Abstract |
| LoCoco PM, Risinger AL, Mooberry SL, Berg KA, Clarke WP. The neuroprotective agent, P7C3-A20, prevents paclitaxel-induced allodynia in the rat; 2015 Nov. (Presented at the Society for Neuroscience Meeting).
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| LoCoco PM, Chavera TA, Scofield HO, Jamshidi RJ, Mooberry SL, Berg KA, Clarke WP. Subpopulations of peripheral sensory neurons are differentially sensitive to the microtubule-targeting agent, paclitaxel; 2015 Jan. (Presented at the Chemotherapy-Induced Peripheral Neuropathy Symposium, Santa Barbara, CA).
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| LoCoco PM, Chavera TA, Scofield HO, Jamshidi RJ, Mooberry SL, Berg KA, Clarke WP. Subpopulations of peripheral sensory neurons are differentially sensitive to the microtubule-targeting agent, paclitaxel; 2014 Nov. (Presented at the Society for Neuroscience Meeting).
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| Sullivan LC, Jamshidi RJ, LoCoco PM, Berg KA, Clarke WP. Age-related differences in the sensitivity to allodynia produced by TRP receptor agonists; 2014 Nov. (Presented at the Society for Neuroscience Meeting).
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| McGuire BA, Chavera TA, Clarke WP, Berg KA. Allosteric interactions within delta opioid receptor ? kappa opioid receptor (DOR-KOR) heteromers in peripheral sensory neurons; 2014 Nov. (Presented at the Experimental Biology Meeting, San Diego, CA).
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| LoCoco PM, Villarreal G, Dybdal-Hargreaves NF, Mooberry SL, Berg KA, Clarke WP. The neuroprotective agent, P7C3-A20, prevents paclitaxel-induced peripheral neuropathy in the rat; 2014 Oct. (Presented at UTHSCSA Pharmacology/Neuroscience Graduate Student Symposium).
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| Jamshidi RJ, McGuire BA, Sullivan LC, Chavera TA, Clarke WP, Berg KA. Unique regulation of peripheral kappa opioid receptor (KOR) function by the protean ligand, norBNI; 2014 Mar. (Presented at the Behavior, Biology, and Chemistry Conference, San Antonio, TX).
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| LoCoco PM, Scofield HO, Chavera TA, Mooberry SL, Berg KA, Clarke WP. The microtubule-targeting agent, paclitaxel, differentially damages bradykinin (B2) receptor-expressing nociceptors San Antonio TX; 2013 Oct. (Presented at UTHSCSA Pharmacology/Neuroscience Graduate Student Symposium).
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| LoCoco PM, Scofield HO, Chavera TA, Mooberry SL, Berg KA, Clarke WP. Bradykinin (B2) receptor- expressing nociceptors are differentially sensitive to the microtubule-targeting agent, paclitaxel; 2013 Jan. (Presented at Translational Research CTSA Consortium).
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| Jamshidi RJ, McGuire BA, Sullivan LC, Chavera TA, Clarke WP, Berg KA. Long-Term Regulation of Kappa Opioid Receptor (KOR) Function in Peripheral Sensory Neurons In Vivo and Ex Vivo; 2013 Jan. (Presented at the Terry M. Mikiten Graduate Student Research Forum., San Antonio, TX).
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| Jamshidi RJ, McGuire BA, Sullivan LC, Clarke WP, Berg KA. KOR agonist function selectivity in peripheral sensory neurons in vivo and ex vivo; 2012 Jan. (Presented at the International Narcotics Research Conference).
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| Sullivan LC, Berg KA, Clarke WP. Differential effects of bradykinin and exogenous arachidonic acid on delta opioid receptor function in peripheral sensory neurons; 2012 Jan. (Presented at the Behavior, Biology, and Chemistry: Translational Research in Addiction Meeting).
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| McGuire BA, Sullivan LC, Clarke WP, Berg KA. Delta and kappa opioid receptor (D-KOR) heteromers in peripheral sensory neurons ex vivo and in vivo; 2012 Jan. (Presented at the Behavior, Biology, and Chemistry: Translational Research in Addiction Meeting).
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| Jamshidi RJ, McGuire BA, Sullivan LC, Berg KA, Clarke WP. Functional selectivity kappa opioid receptor (KOR) agonists in peripheral sensory neurons; 2012 Jan. (Presented at the Behavior, Biology, and Chemistry: Translational Research in Addiction Meeting).
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| Sullivan LC, Berg KA, Clarke WP. Lipoxygenase-mediated regulation of delta opioid receptor function in peripheral sensory neurons; 2012 Jan. (Presented at the International Narcotics Research Conference).
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Journal Article |
| Sullivan LC, Chavera TA, Jamshidi RJ, Berg KA, Clarke WP. Constitutive desensitization of opioid receptors in peripheral sensory neurons J Pharmacol Exp Ther 2016 Jan;359(3):411-419.
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| Sullivan LC, Clarke WP, Berg KA. Atypical antipsychotics and inverse agonism at 5-HT2 receptors Curr Pharm Des 2015 Jan;21(26):3732-3738.
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| Rowan MP, Berg KA, Roberts JL, Hargreaves KM, Clarke WP. Activation of estrogen receptor alpha enhances bradykinin signaling in peripheral sensory neurons of female rats J Pharmacol Exp Ther 2014 Jan;349(3):526-532.
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| Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B, Leeb-Lundberg LM. G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production J Biol Chem 2014 Jan;289(32):22117-22127.
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| Clarke WP, Chavera, TA, Silva M, Sullivan LC, Berg KA. Signalling profile differences: paliperidone versus risperidone Br J Pharmacol 2013 Jan;170(3):532-545.
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| Berg KA, Rowan MP, Gupta A, Sanchez TA, Silva M, Gomes I, McGuire BA, Portoghese PS, Hargreaves KM, Devi LA, Clarke WP. Allosteric Interactions between Delta and Kappa Opioid Receptors in Peripheral Sensory Neurons Mol Pharmacol 2012 Feb;81(2):264-272.
|
Federal |
| Funding Agency |
ASPET |
| Title |
ASPET Fellowship Program for Undergraduate Students |
| Status |
Active |
| Period |
6/2007 - Present |
| Role |
Principal Investigator |
| Grant Detail |
|
| Funding Agency |
NIH/NIA |
| Title |
Aging, peripheral pain and analgesia |
| Status |
Active |
| Period |
2/2015 - 1/2018 |
| Role |
Principal Investigator |
| Grant Detail |
We propose to evaluate the effect of aging on the function and regulation of peripheral, pain-sensing neurons and opioid receptor systems expressed by these neurons. Our ultimate goal is to develop analgesics with improved efficacy and safety for use in the elderly population |
| Funding Agency |
NIH/NGMS |
| Title |
Regulation of Kappa opioid receptor-mediated signaling and peripheral analgesia |
| Status |
Active |
| Period |
1/2014 - 11/2017 |
| Role |
Principal Investigator |
| Grant Detail |
The major goal of this project is to study the regulation of kappa opioid receptor (KOR) signaling systems by the MAPKinases, ERK and JNK, as well as acute desensitization of KOR agonist signaling in peripheral sensory neurons, using primary cultures of adult rat sensory neurons and a behavioral model of nociception |
| Funding Agency |
NIH/NIDA |
| Title |
Regulation of DOR-KOR heteromer formation in pain-sensing neurons |
| Status |
Active |
| Period |
9/2014 - 8/2017 |
| Role |
Principal Investigator |
| Grant Detail |
We propose to validate approaches to disrupt the formation or function of delta-kappa opioid receptor heteromers expressed by pain-sensing neurons in vivo and ex vivo. |
| Funding Agency |
NIH/IIMS-CTRC Pilot Award |
| Title |
Efficacy of P7C3-A20 to prevent pain symptoms of chemotherapy-induced peripheral neuropathy |
| Status |
Active |
| Period |
5/2015 - 4/2016 |
| Role |
Principal Investigator |
| Grant Detail |
In this pilot project, we will focus on pain behavioral assays (measuring changes in three different pain modalities) to assess if a novel neuroprotective agent, P7C3-A20, is effective against development of signs of CIPN.
We will test the hypothesis that P7C3-A20 prevents development of signs of CIPN (pain) in rats produced by treatment with paclitaxel, vincristine, oxaliplatin, and bortezomib. These drugs are prototypical members of different classes of anticancer drugs with different mechanisms of anticancer action, but all produce painful peripheral neuropathy. Protection of peripheral pain-sensing neurons from damage will be evaluated using behavioral pain assays (thermal heat, thermal cold and mechanical allodynia) |
| Funding Agency |
NIH/NIGMS |
| Title |
Regulation of Kappa opioid receptor-mediated signaling and peripheral analgesia in female rats |
| Status |
Active |
| Period |
1/2014 - 11/2015 |
| Role |
Principal Investigator |
| Grant Detail |
This is an administrative supplement to extend the study of regulation of kappa opioid receptor (KOR) signaling in peripheral sensory neurons to female rats. The goals of this project are to assess the antinociceptive effects of peripherally-restricted KOR agonists in female rats using behavioral assays of nociception and to assess the cellular signaling of KOR agonists in peripheral sensory neurons derived from female rats. |
| Funding Agency |
NIH |
| Title |
South Texas Advanced Research Training: Undergraduate Program (START-UP) |
| Status |
Complete |
| Period |
9/2010 - 8/2015 |
| Role |
Contributor |
| Grant Detail |
The purpose of this program is to increase the number of underrepresented minorities (URMs) entering doctoral programs in the neurosciences and then the biomedical workforce as Ph.D.?s. URMs are defined by ethnicity, socio-economic status and disabilities. |
Private |
| Funding Agency |
William and Ella Owens Medical Research Foundation |
| Title |
Opioid receptor functional competence in peripheral sensory neurons |
| Status |
Active |
| Period |
1/2013 - 12/2015 |
| Role |
Principal Investigator |
| Grant Detail |
The major goal of this project is to identify the COX and LOX metabolites that regulate the responsiveness of the opioid receptor systems in pain-sensing neurons (nociceptors) |
