Steffensen, BjornDental School |
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Bjorn Steffensen is an Associate Dean for Research in the Dental School and a Professor in the Department of Periodontics and the Department of Biochemistry at the University of Texas Health Science Center at San Antonio, Texas. He received his dental degree from the Royal Dental College of Copenhagen, Denmark in 1978. Subsequently, he taught part-time at the Royal Dental College and practiced dentistry first in Denmark and then in Switzerland where he also attended postdoctoral courses in the Departments of Periodontics and Crown and Bridge Dentistry at The University of Berne. During 1983-1986, Dr. Steffensen completed specialty training as a periodontist and completed his M.S. degree from The University of Michigan, Ann Arbor, Michigan. From 1992-1997, he attended graduate studies and received his Ph.D. from the University of British Columbia, Vancouver BC, Canada. Dr. Steffensen has held his faculty position at the University of Texas Health Science Center, Department of Periodontics, from 1986‑1992 and from 1997 to present. He is a Diplomate of the
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| 1/2005 - Present | Associate Dean for Research | University of Texas Health Science Center at San Antonio, Dental Deans Office, San Antonio, TX |
| 1/2004 - Present | Professor | University of Texas Health Science Center at San Antonio, Periodontics, San Antonio, TX |
| 1/2004 - Present | Professor | University of Texas Health Science Center at San Antonio, Biochemistry, San Antonio, TX |
| 1/2000 - Present | Staff Member | The University Health System, Department of Hospital Dentistry, San Antonio, TX |
| 1/1999 - Present | Member | San Antonio Cancer Institute, Experimental Therapeutics and Metastasis Groups, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1997 | PhD | Oral Biology | University of British Columbia Vancouver , Canada |
| 1990 | Residency | Research | Cellular and Structural Biology, University of Texas Health Science Center San Antonio , TX |
| 1986 | MS | Periodontics | University of Michigan Ann Arbor , MI |
| 1986 | Postdoctoral Fellowship | Research | Dental Research Institute, University of Michigan Ann Arbor , MI |
| 1983 | Postdoctoral Training | Crown/Bridge/Periodontics | School of Dental Medicine Berne , Switzerland |
| 1980 | Postdoctoral Training | Research | Department of Cellular and Structural Biology, UTHSCSA Dental School San Antonio , TX |
| 1980 | Postdoctoral Training | Occlusion | The Royal Dental College Copenhagen , Denmark |
| 1979 | Residency | Required for Licensure (Jus Practicandi) | Private General Practice Residency Copenhagen , Denmark |
| 1978 | DDS | Dentistry | The Royal Dental College of Copenhagen Denmark |
| 1973 | BS | Equivalent to BS | Hobro Gymnasium Denmark |
Extracellular matrix molecules |
Matrix metalloproteinases |
Periodontal disease |
| Date | Description | Institution | # Students |
| 1/2010 - Present | Membership on Supervising Committee | The University of Texas Health Science Center at San Antonio | |
| 7/2007 - Present | Pre-Doctoral Student Supervision | University of Texas Health Science Center at San Antonio | |
| 7/2007 - Present | Pre-Doctoral Student Supervision | University of Texas Health Science Center at San Antonio | |
| 7/2007 - Present | Pre-Doctoral Student Supervision | University of Texas Health Science Center at San Antonio | |
| 1/2006 - Present | Individual Instruction | University of Texas Health Science Center at San Antonio | |
| 8/2003 - Present | Individual Instruction | UTHSCSA | |
| 6/2001 - Present | Dental Biomed Core I | The University of Texas Health Science Center | |
| 1/2001 - Present | Dental Biomed Core II | The University of Texas Health Science Center | |
| 8/2000 - Present | Research Protocol Develop | The University of Texas Health Science Center | 10 students |
| Course Director | |||
| 8/2000 - Present | Individual Instruction | University of Texas Health Science Center at San Antonio | |
| 8/2000 - Present | Individual Instruction | University of Texas Health Science Center at San Antonio | |
| 8/2000 - Present | Periodontics | The University of Texas Health Science Center | 100 students |
| 8/2000 - Present | Biochemistry | The University of Texas Health Science Center | 30 students |
| 1/1998 - Present | Bone & Connective Tissue Biology | The University of Texas Health Science Center | |
| 8/1997 - Present | Current Lit Seminar | The University of Texas Health Science Center | |
| 7/1997 - Present | Literature Seminars | The University of Texas Health Science Center | |
| 7/1997 - Present | Peri Lecture Series | The University of Texas Health Science Center | |
Journal Article |
| Xu X, Mikhailova M, Chen Z, Pal S, Robichaud TK, Lafer EM, Baber S, Steffensen B. Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2) Matrix Biol 2011 Sep;30(7-8):404-412. |
| Robichaud TK, Steffensen B, Fields GB. Exosite interactions impact matrix metalloproteinase collagen specificities J Biol Chem 2011 Sep;. |
| Steffensen B, Chen Z, Pal S, Mikhailova M, Su J, Wang Y, Xu X. Fragmentation of fibronectin by inherent autolytic and matrix metalloproteinase activities Matrix Biol 2011 Jan;30(1):34-42. |
| Jacobsen JN, Steffensen B, Hkkinen L, Krogfelt KA, Larjava HS. Skin wound healing in diabetic 6 integrin-deficient mice APMIS 2010 Oct;118(10):753-764. |
| Pal S, Chen Z, Xu X, Mikhailova M, Steffensen B. Co-purified gelatinases alter the stability and biological activities of human plasma fibronectin preparations J Periodontal Res 2010 Apr;45(2):292-295. |
| Xu X, Mikhailova M, Ilangovan U, Chen Z, Yu A, Pal S, Hinck AP, Steffensen B. Nuclear magnetic resonance mapping and functional confirmation of the collagen binding sites of matrix metalloproteinase-2 Biochemistry 2009 Jun;48(25):5822-5831. |
| Johnson DL, Carnes D, Steffensen B, Cochran DL. Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chromatography J Periodontol 2009 Apr;80(4):648-656. |
| Stanley CM, Wang Y, Pal S, Klebe RJ, Harkless LB, Xu X, Chen Z, Steffensen B. Fibronectin fragmentation is a feature of periodontal disease sites and diabetic foot and leg wounds and modifies cell behavior J Periodontol 2008 May;79(5):861-875. |
| Dodge WW, Glass BJ, Kalkwarf KL, Neenan ME, Steffensen B, Thomas DD. University Spotlight - The University of Texas Health Science Center at San Antonio Inside Dentistry 2008 Feb;4(2):120-121. |
| Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B. Interleukin-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK 1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation Am J Physiol Heart Circ Physiol 2007 Dec;293(6):H3356-H3365. |
| Xu X, Chen Z, Wang Y, Bonewald L, Steffensen B. Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions Biochem J 2007 Aug;406(1):147-155. |
Abstract |
| Gonzalez O, Yuan G, Yang G, Wu LA, Gluhak-Heinrich J, Donly K, Xu X, Steffensen B, MacDougall M, Chen S. MMP-9 is essential for alveolar bone and tooth development; 2010 May. (J Dent Res; vol. 89, no. A). |
| Zhu X, Xu X, Chen Z, Mikhailova M, Pal S, Steffensen B. Fibronectin and collagen glycation alter MMP expression in periodontal fibroblasts; 2010 May. (J Dent Res; vol. 89, no. A). |
| Ortiz Gonzalez I, Yang G, Yuan G, Deas D, Wu L, Gluhak-Heinrich J, Donly KJ, Xu X, Steffensen B, MacDougall M, Chen S. MMP-9 is Essential for Alveolar Bone Formation and Tooth Development. 88th /American Association for Dental Research. Washington, D.C; 2010 Jan. |
| Ortiz Gonzalez I, Yang G, Yuan G, Deas D, Wu L, Gluhak-Heinrich J, Donly KJ, Xu X, Steffensen B, MacDougall M, Chen S. MMP-9 is Essential for Alveolar Bone Formation and Tooth Development. 88th/American Association for Dental Research. Washington D.C; 2010 Jan. |
| Yuan G, Yang G, Gonzalez O, Gluhak-Heinrich J, Xu X, Chen Z, Steffensen B, Donly K, MacDougall M, Chen Z, Chen S. Tooth defects and DSP/DSPP processing interference in MMP-9 knock-out mice; 2009 Apr. (J Dent Res; vol. 88, no. A). |
| Baber S, Steffensen B, Chen Z, Mikhailova M, Pal S, Xu X. Competitive inhibition of proMMP-2 activation; 2008 Mar. (J Dent Res; vol. 87, no. A). |
| Pal S, Chen Z, Xu X, Mikhailova M, Wang Y, Steffensen B. Cleavage of fibronectin by MMP-2 generates fragments with distinct biological activities; 2008 Jan. (Mol Biol Cell; vol. 19, no. suppl). |
| Xu X, Baber S, Chen Z, Pal S, Mikhailova M, Steffensen B. Inhibition of proMMP-2 activation by carboxyl-terminal domain of TIMP-2 in vitro; 2008 Jan. (Mol Biol Cell; vol. 19, no. suppl). |
Federal |
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| Funding Agency | National Institutes of Health |
| Title | Bridging Oral Health Science, Education, and Practice: A CATs Initiative |
| Status | Active |
| Period | 12/2007 - 1/2013 |
| Role | Co-Investigator |
| Grant Detail | This Educational Research Program establishes and systematically evaluates an innovative, comprehensive, school wide educational program to build skills needed for lifelong learning and evidence-based dental practice. |
| Funding Agency | NIDCR |
| Title | Institutional Research Training Grant-T32 |
| Status | Active |
| Period | 1/2007 - 12/2012 |
| Role | Principal Investigator |
| Grant Detail | This grant supports student training in research. |
| Funding Agency | National Institute of Dental and Craniofacial Research |
| Title | NIDCR NRSA Training Grant: Craniofacial Oral-Biology Student Training in Academic Research (CO-STAR) |
| Status | Active |
| Period | 1/2007 - 12/2012 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIDCR |
| Title | CO*STAR Training Grant |
| Status | Active |
| Period | 5/2007 - 6/2012 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | NIH/NIDCR |
| Title | MMP-2 and Fibronectin Fragmentation in Periodontal Diseases and Oral Cancer |
| Status | Active |
| Period | 1/2006 - 12/2011 |
| Role | Principal Investigator |
| Grant Detail | |