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Thompson, Peter M

School of Medicine
Psychiatry
(210) 567-5396
thompsonp@uthscsa.edu

Dr. Thompson is a tenured Professor in the Department of Psychiatry whose research effort is focused on understanding the biology and improving treatments for bipolar disorder. His research approach includes conducting treatment trials, phenomenological studies of symptoms, and measurement of molecular biological markers in human post mortem brain tissue. Dr. Thompson has been continuously funded since 1997 and published in leading neuroscience and psychiatric research journals.

Appointments Education Expertise Teaching Publications Grants

7/2012 - Present	Professor/Clinical and Inpatient Unit Medical Director	University Hospital, Psychiatry, San Antonio, TX
1/2011 - Present	Adjunct Professor	UTHSCSA, Clinical Laboratory Sciences
9/2010 - Present	Professor	University of Texas Health Science Center San Antonio
1/2005 - Present	Consultant	Texas Medical Board
5/2003 - Present	Director	Southwest Brain Bank, Psychiatry, San Antonio, TX

Journal Article

Thompson PM, Carmina G. Bernardo, Norma S. Ketchum, Joel E. Michalek. Concordance of psychiatric symptom ratings between a subject and informant, relevancy to postmortem research Translational Psychiatry 2012 Dec;.

Scott T. Aaronson, Linda L. Carpenter, Charles R. Conway, Frederic W. Reimherr, Sara H. Lisanby, Thomas L. Schwartz, Francisco A. Moreno, David L. Dunner, Michael D. Lesem, Thompson PM, Mustafa Husain, Craig J. Vine, Michael D. Banov, Lawrence P. Bernstein, Robert B. Lehman, Guy E. Brannon, George A. Keepers, John P. OReardon, Richard L. Rudolph, Mark Bunker. Vagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic Effects Brain Stimulation 2012 Nov;.

Bowden CL, Singh V, Weisler, R., Thompson PM, Chang X, Quinones MP, Mintz J. Lamotrigine vs. lamotrigine plus divalproex in randomized, placebo-controlled maintenance treatment for bipolar depression Acta Psychiatr Scand 2012 Nov;126(5):342-350.

Singh V, Bowden CL, Gonzalez J, Thompson PM, Prihoda TJ, Katz MM, Bernardo CG. Discriminating Primary Clinical States in Bipolar Disorder with a Comprehensive Symptom Scale [Epub ahead of print] Acta Psychiatrica Scandinavica 2012 Jul;:1-8.

Marballi K, Cruz D, Thompson P, Walss-Bass C. Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings PLOS One 2012 May;7(5):1-10.

Thompson PM, Cruz DA, Olukotun DY, Delgado PL, Cruz D. Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide Acta Psychiatr Scand 2011 Dec;.

Gonzalez JM, Thompson PM, Moore TA. Review of the safety, efficacy and side effect profile of asenapine in the treatment Patient Preference and Adherence 2011 Jul;2011(5):333-341.

Thompson PM, Gonzalez JM, Singh V, Schoolfield, John, Katz, Martin M, Bowden CL. Principal domains of behavioral psychopathology identified by the Bipolar Inventory of Signs and Symptoms Scale (BISS) Psychiatry Research 2010 Feb;175(3):221-226.

Barbee, James G, Thompson, Thomas R, Jamhour, Nowal J, Stewart Jonathan W, Conrad, Erich J, Reimherr, Fredrick W, Thompson PM, Shelton, Richard C. A Double-Blind Placebo Controlled Trial of Lamotrigine as an Antidepressant Augmentation Agent in Treatment Refractory Unipolar Depression Journal of Clinical Psychiatry 2010 Jan;.

Kogan JN, Bauer MS, Dennehy EB, Miklowitz DJ, Gonzalez JM, Thompson PM, Sachs GS. Increasing minority research participation through collaboration with community outpatient clinics: The STEP-BD Community Partners experience Clinical Trials 2009 Jan;6:344-354.

Gonzalez JM, Bowden CL, Katz MM, Thompson PM, Singh V, Prihoda TJ, Dahl M. Development of the Bipolar Inventory of Symptoms Scale: Concurrent validity, discriminant validity and retest reliability International Journal of Methods in Psychiatric Research 2008 Jan;17(4):198-209.

Bernardo CG, Singh V, Thompson PM. Safety and Efficacy of Psychopharmacological Agents Used to Treat the Psychiatric Sequelae of Common Neurological Disorders-Accepted Expert Opinion in Drug Safety 2008 Jan;.

Bowden CL, Singh V, Thompson PM, Gonzalez JM, Katz, MM, Dahl, M, Prihoda TJ, Chang, X. Development of the Bipolar Inventory of Symptoms Scale Acta Psychiatrica Scandinavica 2007 Sep;116(3):189-194.

Abstract

Kos, MZ, Neary, J, Cruz D, Kulkarni, H, Duggirala, R, Curran, JE, Blangero, J, Almasy, L, Thompson PM, Glahn D, Carless MA. Association of MicroRNA Expression with Diagnoses of Major Depression (MDD) and Beck Depression Inventory (BDI) Scores Port Douglas Australia; 2012 Sep. (Genemappers).

Thompson PM. Agreement between symptoms from subjects with severe Mental Illness and that seen by next of kin, relevance to postmortem psychological autopsy; 2012 Apr. (Biological Psychiatry; vol. 71, no. 8S).

Quinones J, Bowden CL, Tohen M, Gonzalez JM, Singh V, Thompson PM. Deconstructing the clinical effects of antidepressants in bipolar disorder using symptom domains derived from the bipolar inventory of signs and symptoms scale (BISS); 2012 Feb. (Biological Psychiatry; vol. 71, no. 8S).

Thompson PM, Cruz D, Olukoton, DY. SNAP-25 Vesicular Docking Protein mRNA in Bipolar Disorder; 2011 May. (Biological Psychiatry; vol. 69).

Bernardo CG, Thompson PM, Cruz D. Per1, Per2 and Per3 and Symptoms Severity in Postmortem Subjects with Mood Disorder; 2011 May. (Biological Psychiatry; vol. 69).

Bernardo CG, Thompson PM, Ogbur, Kelin M., Cruz D, Delgado PL. Serotonin Transporter (SERT) Polymorphisms and Corticotripin- Releasing Factor (CRF) Levels in Alcoholism and Suicide; 2010 May. (Biological Psychiatry; vol. 67).

Bernardo CG, Ogburn, Kelin M., Cruz D, Thompson PM. Serotonin Receptor Levels and Mood States in Alcoholism and Suicide; 2010 May. (Biological Psychiatry; vol. 67).

Singh V, Bowden CL, Weisler, Richard, Thompson PM, Mintz J. Randomized, Double Blind 8-MonthMaintenance Study of Bipolar Depression with Lamotrigine or Divalproex ER plus Lamotrigine; 2009 Nov. (American College of Neuropsychopharmacology Annual Meeting).

Bowden CL, Gonzalez JM, Singh V, Thompson PM, Bernardo CG,. Sensitivity of a Comprehensive Rating Scale for Bipolar Disorders (BD) to Assess Improvements with Treatment; 2009 Aug. (European Neuropsychopharmacology Annual Meeting).

Thompson PM, Ogburn, K, Cruz, D, Delgado PL. Frontal and Cingulate Serotonin Receptor Levels in Alcoholism, Suicide; 2009 May. (Biological Psychiatry).

Singh V, Bowden CL, Bernardo CG, Thompson PM. 8-Month Maintenance Treatment of Bipolar Depression (BD) with Lamotrigine (LAM) or Divalproex (DIV) plus LAM: Acute Phase Safety and Efficacy of Combined LAM and DIV Treatment of BD; 2008 Apr. (Society of Biological Psychiatry Annual Meeting; vol. 63, no. 7S).

Singh V, Thompson PM, Bernardo CG, Bowden CL. Safety and Efficacy of Lamotrigine As Add on Treatment in Mixed States (MS) of Bipolar Disorder (BD); 2008 Apr. (Society of Biological Psychiatry Annual Meeting; vol. 63, no. 7S1).

Singh V, Bowden CL, Weisler, R., Thompson PM. Open phase safety and efficacy of lamotrigine (LAM) plus divalproex (DIV) treatment of bipolar depression (BD) in patients with bipolar disorder (BP); 2008 Feb. (Internation Society for Bipolar Disorders Annual Meeting; vol. 10, no. Supl-).

Thompson PM, Gonzalez JM, Singh V, Schoolfield, J, Bowden CL. Principal Domains of Behavioral Psychopathology Identified by the Bipolar Inventory of Symptoms Scale (BISS) Annual Meeting; 2007 Dec. (American College of Neuropsychopharmacology Annual Meeting).

Federal
Funding Agency	Fogarty-NIMH
Title	U.S./Costa Rica Neuropsychiatric Genetics Research Training Program
Status	Active
Period	8/2009 - 7/2014
Role	Principal Investigator
Grant Detail	Train graduate students from Costa Rica in neuropsychiatric genetics PI 2009-2011, consultant 2011-current
Funding Agency	DOD
Title	Contract W81XWH-07-1-0244 The Root Cause of Post Traumatic Stress Disorder, Dr. Keith Young TAMU
Status	Active
Period	3/2008 - 5/2013
Role	Principal Investigator
Grant Detail
Funding Agency	NIMH
Title	Southwest Brain Bank R24MH07603901A1
Status	Complete
Period	4/2009 - 4/2012
Role	Principal Investigator
Grant Detail	The goal of this proposal is to create and maintain a resource of postmortem bipolar disorder brain tissue that will be available nation-wide to qualified researchers.
Funding Agency	NIMH
Title	P20 Center for Bipolar Illness Interventions in Hispanic Communities
Status	Active
Period	1/2005 - 1/2011
Role	Co-Investigator
Grant Detail
Private
Funding Agency	Cyberonics, Inc.
Title	Randomized Comparison of Outcomes in Patients with Treatment-Resistant Depression who receive VNS Therapy Administered at Different Amounts of Electrical Charge
Status	Active
Period	12/2005 - Present
Role	Principal Investigator
Grant Detail	This study is being done to compare different device settings(doses)for VNS Therapy with people who have treatment resistant depression.
Funding Agency	Repligin Corporation
Title	A Phase II Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Study to Assess the Safety, Tolerability and Efficacy of RG2417 (Uridine) in the Treatment of Bipolar I Depression (RG2417-03)
Status	Active
Period	5/2009 - 5/2011
Role	Co-Investigator
Grant Detail
Funding Agency	Department of Psychiatry, UTHSCSA
Title	Inflammation and Microglial Activation in Bipolar Disorder
Status	Active
Period	9/2009 - 8/2010
Role	Co-Investigator
Grant Detail	This study examines the effects of microglia as contributors to the inflammatory response and oxidative stress pathways in the postmortem brains of bipolar subjects. Due to the limited availability of postmortem human brain tissue, these studies will provide critical information in the understanding of immune and oxidative stress pathways in the neuropathophysiology of bipolar disorder.

Year	Degree	Discipline	Institution
1994	Postdoctoral Fellowship	Molecular Biology Training	Scripps Research Institute, in University of California at San Diego San Diego , CA
1994	Postdoctoral Fellowship	Psychopharmacology & Psychobiology Research	University of California at San Diego, Department of Psychiatry San Diego , CA
1992	Residency	Psychiatry	Tufts University School of Medicine Boston , MA
1989	Internship	Psychiatry	Tufts University School of Medicine Boston , MA
1988	MD	Medicine	Tufts University School of Medicine Boston , MA
1982	MS	Biology - cellular and molecular biology	California State University Northridge , CA
1979	BA	Biology	Sonoma State University Rohnert Park , CA

Date	Description	Institution	# Students
6/2012 - Present	Post Graduate Rotation Supervision	UH

6/2012 - Present	Post-Doctoral Student Supervision	UH

10/2007 - Present	Rotation Student Supervision	UTHSCSA

5/2004 - Present	Post Graduate Rotation Supervision	UTHSCSA

3/2004 - Present	Psychopharmacology		60 students
Provides lectures on treatment of bipolar disorder to psychiatric residents and fellows
7/2001 - Present	Post-Doctoral Student Supervision	UTHSCSA

9/1994 - Present	Psychoneuropharmacology		12 students
Course Director - PGY 2 Psychiatry Class,

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Thompson, Peter M

Biology of major mental disorders

Treatment of Bipolar Disorder

Treatment of Treatment Resistant Depression

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