UTHSCSA Faculty Profiles v1.0

Hart, Peter John

Graduate School of Biomedical Sciences
(210) 567-0751

Researchers in the Hart laboratory use single crystal X-ray diffraction, computational biology, molecular biology, and a range of biophysical and biochemical methods to characterize structure and action of biological macromolecules important in human health. Current research projects include structure/function relationships the RNA lariat debranching enzyme (DBR1), matrix metalloproteinase 13 (MMP-13), sulfotransferases from schistosome parasites, CARDS toxin from Mycoplasma pneumoniae, copper-zinc superoxide dismutase (SOD1), and the copper chaperone for SOD1 (Ccs1). Each of these distinct projects has a translational component involving structure-based design of small molecule therapeutic agents. I have served as Director of the UTHSCSA X-ray Crystallography Core Laboratory (http://xray.uthscsa.edu) since its inception in 1999. The mission of the X-ray Core Lab is to bring structure determination technology to all researchers so that they may obtain structures of their own proteins of interest. I am also appointed as a Research Scientist in the Department of Veterans Affairs in the South Texas Veterans Health Care System.

9/2015 - Present Research Health Scientist GS-15 Veteran`s Administration, STVHCS, Research, San Antonio, TX
9/2006 - Present Ewing Halsell/President's Council Distinguished Chair in Biochemistry UTHSCSA, Biochemistry, San Antonio, TX
9/2006 - Present Professor of Biochemistry UTHSCSA, Biochemistry, San Antonio, TX
9/1999 - Present Director, X-ray Crystallography Core Laboratory UTHSCSA, San Antonio, TX