib decreases endometrial stromal cell Transmesothelial migration and proliferation in the extracellular matrix of modeled peritoneum. 88(suppl.1):S60-61; 2007 Jan. (Fertil. Steril).
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| Griffith JS, Liu Ya-Guang, Binkley PA, Witz CA, Tekmal RR, and Schenken RS. Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and express several CD44 splice variants. 88(suppl.1):S207; 2007 Jan. (Fertil. Steril).
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| Kirma N, Nair HB, Hammes L, Liu Y, Hall K, Valente PT, and Tekmal RR. Induction of aromatase in cervical carcinomas Baltimore, MD; 2006 Sep. (VIII International Aromatase Conference).
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| Vadlamudi RK , Rajib R, Nair H, Kirma N, Chen S, Kumar R, Tekmal RR. Potentiation of E2-ER autocrine signaling loop by ER Coregulator PELP1/MNAR Baltimore, MD; 2006 Sep. (VIII International Aromatase Conference).
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| Hammes, LS, Korte JE, Tekmal RR, Naud P, Edelweiss MI, Kirma N, Valente PT, Filho JSL. Cox-2 and VEGF expression in cervical carcinoma. (Abstract PO3-01A) Paris; 2006 Apr. (Eurogen 2006, 6th International Multidisciplinary Congress).
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| Hammes LS, Korte JE, Tekmal RR, Naud P, Edelweiss MI, Kirma N, Valente PT, Filho JSL. Computer assisted analysis of biomarkers for cervical cancer. (Abstract PO3-01B) Paris; 2006 Apr. (Eurogen 2006, 6th International Multidisciplinary Congress).
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| Park Ho-Yong, Fan P, Wang J, Yue Wei, Song RX, Kim S-H, Tekmal RR, and Santen RJ. Prevention of breast cancer and treatment of hormone resistant breast cancer with new inhibitor of catecholestrogens (A# 3662); 2006 Mar. (Proc. Amer. Assoc. Cancer Res; vol. 47).
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| Silva JM, Lin Y, Nielsen A, Friedrichs WE, Beeram M, Tekmal RR, and DeGraffenried LA. Akt-induced supression of the ASK/JNK pathway in resistant breast cancer cell; 2006 Jan. (Proc. Amer. Assoc. Cancer Res; vol. 47, no. 5068).
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| Nagpal J, Nair S, Saikumar P, Kumar R, Tekmal RR, Kumar R and Vadlamudi RK. Growth factor regulation of PELP-1/MNAR functions: Role of PKA-dependent phosphorylation; 2006 Jan. (Proc. Am. Assn. Cancer Res; vol. 47, no. 2933).
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| Tekmal RR, Liu Y-G, Kirma N, Hall K, Annam D, Hammes L and Bhaskaran Nair H. Aromatase induction in cervical carcinomas: A potential role of tumor necrosis factor alpha; 2006 Jan. (Proc. Am. Assn. Cancer Res; vol. 47, no. 4432).
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| Rajhans R, Nair S, Tekmal RR, Kumar R and Vadlamudi RK. Cellular transformation and oncogenesis by PELP-1/MNAR, a major broad coactivator in mammalian cells; 2006 Jan. (Proc. Assn. Cancer Res; vol. 47, no. 4215).
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| Perla RP, Liu Y-G, Nair HB, Tekmal RR, Kirma NB. Regulation of macrophage colony-stimulating factor receptor c-fms by steroid receptors in mammary carcinogenesis; 2006 Jan. (Proc. Am. Assn. Cancer Res; vol. 47, no. 2848).
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| Nair AS, Witz CA, Nair HB, Tekmal RR, and Schenken RS. Inhibition of CD44 N-linked glycosylation inhibits endometrial cell binding to peritoneal mesothelial cells.86(suppl 2):S33; 2006 Jan. (Fertil. Steril).
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| Nair AS, Lucidi RS, Ferriera MC, Nair HB, Tekmal RR, and Witz CA. Endometrial cell binding to mesothelial cells enhances invasion of endometrial cells in a 3-dimensional model of human peritoneum. 86 (suppl 2): S262; 2006 Jan. (Fertil. Steril).
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| Rajhans R, Nair SS, De La Pena Alan H, Kumar R, Tekmal RR, and Vadlamudi RK. The role of PELP1/MNAR in progression and metastasis of breast cancer. 100(suppl.1):S13; 2006 Jan. (Breast Cancer Res. Treat).
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| Park HY,Fan P, Wang JP, Yue W, Hong SM, Mohammad K, Tekmal RR, Jordan MA, Demers LM, Chandrashekar V, Kim SH, Lee YH, and Santen RJ. Could inhibitor of catecholestrogens be an ideal agent to prevent breast cancer in premenopausal women? 100(suppl.1):S59; 2006 Jan. (Breast Cancer Res).
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| Esquivel M, Silva J, Donzis E, Lin Y, Friedrichs W, Beeram M, Tekmal RR, DeGraffenried LA. mTOR Suppression of the ASK/JNK pathway in breast cancer cells results in decreased sensitivity to endocrine therapy. 100(suppl.1):S245; 2006 Jan. (Breast Cancer Res. Treat).
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| Nair HB, Rao P Perla, Liu Ya-Guang, Kirma NB, Rajhans R, Chen S, Pothana S, Vadlamudi RK, and Tekmal RR. Estrogen receptor plays an important role in mammary tumorigenesis in Aromatase x HER2/neu double transgenic mice. 100(suppl.1):S248; 2006 Jan. (Breast Cancer Res. Treat).
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| Tekmal RR, Lucidi R, Liu Y-G, Robinson RR, Schenken R and Witz C. Colony stimulating factor-1 promotes endometria cell migration and proliferation in two and three dimensional culture; 2005 Jan. (Fertil. Steril; vol. 84, no. S121).
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| Nair HB, Luthra R, and Tekmal RR. Importance of estrogen-estrogen receptor in cervical cancer Trivandrum, Kerala, India; 2005 Jan. (Int. Symp. On Steroid Hormone Receptor Superfamily and Molecular Signaling).
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| Kirma N, Rao P Perla, Nair HB, and Tekmal RR. The importance of steroid hormones and their receptors in CSF-1/c-fms mediated mammary tumorigenesis; 2005 Jan. (Proc. Am. Assn. Cancer Res; vol. 46, no. 3904).
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| Nair HB, Liu Y-G, Kirma N, and Tekmal RR. Role of estrogen and CSF-1/c-fms in cervical cancer; 2005 Jan. (Proc. Am. Assn. Cancer Res; vol. 46, no. 4025).
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| Liu Y-G, Nair HB, Rao P Perla, Kirma NB,Tekmal RR. Aromatase x Her-2/neu double transgenic model: Importance of local estrogen and Her-2 in breast cancers; 2005 Jan. (Proc. Am. Assn. Cancer Res; vol. 46, no. 5250).
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| Kirma NB, Liu Y-G, Nair HB, Tekmal RR. Macrophage colony-stimulating factor (CSF-1) overexpression leads to mammary tumorigenesis: Induction of CSF-1 receptor, c-fms by steroid hormones. 94(Supplement 1)S202(A# 4107); 2005 Jan. (Breast Cancer Res. Treat).
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| Nair AS, Lucidi RS, Binkley PA, Tekmal RR, Schenken RS, Witz CA. Protein kinase C (PKC)-dependent signaling pathways promote the genesis of the early endometrial lesion; 2005 Jan. (Fertil. Steril; vol. 84, no. S188).
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| Tekmal RR, Perla RP, Nair HB, Liu Y-G, Kirma NB. Aromatase x HER2/neu double transgenic mice: Effect of local estrogen on mammary development and carcinogenesis. 94(Supplement 1)S203(A#4109); 2005 Jan. (Breast Cancer Res. Treat).
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| Beeram M, Tan Q-TN, Tekmal RR, deGraffenried LA. Akt-induced endocrine therapy resistance is reversed by inhibition of MTOR signaling (A# 413); 2004 Dec. (Breast Cancer Res. Treat; vol. S1, no. S39).
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| Liu Y-G, Jones J, Lucidi RS, Witz CA, Schenken RS and Tekmal RR. Tumor necrosis factor-alpha induces peritoneal mesothelial, endometrial epithelial and endometrial stromal cell expression of genes involved in invasion and metastasis; 2004 Sep. (Fertil. Steril; vol. 82, no. S168).
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| Witz CA, Lucidi RS, Centonze VE, Liu Y-G, Jones J and Tekmal RR. Characterization of a novel three-dimensional model of the early endometriotic lesion; 2004 Sep. (Fertil. Steril; vol. 82, no. S72).
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| Lucidi RS, Jones J, Witz CA, Binkley PA, Schenken RS and Tekmal RR. Peritoneal mesothelial cell co-culture with endometrial cell increases mesothelial cell expression of macrophage colony-stimulating factor; 2004 Sep. (Fertil. Steril; vol. 82, no. S167).
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| Tekmal RR, Nair, HB, Liu Y-G, Flowers L and Hall K. Effect of endogenous estrogen on cervical carcinogenesis (A# 1031); 2004 Jan. (Proc. 12th Int. Congress of Endocrinology).
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| Liu Y, Jones J, Rao P Perla, Sidell N, and Tekmal RR. ER plays a critical role aromatase-induced mammary hyperplasia and the use of aromatase transgenic mice in breast cancer prevention studies; 2004 Jan. (Proc. Am. Assn. Cancer Res; vol. 45, no. A461).
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| Nair HB, Luthra R, Liu Y, Flowers L,and Tekmal RR. Aromatase expression and its role in cervical cancer; 2004 Jan. (Proc. Am. Assn. Cancer Res; vol. 45, no. A#461).
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