UTHSCSA Faculty Profiles v1.0

Hart, Peter John

Graduate School of Biomedical Sciences
(210) 567-0751

Researchers in my laboratory use single crystal X-ray diffraction, computational biology, molecular biology, and a range of biophysical and biochemical methods to characterize structure and action of biological macromolecules important in human health. Current research projects include structure/function relationships in human copper-zinc superoxide dismutase (SOD1), the RNA lariat debranching enzyme (DBR1), matrix metalloproteinase 13 (MMP-13), sulfotransferases from schistosome parasites, and CARDS toxin from Mycoplasma pneumoniae. Each of these distinct projects has a translational component centered on structure-based design of small molecule therapeutic agents. I have served as Director of the UTHSCSA X-ray Crystallography Core Laboratory (http://xray.uthscsa.edu) since its inception in 1999. The mission of the X-ray Core Lab is to bring structure determination technology to all researchers so that they may obtain structures of their own proteins of interest. I am also appointed as a Research Scientist in the Department of Veterans Affairs in the South Texas Veterans Health Care System.

9/2006 - Present Ewing Halsell/President''s Council Distinguished Chair in Biochemistry UTHSCSA, Biochemistry, San Antonio, TX
8/2005 - Present Research Health Scientist VA, San Antonio, TX
9/1999 - Present Director, X-ray Crystallography Core Laboratory UTHSCSA, San Antonio, TX