Saikumar, PothanaGraduate School of Biomedical Sciences |
| 9/2005 - Present | Associate Professor | University of Texas Health Science Center at San Antonio, TX, Pathology, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1992 | Postdoctoral Fellowship | Molecular Oncology | The Wistar Institute Philadelphia , PA |
| 1988 | Postdoctoral Fellowship | Molecular Oncology | National Cancer Institute - Frederick Cancer Research Facility Frederick , MD |
| 1985 | PhD | Biochemistry | Indian Institute of Science Bangalore , India |
| 1979 | Molecular Biophysics | Indian Institute of Science Bangalore , India |
|
| 1978 | MS | Biochemistry | Banaras Hindu University Varanasi , India |
| 1976 | BS | Chemistry (Major) Math and Physics (Minors) | Andhra University Waltair , India |
Bioenergetics and Mitochondrial Function- Mitochondrial Oxidative Phosphorylation, Mitochondrial Morphological Changes etc. |
Cell Injury and Cell Death- Cell Injury, Apoptosis, Ischemic Cell Death and Molecular Oncology. |
Molecular Oncology- Oncogenes, Transcription factors, small G-proteins |
Journal Article |
| Singha PK, Pandeswara S, Venkatachalam MA, Saikumar P. Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death Cell Death Dis 2013 Jan;4:457-457. |
| Nair HB, Perla RP, Kirma NB, Krishnegowda NK, Ganapathy M, Rajhans R, Nair SS, Saikumar P, Vadlamudi RK, Tekmal RR. Estrogen receptor-beta mediates the protective effects of aromatase induction in the MMTV-Her-2/neu x aromatase double transgenic mice Horm Cancer 2012 Apr;3(1-2):26-36. |
| Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R, Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA. PTEN loss defines a TGF induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis Am J Physiol Renal Physiol 2012 Jan;. |
| Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM, Weinberg JM, Saikumar P, Venkatachalam MA. Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gaq-Mediated Rho and av6 Integrin-Dependent Activation of TGF- Am J Pathol 2012 Jan;. |
| Singha PK, Yeh IT, Venkatachalam MA, Saikumar P. Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer Cancer Res 2010 Jan;70(15):6377-6383. |
| Kar R, Mishra N, Singha P, Venkatachalam MA and Saikumar P. Mitochondrial Remodeling Following Fission Inhibition by 15d-PGJ2 Involves Molecular Changes in Mitochondrial Fusion Protein OPA1 Biochem Biophys Res Comm 2010 Jan;399(4):548-554. |
| Mishra N, Kar R, Singha PK, Venkatachalam MA, McEwen DG, Saikumar P. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2 Biochem Biophys Res Commun 2010 Jan;395(1):17-24. |
| Rongpei Lan, Hui Geng, Yoon Hwang, Pramod Mishra, Wayne L.Skloss, Eugene A. Sprague, Pothana Saikumar, and Manjeri A. Venkatachalam. A Novel Wounding Device Suitable for Quantitative Biochemical Analysis of Wound Healing and Regeneration of Cultured Epithelium Wound Repair and Regeneration 2010 Jan;18:159-167. |
| Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK. Acute kidney injury: a springboard for progression in chronic kidney disease Am J Physiol Renal Physiol 2010 Jan;298(5):F1078-F1094. |
| Prajjal K. Singha, I-Tien Yeh, Manjeri A. Venkatachalam and Pothana Saikumar. Transforming Growth Factor-β (TGF-β)Inducible Gene TMEPAI Converts TGF-β from a Tumor Suppressor to a Tumor Promoter in Breast Cancer Cancer Research 2010 Jan;70:6377-6383. |
| Geng H, Lan R, Wang G, Siddiqi AR, Naski MC, Brooks AI, Barnes JL, Saikumar P, Weinberg JM, Venkatachalam MA. Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia Am J Pathol 2009 Jan;174(4):1291-1308. |
| Kar R, Singha PK, Venkatachalam MA, Saikumar P. A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells Oncogene 2009 Jan;28(28):2556-2568. |
| Geng, H, Lan, R, Wang, G, Siddiqi, AR, Naski MC, Brooks, AI, Barnes JL, Saikumar P, Weinberg, JM, Venkatachalam MA. Inhibition of autoregulated TGFβ signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia Am J Pathol 2009 Jan;174(4):1291-1308. |
| Nagpal JK, Nair SS, Chakravarty D, Rajhans R, Saikumar P, Brann DW, Tekmal RR, and Vadlamudi RK. Growth Factor Regulation of ER-coregulator PELP1 Functions via PKA Pathway Molecular Cancer Research 2008 Jan;6(5):851-861. |
| Saikumar P, Mikhailova M, Pandeswara SL. Regulation of caspase-9 activity by differential binding to the apoptosome complex Front Biosci 2007 Jan;12:3343-3354. |
| Mikhailov V, Mikhailova M, Degenhardt K, Venkatachalam MA, White E, Saikumar P. Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release J Biol Chem 2003 Jan;278(7):5367-5376. |
| Mikhailov V, Mikhailova M, Pulkrabek DJ, Dong Z, Venkatachalam MA, Saikumar P. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane J Biol Chem 2001 Jan;276(21):18361-18374. |
Book/Monograph |
| Saikumar P and Venkatachalam, MA. Apoptosis and Cell Death New York, NY: Molecular Pathology Library, Springer; 2009. 12 p. |
Abstract |
| Singha PK, Pandeswara S, Venkatachalam MA, and Saikumar P. TMEPAI , A Negative Regulator of Smad Signaling Switches Tumor Suppressive TGF- to a Tumor Promoter in Breast Tumorigenesis; 2012 Jan. (AACR Annual Meeting). |
| Singha PK, Pandeswara S, Venkatachalam MA, and Saikumar P. Targeting TMEPAI in Breast Cancer Therapy and Prevention; 2012 Jan. (AACR Annual meeting). |
| Singha PK, Pandeswara S, Venkatachalam MA, and Saikumar P. Role of MAP1LC3 in 15d-PGJ2 induced non-apoptotic and non-autophagic cell death in therapy-resistant triple negative breast tumors; 2012 Jan. (AACR Annual Meeting). |
| Samarnthai N, Saikumar P, Singha P, Ventkatachalam MA, Gunn SR, Yeh I. TMEPAI Gene Amplification in Triple Negative Breast Cancers; 2010 Jan. (Lab Invest; vol. 90). |
| Samarnthai N, Saikumar P, Singha P, Venkatachalam MA, Gunn SR, Yeh I. TMEPAI gene amplification in triple negative breast cancers; 2010 Jan. (Mod Pathol; vol. 23, no. 1s). |
| Singha PK, Pandeswara S, Venkatachalam MA, Saikumar P. TMEPAI, a Novel Prognostic Marker for TGF-β Dependency of Metastatic Breast Cancers: Converts Tumor Suppressive TGF-β into a Tumor Promoter; 2010 Jan. (SABCS Annual Meeting). |
| Prajjal Kanti Singha, Nandita Mishra, Rekha Kar, Srilakshmi Pandeswara, Manjeri A. Venkatachalam, Pothana Saikumar. Targeting LC3-SQSTM1 (p62) signaling axis to treat apoptosis-resistant and metastatic breast cancers; 2010 Jan. (AACR). |
| Lan R, Geng H, Hwang Y, Mishra P, Skloss, W, Sprague E, Saikumar P and Venkatachalam, MA. Epithelial regenerative signaling studies using a novel wounding device; 2009 Jan. (Wound Repair and Regeneration; vol. 17, no. 2). |
| Nandita Mishra, Rekha Kar, Prajjal K. Singha, Manjeri A. Venkatachalam and Pothana Saikumar. Inhibition of Drp1 Disassembly in Mitochondrial Remodeling; 2009 Jan. (Keystone Symposia Abstracts). |
| Saikumar P. Mitochondrial Fusion Precedes Cell Death Induced by 15 Deoxy Δ12,14 Prostaglandin J2; 2008 Jan. (Mol Biol Cell; vol. 19). |
| Saikumar P, Mikhailov VI, Mikhailova M, Venkatachalam MA, Kar R. Bax mediated release of apoptosis inducing factors requires its dissociation from the inner mitochondrial membrane; 2004 Jan. (FASEB J; vol. 18, no. 8). |
| Saikumar P, Mikhailov VI, Mikhailova M, Venkatachalam MA. Rapid cell death in Bcl-2 overexpressing rat proximal tubule cells exposed to cold and rewarming; 2003 Jan. (J Am Soc Nephrol; vol. 14). |
| Saikumar P, Mikhailova M, Mikhailov VI, Venkatachalam MA, Denton ML. Caspase activation through formation of protein complexes during hypoxia or ATP depletion; 2002 Jan. (FASEB J; vol. 16, no. 4). |
| Mikhailov VI, Mikhailova M, Venkatachalam MA, Saikumar P. Bax dependent release of apoptogenic factors from mitochondria by t-Bid; 2002 Jan. (J Am Soc Nephrol; vol. 13). |
| Mikhailova M, Mikhailov VI, Denton ML, Dong Z, Venkatachalam MA, Saikumar P. Apoptotic protein complexes in hypoxic rat kidney proximal tubule cells; 2001 Jan. (J Am Soc Nephrol; vol. 12). |
Private |
|
| Funding Agency | Susan G. Komen |
| Title | Susan G. Komen |
| Status | Active |
| Period | 8/2010 - 8/2013 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | Morrison trust |
| Title | Cancer prevention and tumor regression by isothiocyanates from cruciferous vegetables |
| Status | Active |
| Period | 10/2009 - 9/2010 |
| Role | Principal Investigator |
| Grant Detail | |