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Bowden, Charles L.

School of Medicine
Psychiatry
(210) 567-5405
bowdenc@uthscsa.edu

Appointments Education Expertise Publications Grants

1/2005 - Present	Clinical Professor	The University of Texas Health Science Center at San Antonio, Psychiatry, San Antonio, TX
1/2004 - Present	Director	Center for Bipolar Illness Interventions in Hispanic Communities, Psychiatry, San Antonio, TX
1/2001 - Present	Professor	University of Texas Health Science Center at San Antonio, Radiology, San Antonio, TX
1/1981 - Present	Professor	The University of Texas Health Science Center at San Antonio, Pharmacology, San Antonio, TX
1/1974 - Present	Nancy U. Karren Endowed Chair of Psychiatry	The University of Texas Health Science Center at San Antonio, Psychiatry, San Antonio, TX

Journal Article

Katz MM, Berman N, Bowden CL, Frazer A. The componential approach enhances the effectiveness of 2-week trials for new antidepressants J Clin Psychopharmacol 2011 Apr;31(2):253-254.

Brooks JO, Goldberg JF, Ketter TA, Miklowitz DJ, Calabrese JR, Bowden CL, Thase ME. Safety and tolerability associated with second-generation antipsychotic polytherapy in bipolar disorder: findings from the Systematic Treatment Enhancement Program for Bipolar Disorder J Clin Psychiatry 2011 Feb;72(2):240-247.

Bowden CL. Treatment strategies for bipolar depression J Clin Psychiatry 2010 May;71(5):10-10.

Smith LA, Cornelius VR, Azorin JM, Perugi G, Vieta E, Young AH, Bowden CL. Valproate for the treatment of acute bipolar depression: systematic review and meta-analysis J Affect Disord 2010 Apr;122(1-2):1-9.

Azorin JM, Bowden CL, Garay RP, Perugi G, Vieta E, Young AH. Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism Neuropsychiatr Dis Treat 2010 Mar;6:37-46.

Bowden CL, Vieta E, Ice KS, Schwartz JH, Wang PP, Versavel M. Ziprasidone plus a mood stabilizer in subjects with bipolar I disorder: a 6-month, randomized, placebo-controlled, double-blind trial J Clin Psychiatry 2010 Feb;71(2):130-137.

Gonzalez JM, Bowden CL, Berman N, Frank E, Bauer MS, Kogan JN, Alegra M, Miklowitz DJ. One-year treatment outcomes of African-American and Hispanic patients with bipolar I or II disorder in STEP-BD Psychiatr Serv 2010 Feb;61(2):164-172.

Thompson PM, Gonzalez JM, Singh V, Schoolfield, John, Katz, Martin M, Bowden CL. Principal domains of behavioral psychopathology identified by the Bipolar Inventory of Signs and Symptoms Scale (BISS) Psychiatry Research 2010 Feb;175(3):221-226.

Bowden CL. Diagnosis, treatment, and recovery maintenance in bipolar depression J Clin Psychiatry 2010 Jan;71(1):01-01.

Fan J, Ionita-Laza I, McQueen MB, Devlin B, Purcell S, Faraone SV, Allen MH, Bowden CL, Calabrese JR, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TB, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel JK, Sachs GS, Thase ME, Molay FB, Escamilla MA, Nimgaonkar VL, Sklar P, Laird NM, Smoller JW. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus Am J Med Genet B Neuropsychiatr Genet 2010 Jan;153B(1):29-37.

Nierenberg AA, Sylvia LG, Leon AC, Reilly-Harrington NA, Ketter TA, Calabrese JR, Thase ME, Bowden CL, Friedman ES, Ostacher MJ, Novak L, Iosifescu DV. Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and design Clin Trials 2009 Dec;6(6):637-648.

Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El-Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL. Association Study of 21 Circadian Genes with Bipolar I Disorder, Schizoaffective Disorder, and Schizophrenia Bipolar Disorder 2009 Nov;11(7):701-710.

Bowden CL. Diagnosis and impact of bipolar depression J Clin Psychiatry 2009 Sep;70(9):32-32.

Matsuo K, Nicoletti MA, Peluso MA, Hatch JP, Nemoto K, Watanabe Y, Nery FG, Monkul ES, Zunta-Soares GB, Bowden CL, Soares JC. Anterior cingulate volumes associated with trait impulsivity in individuals with bipolar disorder Bipolar Disord 2009 Sep;11(6):628-636.

Tohen M, Frank E, Bowden CL, Colom F, Ghaemi SN, Yatham LN, Malhi GS, Calabrese JR, Nolen WA, Vieta E, Kapczinski F, Goodwin GM, Suppes T, Sachs GS, Chengappa KR, Grunze H, Mitchell PB, Kanba S, Berk M. The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders Bipolar Disord 2009 Aug;11(5):453-473.

Tohen M, Sutton V, Calabrese J, Bowden CL, Sachs G. Maintenance of Response Following Stabilization of Mixed Index Episodes with Olanzapine Monotherapy from a Randomized, Double-Blind, Placebo-Controlled Study J Affect Disord 2009 Jul;116(1-2):43-50.

Matsuo K, Walss-Bass C, Nery FG, Nicoletti MA, Hatch JP, Frey BN, Monkul ES, Zunta-Soares GB, Bowden CL, Escamilla MA, Soares JC. Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder Neuropsychopharmacology 2009 Jul;34(8):1904-1913.

Perlis RH, Dennehy EB, Miklowitz DJ, Delbello MP, Ostacher M, Calabrese JR, Ametrano RM, Wisniewski SR, Bowden CL, Thase ME, Nierenberg AA, Sachs G. Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study Bipolar Disord 2009 Jun;11(4):391-400.

Bowden CL. Anticonvulsants in bipolar disorders: current research and practice and future directions Bipolar Disord 2009 Jun;11 Su:20-33.

Goldberg JF, Perlis RH, Bowden CL, Thase ME, Miklowitz DJ, Marangell LB, Calabrese JR, Nierenberg AA, Sachs GS. Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD Am J Psychiatry 2009 Feb;166(2):173-181.

Katz MM, Frazer A, Bowden CL. Rethinking depression and the action of antidepressants: uncovering the links between the neural and behavioral elements J Affect Disord 2009 Jan;120(1-3):16-23.

Tohen M, Vieta E, Goodwin GM, Sun B, Amsterdam JD, Banov M, Shekhar A, Aaronson ST, Bardenstein L, Grecu-Gabos I, Tochilov V, Prelipceanu D, Oliff HS, Kryzhanovskaya L, Bowden CL. Olanzapine versus divalproex versus placebo in the treatment of mild to moderate mania: a randomized, 12-week, double-blind study J Clinical Psychiat 2008 Nov;69(11):1776-1789.

Bowden CL. Bipolar pathophysiology and development of improved treatments Brain Res 2008 Oct;1235:92-97.

Nery FG, Hatch JP, Glahn DC, Nicoletti MA, Monkel SE, Najt P, Fonseca M, Bowden CL, Cloninger RC, Soares JC. Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders J Psychiatr Res 2008 Jun;42(7):569-577.

Weisler RH, Calabrese JR, Bowden CL, Ascher JA, DeVeaugh-Geiss J, Evoniuk G. Discovery and development of lamotrigine for bipolar disorder: a story of serendipity, clinical observations, risk taking, and persistence J Affect Disord 2008 May;108(1-2):1-9.

Nery FG, Monkul ES, Hatch JP, Fonseca M, Zunta-Soares GB, Frey BN, Bowden CL, Soares JC. Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study Hum Psychopharmacol 2008 Mar;23(2):87-94.

Thase ME, Jonas A, Khan A, Bowden CL, Wu X, McQuade RD, Carson WH, Marcus RN, Owen R. Aripiprazole monotherapy in nonpsychotic bipolar I depression: results of 2 randomized, placebo-controlled studies J Clin Psychopharmacol 2008 Feb;28(1):13-20.

Tohen M, Bowden CL, Smulevich AB, Bergstrom R, Quinlan T, Osuntokun O, Wang WV, Oliff HS, Martenyi F, Kryzhanovskaya LA, Greil W. Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes Br J Psychiatry 2008 Feb;192(2):135-143.

Bowden CL, Edwards S, Evoniuk G. Open-label, concomitant use of lamotrigine and other medications for bipolar disorder CNS Spectr 2008 Jan;13(1):75-83.

Goldberg JF, Bowden CL, Calabrese JR, Ketter TA, Dann RS, Frye MA, Suppes T, Post RM. Six-Month Prosepective Life Charting of Mood Symptoms with Lamotrigine Monotherapy Versus Placebo in Rapid Cycling Bipolar Disorder Biological Psychiatry 2008 Jan;63:125-130.

Gonzalez JM, Bowden CL, Katz MM, Thompson PM, Singh V, Prihoda TJ, Dahl M. Development of the Bipolar Inventory of Symptoms Scale: Concurrent validity, discriminant validity and retest reliability International Journal of Methods in Psychiatric Research 2008 Jan;17(4):198-209.

Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F. Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population J Clin Psychopharmacol 2008 Jan;28(1):84-88.

Bowden CL. Bipolar Pathophysiology and development of improved treatments: review and recommendations for innovative studies Brain Research 2008 Jan;1235:92-97.

Goodwin GM, Anderson I, Arango, C, Bowden CL, Henry C, Mitchell PB, Nolen WA, Vieta E, Wittchen HU,. ECNP Consensus Meeting. Bipolar Depression European Neuropsychopharmacology 2008 Jan;18:535-549.

Bowden CL, Gogus A, Grunze H, Haggstom L, Rybakowski J, Vieta E. A 12-week, open, randomized trial comparing sodium valproate to lithium in patients with bipolar I disorder suffering from a manic episode International Clinical Psychopharmacology 2008 Jan;23(5):254-262.

Frey BN, Walss-Bass C, Stanley JA, Nery FG, Matsuo K, Nicoletti MA, Hatch JP, Bowden CL, Escamilla MA, Soares JC. Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder Neuroreport 2007 Oct;18(15):1567-1570.

Glahn DC, Bearden CE, Barguil M, Barrett J, Reichenberg A, Bowden CL, Soares JC, Velligan DI. The neurocognitive signature of psychotic bipolar disorder Biological Psychiatry 2007 Oct;62(8):910-916.

McElroy SL, Bowden CL, Collins MA, Wozniak PJ, Keck PE, Calabrese JR. Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorder J Affect Disord 2007 Sep;.

Bowden CL, Singh V, Thompson PM, Gonzalez JM, Katz, MM, Dahl, M, Prihoda TJ, Chang, X. Development of the Bipolar Inventory of Symptoms Scale Acta Psychiatrica Scandinavica 2007 Sep;116(3):189-194.

Abstract

Singh V, Bowden CL, Weisler, Richard, Thompson PM, Mintz J. Randomized, Double Blind 8-MonthMaintenance Study of Bipolar Depression with Lamotrigine or Divalproex ER plus Lamotrigine; 2009 Nov. (American College of Neuropsychopharmacology Annual Meeting).

Bowden CL. Treating the whole patient: understanding the complexitites of bipolar disorder; 2009 Sep. (22nd ECNP Congress, Istanbul, Turkey).

Bowden CL. Valproate for acute bipolar depression: systematic review and meta-analysis; 2009 Sep. (22nd ECNP Congress, Istanbul, Turkey).

Grunze H, Vieta E, Goodwin G, Bowden C, Licht R, Moeller HJ, Kasper S. Treatment guidelines for bipolar disorder updated; 2009 Sep. (22nd ECNP Congress, Istanbul, Turkey).

Bowden CL, Gonzalez JM, Singh V, Thompson PM, Bernardo CG,. Sensitivity of a Comprehensive Rating Scale for Bipolar Disorders (BD) to Assess Improvements with Treatment; 2009 Aug. (European Neuropsychopharmacology Annual Meeting).

Gonzalez JM, Berman N, Bowden CL, Miklowitz DJ, Frank E. Psychosis and personality type: Self report by ethnicity/race in STEP-BD; 2009 Jun. (Bipolar Disorders; vol. 11, no. s1).

Singh V, Thompson PM, Bernardo CG, Bowden CL. Safety and Efficacy of Lamotrigine As Add on Treatment in Mixed States (MS) of Bipolar Disorder (BD); 2008 Apr. (Society of Biological Psychiatry Annual Meeting; vol. 63, no. 7S1).

Singh V, Bowden CL, Bernardo CG, Thompson PM. 8-Month Maintenance Treatment of Bipolar Depression (BD) with Lamotrigine (LAM) or Divalproex (DIV) plus LAM: Acute Phase Safety and Efficacy of Combined LAM and DIV Treatment of BD; 2008 Apr. (Society of Biological Psychiatry Annual Meeting; vol. 63, no. 7S).

Singh V, Bowden CL, Weisler, R., Thompson PM. Open phase safety and efficacy of lamotrigine (LAM) plus divalproex (DIV) treatment of bipolar depression (BD) in patients with bipolar disorder (BP); 2008 Feb. (Internation Society for Bipolar Disorders Annual Meeting; vol. 10, no. Supl-).

Tohen M, Bowden C, Calabrese J, Yatham L, Vieta E, Goodwin G, Frank E, Suppes T, Sachs G, Chengappa R, Grunze H, Mitchell P, Berk M, Kapczinski F, Ghaemi N, Malhi G, Nolen W, Colom F. Plenary Session: ISBD Moving the Field ForwardThe International Society of Bipolar Disorders Task Force on the Nomenclature of Course and Outcome in Bipolar Disorders; 2008 Jan. (Bipolar Disorders; vol. 10, no. 1).

Thompson PM, Gonzalez JM, Singh V, Schoolfield, J, Bowden CL. Principal Domains of Behavioral Psychopathology Identified by the Bipolar Inventory of Symptoms Scale (BISS) Annual Meeting; 2007 Dec. (American College of Neuropsychopharmacology Annual Meeting).

Review Article

Katz MM, Bowden CL, Frazer A. Rethinking depression and the actions of antidepressants: Uncovering the links between the neural and behavioral elements Journal of Affective Disorders 2010 Jan;120:16-23.

Editorial

Berman N, Bowden CL, Frazer A, Katz MM. The Componential Approach Enhances the Effectiveness of Two Week Trials for New Antidepressants (IN PRESS) The Journal of Clinical Psychopharmacology 2011 Apr;31(2).

Not Specified

Hirschfeld RM, Bowden CL, Vigna NV, Wozniak P, Collins M. A randomized, placebo-controlled, multicenter study of divalproex sodium extended-release in the acute treatment of mania J Clin Psychiatry 2010 Apr;71(4):426-432.

Bowden CL, Mosolov S, Hranov L, Chen E, Habil H, Kongsakon R, Manfredi R, Lin HN. Efficacy of valproate versus lithium in mania or mixed mania: a randomized, open 12-week trial Int Clin Psychopharmacol 2010 Mar;25(2):60-67.

Bowden CL. Comorbidities with bipolar disorders: significance, recognition, and management CNS Spectr 2010 Feb;15(2 Sup):8-9.

Frye MA, Yatham L, Ketter TA, Goldberg J, Suppes T, Calabrese JR, Bowden CL, Bourne E, Bahn RS, Adams B. Depressive relapse during lithium treatment associated with increased serum thyroid-stimulating hormone: results from two placebo-controlled bipolar I maintenance studies Acta Psychiatr Scand 2009 Jul;120(1):10-13.

McElroy SL, Bowden CL, Collins MA, Wozniak PJ, Keck PE, Calabrese JR. Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorder J Affect Disord 2008 Apr;107(1-3):127-133.

Houston JP, Lipkovich IA, Ahl J, Rotelli MD, Baker RW, Bowden CL. Initial symptoms of manic relapse in manic or mixed-manic bipolar disorder: post hoc analysis of patients treated with olanzapine or lithium J Psychiatr Res 2007 Oct;41(7):616-621.

Goldberg JF, Perlis RH, Ghaemi SN, Calabrese JR, Bowden CL, Wisniewski S, Miklowitz DJ, Sachs GS, Thase ME. Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD Am J Psychiatry 2007 Sep;164(9):1348-1355.

Federal
Funding Agency	NIMH
Title	Genetics Repository of Bipolar Disorder, University of Pittsburg Subcontract.
Status	Active
Period	1/2004 - Present
Role	Principal Investigator
Grant Detail
Funding Agency	FasStep
Title	FasStep, University of Pittsburgh, (Subcontract no. MH063420-01).
Status	Active
Period	1/2004 - Present
Role	Principal Investigator
Grant Detail
Funding Agency	National Institute of Mental Health (NIMH)
Title	Optiminzing Outcomes in Bipolar illness Interventions in Hispanic Communities
Status	Active
Period	9/2011 - 6/2016
Role	Principal Investigator
Grant Detail	An Advanced Center for Interventions and/or Service Research was established to conduct research that will personalize community based treatment of bipolar disorders to improve outcomes. We will investigate interactions of cultural factors, adherence and engagement, behavioral domains and biological factors with outcomes, thereby providing a model that can transform current diagnostic and treatment paradigms for bipolar disorder. A major aim of this proposal is to better develop our understanding of bipolar disorder in the Hispanic American population, in particular the impact of acculturation on adherence to treatment programs. These efforts will equip us to serve as a national resource to advance the NIMH mission of reducing the burden of bipolar illness and improve outcomes through the efforts of research about treatments and their acceptability to patients, and broadly disseminate this research for the purposes of improving clinical care, public education and public health planning.
Funding Agency	NIMH
Title	Influence of Psychosis of Brain-Behavior Endophenotypes for Bipolar Disorder.
Status	Active
Period	5/2008 - 1/2013
Role	Co-Investigator
Grant Detail	The goal of this study was to establish biomarkers that could improve the identification and treatment of bi-polar I disorder patients.
Private
Funding Agency	Glaxo Wellcome
Title	A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Fixed-Dose Evaluation of the Safety and Efficacy of Lamotrigine in the Long-Term Prevention of Relapse and Recurrence of Depression and/or Mania in Patients with Bipolar I Disorder.
Status	Active
Period	1/1997 - Present
Role	Principal Investigator
Grant Detail
Funding Agency	Cyberonics, Inc.
Title	Randomized Comparison of Outcomes in Patients with Treatment-Resistant Depression who receive VNS Therapy Administered at Different Amounts of Electrical Charge
Status	Active
Period	12/2005 - Present
Role	Co-Principal Investigator
Grant Detail	This study is being done to compare different device settings(doses)for VNS Therapy with people who have treatment resistant depression.
Funding Agency	Abbott Laboratories, Inc.
Title	Safety and Efficacy of Depakote in the Prevention of Mania in Patients with Bipolar Disorder.
Status	Active
Period	1/1993 - Present
Role	Principal Investigator
Grant Detail
Funding Agency	Glaxo Wellcome
Title	A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Fixed-Dose Evaluation of the Safety and Efficacy of Lamotrigine in the Long-Term Prevention of Relapse and Recurrence of Depression and/or Mania in Patients with Bipolar I Disorder
Status	Complete
Period	1/1997 - Present
Role	Principal Investigator
Grant Detail
Funding Agency	Glaxo SmithKline
Title	Lamotrigine in the Treatment of Bipolar Disorder in Women of Reproductive Age.
Status	Active
Period	1/2005 - Present
Role	Principal Investigator
Grant Detail

Year	Degree	Discipline	Institution
1968	Postdoctoral Fellowship	Candidate in Psychoanalytic Training	Columbia Psychoanalytic Clinic for Training and Research New York , NY
1968	Residency	Psychiatry	New York State Psychiatric Institute and Presbyterian Hospital New York , NY
1965	Internship	Medicine	Presbyterian-St. Luke''s Hospital Chicago , IL
1964	MD	Medicine	Baylor College of Medicine Houston , TX
1960	BS	Pre-med	The University of Texas at Austin Austin , TX

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Bowden, Charles L.

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