Infectious diseases -
Prophylaxis of leptospiral infections and shigellosis; Pathogenic bacteria in chronic bronchitis including isolation and characterization of oral bacteria as pathogenic reagents; Fractionation, purification and charaterization of IgE and anti-IgE including using gel chromatography, ion exchange chromatography, affinity chromatography, preparatory electrophorresis and immunochemical analysis. Detection of micro antigens and antibodies by using autoradiography, RIA, EKISA- ABC BA-EKISE.
Study of imunoadjuvant effect of liposomes, polysaccharide and lipopolysccharide including preparations, analysis and observations of immunoadjuvant effect. Studies of outer membrance proteins and Shigella flexneri 2a: fractionation, charaterization and observation of the immunizing effect of OMP by cross-immunoelectrophoresis, Western blot, plasmid analysis and some others.
Research for potential pathogenic bacteria in periodontal diseases including analysis of hemolysins in P. gingivalis and T. deticola; proteins, DNA cloning, sequencing and expressing, enzymatic analysis and other biological function analysis.
Recent years, he focuses the research areas to the virulence expressions of glutathione catabolism in multiple inflammations of periodontal pathogens and the influence of stress-hormones on growth and virulence of periodontal pathogens. |
Journal Article |
| C. Fan, L. Chu, H.R. Rawls, B.K. Norling, H.L. Cardenas, and K. Whang. Development of an antimicrobial resin - a pilot study Dental Materials 2011 Mar;27:322-328.
|
| Zhang JH, Dong Z, Chu L. Hydrogen sulfide induces apoptosis in human periodontium cells J Periodontal Res 2009 Jul;.
|
| Chu L, Xu X, Su J, Song L, Lai Y, Dong Z, Cappelli D. Role of Aggregatibacter actinomycetemcomitans in glutathione catabolism Oral Microbiol Immunol 2009 Jun;24(3):236-242.
|
| Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D. A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism J Biol Chem 2008 Jul;283(28):19351-19358.
|
| Lai Y, Chu L. Novel mechanism for conditional aerobic growth of the anaerobic bacterium Treponema denticola Appl Environ Microbiol 2008 Jan;74(1):73-79.
|
Abstract |
| Chu, L., X. Xu, D. Cappelli, J. Rugh. Treponema denticola conditionally provides environment for Porphyromonas gingivalis aerobic growth; 2009 Jan. (International Association for Dental Research/American Association for Dental Research Meeting).
|
| Lai Y, Xu X, Kolodrubetz DJ, Chu L. Cysteinyglycinase A mutant construction and the role of the enzyme in glutathione catabolism of Treponema denticola; 2009 Jan. (IADR/AADR Meeting).
|
| Rupp, Q., Lai, D. Cappelli, J.P.Hatch, J.D.Rugh, L.Chu. The influence of neurohormones on periodontal pathogens; 2008 Jan. (American Association for Dental Research/AADR).
|
