Cochran, David LDental School |
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Dr. David L. Cochran is a graduate of the University of Virginia and received his D.D.S., M.S. and Ph.D. in Biochemistry from the Medical College of Virginia (MCV). He was trained in Periodontology at the Harvard School of Dental Medicine where he also obtained a second Masters degree. He recently received an Honorary Doctorate from the University of Bern in Switzerland. Dr. Cochran is currently Professor and Chairman of the Department of Periodontics at The University of Texas Health Science Center at San Antonio, Dental School. Prior to his appointment at San Antonio, Dr. Cochran was Director of Postgraduate Periodontics at MCV. Dr. Cochran is a member of many professional dental organizations and is a Diplomate of the American Board of Periodontology. He is a fellow of the American College of Dentistry and the International College of Dentistry. Dr. Cochran has published numerous scientific articles and abstracts on various periodontal, biochemistry, and implant topics. He has received awards for his research work at both the national and international levels. Dr. Cochran is an active basic science and clinical researcher who has received funding from both the NIH-NIDCR and private industry. |
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| 1/2004 - Present | Medical-Dental Staff | University Health System, Ob-Gyn, San Antonio, TX |
| 1/1992 - Present | Professor and Chairman | The University of Texas Health Science Center at San Antonio, Periodontics, San Antonio, TX |
| 1/1992 - Present | Affiliate Professor | Medical College of Virginia/VCU, Biochemistry, Richmond, VA |
| Year | Degree | Discipline | Institution |
| 2010 | Dentistry | University of Bern Bern , Switzerland |
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| 1985 | MMS | Oral Biology | Harvard Medical School Boston , MA |
| 1985 | Certificate | Periodontology | Harvard School of Dental Medicine Boston , MA |
| 1982 | PhD | Biochemistry | Medical College of Virginia/VCU Richmond , VA |
| 1981 | DDS | Dentistry | Medical College of Virginia/VCU Richmond , VA |
| 1977 | MS | Biochemistry | Medical College of Virginia/VCU Richmond , VA |
| 1975 | BA | Biology | University of Virginia VA |
Implantology- Cell biology, bone metabolism, growth factors, regeneration, fibroblasts, implantology |
Periodontics- Cell biology, bone metabolism, growth factors, regeneration, fibroblasts, implantology |
| Date | Description | Institution | # Students |
| 7/2008 - Present | Membership on Supervising Committee | University of Texas Health Science Center at San Antonio | |
| 5/2008 - Present | Membership on Supervising Committee | University of Texas Health Science Center at San Antonio | |
| 9/2004 - Present | Literature Seminars | The University of Texas Health Science Center | |
| 1/1999 - Present | Emergency Care Sem | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Mock Boards | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Research | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Peri Lecture Series | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Research | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Clinical Periodontics II | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Mock Boards | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Peri Lecture Series | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Literature Seminars | The University of Texas Health Science Center | 30 students |
| 1/1999 - Present | Peri Practice Management | The University of Texas Health Science Center | 30 students |
| 9/1995 - Present | Perio Lecture Series | The University of Texas Health Science Center | |
| 9/1992 - Present | Periodontics Clinic | The University of Texas Health Science Center | |
| 1/1992 - Present | Ph.D. Dissertations Directed | UTHSCSA Dental School | |
| 1/1992 - Present | Masters'' Thesis Directed | UTHSCSA Dental School | |
Journal Article |
| Olivares-Navarrete R; Raines AL; Hyzy SL; Park JH; Hutton DL; Cochran DL; Boyan BD; Schwartz. Osteoblast Maturation and New Bone Formation in Response to Titanium Implant Surface Features are Reduced With Age Journal of Bone and Mineral Research 2012 Aug;8:1773-1783. |
| Thoma, DS;Jung RE; Hansler, P; Hammerle, CHF; Cochran DL; Franz EW. Impact of Recombinant platelet-derived growth facto BB on Bone Regeneration: A Study in Rabbits The International journal of Periodontics & Restorative Dentistry 2012 Apr;32(02):195-202. |
| Mau, LP; Pang I; Tseng C; Chen YM;Cochran DL. Treatment Alternative for Root Resorption of an Avulsed Tooth in a Growing Child. A Case Report With a 4-year Follow-up Clinical Advances in Periodontics 2012 Mar;10(1902). |
| Cochran DL, Jackson JM, Bernard JP, Ten Bruggenkate CM, Buser D, Taylor TD, Weingart D, Schoolfield JD, Jones AA, Oates TW. A 5-year prospective multicenter study of early loaded titanium implants with a sandblasted and Acid-etched surface Int J Oral Maxillofac Implants 2011 Nov;26(6):1324-1332. |
| Thoma DS, Villar CC, Cochran DL, Hmmerle CH, Jung RE. Tissue integration of collagen-based matrices: an experimental study in mice Clin Oral Implants Res 2011 Nov;. |
| Thoma DS, Hmmerle CH, Cochran DL, Jones AA, Grlach C, Uebersax L, Mathes S, Graf-Hausner U, Jung RE. Soft tissue volume augmentation by the use of collagen-based matrices in the dog mandible -- a histological analysis J Clin Periodontol 2011 Nov;38(11):1063-1070. |
| McGuire MK, Scheyer ET, Nevins ML, Neiva R, Cochran DL, Mellonig JT, Giannobile WV, Bates D. Living cellular construct for increasing the width of keratinized gingiva: results from a randomized, within-patient, controlled trial J Periodontol 2011 Oct;82(10):1414-1423. |
| Thoma DS, Jones AA, Dard M, Grize L, Obrecht M, Cochran DL. Tissue Integration of a New Titanium-Zirconium Dental implant: A Comparative Histologic and Radiographic Study in the Canine J Periodontol 2011 Oct;:1453-1461. |
| Hermann JS, Jones AA, Bakaeen LG, Buser D, Schoolfield JD, Cochran DL. Influence of a machined collar on crestal bone changes around titanium implants: a histometric study in the canine mandible J Periodontol 2011 Sep;82(9):1329-1338. |
| Emerton KB, Drapeau SJ, Prasad H, Rohrer M, Roffe P, Hopper K, Schoolfield J, Jones AA, Cochran DL. Regeneration of Periodontal Tissues in Non-human Primates with rhGDF-5 and Beta-Tricalcium Phosphate J Dent Res 2011 Sep;. |
| Yan SG, Zhang J, Tu QS, Ye JH, Luo E, Schuler M, Kim MS, Griffin T, Zhao J, Duan XJ, Cochran DL, Murray D, Yang PS, Chen J. Enhanced Osseointegration of Titanium Implant Through the Local Delivery of Transcription Facor SATB2 Biomaterials 2011 Sep;10(1016). |
| Valderrama P, Bornstein MM, Jones AA, Wilson TG, Higginbottom FL, Cochran DL. Effects of implant design on marginal bone changes around early loaded, chemically modified, sandblasted Acid-etched-surfaced implants: a histologic analysis in dogs J Periodontol 2011 Jul;82(7):1025-1034. |
| Cochran DL, Jackson JM, Jones AA, Jones JD, Kaiser DA, Taylor TD, Weber HP, Higginbottom FL, Richardson JR, Oates T. A 5-year prospective multicenter clinical trial of non-submerged dental implants with a titanium plasma-sprayed surface in 200 patients J Periodontol 2011 Jul;82(7):990-999. |
| Mamalis AA, Cochran DL. The therapeutic potential of oxygen tension manipulation via hypoxia inducible factors and mimicking agents in guided bone regeneration. A review Arch Oral Biol 2011 May;. |
| Thoma DS, Villar CC, Carnes DL, Dard M, Chun YH, Cochran DL. Angiogenic activity of an enamel matrix derivative (EMD) and EMD-derived proteins: an experimental study in mice J Clin Periodontol 2011 Mar;38(3):253-260. |
| McGuire MK, Scheyer ET, Nevins M, Neiva R, Cochran DL, Mellonig JT, Giannobile WV, Bates D. Living Cellular Construct for Increasing the Width of Keratinized Gingiva. Results from a Randomized, Within-Patient, Controlled Trial J Periodontol 2011 Mar;. |
| Graves DT, Li J, Cochran DL. Inflammation and uncoupling as mechanisms of periodontal bone loss J Dent Res 2011 Feb;90(2):143-153. |
| Thoma DS, Villar CC, Carnes DL, Dard M, Chun YP, Cochran DL. Angiogenic activity of enamel matrix derivative (EMD) and EMD-derived proteins: an experimental study in mice Journal of Clinical Periodontology 2011 Jan;38:253-260. |
| Thoma DS, Jones AA, Yamashita M, Edmunds R, Nevins M, Cochran DL. Ridge augmentation using recombinant bone morphogenetic protein-2 techniques: an experimental study in the canine J Periodontol 2010 Dec;81(12):1829-1838. |
| Yamashita M, Nevins M, Jones AA, Schoolfield J, Cochran DL. A pilot experimental lateral ridge augmentation study using bone morphogenetic protein 2 in dogs Int J Periodontics Restorative Dent 2010 Oct;30(5):457-469. |
| Thoma DS, Jung RE, Schneider D, Cochran DL, Ender A, Jones AA, Grlach C, Uebersax L, Graf-Hausner U, Hmmerle CH. Soft tissue volume augmentation by the use of collagen-based matrices: a volumetric analysis J Clin Periodontol 2010 Jul;37(7):659-666. |
| Raines AL, Olivares-Navarrete R, Wieland M, Cochran DL, Schwartz Z, Boyan BD. Regulation of angiogenesis during osseointegration by titanium surface microstructure and energy Biomaterials 2010 Jun;31(18):4909-4917. |
| Fang M, Olivares-Navarrete R, Wieland M, Cochran DL, Boyan BD, Schwartz Z. The role of phospholipase D in osteoblast response to titanium surface microstructure J Biomed Mater Res A 2010 Jun;93(3):897-909. |
| Yamashita M, Lazarov M, Jones AA, Mealey BL, Mellonig JT, Cochran DL. Periodontal regeneration using an anabolic peptide with two carriers in baboons J Periodontol 2010 May;81(5):727-736. |
| Kauvar AS, Thoma DS, Carnes DL, Cochran DL. In Vivo Angiogenic Activity of Enamel Matrix Derivative J Periodontol 2010 May;. |
| Valderrama P, Jung RE, Thoma DS, Jones AA, Cochran DL. Evaluation of parathyroid hormone bound to a synthetic matrix for guided bone regeneration around dental implants: a histomorphometric study in dogs J Periodontol 2010 May;81(5):737-747. |
| Mellonig JT, Valderrama P, Cochran DL. Clinical and histologic evaluation of calcium-phosphate bone cement in interproximal osseous defects in humans: a report in four patients Int J Periodontics Restorative Dent 2010 Apr;30(2):121-127. |
| Neeley WW, Carnes DL, Cochran DL. Osteogenesis in an in vitro coculture of human periodontal ligament fibroblasts and human microvascular endothelial cells J Periodontol 2010 Jan;81(1):139-149. |
| Villar CC, Cochran DL. Regeneration of periodontal tissues: guided tissue regeneration Dent Clin North Am 2010 Jan;54(1):73-92. |
| Mellonig JT, Valderrama P, Gregory HJ, Cochran DL. Clinical and histologic evaluation of non-surgical periodontal therapy with enamel matrix derivative: a report of four cases J Periodontol 2009 Sep;80(9):1534-1540. |
| Offenbacher S, Beck JAMES, Jared HEATHER, Mauriello SALLY, Mendoza LUISTO, Couper DAVID, Stewart DAWN, Murtha AMY, Cochran DAVID, Dudley DONALD, Reddy MICHAEL, Geurs NICOLAAS, Hauth JOHN, Cochran DL. Effects of Periodontal Therapy on Rate of Preterm Delivery: A Randomized Controlled Trial Obstet Gynecol 2009 Sep;114(3):551-559. |
| Fang M, Olivares-Navarrete R, Wieland M, Cochran DL, Boyan BD, Schwartz Z. The role of phospholipase D in osteoblast response to titanium surface microstructure J Biomed Mater Res A 2009 Aug;. |
| Bakaeen L, Quinlan P, Schoolfield J, Lang NP, Cochran DL. The biologic width around titanium implants: histometric analysis of the implantogingival junction around immediately and early loaded implants Int J Periodontics Restorative Dent 2009 Jun;29(3):297-305. |
| Cochran DL, Nummikoski PV, Schoolfield JD, Jones AA, Oates TW. A prospective multicenter 5-year radiographic evaluation of crestal bone levels over time in 596 dental implants placed in 192 patients J Periodontol 2009 May;80(5):725-733. |
| Johnson DL, Carnes D, Steffensen B, Cochran DL. Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chromatography J Periodontol 2009 Apr;80(4):648-656. |
| Cochran DL, Bosshardt DD, Grize L, Higginbottom FL, Jones AA, Jung RE, Wieland M, Dard M. Bone response to loaded implants with non-matching implant-abutment diameters in the canine mandible J Periodontol 2009 Apr;80(4):609-617. |
| Mellonig JT, Valderrama MDEL P, Cochran DL. Histological and clinical evaluation of recombinant human platelet-derived growth factor combined with beta tricalcium phosphate for the treatment of human class III furcation defects Int J Periodontics Restorative Dent 2009 Apr;29(2):169-177. |
| Schwartz Z, Olivares-Navarrete R, Wieland M, Cochran DL, Boyan BD. Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces Biomaterials 2009 Apr;. |
| Schwarz F, Wieland M, Schwartz Z, Zhao G, Rupp F, Geis-Gerstorfer J, Schedle A, Broggini N, Bornstein MM, Buser D, Ferguson SJ, Becker J, Boyan BD, Cochran DL. Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants J Biomed Mater Res B Appl Biomater 2009 Feb;88(2):544-557. |
| Cochran DL, Schou S, Heitz-Mayfield LJ, Bornstein MM, Salvi GE, Martin WC. Consensus statements and recommended clinical procedures regarding risk factors in implant therapy Int J Oral Maxillofac Implants 2009 Jan;24 Su:86-89. |
| Cochran D, Cochran DL. Periodontology in the age of inflammation: a changing landscape J Am Coll Dent 2009 Jan;76(1):23-26. |
| Schwarz F, Wieland M, Schwartz Z, Zhao G, Rupp F, Geis-Gerstorfer J, Schedle A, Broggini N, Bornstein M, Buser D, Ferguson S, Becker J, Boyan B, Cochran DL. Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants J Biomed Mat Res: Pt B - Applied Biomat 2008 Aug;. |
| Cochran DL. Inflammation and bone loss in periodontal disease J Periodontol 2008 Aug;79(8 Sup):1569-1576. |
| Ridgway HK, Mellonig JT, Cochran DL. Human histologic and clinical evaluation of recombinant human platelet-derived growth factor and beta-tricalcium phosphate for the treatment of periodontal intraosseous defects Int J Periodontics Restorative Dent 2008 Apr;28(2):171-179. |
| Bornstein MM, Valderrama P, Jones AA, Wilson TG, Seibl R, Cochran DL. Bone apposition around two different sandblasted and acid-etched titanium implant surfaces: a histomorphometric study in canine mandibles Clin Oral Implants Res 2008 Mar;19(3):233-241. |
| Jackson A, Lemke RR, Hatch JP, Salome N, Gakunga PT, Cochran DL. A comparison of stability between delayed versus immediately loaded orthodontic palatal implants Journal of Esthetic and Restorative Dentistry 2008 Mar;20(3):174-184. |
| Jung RE, Weber FE, Thoma DS, Ehrbar M, Cochran DL, Hmmerle CH. Bone morphogenetic protein-2 enhances bone formation when delivered by a synthetic matrix containing hydroxyapatite/tricalciumphosphate Clin Oral Implants Res 2008 Feb;19(2):188-195. |
| Jung RE, Jones AA, Higginbottom FL, Wilson TG, Schoolfield J, Buser D, Hmmerle CH, Cochran DL. The Influence of Non-Matching Implant and Abutment Diameters on Radiographic Crestal Bone Levels in Dogs J Periodontol 2008 Feb;79(2):260-270. |
| Neeley WW, Carnes DL, Cochran DL. Osteogenesis in an in vitro co-culture of human microvascular endothelial cells and human periodontal ligament fibroblasts Pending 2008 Jan;. |
| Schwartz Z, Denison TA, Bannister SR, Cochran DL, Liu YH, Lohmann CH, Wieland M, Boyan BD. Osteoblast response to fluid induced shear depends on substrate microarchitecture and varies with time J Biomed Mater Res A 2007 Oct;83(1):20-32. |
| Mumulidu A, Hildebrand B, Fabi B, Hammarstrm L, Cochran DL, Dard M, Lemoult S. Purification and analysis of a 5kDa component of enamel matrix derivative J Chromatogr B Analyt Technol Biomed Life Sci 2007 Oct;857(2):210-218. |
| Oates TW, Valderrama P, Bischof M, Nedir R, Jones AA, Simpson, J, Toutenburg H, Cochran DL. Enhanced implant stability with a chemically modified SLA surface: a randomized pilot study Int J Oral Maxillofac Implants 2007 Sep;22(5):755-760. |
| Cochran D, Oates T, Morton D, Jones A, Buser D, Peters F, Cochran DL. Clinical field trial examining an implant with a sand-blasted, acid-etched surface J Periodontol 2007 Jun;78(6):974-982. |
| Jung RE, Cochran DL, Domken O, Seibl R, Jones AA, Buser D, Hammerle CH. The effect of matrix bound parathyroid hormone on bone regeneration Clin Oral Implants Res 2007 Jun;18(3):319-325. |
Book Chapter |
| Cochran D. Wound Healing Around Dental Implants. In: Villar CC; Huynh-Ba G; Mills M; Cochran DL. Wound Healing Around Dental Implants. West Sussex, UK: John Wiley & Sons, Ltd; 2012. p. 287-304. |
Abstract |
| Mau LP; Bosshardt D; Schoolfield J; Cochran DL. Biological Width of Non-matching Implant-abutment Diameters in a Canine Model; 2012 Sep. (Abstract for Academy of Osseointegration Meeting 2012). |
| Villar CC; Cochran DL; Zhao X. Angiogenic potential of tissue-engineered living cellular constructs; 2012 Jun. (Oral Session at IADR, Brazil). |
| Schwartz Z, Olivares-Navarrete R, Hyzy SL, Hutton D, Cochran DL, Dard M, Boyan BD. Microtextured-titanium Decreases and BMP2 Increases Pro-inflammatory Cytokine Production by Osteoblasts; 2011 Mar. (J Dent Res; vol. 86, no. A). |
| Boyan BD, Olivares-Navarrete R, Haithcock D, Hyzy SL, Mauth C, Berner S, Cochran DL, Schwartz Z. Surface-energy and Micron/Sub-micron Topography Contribute Separately to HMSC Osteoblastic Differentiation; 2011 Mar. (J Dent Res; vol. 86, no. A). |
| Thoma DS, Jones AA, Dard M, Obrecht M, Hammerle CHF, Cochran DL. Evaluation of a new titanium-zirconium dental implant. Histologic and histomorphometric outcomes of a comparative study in the canine mandible; 2010 Mar. (Proceedings of the Academy of Osseointegration 2010 Meeting). |
| Schwartz Z, Olivares-Navarrete R, Erdman CP, Wieland M, Cochran DL, Boyan BD. Microstructured Ti-Surfaced Directly and Indirectly Induce Osteoblastic Differentiation of MSCs; 2009 Apr. (J Dent Res; vol. 84, no. A). |
| Thoma DS, Jones AA, Wieland M, Dard M, Buser D, Hammerle CHF, Cochran DL. Evaluation of a new titanium-zirconium dental implant. A comparative radiographic study in the canine mandible; 2009 Feb. (Proceedings of the Academy of Osseintegration 2009 Annual Meeting). |
| Navarrete RO, Cochran DL. Surface microtopographies regulate human mesenchymal cells both directly and indirectly; 2009 Feb. (Proceedings of the Orthopaedic Research Society 55th Annual Meeting; vol. ORS, no. 2009). |
| Offenbacher S, Beck J, Jared H, Mauriello S, Mendoza L, Couper D, Steward D, Murtha A, Cochran DL, Dudley DJ. Maternal Oral Therapy to Reduce Obstetric Risk (MOTOR): A report of a multi-centered periodontal therapy randomized-controlled trial on rate of preterm delivery; 2009 Jan. (Plenary Presentation at Society for Maternal-Fetal Medicine in San Diego, CA). |
| Olivares-Navarrete R, Raz P, Zhao G, Chen J, Wieland M, Cochran DL, Chaudhri RA, Ornoy A, Boyan BD, Schwartz Z. Integrin alpha2beta1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates; 2008 Oct. (Proc Natl Acad Sci U S A; vol. 105, no. 41). |
| Thoma DS, Bosshardt D, Jung RE, Higginbottom F, Hammerle CHF, Buser D, Wieland M, Cochran DL. Location of bone margin around loaded implants incorporating platform-shifting; 2008 Sep. (Proceedings of the EAO Congress, Warsaw). |
| Schwartz Z, Olivares-Navarrete R, Cochran DL, Wieland M, Boyan BD. TGF-beta and PKC-signaling regulate surface-dependent osteoprotegerin production by osteoblasts; 2008 Jul. (J Dent Res; vol. 87, no. B). |
| Valderrama MP, Cochran DL. Bone changes around early loaded chemically-modified sand blasted, acid etched (SLA) surfaced implants with and without machined collar. A radiographic, histological and resonance frequency analysis in the canine mandible; 2008 Apr. (Proceedings of the AAP Annual Meeting). |
| Cochran DL, Jung RE, Higginbottom FL, Jones AA, Wieland M. Platform shifting and the reality of crestal bone; 2007 Oct. (Proceedings of the American Academy of Periodontolgy 93rd Annual Meeting, Washington, DC). |
Editorial |
| Cochran DL, Nevins M. Biologic width: a physiologically and politically resilient structure Int J Periodontics Restorative Dent 2012 Aug;32(4):371-373. |
Not Specified |
| Mau LP, Pang I, Tseng C, Chen YM, Cochran DL. Treatment Alternative for Root Resorption of an Avulsed Tooth in a Growing Child: A Case Report With a 4-Year Follow-Up Clinical Advances in Periodontics 2012 Nov;2(4):241-247. |
Private |
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| Funding Agency | Genetics Institute |
| Title | Pilot Study Evaluation of rhBMP-2/Absorbable Collagen Sponge Device for Alveolar Ridge Preservation or Augmentation |
| Status | Complete |
| Period | - Present |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | OraPharma |
| Title | Multicenter Phase III Trial of Minocycline Periodontal Therapeutic System |
| Status | Complete |
| Period | - Present |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Genetics Institute |
| Title | Bone Morphogenic Protein-2/Healing of Osseous Defects Surrounding Dental Implants |
| Status | Complete |
| Period | - Present |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Straumann, Inc. |
| Title | The Use of ITI SLA Implants as Immediate Implants in Extraction Sites, A Pilot Study |
| Status | Complete |
| Period | - Present |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Genetics Institute |
| Title | Periodontal Defect Regeneration |
| Status | Complete |
| Period | - Present |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | Organogenesis, Inc. |
| Title | A Clinical Trial to Evaluate CelTx (Apligraf) as an Alternative to Tissue from the Palate to Enhance Oral Soft Tissue Regeneration and Would Healing |
| Status | Complete |
| Period | 3/2008 - 1/2029 |
| Role | Principal Investigator |
| Grant Detail | CelTx is a two-layered sheet, made from purified cow tendon collagen, living human cells, and a substance to maintain (feed) the cells until they are placed on a wound. This is a research study to evaluate the safety and effectiveness of an experimental therapy called CelTx in the treatment of shrinkage of the gums around teeth. This study compares conventional therapy (placement of tissue from the roof the mouth on gum tissue at the area of shrinkage) to treatment with CelTx (placed at the area of shrinkage). The purpose of this research study is to evaluate the safety and effectiveness of treating gum shrinkage with CelTx compared to conventional treatment (tissue from the roof of your mouth). |
| Funding Agency | International Team for Implantology (ITI) |
| Title | A Comparative, Randomized, Prospective, Clinical Study to Evaluate the Facial Bone Height and Thickness and the Esthetic Outcome of Two Different Bone Grafting Techniques in Early Implant Placement |
| Status | Active |
| Period | 10/2012 - 12/2014 |
| Role | Principal Investigator |
| Grant Detail | To evaluate the facial bone height and thickness and the esthetic outcome of two different bone grafting techniques in early implant placement. |
| Funding Agency | ITI Foundation |
| Title | Evaluation of a Zirconia Implant in the Mandible of Canines |
| Status | Active |
| Period | 10/2012 - 8/2014 |
| Role | Principal Investigator |
| Grant Detail | This study will evaluate histologically the ability of this new, full ceramic material to enhance the growth and integration of the surrounding (new) bone (osseointegration) and gums at the surface. |
| Funding Agency | Geistlich Pharma |
| Title | Treatment Outcomes of Implant Placement with Simultaneous Contour Augmentation Using Guided Bone Regeneration (GBR) |
| Status | Active |
| Period | 12/2012 - 6/2013 |
| Role | Principal Investigator |
| Grant Detail | To analyze the radiologic, histologic and histomorphometric outcomes of contour augmentation in esthetic implant sites treated with four different augmentation procedures in the canine maxilla at two healing times (4 and 12 weeks) and to analyze the influence of the biomaterial component (autogenous bone chips, DBBM particles and collagen membrane) on the healing outcomes. |
| Funding Agency | International Team for Implantology (ITI) |
| Title | An Experimental Lateral Ridge Augmentation Study to Evaluate a New Membrane for Guided Bone Regeneration in Canines |
| Status | Active |
| Period | 1/2011 - 12/2012 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Straumann |
| Title | A Randomized, Controlled Trial Comparing the Stability of SLA Implants and SLActive implants Using Resonance Frequency Analysis for Patients with Type 2 Diabetes Mellitus |
| Status | Complete |
| Period | 8/2008 - 7/2012 |
| Role | Co-Investigator |
| Grant Detail | Research study comparing how fast bone heals around two different types of Straumann dental implants for patients with diabetes. We want to learn if the different surface in the new implant can improve the healing of the bone against the implants. |
| Funding Agency | |
| Title | Phase II study: Evaluate dose-response of the oral rinse in a human clinical trial of gingival inflammation and investigate effects on biological markers indicative of systemic disease. |
| Status | Complete |
| Period | 9/2009 - 1/2012 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Organogenesis |
| Title | Angiogenic potential of tissue-engineered constructs |
| Status | Complete |
| Period | 8/2010 - 7/2011 |
| Role | Principal Investigator |
| Grant Detail | One of the fundamental issues limiting the clinical efficacy of conventional surgical therapies directed to correct periodontal mucogingival defects is that new tissues must be formed directly onto avascular tooth root surfaces and rely only on limited sources of blood supply from the adjacent recipient bed. Accordingly, tissue-engineered-based therapies represent a promising alternative for the treatment of periodontal mucogingival defects by inducing and supporting adequate local vascularization during the various phases of healing. The aim of this study is to evaluate the effect of tissue-engineered constructs (Apligraf) on the proliferation, and gene and protein expression profiles of endothelial cells. Moreover, the ability of tissue-engineered constructs (Apligraf) to direct endothelial cell migration and formation of vascular networks will be investigated. |
| Funding Agency | Medtronics |
| Title | An open label, non-randomized, single-arm multi-center study to assess localized alveolar ridge augmentation uitlizing Infuse Bone Graft concurrent with dental implant placement. |
| Status | Complete |
| Period | 2/2010 - 3/2011 |
| Role | Co-Principal Investigator |
| Grant Detail | |