Hargreaves, Kenneth MDental School |
|
|
Dr. Hargreaves received his BA in neurobiology from the Univeristy of California at Berkeley in 1977, his DDS from Georgetown University in Washington DC in 1983, and his PhD in Physiology from the Uniformed Services University of the Health Sciences in Bethesda, Maryland in 1986. From 1986 to 1990, he was a Staff Fellow and Senior Staff Fellow at the Neurobiology and Anesthesiology Branch of the National Institute of Dental Research (now NIDCR) at the NIH. He completed his residency in Endodontics at the University of Minnesota in 1993 and is a Diplomate of the American Board of Endodontics. Dr. Hargreaves is currently Professor and Chair of the Departent of Endodontics, and Professor in the Department of Pharmacology, Department of Physiology and Department of Surgery at The University of Texas Health Science Center at San Antonio. He also maintains a private practice limited to endodontics. |
|
| 5/2009 - Present | Adjunct Professor | Texas A&M Health Science Center Baylor College of Dentistry, Biomedical Sciences, Dallas, TX |
| 3/2007 - Present | Professor | University of Texas Health Science Center at San Antonio, Physiology, San Antonio, TX |
| 3/2007 - Present | Professor | University of Texas Health Science Center at San Antonio, Surgery, San Antonio, TX |
| 9/2005 - Present | Presidents Council Chair in Dental Research Endowment | University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX |
| 1/2003 - Present | Editor-in-Chief | Journal of Endodontics, official journal of the American Association of Endodontists |
| 7/1997 - Present | Professor and Chair and Department Chair | University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX |
| 7/1997 - Present | Endodontist | University of Texas Health Science Center at San Antonio, Faculty Practice, Faculty Practice, San Antonio, TX |
| 7/1997 - Present | Professor | University of Texas Health Science Center at San Antonio, Pharmacology, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1993 | Certificate | Endodontics | University of Minnesota School of Dentistry Minneapolis , MN |
| 1993 | Postdoctoral Training | Endodontics | University of Minnesota, School of Dentistry Minneapolis , MN |
| 1990 | Postdoctoral Fellowship | Sr Staff Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1988 | Postdoctoral Fellowship | Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1986 | PhD | Physiology | Uniformed Services University of the Health Sciences Bethesda , MD |
| 1985 | Postdoctoral Fellowship | NRSA Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1983 | DDS | Dentistry | Georgetown University Washington , DC |
| 1981 | Internship | Research Assistant, Pharmacology | Georgetown University Washington , DC |
| 1980 | Internship | Predoc Research Fellow, School of Dentistry | Georgetown University Washington , DC |
| 1979 | MS | Master of Science Program - Endocrinology | University of California at Davis Davis , CA |
| 1977 | BA | Neurobiology | University of California at Berkeley Berkeley , CA |
Analgesics |
Clinical Therapeutics in Endodontics |
Hyperalgesia |
Inflammation |
Pain |
Pain & Inflammation, Analgesics, Hyperalgesia.....- Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics: Primary research interests are in the areas of pain and inflammation. His research team has published more than one hundred papers and one book, "Seltzer and Benders Dental Pulp," co-edited with Dr. Harold Goodis. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures. |
| Date | Description | Institution | # Students |
| 9/2011 - Present | Ph.D. Dissertations Directed | PhD Program in Pharmacology, UTHSCSA | |
| 6/2011 - Present | Masters'' Thesis Directed | Graduate Program in Clinical Investigation | |
| 4/2011 - Present | Pharmacology | The University of Texas Health Science Center | |
| Opiates/NSAIDS | |||
| 9/2010 - Present | Ph.D. Dissertations Directed | PhD program in Physiology, UTHSCSA | |
| 1/2010 - Present | Membership on Supervising Committee | Physiology, UTHSCSA | |
| 1/2009 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
| 8/2008 - Present | Fundamentals of Neuroscience II | The University of Texas Health Science Center | |
| Peripheral Sensory Receptors, Receptor Potentials & Sensory Coding; Spinal and Ascending Somatic Sensory Pathways; Pain, Nociception and Antinociception I & II. | |||
| 1/2008 - Present | Graduate (Adv Education in Endodontics) | ||
| Course Director | |||
| 1/2007 - Present | Ph.D. Dissertations Directed | PhD Program, Cellular & Structural Biology, UTHSCSA | |
| 4/2005 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
| 7/1999 - Present | Endodontics Clinic | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endodontics II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endo II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endo II | The University of Texas Health Science Center | |
| 1/1999 - Present | Core Course Oral Biology (Dental Biomedical Core II) | ||
| 1/1999 - Present | Clincial Endodontics I | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endodontics | ||
| 1/1999 - Present | Clinical Endodontics I | The University of Texas Health Science Center | |
| 7/1998 - Present | Neuropsychopharmacology | ||
| 7/1998 - Present | Endodontics Seminar | The University of Texas Health Science Center | |
| 1/1998 - Present | Endodontics Clinic | The University of Texas Health Science Center | |
| Junior | |||
| 1/1998 - Present | Periodontal Topics | ||
| 1/1998 - Present | Endodontics Lecture | The University of Texas Health Science Center | |
| Sophmore | |||
| 1/1998 - Present | Clinical Endodontics | ||
| 1/1998 - Present | Clinical Seminar I | The University of Texas Health Science Center | |
| 1/1998 - Present | Graduate Endodontics | ||
| 1/1998 - Present | Sophomore Endodontics | ||
| 9/1997 - Present | Endodontics Lecture | The University of Texas Health Science Center | |
| 1/1997 - Present | Junior Endodontics | ||
Journal Article |
| Hargreaves KM, Diogenes AR, Teixeira FB. Treatment options: biological basis of regenerative endodontics (in press) Journal of Endodontics 2013 Jan;. |
| Ruparel S, Green D, Chen P, Hargreaves KM. The cytochrome P450 inhibitor, ketoconazole, inhibits OLAM-mediated peripheral inflammatory pain Molecular Pain 2012 Sep;8(73). |
| Berg KA, Rowan MP, Gupta A, Sanchez TA, Silva M, Gomes I, McGuire BA, Portoghese PS, Hargreaves KM, Devi LA, Clarke WP. Allosteric Interactions between Delta and Kappa Opioid Receptors in Peripheral Sensory Neurons Mol Pharmacol 2012 Feb;81(2):264-272. |
| Niu L, Jiao K, Oi Y, Nikinov S, Yiu C, Arola D, Gong S, El-Marakby A, Carrilho M, Hamrick M, Hargreaves KM, Diogenes AR, Chen J, Pashley D, Tay F. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regenration FASEB 2012 Jan;26:4517-4529. |
| Loyd D, Sun X, Locke E, Salas M, Hargreaves KM. Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp Pain 2012 Jan;. |
| Fehrenbacher J, Wasky P, Locke E, Schwesinger WH, Van Sickle KR, Bingener-Casey J, Hargreaves KM. Sex differences in cytokine levels in gall bladder interstitial fluid from patients with acute cholecystitis (in review) 2012 Jan;. |
| Ruparel S, Henry MA, Akopian AN, Patil M, Zeldin D, Roman LJ, Hargreaves KM. Plasticity of cytochrome P450 isozyme expression in rat trigeminal neurons during inflammation Pain 2012 Jan;153:2013-2029. |
| Jeeruphan T, Jantarat J, Yanpiset K, Suwannapan L, Khewsawai P, Hargreaves KM. Mahidol Study 1: Comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: A retrospective study Journal of Endodontics 2012 Jan;38:1330-1336. |
| Loyd D, Henry MA, Hargreaves KM. Serotonergic Neuromodulation of Peripheral Nociceptors (in press) Stem Cell Develop Biol 2012 Jan;. |
| Dissanayaka W, Zhan X, Zhang C, Hargreaves KM, Jin L, Tong E. Co-culture of dental pulp stem cells with endothelial cells enhances osteo/ondontgenic and angiogenic potential in vitro J Endod 2012 Jan;38:454-463. |
| Loyd DR, Chen PB, Hargreaves KM. Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat Neuroscience 2011 Dec;. |
| Patil M, Patwardhan A, Salas MM, Hargreaves KM, Akopian AN. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons Neuropharmacology 2011 Sep;61(4):778-788. |
| Scotland PE, Patil M, Belugin S, Henry MA, Goffin V, Hargreaves KM, Akopian AN. Endogenous prolactin generated during peripheral inflammation contributes to thermal hyperalgesia Eur J Neurosci 2011 Sep;34(5):745-754. |
| Trevino EG, Patwardhan AN, Henry MA, Perry G, Dybdal-Hargreaves N, Hargreaves KM, Diogenes AR. Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet-rich plasma scaffold in human root tips J Endod 2011 Aug;37(8). |
| Bowles WR, Burke R, Sabino M, Harding-Rose C, Lunos S, Hargreaves KM. Sex differences in neuropeptide content and release from rat dental pulp J Endod 2011 Aug;37(8):1098-1101. |
| Berg KA, Rowan MP, Sanchez TA, Silva M, Patwardhan AM, Milam SB, Hargreaves KM, Clarke WP. Regulation of kappa-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo J Pharmacol Exp Ther 2011 Jul;338(1):92-99. |
| Ruparel NB, Patwardhan AM, Akopian AN, Hargreaves KM. Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine Mol Pharmacol 2011 Jul;80(1):117-123. |
| Ruparel NB, Patwardhan AM, Akopian AN, Hargreaves KM. Desensitization of TRPA1 by the TRPV1-selective cannabinoid arachidonoly-2 chloroethanolamine (ACEA) Mol Pharmacol 2011 Mar;. |
| Hargreaves KM. Orofacial pain Pain 2011 Mar;152(3 Sup):25-32. |
| Lautner MA, Ruparel SB, Patil MJ, Hargreaves KM. In vitro sarcoma cells release a lipophilic substance that activates the pain transduction system via TRPV1 Ann Surg Oncol 2011 Mar;18(3):866-871. |
| Diogenes A, Ferraz CC, Akopian AN, Henry MA, Hargreaves KM. LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons J Dent Res 2011 Mar;90(6):759-764. |
| Lovelace TW, Henry MA, Hargreaves KM, Diogenes A. Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure J Endod 2011 Feb;37(2):133-138. |
| Diogenes AR, Ferraz CC, Henry MA, Hargreaves KM. Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors Journal of Endodontics 2011 Jan;37(1):45-48. |
| Henry MA, Trevino E.N, Patwardhan A.N, Perry G.M, Dybal-Hargreaves N, Hargreaves KM, Diogenes AR. Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet rich plasma scaffold in human root tips Journal of Endodontics 2011 Jan;37(8):1109-1115. |
| Loyd C, Weiss G, Henry MA, Hargreaves KM. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via pheripheral serotonin receptors. (doi: 10.1016/j.pain.2011.06.002) Pain 2011 Jan;. |
| Akopian AN, Ruparel N, Patwardhan A, Hargreaves KM. Cannabinoid inhibition of TRPA1 via TRPV1 activation via the TRPV1-selective cannabinoid Arachidonoly-2 Chloroethanolamine (ACEA) Mol Pharm 2011 Jan;. |
| Akopian AN, Scotland, PE, Patil M, Belugin S, Henry MA, Goffin V, Hargreaves KM. Endogenous prolactin generated during peripheral inflammation contributes to thermal hyperalgesia Eur. J. Neurosci 2011 Jan;. |
| Ferraz CC, Henry MA, Hargreaves KM, Diogenes A. Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors J Endod 2011 Jan;37(1):45-48. |
| McNamara RP, Henry MA, Schindler WG, Hargreaves KM. Biocompatibility of accelerated mineral trioxide aggregate in a rat model J Endod 2010 Nov;36(11):1851-1855. |
| Rowan MP, Berg KA, Milam SB, Jeske NA, Roberts JL, Hargreaves KM, Clarke WP. 17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo J Pharmacol Exp Ther 2010 Oct;335(1):190-196. |
| Hargreaves KM. Capsicum and local anesthetic cocktails for trigeminal pain Pain 2010 Jul;150(1):3-3. |
| Patwardhan AM, Akopian AN, Ruparel NB, Diogenes A, Weintraub ST, Uhlson C, Murphy RC, Hargreaves KM. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents J Clin Invest 2010 May;120(5):1617-1626. |
| Lovelace T.W., Diogenes AR, Henry MA, Hargreaves KM. Evaluation of clinically deliverred SCAP cells in regenerative endodontic procedures J Endo 2010 Mar;36:554-554. |
| Hargreaves KM, Diogenes A. Effects of cxytocin and prolactin on stress-induced bladder hypersensitivity in female rats J Pain 2010 Feb;11(2):197-197. |
| Khan A, Hargreaves KM. Animal models of orofacial pain Methods Mol Biol 2010 Jan;617:93-104. |
| Glickman GN, Bakland LK, Fouad AF, Hargreaves KM, Schwartz SA. Diagnostic terminology: report of an online survey J Endod 2009 Dec;35(12):1625-1633. |
| Fehrenbacher JC, Sun XX, Locke EE, Henry MA, Hargreaves KM. Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue Pain 2009 Aug;144(3):253-261. |
| Simonton JD, Azevedo B, Schindler WG, Hargreaves KM. Age- and gender-related differences in the position of the inferior alveolar nerve by using cone beam computed tomography J Endod 2009 Jul;35(7):944-949. |
| Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK, Clarke WP. Rapid pain modulation with nuclear receptor ligands Brain Res Rev 2009 Apr;60(1):114-124. |
| Salas MM, Hargreaves KM, Akopian AN. TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1 Eur J Neurosci 2009 Apr;29(8):1568-1578. |
| Akopian AN, Ruparel NB, Jeske NA, Patwardhan A, Hargreaves KM. Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia Trends Pharmacol Sci 2009 Feb;30(2):79-84. |
| Patwardhan AM, Scotland, PE, Akopian AN, Hargreaves KM. Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia Proc Natl Acad Sci (USA) 2009 Jan;106(44):18820-18824. |
| Patwardhan AM, Scotland P, Akopian AN, Hargreaves KM. Oxidized linoleic acid metabolites activate TRPV1 in the spinal cord and evoke inflammatory hyperalgesia Proc Natl Acad Sci USA 2009 Jan;106:18820-18824. |
| Bose R, Nummikoski PV, Hargreaves KM. A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedure J Endod 2009 Jan;35:1343-1349. |
| Rowan MP, Ruparel NB, Patwardhan AM, Berg KA, Clarke WP, Hargreaves KM. Peripheral delta opioid receptors require priming for functional competence in vivo Eur J Pharmacol 2009 Jan;602(2-3):283-287. |
| Khan AA, Sun X, Hargreaves KM. Effect of calcium hydroxide on proinflammatory cytokines and neuropeptides J Endod 2008 Nov;34(11):1360-1363. |
| Gibbs JL, Hargreaves KM. Neuropeptide Y Y1 receptor effects on pulpal nociceptors J Dent Res 2008 Oct;87(10):948-952. |
| Jeske NA, Diogenes A, Ruparel NB, Fehrenbacher JC, Henry M, Akopian AN, Hargreaves KM. A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 Pain 2008 Sep;138(3):604-616. |
| Khan AA, Diogenes A, Jeske NA, Henry MA, Akopian A, Hargreaves KM. Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin Neuroscience 2008 Aug;155(2):503-509. |
| Cotton TP, Schindler WG, Schwartz SA, Watson WR, Hargreaves KM. A Retrospective Study Comparing Clinical Outcomes After Obturation with Resilon/Epiphany or Gutta-Percha/Kerr Sealer J Endod 2008 Jul;34(7):789-797. |
| Jung IY, Lee SJ, Hargreaves KM. Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series J Endod 2008 Jul;34(7):876-887. |
| Ruparel NB, Patwardhan AM, Akopian AN, Hargreaves KM. Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors Pain 2008 Apr;135(3):271-279. |
| Patwardhan AM, Vela J, Farugia J, Vela K, Hargreaves KM. Trigeminal nociceptors express prostaglandin receptors J Dent Res 2008 Mar;87(3):262-266. |
| Akopian AN, Ruparel N, Patwardhan AM, Hargreaves KM. Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation J. Neurosci 2008 Jan;28(5):1064-1075. |
| Ruparel NB, Jeske NA, Patwardhan A, Akopian AN, Hargreaves KM. Desensitization of capsaicin and mustard oil responses in rat sensory neurons via heterologous TRPV1-TRPA1 interaction (submitted) J. Physiol 2008 Jan;. |
| Hargreaves KM, Giesler T, Wang Y, Henry MA. Regeneration potential of the young permanent tooth: What does the future hold? J Endod 2008 Jan;34:S51-S56. |
| Kitchens J, Schwartz SA, Schindler WG, Hargreaves KM. Iontophoresis significantly increases the transdentinal delivery of osteoprotegerin, alendronate, and calcitonin J Endod 2007 Oct;33(10):1208-1211. |
| Akopian AN, Ruparel NB, Jeske NA, Hargreaves KM. Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization J Physiol 2007 Aug;583:175-193. |
| Berg KA, Patwardhan AM, Sanchez TA, Silva YM, Hargreaves KM, Clarke WP. Rapid modulation of micro-opioid receptor signaling in primary sensory neurons J Pharmacol Exp Ther 2007 Jun;321(3):839-847. |
| Khan AA, McCreary B, Owatz CB, Schindler WG, Schwartz SA, Keiser K, Hargreaves KM. The development of a diagnostic instrument for the measurement of mechanical allodynia J Endod 2007 Jun;33(6):663-666. |
| Diogenes A, Akopian AN, Hargreaves KM. NGF up-regulates TRPA1: implications for orofacial pain J Dent Res 2007 Jun;86(6):550-555. |
Book/Monograph |
| Hargreaves KM, Goodis, HE, Tay, F. Seltzer and Benders Dental Pulp 2nd Edition Chicago: Quintessence; 2012. |
| Hargreaves KM, Cohen S (eds). Cohens Pathways of the Pulp, 10 Edition St. Louis: Elsevier; 2010. |
Book Chapter |
| Gibbs JL, Hargreaves KM. Acute and Chronic Orofacial/Dental Pain. In: Koltzenberg M. Pain. Amsterdam: Elsevier; 2012. |
| Khan A, Hargreaves KM. Animal models of orofacial pain. In: A. Szallasi (Ed). Analgesia: Methods and Protocols. 2010. p. 93-104. |
| Bereiter DA, Hargreaves KM, Hu JW. Trigeminal mechanismsm of nociception: peripheral and brain stem organization. In: C Bushnell and A Basbaum. Handbook of the Senses: A Comprehensive Reference. San Diego, Academic Press; 2008. p. 435-460. |
| Diogenes AR, Hargreaves KM. Analgesics in Endodontics. In: Diogenes AR, Hargreaves KM. Analgesic in Endodontics. 2008. p. 775-789. |
| Khan A, Ren K, Hargreaves KM. Neurochemical Factors in Injury and Inflammation of Orofacial Tissues. In: B Sessle, G Lavigne, J Lund, R Dubner. Orofacial Pain: Basic Sciences to Clinical Management. Chicago: Quintessence; 2008. |
Abstract |
| Hargreaves KM, Loyd DR, Weiss G, Henry MA. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors; 2011 Jul. (Pain). |
| Diogenes AR, Pacheco M, Teixeira FB, Hargreaves KM. A Prevalence of Mechanical Allodynia in Endodontic Patients; 2011 Jan. (Journal of Endodontics; vol. 37, no. 3). |
| Bose R.S, Diogenes AR, Henry MA, Khaing Z, Schmidt C, Hargreaves KM. Comparison of two different scaffolds used in the regeneration of the pulp-dentin complex; 2011 Jan. (Journal of Endodontics; vol. 37, no. 3). |
| Loyd D, Sun X, Henry MA, Hargreaves KM. Serotonin enhances CGRP release from female human trigeminal nociceptors; 2011 Jan. (Journal of Pain; vol. 12, no. 4). |
| Quang P.N, Martin D.E, Ishikawa B, Althumairy R, Henry MA, Teixeira FB, Hargreaves KM, Diogenes AR. Understanding regenerative endodontic treatments: scaffolds; 2011 Jan. (TC23, American Association of Endodontists 2011 Annual Meeting). |
| McNamara RP Henry MA Schindler WG Hargreaves KM. Biocompatability of Accelerated Mineral Trioxide Aggregate in a Rat Model; 2010 Mar. (J Endod; vol. 36, no. 3). |
| Shiloah Y, Diogenes AR, Henry MA, Hargreaves KM. Anatomical characterization of stem cell markers within human dental pulp; 2010 Mar. (J Endo, Abstract #OR20; vol. 36). |
| Lovelace T, Diogenes AR, Hargreaves, KM. Evaluation of clinically delivered SCAP in regenerative procedures: American Association of Endodontists; 2010 Jan. |
| Subhani M, Perry G, Luo S, Levinson S.R., Hargreaves KM, Henry MA. Neurovascular relationships in normal and painful human dental pulp; 2010 Jan. (J Dent, Special Issue A, Abstract #994; vol. 89). |
| Henry MA, Loyd, D.R, Helesic G, Hargreaves KM. Serotonin enhances capsaicin- sensitive trigeminal nociceptor function via serotonin receptor colocalization with TRPV1 in rat trigeminal sensory neurons; 2010 Jan. (2010 ISAP 13th World Congress on Pain, Montreal Canada, Abstract #313). |
| Ruparel S.B., Helesic G, Patil M, Henry MA, Hargreaves KM, Green D. Expression of cytochrome P450 isoforms in rat nociceptive neurons; 2010 Jan. (2010 IASP 13th World Congress on Pain, Montreal, Canada, Abstract #313). |
| Patil M.J, Belugin S, Henry MA, Hargreaves KM, Akopian AN. Regulation of prolactin system in sensory neurons by estrogen and testosterone; 2010 Jan. (Poster #78.17, Society for Neuroscience 2010). |
| Scotland PE, Fehrenbacher JC, Sun XX, Locke EE, Hargreaves KM, Akopian AN. A role for prolactin signaling in human orofacial nociception; 2010 Jan. (13th World IASP, PH 310, Montreal, Canada). |
| Salas MM, Hargreaves KM, Akopian AN. Molecular domains involved in interaction between TRPA1 and TRPV1 channels; 2010 Jan. (13th World IASP, PH 159, Montreal, Canada). |
| Simonton JD, Azevedo B, Schindler WG, Hargreaves, KM. Evaluation of Gender- and age-Related Differences in the Position of the Inferior Alveolar Nerve Using Cone Beam CT; 2009 Mar. (J Endod; vol. 35, no. 3). |
| Trevino EG, Henry MA, Patwardhan AM, Perry, GM, Sun, X, Helesic, G, Locke, E, Hargreaves KM. The effect of different irrigants on SCAP in human roots; 2009 Jan. (J Dent Res, Special Issue A, Abstract #1603; vol. 88). |
| Salas MM, Hargreaves KM, Akopian AN. The molecular domains involved in the interaction between TRPA1 and TRPV1 channels; 2009 Jan. (Soc Neurosci Abstr). |
| Scotland PE, Diogenes AR, Hargreaves KM, Akopian AN. Hormonal regulation of prolactin-induced TRPV1 sensitization in male rats; 2009 Jan. (Soc Neurosci Abstr; vol. 268, no. 22). |
| Fehrenbacher JC. Effects of estrogens on human nociceptor sensitivity: Society for Neroscience; 2009 Jan. (National Institute for Drug Abuse Frontiers in Addiction Research Mini-Convention). |
| Fehrenbacher JC, Locke EE, Sun XX, Henry MA, Hargreaves KM. Effects of estrogens on human nociceptor sensitivity: Society for Neuroscience; 2009 Jan. (2009 abstract viewer and itinerary planner (online), Washington D.C). |
| Rowan M, Berg KA, Milam SB, Roberts JL, Hargreaves KM, Clarke WP. Activation of estrogen receptor enhances bradykinin signaling in female rats; 2009 Jan. (Society for Neuroscience Abstr). |
| Millar GC, Luo S, Perry GM, Hargreaves KM, Henry MA. Immunohistochemical characterization of TRPV1 staining in human dental pulp; 2009 Jan. (J Dent Res, Special Issue A, Abstract #1429; vol. 88). |
| Diogenes AR, Akopian AN, Henry MA, Perry GM, Hargreaves KM. A mechanism for abscess-related pain: How bacteria directly sensitizes trigeminal nociceptors; 2009 Jan. (J Endod, Abstract #OR24; vol. 35, no. 432). |
| Trevino EG, Henry MA, Patwardhan AM, Perry GM, Sun X, Helesic G, Locke E, Hargreaves KM. The effect of different irrigation solutions on the survival of stem cells of the apical papilla (SCAP) in a PRP scaffold in human root tips; 2009 Jan. (J Endod, Abstract #OR; vol. 35, no. 428). |
| Cotton TP, Schindler WG, Schwartz SA, Watson, WR, Hargreaves KM. Resilon and Gutta-Percha: A Retrospective Clinical Study of Healed vs. Nonhealed; 2008 Mar. (J Endod; vol. 34, no. 3). |
| Scotland PE, Helesic G, Perry G, Henry MA, Hargreaves KM, Akopian AN. Colocalization of prolactin and TRPV1 in inflamed rat hindpaw skin; 2008 Jan. (IASP 12th World Congress on Pain, Dublin, Scotland, Anstract #PT163). |
| Patil, MJ, Hargreaves KM, Akopian AN. Regulation of TRPV1 and TRPA1 activities by PIP2 in TRPA1/TRPV1 expressing cell; 2008 Jan. (Soc Neurosci Abstr). |
| Salas MM, Akopian AN, Hargreaves KM. Role of extracellular Ca2+ in regulation of mustard oil responses in TRPA1 and TRPA1/TRPV1 expressing sensory neurons; 2008 Jan. (Soc Neurosci Abstr). |
| Fehrenbacher JC. Men exhibit markedly increased tissue level cytokines in acute cholecystitis: Academic Surgical Congress; 2008 Jan. (Association for Academic Surgery). |
| Fehrenbacher JC, Hargreaves KM. GPR30 sensitization of trigeminal neurons enhances inflammatory hyperalgesia: Society of Neuroscience; 2008 Jan. (Abstract Viewer and Itinerary Planner (online), Washington D.C). |
| Berg KA, Rowan M, Sanchez T, Silva M, Hargreaves KM, Clarke WP. Regulation of delta opioid receptor (DOR) responsiveness in vitro and in vivo by antagonist occupancy of the kappa opioid receptor (KOR); 2008 Jan. (Society for Neuroscience Abstr). |
| Rowan M, Berg KA, Milam SB, Roberts JL, Hargreaves KM, Clarke WP. 17Beta-estradiol rapidly enhances bradykinin responses in sensory neurons in vitro and in vivo; 2008 Jan. (Society for Neuroscience Abstr). |
| Berg KA, Sanchez T, Silva M, Rowan M, Hargreaves KM, Clarke WP. Regulation of delta opioid receptor (DOR) responsiveness in vitro by antagonist occupancy of kappa opioid receptors (KOR); 2008 Jan. (Experimental Biology Abstr). |
| Rowan M, Patwardhan AM, Ruparel NB, Berg KA, Hargreaves KM, Clarke WP. Peripheral delta opioid receptors (DOR) require priming for functional competence In Vivo; 2008 Jan. (Experimental Biology Abstr). |
| Maggio A, Vela J, Perry GM, Henry MA, Hargreaves KM. B1 adrenergic receptor expression on human dental pulp neurons; 2008 Jan. (J. Dent. Res., Special Issue A, Abstract #0493). |
| Luff KC, Khan A, Perry GM, Henry MA, Hargreaves KM. Tumor necrosis factor receptor I expression in inflamed human pulps; 2008 Jan. (J Dent Res, Special Issue A, Abstract #0484). |
| Scotland PE, Diogenes AR, Jeske NA, Patwardhan AM, Henry MA, Hargreaves KM, Akopian AN. Prolactin sensitizes TRPV1 and produces hyperalgesia in male rats; 2008 Jan. (Soc Neurosci Abstr, poster #265; vol. 265, no. 17). |
| Geisler TM, Wang Y, Perry GM, Henry MA, Sun X, Locke E, Hargreaves KM. Regenerative endodontics: growth factors control the phenotype of human dental pulp stem/progenitor cells; 2008 Jan. (J Endod; vol. 34, no. 341). |
| Rowan MP, Ruparel NB, Patwardhan AM, Berg KA, Clarke WP, Hargreaves KM. Peripheral Delta Opioid Receptors (DOR) require priming for functional competence In Vivo; 2008 Jan. (The FASEB Journal; vol. 22). |
Editorial |
| Hargreaves KM, Law A. The wrong emperor Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Mar;109(3):327-328. |
| Hargreaves KM. Save the baby Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Dec;104(6):730-730. |
Federal |
|
| Funding Agency | NIDR |
| Title | Oral Surgery & Initiation of Neurogenic Inflammation |
| Status | Complete |
| Period | - Present |
| Role | Co-Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH-NINDS |
| Title | Role of Oxidized Linoleic Acid Metabolites in Pain |
| Status | Active |
| Period | 9/2010 - 8/2015 |
| Role | Principal Investigator |
| Grant Detail | This R01 utilizes molecular, electrophysiologic anatomical, biochemical and behavior methods to evaluae the role of endogenous TRPV1 agonists (OLAMS) in inflammatory pain. |
| Funding Agency | US Department of Defense |
| Title | Endogenous Mediators of Burn Pain: Mechanisms and Therapeutics |
| Status | Active |
| Period | 4/2011 - 9/2013 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH- NIDCR |
| Title | Prolactin Regulation of Trigeminal Nociceptors |
| Status | Active |
| Period | 8/2007 - 5/2013 |
| Role | Co-Investigator |
| Grant Detail | This series of studies utilizes molecular neuroscience, anatomical and behavior methods to test the hypothesis that prolactin (sex related hormone) regulates the activity of nociceptive sensory neurons of male and female rat trigeminal ganglia. |
| Funding Agency | NIH / NCRR |
| Title | Institute for Integration of Medicine & Science: A Partnership to Improve Health |
| Status | Active |
| Period | 5/2008 - 4/2013 |
| Role | Co-Principal Investigator |
| Grant Detail | This Clinical and Translational Science Award (CTSA) provides a broad range of infrastructure support across the institution and its CTSA partners. |
| Funding Agency | NIH-NIGMS |
| Title | Development of Anti-OLAM Aptamers as Novel Analgesics |
| Status | Active |
| Period | 9/2012 - 2/2013 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIDCR |
| Title | CO*STAR Training Grant |
| Status | Active |
| Period | 5/2007 - 6/2012 |
| Role | Contributor |
| Grant Detail | |
| Funding Agency | NIH - NIDCR |
| Title | Interactions of TRPV1 and TRPA1 in Inflammatory Pain |
| Status | Active |
| Period | 7/2009 - 6/2012 |
| Role | Co-Investigator |
| Grant Detail | This series of studies utilizes molecular neuroscience, anatomical, behavior and electrophysiology methods to test the hypothesis that a functional interaction between TRPA1 and TRPV1 channels plays a key role in integration of inflammation-induced stimuli by sensory neurons. |
| Funding Agency | NIH - NINDS |
| Title | Cannabinoid Modulation of Capsaicin-Sensitive Neurons |
| Status | Active |
| Period | 3/2006 - 2/2011 |
| Role | Principal Investigator |
| Grant Detail | This series of studies utilizes biochemical, molecular and anatomical methods to test the hypothesis that peripheral cannabinoid antihyperalgesia/antiallodynia is mediated, at least in part by peripheral cannabinoid ionotropic receptors. |
Private |
|
| Funding Agency | USAA Foundation |
| Title | New Method to Treat Burn Pain in Our Wounded Warriors |
| Status | Active |
| Period | 6/2010 - 1/2029 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Elizabeth Huth Coates Charitable Foundation |
| Title | A New Method to Treat Burn Pain in Our Wounded Warriors |
| Status | Active |
| Period | 5/2011 - 4/2013 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Owens Foundation |
| Title | A Novel Approach to Pain Control |
| Status | Active |
| Period | 12/2011 - 12/2012 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIDCR-NIH |
| Title | Regeneration of pulp-dentin development in immature permanent teeth with necrosis |
| Status | Active |
| Period | 1/2010 - 1/2012 |
| Role | Principal Investigator |
| Grant Detail | This is a one year planning grant to develop a proposal for a multi-center clinical trial comparing a regenerative endodontic treatment to MTA apexification. |