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Royall, Donald R MD

School of Medicine
Psychiatry
(210) 567-1255
royall@uthscsa.edu

Objectives: clinical /translational geriatric research with special interests in geriatric assessment, the cognitive correlates of functional outcomes, executive function, and dementing illnesses.

Appointments Education Expertise Teaching Publications Grants

10/2019 - Present	Research Investigator and Without Compensation (WOC) research appointment	Audie L. Murphy VA Hospital, Research Service, San Antonio, TX
9/2019 - Present	Research Investigator and Research Professor	Glenn Biggs Institute for Alzheimer`s and Neurodegenerative Disorders, San Antonio, TX
10/2009 - Present	Professor; Department of Family & Community Medicine	University of Texas Health Science Center at San Antonio, Family & Community Medicine, San Antonio, TX
1/2000 - Present	Professor; Department of Medicine	University of Texas Health Science Center at San Antonio, Medicine, San Antonio, TX
1/2000 - Present	Professor; Department of Psychiatry	University of Texas Health Science Center at San Antonio, Psychiatry, San Antonio, TX
1/1994 - Present	Director of Research	Freedom House Foundation, San Antonio, TX
1/1994 - Present	Geriatric Psychiatry Consultant	Air Force Village Retirement Community, Psychiatry, San Antonio, TX

Abstract

Colmenarez M, Silzer T, Royall DR, Palmer RF, Barber R, Phillips N. `D? is for Dementia: Genomic architecture of the latent variable δ in Mexican Americans and non-Hispanic whites; 2020 Jan. (TARCC 2020 Scientific Symposium- An Investigator Meeting. January 30, 2020. Austin, TX).

Royall DR, Palmer RF. Serum Resistin Mediates the Effect of Cholinesterase Inhibitors on Prospective Cognitive Performance. Depression Symptoms Attenuate it; 2020 Jan. (TARCC 2020 Scientific Symposium- An Investigator Meeting. January 30, 2020. Austin, TX).

Palmer RF, Royall DR. Frailty Mediates Senility in Mexican Americans; 2019 Jan. (Innovation in Aging; vol. 3, no. S1).

Palmer RF, Royall DR. Frailty Mediates Senility in Mexican-Americans; 2019 Jan. (Journal of Frailty and Aging; vol. 8, no. S1).

Royall DR. δ Predicts General Psychopathology; 2019 Jan. (Innovation in Aging; vol. 3, no. S1).

Al-Rubaye S, Palmer RF, Royall DR. Epidermal Growth Factor Family: Biomarkers of Education?s Effect on Cognition; 2018 Jan. (American Journal of Geriatric Psychiatry; vol. 26).

Al-Rubaye S, Palmer RF, Royall DR. CRP as a mediator of APOE on dementia; 2018 Jan. (The American Journal of Geriatric Psychiatry; vol. 25).

Royall DR. Serum protein mediators of gender?s association with dementia; 2018 Jan. (Pathology of Aging and Age-related Disease; vol. 8).

Royall DR, Bishnoi R, Palmer RF. A δ Homolog for Dementia Case Finding with Replication in ADNI; 2018 Jan. (Alzheimer?s & Dementia: The Journal of the Alzheimer's Association; vol. 14).

Benavente KSK, Palmer R, Royall DR. Serum Adiponectin is related to dementia; 2018 Jan. (American Association for Geriatric Psychiatry; vol. 26).

Royall DR, Bishnoi R, Palmer RF. Blood-based protein predictors of dementia severity as measured by δ: Replication across biofluids and cohorts; 2018 Jan. (Alzheimer?s & Dementia: The Journal of the Alzheimer's Association; vol. 14).

Rodriguez P, Woolsey M, Polk M, Altmeyer W, Fox PT, Royall DR, Gonzalez-Lima F, Duong TQ. Methylene blue modulates resting functional connectivity in the elderly human brain; 2018 Jan. (American Society of Neuroradiology (ASNR) 56th Annual Meeting Proceedings).

Royall DR, Palmer RF. Amyloid burden predicted by cognitive assessment; 2018 Jan. (Alzheimer?s & Dementia: The Journal of the Alzheimer's Association; vol. 14).

Royall DR. Interleukins as biomarkers of education?s effect on cognition; 2018 Jan. (Journal of Neuropsychiatry and Clinical Neurosciences; vol. 30).

Royall DR, Palmer RF. Prediction of APOE ε4 Burden from cognitive assessment; 2018 Jan. (Alzheimer?s & Dementia: The Journal of the Alzheimer's Association; vol. 14).

Al-Rubaye S, Royall DR, Palmer RF. S100B Mediates Depression?s Effect on Cognition; 2017 Jan. (Alzheimer?s & Dementia: The Journal of the Alzheimer's Association; vol. 13).

Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF. Serum protein mediators of Age?s association with dementia; 2017 Jan. (Proceedings of the 2017 Dallas Aging and Cognition Conference).

Royall DR. Anticholinergic risk scale was not associated with cognition or disability in older veterans referred to a geriatrics memory clinic; 2017 Jan. (Journal of the American Geriatrics Society; vol. 65, no. S1).

Al-Rubaye S, Palmer RF, Royall DR. Serum resistin mediates depression?s effect on cognition; 2017 Jan. (Journal of Neuropsychiatry and Clinical Neurosciences; vol. 29).

Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF. Serum Proteins Mediate Depression?s Association with Dementia; 2016 Jan. (Journal of Prevention of Alzheimer?s Disease; vol. 3).

Al-Rubaye S, Palmer RF, Royall DR. Serum IGF-1 Mediates Age?s Effect on Cognition; 2016 Jan. (Journal of Neuropsychiatry and Clinical Neurosciences; vol. 28).

Al-Rubaye S, Palmer RF, Royall DR. Amphiregulin Mediates APOE?s Association with Demntia and Ethnicity Moderates both Associations; 2016 Jan. (Alzheimer?s & Dementia: The Journal of the Alzheimer's Association; vol. 12).

Royall DR, Al-Rubaye S, Bishnoi, R, Palmer RF. Serum protein biomarkers of δ fully mediate multiple AD conversion risks and offer targets for intervention; 2016 Jan. (Journal of Prevention of Alzheimer?s Disease; vol. 3).

Royall DR, Palmer RF. δ Scores Predict MCI and AD Conversions from Non-Demented States; 2015 Jan. (Journal of Prevention of Alzheimer?s Disease; vol. 2).

Horton MS, Schillerstrom JE, Earthman BS, Joshi KG, Schillerstrom TL, Velez AM, Royall DR. Prevalence of executive impairment on a general medicine ward; 2003 Jan. (Journal of the American Geriatrics Society; vol. 51).

Book Chapter

Royall DR. Executive Interview. In: Kreutzer J, DeLuca J, Caplan B (Eds.). Encyclopedia of Clinical Neuropsychology. 2nd. Ed. 2018. p. 992-997.

Editorial

Royall DR. The assessment of dementia by the latent variable ?δ? Journal of Alzheimer?s Disease, 2016 Jan;49:515-519.

Journal Article

Benavente KSK, Palmer R, Royall DR. Serum Adiponectin is related to dementia Journals of Gerontology: Series A: Medical Science 2020 Jan;75:779-783.

Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang LS, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR; Alzheimer?s Disease Genetics Consortium. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study Nature Communications 2020 Jan;11.

Royall DR, Palmer, RF. δ-related biomarkers attenuate multiple AD conversion risks and offer targets for intervention Journals of Gerontology: Series A: Medical Science, in press 2020 Jan;.

Royall DR. Blood-based protein mediators of senility with replications across biofluids and cohorts Brain Communications 2020 Jan;.

Royall DR, Palmer, RF. Selection for depression-specific dementia cases with replication in two cohorts PLoS ONE 2019 Jan;14.

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg Sealock JS, Karlsson IK, Hagg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, Almdahl IS, Andersen F, Bergh S, Bettella F, Bjornsson S, Br?khus A, Br?then G, de Leeuw C, Desikan RS, Djurovic S, Dumitrescu L, Fladby T, Hohman TJ, Jonsson PV, Kiddle SJ, Rongve A, Saltvedt I, Sando SB, Selb?k G, Shoai M, Skene NG, Snaedal J, Stordal E, Ulstein ID, Wang Y, White LR, Hardy J, Hjerling-Leffler J, Sullivan PF, van der Flier WM, Dobson R, Davis LK, Stefansson H, Stefansson K, Pedersen NL, Ripke S, Andreassen OA, Posthuma D. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer?s disease risk Nature Genetics 2019 Jan;51:404-413.

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernandez I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, ?Schneider LS, Slifer S, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y; Alzheimer Disease Genetics Consortium (ADGC),; European Alzheimer?s Disease Initiative (EADI),; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),; Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer?s Disease Consortium (GERAD/PERADES),, Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett D, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, C O'Donovan M, DeStefano AL, Jones L, Haines JL, Deleuze JF,. Meta-analysis of genetic association with diagnosed Alzheimer`s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing Nature Genetics 2019 Jan;51:414-430.

Royall DR. A δ homolog for dementia case finding with replication in the Alzheimer's Disease Neuroimaging Initiative Journal of Alzheimer?s Disease 2019 Jan;67:67-79.

Royall DR, Palmer RF. δ scores identify subsets of ?Mild Cognitive Impairment? with variable conversion risks Journal of Alzheimer?s Disease 2019 Jan;70:199-210.

Royall DR, Bishnoi R, Palmer RF. Blood-based protein predictors of dementia severity as measured by δ: Replication across biofluids and cohorts Alzheimer?s & Dementia: Diagnosis, Assessment & Disease Monitoring 2019 Jan;11:763-774.

Royall DR. A potential telephone assessment of dementia diagnosis and severity Journal of Neuropsychiatry and Clinical Neurosciences 2018 Jan;30:202-207.

Peloso GM, van der Lee SJ; International Genomics of Alzheimer's Project (IGAP), Destefano AL, Seshardi S. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease Alzheimers & Dementia (Amst) 2018 Jan;10:595-598.

Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Gifford KA, Bush WS, Chibnik, LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Bennett DA, Schneider J, Jefferson AL, Blennowe K, Abner E, Adams P, Albin R, Apostolova L, Arnold S, Asthana S, Atwood C, Baldwin C, Barber R, Barral S, Beach T, Becker J, Beekly D, Bennett D, Bigio E, Bird T, Blacker D, Boeve B, Bowen J, Boxer A, Burke J, Burns J, Buxbaum J, Cairns N, Cantwell L, Cao C, Carlson C, Carlsson C, Carney R, Carrasquillo M, Chui H, Crane P, Cribbs D, Crocco E, Cruchaga C, De Jager P, DeCarli C, Dick, M, Dickson D, Doody R, Duara R, Ertekin-Taner N, Evans D, Faber K, Fairchild T, Fallon K, Fardo D, Farlow M, Farrer L, Ferris S, Foroud T, Frosch M, Galasko D, Gearing M, Geschwind, D, Ghetti B, Gilbert J, Goate A, Graff-Radford N, Green R, Growdon, J, Haines J, Hakonarson, H., Hamilton, R., Hamilton-Nelson, K.aj, Hardy, J.bm, Harrell, L.bd, Honig, L.ag, Huebinger, R.x, Huentelman, M.bn, Hulette, C.aq, Hyman, B.bf, Jarvik, G.ak, Jin, L.-W.ba, Jun, G.ad, Kamboh, M.I.bl, Karydas, A.ap, Katz, M.bo, Kauwe, J.bp, Kaye, J.bq, Kim, R.ax, Kowall, N.ad, Kramer, J.ap, Kuzma, A.ab, LaFerla, F.ax, Lah, J.bh, Larson, E.ak, Leverenz, J.br, Levey, A.bh, Li, G.bs, Lieberman, A.z, Lipton, R.bo, Lopez, O.bt, Lunetta, K.ad, Lyketsos, C.y, Malamon, J.ab, Marson, D.bd, Martin, E.aj, Martiniuk, F.be, Mash, D.aj, Masliah, E.bg, Mayeux, R.ag, McCormick, W.ak, McCurry, S.ak, McDavid, A.av, McDonough, S.bu, McKee, A.ad, Mesulam, M.al, Miller, B.ap, Miller, C.aw, Miller, J.ba, Montine, T.ak, Morris, J.at, Myers, A.aj, Naj, A.ab, O'Bryant, S.ae, Olichney, J.ba, Parisi, J.an, Paulson, H.z, Pericak-Vance, M.aj, Peskind, E.bv, Petersen, R.an, Pierce, A.ax, Poon, W.ax, Potter, H.bw, Qu, L.ab, Quinn, J.bq, Raj, A.au, Raskind, M.bv, Reiman, E.bn, Reisberg, B.be, Reisch, J.x, Reitz, C.ag, Ringman, J.aw, Roberson, E.bd, Rogaeva, E.bx, Rosen, H.ap, Rosenberg, R.by, Royall, D.bz, Sager, M.ac, Sano, M.as, Saykin, A.aa, Schellenberg, G.ab, Schneider, J.af, Schneider, L.aw, Seeley, W.ap, Smith, A.au, Sonnen, J.ak, Spina, S.aa, St George-Hyslop, P.bx, Stern, R.ad, Swerdlow, R.ar, Tanzi, R.bf, Trojanowski, J.ab, Troncoso, J.y, Tsuang, D.bs, Valladares, O.ab, Van Deerlin, V.ab, Van Eldik, L.w, Vardarajan, B.ag, Vinters, H.bi, Vonsattel, J.P.ag, Wang, L.-S.ab, Weintraub, S.al, Welsh-Bohmer, K.aq, Wilhelmsen, K.ca, Williamson, J.ag, Wingo, T.bh, Woltjer, R.bq, Wright, C.aj, Wu, C.-K.cb, Younkin, S.an, Yu, C.-E.ak, Yu, L.af, Zhao, Y. Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau JAMA Neurology 2018 Jan;75:989-998.

Deming, Y.a, Dumitrescu, L.b, Barnes, L.L.c, Thambisetty, M.d, Kunkle, B.e, Gifford, K.A.b, Bush, W.S.e, Chibnik, L.B.f,g, Mukherjee, S.h, de Jager, P.L.i,j, Kukull, W.k, Huentelman, M.l, Crane, P.K.h, Resnick, S.M.d, Keene, C.D.m, Montine, T.J.n, Schellenberg, G.D.o, Haines, J.L.e, Zetterberg, H.p,q,r,s, Blennow, K.p,q, Larson, E.B.h,t, Johnson, S.C.u,v, Albert, M.w, Moghekar, A.w, Del Aguila, J.L.a, Fernandez, M.V.a, Budde, J.a, Hassenstab, J.a, Fagan, A.M.x, Riemenschneider, M.y, Petersen, R.C.z, Minthon, L.aa, Chao, M.J.ab, van Deerlin, V.M.ac, Lee, V.M.-Y.ac, Shaw, L.M.ac, Trojanowski, J.Q.ac, Peskind, E.R.ad, Li, G.ad,ae, Davis, L.K.af, Sealock, J.M.af, Cox, N.J.af, Weiner, M.W.ag, Petersen, R.ag, Aisen, P.ag, Jack, C.ag, Jagust, W.ag, Shaw, L.M.ag, Trojanowski, J.ag, Beckett, L.ag, Toga, A.ag, Saykin, A.ag, Morris, J.C.ag, Montine, T.ag, Green, R.ag, Abner, E.ag, Adams, P.ag, Albert, M.ag, Albin, R.ag, Apostolova, L.ag, Arnold, S.ag, Asthana, S.ag, Atwood, C.ag, Baldwin, C.ag, Barber, R.ag, Barnes, L.ag, Barral, S.ag, Beach, T.ag, Becker, J.ag, Beecham, G.ag, Beekly, D.ag, Bennett, D.ag, Bigio, E.ag, Bird, T.ag, Blacker, D.ag, Boeve, B.ag, Bowen, J.ag, Boxer, A.ag, Burke, J.ag, Burns, J.ag, Buxbaum, J.ag, Cairns, N.ag, Cantwell, L.ag, Cao, C.ag, Carlson, C.ag, Carlsson, C.ag, Carney, R.ag, Carrasquillo, M.ag, Chui, H.ag, Crane, P.ag, Cribbs, D.ag, Crocco, E.ag, Cruchaga, C.ag, de Jager, P.ag, DeCarli, C.ag, Dick, M.ag, Dickson, D.ag, Doody, R.ag, Duara, R.ag, Ertekin-Taner, N.ag, Evans, D.ag, Faber, K.ag, Fairchild, T.ag, Fallon, K.ag, Fardo, D.ag, Farlow, M.ag, Farrer, L.ag, Ferris, S.ag, Foroud, T.ag, Frosch, M.ag, Galasko, D.ag, Gearing, M.ag, Geschwind, D.ag, Ghetti, B.ag, Gilbert, J.ag, Goate, A.ag, Graff-Radford, N.ag, Green, R.ag, Growdon, J.ag, Haines, J.ag, Hakonarson, H.ag, Hamilton, R.ag, Hamilton-Nelson, K.ag, Hardy, J.ag, Harrell, L.ag, Honig, L.ag, Huebinger, R.ag, Huentelman, M.ag, Hulette, C.ag, Hyman, B.ag, Jarvik, G.ag, Jin, L.-W.ag, Jun, G.ag, Ilyas Kamboh, M.ag, Karydas, A.ag, Katz, M.ag, Kauwe, J.ag, Kaye, J.ag, Dirk Keene, C.ag, Kim, R.ag, Kowall, N.ag, Kramer, J.ag, Kukull, W.ag, Kunkle, B.ag, Kuzma, A.ag, LaFerla, F.ag, Lah, J.ag, Larson, E.ag, Leverenz, J.ag, Levey, A.ag, Li, G.ag, Lieberman, A.ag, Lipton, R.ag, Lopez, O.ag, Lunetta, K.ag, LyketsosC.ag, Malamon, J.ag, Marson, D.ag, Martin, E.ag, Martiniuk, F.ag, Mash, D.ag, Masliah, E.ag, Mayeux, R.ag, McCormick, W.ag, McCurry, S.ag, McDavid, A.ag, McDonough, S.ag, McKee, A.ag, Mesulam, M.ag, Miller,B.ag, Miller, C.ag, Miller, J.ag, Montine, T.ag, Morris, J.ag, Mukherjee, S.ag, Myers, A.ag, Naj, A.ag, O?Bryant, S.ag, Olichney, J.ag, Parisi, J.ag, Paulson, H.ag, Pericak-Vance, M.ag, Peskind, E.ag, Petersen, R.ag, Pierce, A.ag, Poon, W.ag, Potter, H.ag, Qu, L.ag, Quinn, J.ag, Raj, A.a. Sex-specific genetic predictors of Alzheimer?s disease biomarkers Acta Neuropathologica 2018 Jan;136:857-872.

Woodward MR, Hafeez MU, Qi Q, Riaz A, Benedict RHB, Yan L, Szigeti K, Pavlik V, Massman M, Darby E, Rodriguear M, Khaleeq Ansari A, DeToledo JC, Reddy H, Wilms H, Johnson K, Perez V, Fairchild T, Knebl J, O'Bryant SE, Hall JR, Johnson L, Barber RC, Mains D, Alvarez L, Cullum M, Rosenberg R, Williams B, Quiceno M, Reisch J, Hynan L, Huebinger R, Smith J, Nguyen T, Royall D, Palmer R, Polk M, Stevens A, Ory M, Paydarfar D, Bertelson J, Woon M, Ayres G, Aguirre A, Wilhelmsen KC, Tilson JL and the Texas Alzheimer's Research, Care Consortium. Odorant item specific olfactory identification deficit may differentiate Alzheimer Disease from aging American Journal of Geriatric Psychiatry 2018 Jan;26:835-846.

Talley AE, Schillerstrom JE, Royall DR. Clock Copying Predicts Mortality in Adult Protective Services Clients American Journal of Geriatric Psychiatry 2017 Jan;25:1012-1016.

Salazar R, Alok D, Royall DR. Cross-ethnic Differences in the burdens of Neuropsychiatric Symptoms in persons with Mild Cognitive Impairment and Alzheimer`s Disease Journal of Neuropsychiatry and Clinical Neurosciences 2017 Jan;29:13-21.

Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF. Few serum proteins mediate APOE?s association with dementia PLoS One 2017 Jan;12.

Royall DR. δ scores predict MCI and AD conversions from non-demented states Alzheimer?s & Dementia: Diagnosis, Assessment & Disease Monitoring 2017 Jan;6:214-221.

Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF. Serum protein mediators of depression?s association with dementia PLoS One 2017 Jan;12.

Royall DR. Exportation and validation of latent constructs for dementia case-finding in a Mexican-American Population-based Cohort Journals of Gerontology: Series B: Psychological Science 2017 Jan;72:947-955.

Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JS, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR; Alzheimer's Disease Genetics Consortium., Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer's disease loci Alzheimers & Dementia 2017 Jan;13:727-738.

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nothen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sanchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-Garcia A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henandez I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossu P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairen MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleo A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J; ARUK Consortium, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Mo. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease Nature Genetics 2017 Jan;49:1373-1384.

Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JS; Alzheimer's Disease Genetics Consortium (ADGC). Adams PM, Albert MS, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barber RC, Barmada MM, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, De Jager PL, DeCarli C, Demirci FY, Dick M, Dickson DW, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Frosch MP, Galasko DR, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hamilton-Nelson KL, Hardy J, Harrell LE, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karydas A, Katz MJ, Kauwe JSK, Kaye JA, Kim R, Kowall NW, Kramer JH, Kukull WA, Kunkle BW, LaFerla FM, Lah JJ, Larson EB, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lipton RB, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Mukherjee S, Murrell JR, Myers AJ, Naj AC, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Partch A, Paulson HL, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Wendland JR, Wilhelmsen KC, Williamson J, Wingo TS, Winslow AR, Wishnek S, Woltjer RL, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L. Assessment of the genetic variance of late-onset Alzheimer's disease Neurobiology of Aging 2016 Jan;41:200e13-e20.

Royall DR, Palmer RF. Future dementia severity is almost entirely explained by the latent variable δ?s intercept and slope Journal of Alzheimer?s Disease 2016 Jan;49:521-529.

Royall DR, Palmer RF. Thrombopoietin is associated with δ`s intercept, and only in Non-Hispanic Whites Alzheimer?s & Dementia: Diagnosis, Assessment & Disease Monitoring 2016 Jan;3:35-42.

Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF. Serum protein mediators of dementia and Aging Proper Aging 2016 Jan;8:3241-3254.

Royall DR, Palmer RF, Matsuoka T, Kato Y, Taniguchi S, Ogawa M, Fujimoto H, Okamura A, Shibata K, Nakamura K, Nakaaki S, Koumi H, Mimura M, Fukui K, Narumoto J. Greater than the sum of its parts: δ can be constructed from item-level data Journal of Alzheimer?s Disease 2016 Jan;49:571-579.

Royall DR, Palmer RF, Matsuoka T, Kato Y, Taniguchi S, Ogawa M, Fujimoto H, Okamura A, Shibata K, Nakamura K, Nakaaki S, Koumi H, Mimura M, Fukui K, Narumoto J. δ-scores are exportable across cultural and linguistic boundaries Journal of Alzheimer?s Disease 2016 Jan;49:561-570.

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tarraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdottir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nothen MM, Hofman A, Jones L; IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer disease locus located near the gene encoding tau protein Molecular Psychiatry 2016 Jan;21:108-117.

Bishnoi R Palmer RF Royall DR. Vitamin D Binding Protein as a Serum Biomarker of Alzheimer Disease Journal of Alzheimer?s Disease 2015 Jan;43:37-45.

Royall DR, Matsuoka T, Palmer RF, Kato Y, Taniguchi S, Ogawa M, Fujimoto H, Okamura A, Shibata K, Nakamura K, Nakaaki S, Koumi H, Mimura M, Fukui K, Narumoto J. Greater than the sum of its parts: δ improves upon a battery`s diagnostic performance Neuropsychology 2015 Jan;29:683-692.

Royall DR Bishnoi R Palmer RF. Serum IGF-BP2 Strongly Moderates Age?s Effect on Cognition: A MIMIC Analysis Neurobiology of Aging 2015 Jan;36:2232-2240.

Royall DR, Palmer RF. The temporospatial evolution of neuritic plaque-related and independent tauopathies: implications for dementia staging Journal of Alzheimers Disease 2014 Jan;40(3):541-549.

Royall DR Palmer RF. Does Ethnicity Moderate Dementia?s Biomarkers? Neurobiology of Aging 2014 Jan;35:336-344.

Royall DR, Palmer RF. Alzheimer pathology does not mediate the association between depressive symptoms and subsequent cognitive decline Alzheimer?s Disease & Dementia 2013 Jan;9:318-325.

Royall DR, Palmer RF, Vidoni ED, Honea RA. The Default Mode Network may be the key substrate of depression related cognitive changes Journal of Alzheimer?s Disease 2013 Jan;34:547-560.

Royall DR, Palmer RF, White LR, Petrovitch H, Ross GW, Masaki K. Modeling regional vulnerability to Alzheimer pathology Neurobiology of Aging 2012 Aug;33(08):1556-1563.

Royall DR, Palmer RF, O`Bryant SE. Validation of a Latent Variable Representing the Dementing Process J Alzheimers Dis 2012 Jun;30:639-649.

Royall DR, Palmer R, Chiodo LK, Polk MJ. Depressive symptoms predict longitudinal change in executive control but not memory Int J Geriatr Psychiatry 2012 Jan;27(01):89-96.

Royall DR, Palmer RF, Vidoni ED, Honea RA, Burns JM. The Default Mode Network and Related Right Hemisphere Structures may be the Key Substrates of Dementia J Alzheimers Dis 2012 Jan;32:467-478.

Royall DR, Palmer RF. Getting Past "g": testing a new model of dementing processes in persons without dementia J Neuropsychiatry Clin Neurosci 2012 Jan;24(1):37-46.

King AE, Mintz J, Royall DR. Meta-analysis of (123) I-MIBG cardiac scintigraphy for the diagnosis of Lewy body-related disorders Mov Disord 2011 Jun;26(7):1218-1224.

Kochunov P, Ramage AE, Lancaster JL, Robin DA, Narayana S, Coyle T, Royall DR, Fox P. Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging Neuroimage 2009 Mar;45(1):17-28.

Schillerstrom JE, Rickenbacker D, Joshi KG, Royall DR. Executive function and capacity to consent to a noninvasive research protocol Am J Geriatr Psychiatry 2007 Feb;15(2):159-162.

Royall DR. Aging is a weak but relentless determinant of dementia severity Oncotarget (Gerotarget/Aging) 2001 Feb;7:13307-13318.

Royall DR, Rauch R, Roman GC, Cordes JA, Polk MJ. MRI findings associated with impairment on the Executive Interview (EXIT25) Experimental Aging Research 2001 Jan;27:293-308.

Royall DR, Cordes J, Polk M. Executive control and the comprehension of medical information by elderly retirees Exp Aging Res 1997 Jan;23(4):301-313.

Gallo JJ, Royall DR, Anthony JC. Risk factors for the onset of depression in middle age and later life Soc Psychiatry Psychiatr Epidemiol 1993 Jul;28(3):101-108.

Other

Royall DR. Comment on Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia Journal of the American Geriatrics Society 2019 Jan;67:1098-1099.

Royall DR. Comment on Andrews et al Alzheimer Disease & Associated Disorders 2019 Jan;.

Review Article

Royall DR. Fortress Brain Medical Hypotheses 2013 Jan;80:118-121.

Palmer RF, Royall DR. Missing data? Plan on it! J Am Geriatr Soc 2010 Oct;58:343-348.

Federal
Funding Agency	NIA
Title	Longitudinal Study of Mexican-American Elderly Health
Status	Active
Period	7/2019 - 6/2023
Role	Co-Investigator
Grant Detail
Funding Agency	Dept. of the Army -- USAMRAA
Title	?A Latent Variable Phenotype for Dementia Diagnosis and Biomarker Selection in TBI?
Status	Complete
Period	9/2014 - 8/2020
Role	Principal Investigator
Grant Detail	The major goals of this project are to examine the serum protein biomarkers associated with a latent phenotype representing the cognitive correlates of recent Traumatic Brian Injury among Afghanistan and Iraq (OEF/OIF) veterans.
Private
Funding Agency
Title	?The Effect of Passive Immunization on the Progression of Alzheimer?s Disease: LY2062430 Versus Placebo?
Status	Active
Period	9/2009 - Present
Role	Principal Investigator
Grant Detail
Funding Agency
Title	A Randomized Controlled Trial to Assess the Efficacy of a Medical Food in Patients with Mild to Moderate Alzheimer?s Disease Medication
Status	Active
Period	- Present
Role	Principal Investigator
Grant Detail	Industry Sponsored clinical trial.
Funding Agency
Title	Open Label Study of the Effect of Daily Treatment with MPC-7869 in Subjects with Dementia of the Alzheimer`s Type
Status	Active
Period	2/2007 - Present
Role	Principal Investigator
Grant Detail	A Phase III multi-center clinical trial.
Funding Agency	Eisai
Title	BAN2401-G000-201 A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer?s Disease?
Status	Active
Period	2/2013 - 2/2029
Role	Co-Investigator
Grant Detail
Funding Agency
Title	BAN2401-G000-301 (Industry sponsored clinical trial in closure) ?A Placebo-Controlled, Double-Blind, Parallel-Group, 24-Month Study to Evaluate the Efficacy and Safety of E2609 in Subjects with Early Alzheimer?s Disease?
Status	Complete
Period	1/2017 - 1/2029
Role	Principal Investigator
Grant Detail
State
Funding Agency	the Texas Council on Alzheimer?s Disease
Title	Genetic and Biomarker Study of Alzheimer`s Disease (Longitudinal Continuation of TARCC Hispanic Cohort).
Status	Active
Period	8/2018 - 8/2020
Role	Principal Investigator
Grant Detail	The major goals of this project are to study the longitudinal history and biomarkers associated with the transition to clinical Alzheimer?s disease (AD) among Hispanics.

Year	Degree	Discipline	Institution
1990	Residency	Residency in Psychiatry	Johns Hopkins Hospital Baltimore , MD
1987	Residency	Residency in Internal Medicine	Johns Hopkins Hospital Baltimore , MD
1985	Internship	Internship in Internal Medicine	Johns Hopkins Hospital Baltimore , MD
1984	MD	Psychiatry	University of Texas Medical School at Houston Houston , TX
1980	BS	Psychology (Magna Cum Laude)	Texas A&M University/College Station San Antonio , TX
1980	BS	Biology (Magna Cum Laude)	Texas A&M University/College Station San Antonio , TX

Date	Description	Institution	# Students
9/2019 - Present	Rotation Student Supervision	UTHSA

7/2019 - Present	Individual Instruction	University of Texas Health San Antonio

7/2018 - Present	Individual Instruction	University of Texas Health San Antonio

7/2008 - Present	Individual Instruction	UTHSCSA

1/1999 - Present	PGY-3 Psychiatry: Neurobiology
Course Director - PGY-3 Psychiatry Didactic Semeinar. Co-taught with Jeff Cordes, MD
1/1997 - Present	PGY-1 Medicine/PGY-2 Psychiatry: Clinical Geropsychiatry Seminar
Course Director - Topics in Geropsychiatry to PGY-1 Medicine/PGY-2 Psychiatry residents rotating in Geriatrics
1/1995 - Present	PGY-3-4 Clinical Geropsychiatry Seminar
Course Director - Topics in Geropsychiatry delivered to PGY-III & IV Psychiatry residents rotating through Geropsychiatry
1/1995 - Present	PGY-4 Geropsychiatry Seminar
Course Director - PGY-4 Psychiatry Didactic Seminar. Co-taught with Jeffrey Cordes, MD
1/1992 - Present	Individual Instruction	University of Texas Health Science Center at San Antonio

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Royall, Donald R MD

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Research Interest: Dementia Phenomenology

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Research Interest: Psychometrics

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