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Lamb, Richard Jonathan PhD

School of Medicine
Psychiatry
(210) 567-5483
lamb@uthscsa.edu

Dr. Lamb has been actively involved in building the addiction research program at UTHSCSA through his research, through his collaborations, and through his training and mentoring. The research he directs has brought in over 7 million dollars in NIH R-type funding to UTHSCSA. This work has led to ongoing collaborative research with others at UTHSCSA: Some involving collaboration on his grant projects, e.g., his ongoing work with Dr. Ginsburg investigating the role Pavlovian Conditioned Stimuli in reinvigorating drug-seeking. Other collaborations here stem from the clinical research he has conducted examining how contingencies can be used to treatment substance abuse, e.g., his ongoing work with Dr. Dougherty. These collaborations here have brought in over 14 million dollars in NIH funding. Also, Dr. Lamb is involved in collaborative projects with investigators elsewhere, e.g., National Institute on Drug Abuse, RAND, and the UTSA: Work resulting in over 16 million dollars in NIH funding. Importantly, Dr. Lamb?s research is cross-disciplinary and integrates knowledge across fields. This work has given him a broad perspective that aids him in his training and mentoring in activities like the Addiction Journal Club integral to UTHSCSA?s T-32 postdoctoral training program in addiction. This, also, extends to other activities like his active participation in joint lab meetings and Psychiatry?s grant paper work group. Additionally, this broad perspective has led to several ongoing substantive reviews on addictive behavior. Finally, he works to raise the visibility of UTHSCSA Addiction Research Program through activities like the Behavior, Biology and Chemistry: Translational Research in Addiction meeting held annually in San Antonio.

Appointments Education Expertise Teaching Publications Grants

9/2002 - Present

Professor with Tenure

The University of Texas Health Science Center at San Antonio, Psychiatry and Pharmacology, San Antonio, TX

Biology of Behavior and Behavioral Pathology

- Dr. Lamb is involved in preclinical research investigating addictive behavior. In his preclinical research, he has become particularly interested in the transition between addiction and recovery, and in the relapse to addiction from recovery. On his current NIH grant, He and a former postdoctoral fellow of his who is now a tenured Associate Professor here, Dr. Brett Ginsburg, are examining the role played by Conditioned Stimuli in reinvigorating drug-seeking. Conditioned Stimuli are widely believed to play a crucial role in relapse, but methodological problems have limited the empirical evidence for this. Their current work is overcoming these methodological problems, and rigorously studying Conditioned Stimuli?s role in relapse. Dr. Lamb and Dr. Ginsburg plan to be co-PIs on the renewal of this project. Dr. Ginsburg and Dr. Lamb also developed a model of recovery that reduces an animal?s drug-taking in a more ecologically valid manner. In this model, drug-taking is reduced by reinforcing behavior competing with drug-taking while drug remains available, instead of, as is usually done, simply not delivering drug to the animal. As should happen, the animal?s propensity towards drug-taking declines the longer it is abstinent, which does not happen with the usual model. This idea of reducing drug use through reinforcing competing behavior stemmed from clinical work Dr. Lamb conducted with Dr. Martin Iguchi in 1997 showing that drug use could be reduced through reinforcing the development of behavior competing with drug use in methadone maintenance patients. Dr. Lamb has extended this research by using preclinical findings on how to change behavior to more effectively help smokers who would normally fail to stop smoking. As a result of his expertise in contingency management treatments, Dr. Lamb has an ongoing collaboration at UTHSCSA with Dr. Donald Dougherty developing contingency management treatments to reduce drinking in DWI offenders. Dr. Lamb is also involved in the development of grant applications examining contingency management treatments with Dr. Iguchi at RAND and a former Postdoctoral Fellow of his, Dr. Paul Romanowich at UTSA.

Journal Article

Lu, D, Thakur, GA, Fan, P, Steed, J, Tartal, CL, Hurst, DP, Reggio, PH, Deschaps, JRo, Parrish, DA, George, C, Jarbe, TOC, Lamb RJ, Makriyannis, A. Adamantyl Cannabinoids: A novel class of Cannabinergic ligands Journal of Medicinal Chemistry 2005 Jan;48(14):4576-4585.

Koek W, Carter, LP, Lamb RJ, Chen, W, Wu, H, Coop, A., France CP. Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam Journal of Pharmacology & Experimental Therapeutics 2005 Jan;314:170-179.

Javors MA, Hatch JP, Lamb RJ. Evaluation of cut-off levels for breath carbon monoxide as a marker for cigarette smoking over the past 24 hours Addiction 2005 Jan;100:159-167.

Ginsburg BC, Lamb RJ. Alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol: Substitution and interaction effects Alcoholism: Clinical and Experimental Research 2005 Jan;29(9):1621-1629.

Lamb RJ, Morral AR, Galbicka G, Kirby KC, Iguchi MY. Shaping reduced smoking in smokers without cessation plans Experimental and Clinical Psychopharmacology 2005 Jan;13(2):83-92.

Lamb RJ, Kirby KC, Morral AR, Galbicka G, Iguchi MY. Improving Contingency Management Programs for Addiction Addictive Behaviors 2004 Jan;29:507-523.

Lamb RJ, Morral AR, Kirby KC, Iguchi MY, Galbicka G. Shaping Smoking Cessation Using Percentile Schedules Drug and Alcohol Dependence 2004 Jan;76:247-259.

Kaminski BJ, Sannerud CA, Weerts EM, Lamb RJ, Griffiths RR. Physical dependence in baboons chronically treated with low and high doses of diazepam Behavioral Pharmacology 2003 Jan;14:331-342.

Wu H, Zink N, Carter L, Mehta AK, Hernandez RJ, Ticku MK, Lamb RJ, France CP, Coop A. A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand Journal of Pharmacology and Experimental Therapeutics 2003 Jan;305:675-679.

Jarbe TUC, Lamb RJ, Liu Q, Makriyannis A. (R)-Methanandamide and 9-tetrahydrocannabinol induced operant rate decreases in rats are not readily antagonized by SR-141716A European Journal of Pharmacology 2003 Jan;466:121-127.

Festinger DS, Lamb RJ, Marlowe DB, Kirby KC. From telephone to office: Intake attendance as a function of appointment delay Addictive Behaviors 2002 Jan;27(1):131-137.

Jarbe TUC, Lamb RJ, Lin S, Makriyannis A. (R)-Methanandamide and 9-tetrahydrocannabinol as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide Psychopharmacology 2001 Jan;156:369-380.

Lamb RJ, Jarbe TUC. Effects of Fluvoxamine on Ethanol-Reinforced Behavior in the Rat Journal of Pharmacology and Experimental Therapeutics 2001 Jan;297(3):1001-1009.

Jarbe TUC, Lamb RJ, Lin S, Makriyannis A. 9-THC training dose as a determinant for (R)-methanandamide generalization in rats: A systematic replication Behavioral Pharmacology 2000 Jan;11(1):81-86.

Lamb RJ, Jarbe TUC, Makriyannis A, Lin S, Goutopoulos A. Effects of 9-tetrahydrocannabino, (R)-methanandamide, SR 141716, and d-amphetamine before and during daily 9-tetrahydrocannabinol dosing European Journal of Pharmacology 2000 Jan;398:251-258.

Jarbe TUC, Lamb RJ. Effects of lithium dose (UCS) on the acquisition and extinction of a discriminated morphine aversion: tests with morphine and 9-THC Behavioral Pharmacology 1999 Jan;10:349-358.

Jarbe TUC, Lamb RJ. Discriminated taste aversion and context: a progress report Pharmacology Biochemistry and Behavior 1999 Jan;64(2):403-407.

Jarbe TUC, Sheppard R, Lamb RJ, Markriyannis A, Lin S, Goutopoulos W. Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats Behavioral Pharmacology 1998 Jan;9(2):169-174.

Kirby KC, Marlowe DB, Festinger DS, Lamb RJ, Platt JJ. Schedule of voucher delivery influences cocaine abstinence Journal of Consulting and Clinical Psychology 1998 Jan;66(5):761-767.

Jarbe TUC, Lamb RJ, Makriyannis A, Lin S, Goutopoulos W. delta-9-THC training dose as a determinant for (R)-methanandamide generalization Psychopharmacology 1998 Jan;140(4):519-522.

Iguchi MY, Belding MA, Morral AR, Lamb RJ, Husband SD. Reinforcing operants other than abstinence in drug abuse treatment: An effective alternative for reducing drug use Journal of Consulting and Clinical Psychology 1997 Jan;65(3):421-428.

Lamb RJ, Jarbe TUC. Multi-elemental stimulus control: Effects of saccharin concentration on a discriminated morphine-saccharin taste aversion Experimental and Clinical Psychopharmacology 1997 Jan;5(2):123-129.

Belding MA, Iguchi MY, Lamb P. Stages and processes of change as predictors of drug use among methadone maintenance patients Experimental and Clinical Psychopharmacology 1997 Jan;51(1):63-73.

Morral AR, Iguchi MY, Belding MA, Lamb RJ. Natural classes of treatment response Journal of Consulting and Clinical Psychology 1997 Jan;65(4):673-685.

Husband SD, Marlowe DB, Lamb RJ, Iguchi DA, Kirby KC, Platt JJ. Decline in self-reported dysphoria after treatment entry in inner-city cocaine addicts Journal of Consulting and Clinical Psychology 1996 Jan;64:221-224.

Iguchi MY, Lamb RJ, Belding MA, Platt JJ, Husband SD, Morral AR. Contingent reinforcement of group participation versus abstinence in a methadone maintenance program Experimental and Clinical Psychopharmacology 1996 Jan;4:315-321.

Lamb RJ, Kirby KC, Platt JJ. Treatment retention, occupational role, and cocaine use in methadone maintenance American Journal of Addictions 1996 Jan;5(1):12-17.

Festinger DS, Lamb RJ, Kirby KC, Marlowe DB. The accelerated intake: A method for increasing initial attendance to outpatient cocaine treatment Journal of Applied Behavioral Analysis 1996 Jan;29:387-389.

Belding MA, Iguchi MY, Lamb RJ. Stages of Change in methadone maintenance: Assessing the convergent validity of two measures Psychology of Addictive Behaviors 1996 Jan;10:157-166.

Belding MA, Iguchi MY, Lamb RJ, Lakin M, Terry R. Coping Strategies and Continued Drug Use Among Methadone Maintenance Patients Addictive Behaviors 1996 Jan;21(3):389-401.

Jarbe TUC, Lamb RJ. Discriminated conditioned taste aversion for studying multi-elemental stimulus control Behavioral Pharmacology 1995 Jan;6:149-155.

Bux DA, Lamb RJ, Iguchi MY. Cocaine use and HIV risk behavior in methadone patients Drug and Alcohol Dependence 1995 Jan;37:29-35.

Belding MA, Iguchi MY, Lamb RJ, Lakin M, Terry R. Stages and processes of change among polydrug users in methadone maintenance treatment Drug and Alcohol Dependence 1995 Jan;39:45-53.

Festinger DS, Lamb RJ, Kountz M, Kirby KC, Marlowe D. Pre-treatment dropout as a function of treatment delay and client variables Addictive behaviors 1995 Jan;20(1):111-115.

Marlowe DB, Husband SD, Lamb RJ, Kirby KC, Iguchi MY, Platt JJ. Psychiatric comorbity in cocaine dependence: Diverging trends, axis II spectrum and gender differentials American Journal of Addictions 1995 Jan;4(1):70-81.

Kirby KC, Lamb RJ, Iguchi MY, Husband SD, Platt JJ. Situations occasioning cocaine use and cocaine abstinence strategies Addiction 1995 Jan;90:1241-1252.

Lamb RJ, Henningfield JE. Human d-amphetamine drug discrimination: Methamphetamine and hydromorphone Journal of the Experimental Analysis of Behavior 1994 Jan;61:169-180.

Lamb RJ, Griffiths RR. Behavioral Effects of Pentobarbital, Lorazepam, Ethanol and Chlorpromazine Substitution in Pentobarbital-Dependent Baboons Journal of Phyamacology and Experimental Therapeutics 1993 Jan;265(1):47-52.

Griffiths RR, Lamb RJ, Sannerud CA, Ator NA, Brady JV. Self-injection of barbiturates, benzodiazepines and other sedative-anxiolytics in baboons Psychopharmacology 1991 Jan;103:154-161.

Lamb RJ, Preston KL, Schindler CW, Meisch RA, Davis F, Katz JL, Goldberg SR, Henningfield JE. The reinforcing and subjective effects of morphine in post-addicts: A dose-response study Journal of Pharmacology and Experimental Therapeutics 1991 Jan;259(3):1165-1173.

Lamb RJ, Griffiths RR. Self-Administration in baboons and discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipramine Psychopharmacology 1990 Jan;102:183-190.

Higgins ST, Lamb RJ, Henningfield JE. Dose-dependent effects of atropine on behavioral and physiologic responses in humans Pharmacology Biochemistry and Behavior 1989 Jan;34:303-311.

Lamb RJ, McMillan DE. Some effects of desmethylimipramine and amitriptyline on the schedule-controlled behavior of pigeons and rats Archives internationale de Pharmacodynamics 1989 Jan;302:49-67.

Lamb RJ, Sannerud CA, Griffiths RR. An examination of the intravenous self-administration of phenylpropanolamine using a cocaine substitution procedure in the baboon Pharmacology Biochemistry and Behavior 1987 Jan;28(3):389-392.

Lamb RJ, Griffiths RR. Self-injection of MDMA (3, 4-methylenedioxy-methamphetamine) in the baboon Psychopharmacology 1987 Jan;91:268-272.

Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. Cocaine receptors on dopamine transporters are related to cocaine self-administration Science 1987 Jan;237:1219-1223.

Lamb RJ, Griffiths RR. Effects of Ro 15-1788 and CGS 8216 in diazepam-dependent baboons European Journal of Pharmacology 1987 Jan;143:205-212.

Lamb RJ, McMillan DE. The effects of some putative antidepressant agents on the schedule-controlled behavior of the pigeon Psychopharmacology 1986 Jan;88:368-373.

Griffiths RR, Brady JV, Ator NA, Lamb RJ, Bigelow GE, Roache JD. Progress report from the Division of Behavioral Biology, The Johns Hopkins University School of Medicine. In: Problems of Drug Dependence 1985: Proceedings of the 47th Annual Meeting of the College on Problems of Drug Dependence, National Institute on Drug Abuse Research Monograph 1986 Jan;67:93-97.

Lamb RJ, McMillan DE. Some effects of chlorimipramine and imipramine on the schedule-controlled behavior of the pigeon Psychopharmacology 1985 Jan;87:7-11.

Lamb RJ, Griffiths RR. Effects of repeated Ro 15-1788 administration in benzodiazepine-dependent baboons European Journal of Pharmacology 1985 Jan;110:257-261.

Lamb RJ, Griffiths RR. Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896 Drug and Alcohol Dependence 1984 Jan;14:11-17.

Review Article

Kirby KC, Marlowe DB, Lamb RJ, Platt JJ. Behavioral Treatments of cocaine addiction: Assessing patient needs and improving treatment entry and outcome Journal of Drug Issues 1997 Jan;27(2):417-429.

Compton WM, Lamb RJ, Fletcher BW. Results of the NIDA treatment demonstration grants cocaine workgroup: characteristics of cocaine users and HIV risk behaviors Drug and Alcohol Dependence 1995 Jan;37:1-6.

Lamb RJ, Yeh I. Tuberculosis, AIDS and i.v. Drug Use New Jersey Medicine 1990 Jan;87(5):413-415.

Goldberg SR, Schindler CW, Lamb RJ. Second-Order Schedules and the Analysis of Human Drug-Seeking Behavior Drug Development Research 1990 Jan;20:217-229.

Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. Cocaine receptors related to drug self-administration and substance abuse Progress in Neuropsychopharmacology and Biological Psychiatry 1988 Jan;12:233-239.

Federal
Funding Agency	NIDA
Title	Training in Drug Abuse Research: Behavior and Neurobiology
Status	Active
Period	7/2011 - 3/2021
Role	Contributor
Grant Detail	This postdoctoral training program builds on a rapidly growing community of drug and alcohol abuse researchers and trainees at UTHSCSA. The well recognized need for addiction scientists with interdisciplinary training is addressed by this program in which trainees conduct research on collaborative projects spanning more than one laboratory and more than one experimental approach. An experienced Program Director along with 17 other preceptors and an expert External Advisory Committee will oversee the progress and further growth of drug and alcohol abuse training at UTHSCSA.
Funding Agency	NIH/NIAAA
Title	Rat Ethanol Self-administration and respondent instrumental interactions. formal title:Fluvoxamine on rat ethanol self-administration
Status	Active
Period	9/2001 - 7/2018
Role	Principal Investigator
Grant Detail
Funding Agency	National Institues of Health: National Institute of Alcohol Abuse and Alcoholism
Title	Binge Drinking: Individual Differences in the Capacity to Alter Drinking Patterns
Status	Active
Period	4/2010 - 3/2017
Role	Co-Investigator
Grant Detail	This study of binge and non-binge drinkers will examine how impulsivity is affected by alcohol and/or reductions in serotonin synthesis, and then determine how these observed effects are related to the capacity to modify drinking patterns
Funding Agency
Title	Behavior; Biology; and Chemistry:Translational Research in Addiction
Status	Active
Period	3/2011 - 2/2017
Role	Contributor
Grant Detail
Funding Agency	NIH
Title	South Texas Advanced Research Training: Undergraduate Program (START-UP)
Status	Complete
Period	9/2010 - 8/2015
Role	Contributor
Grant Detail	The purpose of this program is to increase the number of underrepresented minorities (URMs) entering doctoral programs in the neurosciences and then the biomedical workforce as Ph.D.?s. URMs are defined by ethnicity, socio-economic status and disabilities.

Year	Degree	Discipline	Institution
1983	PhD	Pharmacology	University of Arkansas for Medical Science Little Rock , AR
1979	AB	Biology	The University of Chicago Chicago , IL
	Postdoctoral Fellowship	Behavioral Biology	The John Hopkins University School of Medicine, Department of Psychiatry Baltimore , MD
	Clinical Fellowship	Pharmacology	Clinical Pharmacology Branch, Addiction Research Center Baltimore , MD

Date	Description	Institution	# Students
12/2007 - Present		UTHSCSA

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Lamb, Richard Jonathan PhD

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