Hargreaves, Kenneth MDental School |
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Dr. Hargreaves received his BA in neurobiology from the University of California at Berkeley in 1977, his DDS from Georgetown University in Washington DC in 1983, and his PhD in Physiology from the Uniformed Services University of the Health Sciences in Bethesda, Maryland in 1986. From 1986 to 1990, he was a Staff Fellow and Senior Staff Fellow at the Neurobiology and Anesthesiology Branch of the National Institute of Dental Research (now NIDCR) at the NIH. He completed his residency in Endodontics at the University of Minnesota in 1993 and is a Diplomate of the American Board of Endodontics. Dr. Hargreaves is currently Professor and Chair of the Department of Endodontics, and Professor in the Department of Pharmacology, Department of Physiology, and Department of Surgery at The University of Texas Health Science Center at San Antonio. He also maintains a private practice limited to endodontics. |
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| 12/2015 - Present | COSTAR Director | University of Texas Health Science Center at San Antonio, San Antonio, TX |
| 3/2007 - Present | Professor | University of Texas Health Science Center at San Antonio, Physiology, San Antonio, TX |
| 3/2007 - Present | Professor | University of Texas Health Science Center at San Antonio, Surgery, San Antonio, TX |
| 9/2005 - Present | President`s Council Chair in Dental Research Endowment | University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX |
| 1/2003 - Present | Editor-in-Chief | Journal of Endodontics, official journal of the American Association of Endodontists |
| 7/1997 - Present | Professor and Chair and Department Chair | University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio, TX |
| 7/1997 - Present | Endodontist | University of Texas Health Science Center at San Antonio, Faculty Practice, Faculty Practice, San Antonio, TX |
| 7/1997 - Present | Professor | University of Texas Health Science Center at San Antonio, Pharmacology, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1993 | Postdoctoral Training | Endodontics | University of Minnesota, School of Dentistry Minneapolis , MN |
| 1990 | Postdoctoral Fellowship | Sr Staff Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1988 | Postdoctoral Fellowship | Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1986 | PhD | Physiology | Uniformed Services University of the Health Sciences Bethesda , MD |
| 1985 | Postdoctoral Fellowship | NRSA Postdoc Fellow-Neurobiol & Anesthes Branch | National Institute of Dental Research, NIH Bethesda , MD |
| 1983 | DDS | Dentistry | Georgetown University Washington , DC |
| 1981 | Internship | Research Assistant, Pharmacology | Georgetown University Washington , DC |
| 1980 | Internship | Predoc Research Fellow, School of Dentistry | Georgetown University Washington , DC |
| 1977 | BA | Neurobiology | University of California at Berkeley Berkeley , CA |
Analgesics |
Clinical Therapeutics in Endodontics |
Hyperalgesia |
Inflammation |
Pain |
Pain & Inflammation, Analgesics, Hyperalgesia.....- Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics: Primary research interests are in the areas of pain and inflammation. His research team has published more than one hundred papers and one book, "Seltzer and Bender`s Dental Pulp," co-edited with Dr. Harold Goodis. His ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures. |
| Date | Description | Institution | # Students |
| 1/2015 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio | |
| 1/2014 - Present | Masters' Thesis Directed | University of Texas Health Science Center at San Antonio | |
| 1/2014 - Present | Ph.D. Dissertations Directed | University of Texas Health Science Center at San Antonio | |
| 9/2011 - Present | Ph.D. Dissertations Directed | PhD Program in Pharmacology, UTHSCSA | |
| 4/2011 - Present | Pharmacology | The University of Texas Health Science Center | |
| Opiates/NSAIDS | |||
| 1/2010 - Present | Membership on Supervising Committee | Physiology, UTHSCSA | |
| 8/2008 - Present | Fundamentals of Neuroscience II | The University of Texas Health Science Center | |
| Peripheral Sensory Receptors, Receptor Potentials & Sensory Coding; Spinal and Ascending Somatic Sensory Pathways; Pain, Nociception and Antinociception I & II. | |||
| 1/2008 - Present | Graduate (Adv Education in Endodontics) | ||
| Course Director | |||
| 7/1999 - Present | Endodontics Clinic | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endodontics I | The University of Texas Health Science Center | |
| 1/1999 - Present | Core Course Oral Biology (Dental Biomedical Core II) | ||
| 1/1999 - Present | Clinical Endodontics | ||
| 1/1999 - Present | Clinical Endo II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endodontics II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clinical Endo II | The University of Texas Health Science Center | |
| 1/1999 - Present | Clincial Endodontics I | The University of Texas Health Science Center | |
| 7/1998 - Present | Endodontics Seminar | The University of Texas Health Science Center | |
| 7/1998 - Present | Neuropsychopharmacology | ||
| 1/1998 - Present | Clinical Seminar I | The University of Texas Health Science Center | |
| 1/1998 - Present | Periodontal Topics | ||
| 1/1998 - Present | Sophomore Endodontics | ||
| 1/1998 - Present | Graduate Endodontics | ||
| 1/1998 - Present | Clinical Endodontics | ||
| 1/1998 - Present | Endodontics Clinic | The University of Texas Health Science Center | |
| Junior | |||
| 1/1998 - Present | Endodontics Lecture | The University of Texas Health Science Center | |
| Sophmore | |||
| 9/1997 - Present | Endodontics Lecture | The University of Texas Health Science Center | |
| 1/1997 - Present | Junior Endodontics | ||
Journal Article |
| Berg KA, Rowan MP, Gupta A, Sanchez TA, Silva M, Gomes I, McGuire BA, Portoghese PS, Hargreaves KM, Devi LA, Clarke WP. Allosteric Interactions between Delta and Kappa Opioid Receptors in Peripheral Sensory Neurons Mol Pharmacol 2012 Feb;81(2):264-272. |
| Loyd DR, Chen PB, Hargreaves KM. Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat Neuroscience 2011 Dec;. |
Federal |
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| Funding Agency | NIDR |
| Title | Oral Surgery & Initiation of Neurogenic Inflammation |
| Status | Complete |
| Period | - Present |
| Role | Co-Principal Investigator |
| Grant Detail | |
| Funding Agency | Department of Defense |
| Title | Developing Novel Analgesics for Treating Burn Pain |
| Status | Active |
| Period | 1/2015 - 1/2018 |
| Role | Principal Investigator |
| Grant Detail | Test novel analgesic regimes targeting TRPV1 in a murine burn model |
| Funding Agency | NIGMS SBIR |
| Title | Development of Anti-OLAM aptamers as novel analgesics |
| Status | Active |
| Period | 1/2015 - 1/2017 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIH-NINDS |
| Title | Role of Oxidized Linoleic Acid Metabolites in Pain |
| Status | Complete |
| Period | 9/2010 - 8/2015 |
| Role | Principal Investigator |
| Grant Detail | This R01 utilizes molecular, electrophysiologic anatomical, biochemical and behavior methods to evaluae the role of endogenous TRPV1 agonists (OLAMS) in inflammatory pain. |
| Funding Agency | NIH |
| Title | South Texas Advanced Research Training: Undergraduate Program (START-UP) |
| Status | Complete |
| Period | 9/2010 - 8/2015 |
| Role | Contributor |
| Grant Detail | The purpose of this program is to increase the number of underrepresented minorities (URMs) entering doctoral programs in the neurosciences and then the biomedical workforce as Ph.D.?s. URMs are defined by ethnicity, socio-economic status and disabilities. |
Private |
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| Funding Agency | USAA Foundation |
| Title | New Method to Treat Burn Pain in Our Wounded Warriors |
| Status | Active |
| Period | 6/2010 - 1/2029 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Barker Foundation |
| Title | Pain Management |
| Status | Active |
| Period | 1/2013 - 1/2018 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | American Association for Endodontists Foundation |
| Title | Regeneration of pulp-dentin development in teeth with necrotic pulps and immature roots |
| Status | Active |
| Period | 1/2013 - 1/2019 |
| Role | Principal Investigator |
| Grant Detail | PI of UTHSCSA Study Site: Dr. Anibal Diogenes. Study Chair: Dr. Ken Hargreaves. This is a multi-center randomized controlled clinical trial evaluating regenerative endodontic therapies to MTA apexification. Although there is no scientific or technical overlap with the proposed application, it documents a strong commitment and foundation in the area of regenerative endodontics. |
| Funding Agency | DSRIP |
| Title | Development of a Dental Pain Emergency Program |
| Status | Active |
| Period | 1/2013 - 1/2016 |
| Role | Principal Investigator |
| Grant Detail | |