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Cavazos, Jose E.

School of Medicine
Neurology
(210) 617-5161
cavazosj@uthscsa.edu

Appointments Education Expertise Teaching Publications Grants

9/2011 - Present	Professor of Neurology, Pharmacology and Physiology (with Tenure)	UTHSCSA, Neurology, San Antonio, TX
6/2011 - Present	Interim Director - MD PhD Program	University of Texas Health Science Center at San Antonio, San Antonio, TX
6/2010 - Present	Director of the San Antonio VA Epilepsy Center of Excellence	Audie L. Murphy Veterans Administration Hospital, San Antonio, TX
10/2006 - Present	Director of the Neurodiagnostic Center	Audie L. Murphy Veterans Administration Hospital, Neurology, San Antonio, TX
9/2005 - Present	Co-Director	South Texas Comprehensive Epilepsy Center, Neurology, San Antonio, TX
9/2005 - Present	Residency Program Director, Clinical Neurophysiology and Program Director of Clinical Neurophysiology Fellowship	University of Texas Health Science Center at San Antonio, Neurology, San Antonio, TX
5/2001 - Present	Staff Physician	Audie L. Murphy Veterans Administration Medical Center, Medicine, San Antonio, TX
5/2001 - Present	Director of Research South Texas Comprehensive Epilepsy Center	UTHSCSA, Neurology, San Antonio, TX

Clinical Neurophysiology

- Clinical Neurophysiology is a tool to understand patients with Epilepsy. I am the director of the ACGME accredited Clinical Neurophysiology Fellowship at our institution.

Epilepsy

- I am a Clinician Scientist in Epilepsy. I have participated in many clinical trials of antiepileptic drugs (AEDs), and I am an expert in their pharmacology. I also study mechanisms of epileptogenesis in the research laboratory using experimental animal models. I teach Mechanisms of Epilepsy and AEDs to graduate students and postdoctoral fellows. I also teach clinical epilepsy to Medical and Pharmacy students, Neurology and Pharmacy residents, and to Clinical Neurophysiology and Epilepsy Fellows. I take care of patients with Seizures and Epilepsy during pre-surgical evaluations and longitudinally in my VA Epilepsy Clinic.

FDA advisory panel for Neurological Drugs

- I participated as a voting member of FDA advisory panel evaluating approval or change of label for Epilepsy medications.

NIH Study section member

- I have served almost continuously since June ''02 in study sections reviewing investigator initiated research grants of R-series and fellowship training grants of F-series, all of them within the scope of NINDS.

The American Epilepsy Society

- At the American Epilepsy Society, I have been involved in crafting the national Epilepsy curriculum for medical students, neurology residents, and have been in the Council of Education overseeing the CME program for 8 out of the past 10 years. For 3 years, I served as the chair of the website committee overhauling the entire content of the website ( www.aesnet.org ), which includes over 200 hrs of lecture/MP3/slide materials from our annual meetings (2004 - present) and abstracts of these meetings since 2000. I was the vice-chair of the scientific program of the 63rd annual meeting of the AES for the December 3-8, 2009 program in Boston, and I served as the chair of the 64th scientific program for the December 3-7, 2010 annual meeting in San Antonio. In recent years, our annual meeting attendance has exceeded 4,000 registrants (1,800 from abroad) and over 1,200 abstracts have been presented. It is the largest world meeting for Epilepsy.

Date	Description	Institution	# Students
6/2011 - Present	Clinical Integration Course	The University of Texas Health Science Center	30 students
Course Director - The Bench to Bedside Seminar of the MD/PhD Program is a 2 hour monthly seminar that is required for all MD/PhD students along the 8 years of their studies in Medical School and Graduate School.
8/2010 - Present	CSBL 6058: Neurobiology of Aging		15 students

8/2006 - Present	PHAR5091.009 Current Issues in Basic Research on Mechanisms of Epilepsy		1 student
Co-Course Director - This is a structured journal club that reviews current articles on basic epilepsy research. http://pharmacology.uthscsa.edu/graduate/5091_09.html
10/2005 - Present	Post-Doctoral Student Supervision	UTHSCSA

8/2005 - Present	Membership on Supervising Committee	UTHSCSA

11/2004 - Present	Pre-Doctoral Student Supervision	UTHSCSA

10/2004 - Present	Neurology Research	The University of Texas Health Science Center	4 students
Clinical research rotations of medical students interested in Neurology.
1/2004 - Present	Fundamentals of Neuroscience II	The University of Texas Health Science Center	6 students
Epilepsy and EEG Lectures
8/2002 - Present	Post-Doctoral Student Supervision	UTHSCSA

7/2001 - Present	Post-Doctoral Student Supervision	UTHSCSA

7/2001 - Present	Post-Doctoral Student Supervision	UTHSCSA

10/2000 - Present	Medicine Clerkship	The University of Texas Health Science Center	12 students
During the Medicine Clerkship, some MS-III students are assigned to the VA ward/consults service for a couple of weeks. Typically, there will be a couple of students. During the 3-months yearly assignment to cover the VA ward/consult service, I spend at least 1 hour per day for teaching rounds, beyond patient care. Thus, each of these students receive about 10 hrs of case-based teaching per clerkship rotation, and I encounter about 10-12 medical students each year.
10/2000 - Present	Post-Doctoral Student Supervision	UTHSCSA

10/2000 - Present	Post-Doctoral Student Supervision	UTHSCSA

Journal Article

Burneo JG, Cavazos JE. Neurocysticercosis and Epilepsy Epilepsy Currents 2012 Jan;.

Cella D, Lai JS, Nowinski DJ, Victorson D, Peterman A, Miller D, Bethoux F, Heinemann A, Rubin S, Cavazos JE, Reder A, Sufit R, Simuni T, Holmes GL, Siderowf A, Wojna V, Bode R, McKinney N, Podrabsky T, Wortman K, Choi S, Gershon R, Rothrock N, Moy C. Neuro-QOL: Brief Measures of Health-related Quality of Life for Clinical Research in Neurology Neurology 2012 Jan;.

Zhang K, Tolstykh GP, Sanchez RM, Cavazos JE. Chronic cellular hyperexcitability in elderly epileptic rats with spontaneous seizures induced by Kainic Acid Status Epilepticus while young adults Aging and Disease 2011 Nov;.

Verellen RM, Cavazos JE. Pathophysiological considerations of seizures, epilepsy, and status epilepticus in the elderly Aging and Disease 2011 Nov;.

Nowinski, Cindy, Victorson, David, Cavazos JE, Gershon, Richard, Cella, David. Neuro-QOL and the NIH Toolbox-Implications for Epilepsy Therapy 2010 Sep;7(5):533-540.

Verellen, Rebecca, Cavazos JE. Post-traumatic Epilepsy: An Overview Therapy 2010 Sep;7(5):527-531.

Jetter GM, Cavazos JE. Epilepsy in the Elderly Seminars in Neurology 2008 Jul;28(3):336-341.

Book Chapter

Rogers SJ, Cavazos JE. Chapter 65: Epilepsy. In: J.T. DiPiro, R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells, L.M. Posey (eds.). DiPiros Pharmacotherapy: A Pathophysiologic Approach. 2011.

Cross, DJ, Cavazos JE. Circuitry Reorganization, Regeneration, and Sprouting. In: P.A. Schwartzkroin (Ed.). Encyclopedia of Basic Epilepsy Research. 2009. p. 1148-1154.

Rogers SJ, Cavazos JE. Chapter 58: Epilepsy. In: J.T. DiPiro, R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells, L. M. Posey. Dipiros Pharmacotherapy: A Pathophysiologic Approach - 7th Edition. 2008. p. 927-951.

Abstract

Cavazos JE. Increased Interconnectivity between Hippocampal Lamellas induced by Seizure-induced Sprouting leads to Circuitry Hyperexcitability in Experimental Temporal Lobe Epilepsy; 2012 Jan. (Epilepsy Currents; vol. 12, no. S1).

Cavazos JE. Update on a Cohort: Changes in Vitamin D Levels Associated with Enzyme-Inducing AEDs in Male Epilepsy Patients; 2012 Jan. (Epilepsy Currents; vol. 12, no. S1).

Velez AM, Morgan L, Karkar K, Gherman E, Cavazos JE, Szabo CA. Does Treatment of Depression Before Neurosurgical Intervention For Epilepsy, Improves Surgical Outcome?; 2012 Jan. (Epilepsy Currents; vol. 12, no. S1).

Cavazos JE. Neuronal loss in the NTS induced by KA induced Status Epilepticus Rats while sparing other Brainstem Nuclei Predisposition to SUDEP; 2012 Jan. (Epilepsy Currents; vol. 12, no. S1).

Jetter, Gina, Moreno, LM, Rogers SJ, Carlson, S., Gentry, W., Lee, S., Cavazos JE. Cross-Section Study of 389 Veterans Analyzing the Effect of on Cholesterol Levels and Simvastatin Dose Utilization in Clinical Practice; 2011 Jan. (Epilepsy Currents; vol. 11, no. S1).

Tolstykh GP, Cavazos JE. KCNQ channels in the nucleus tractus solitarius of the brainstem might be involved in SUDEP; 2011 Jan. (Epilepsy Currents; vol. 11, no. S1).

Cavazos JE, Tolstykh GP. Increased Interconnectivity between Hippocampal Lamella might contribute to Circuitry Hyperexcitability in Experimental Temporal Lobe Epilepsy; 2011 Jan. (Epilepsy Currents; vol. 11, no. S1).

Jetter GM, Birnbaum LA, Ntsoane E, Cavazos JE, Karkar K, Morgan L, Caron JL, Papanastassiou AM, Szabo CA. Fetal PCAs in Medically Refractory Partial Epilepsies; 2011 Jan. (Epilepsy Currents; vol. 12, no. S1).

Szabo CA, Cavazos JE, Morgan L, Rosales SJ. Epilepsy Partnerships that work: The South Texas Border Rio Grande Valley Region; 2011 Jan. (Epilepsy Currents).

Avalos Herrera, Edgar, Cavazos JE. Online Epilepsy Education in ILAE Chapters and other Professional Organizations: Second Phase; 2010 Jan. (6th Latin American Epilepsy Congress proceedings).

Jetter, Gina, Cavazos JE. Cholesterol levels, statins and AEDs; 2010 Jan. (Dept. of Neurology Research Day, UTHSCSA).

Cavazos JE, Cella, David, Nowinski, Cindy, Victorson, David, Lai, Jin-Shei, Moy, Claudia. Neuro-QOL: Cross Validity to Quality of Life Instruments in Adult Epilepsy. (Selected for Platform presentation at Derek Brown Symposium); 2010 Jan. (Annals of Neurology; vol. 67, no. S1).

Lai, Jin-Shei, Cella, David, Zelko, Frank, Nowinski, Cindy, Cavazos JE, Moy, Claudia. Pediatric Neuro-QOL:Health Related Quality of Life for Children with Epilepsy; 2010 Jan. (Annals of Neurology; vol. 67, no. S1).

Contreras, Christine, Cavazos JE. Post-stroke epilepsy: a critical review; 2010 Jan. (Dept. of Neurology Research Day, UTHSCSA).

Verellen, Rebecca, Cavazos JE. Post-traumatic epilepsy: an overview; 2010 Jan. (Dept. of Neurology Research Day, UTHSCSA).

Ntsoane E, Szabo CA, Morgan LC, Mayes BN, Cavazos JE, Bazan C, Cortez A, McCoy KJ, Caron JL. Clinical significance of persistent Fetal PCA in Epilepsy surgery candidates; 2009 Jan. (Neurology; vol. 72).

Jetter, Gina, Moreno, Laura, Perez, A, Rogers SJ, Cavazos JE. Effect of AEDs on Cholesterol levels and Simvastatin dose utilization in clinical practice; 2008 Jan. (Epilepsia; vol. 49, no. S7).

Cross, Devin, Garza, Alex, Cavazos JE. Early Life Seizures increase the Severity of Kainic Acid induced Epilepsy; 2008 Jan. (Gordon Research conference: Mechanisms of Neuronal Synchronization).

Avalos Herrera, Edgar, Cavazos JE. Online Epilepsy Education in ILAE Chapters and Other Professional Organization: Resources and Needs; 2008 Jan. (5th Latin American Epilepsy Congress proceedings).

Cross DJ, Jetter GM, Mayes BN, Morgan LC, Szabo CA, Brenner R, Cavazos JE. Interictal high frequency oscillations in temporal lobe epilepsy might predict the location of seizure onset zone; 2008 Jan. (Epilepsia; vol. 49, no. S7).

Morgan LC, Cavazos JE, Mayes BN, Szabo CA. Electroclinical and Psychiatric Features of Frontal Opercular Epilepsy: a Report of Five Surgical Cases; 2008 Jan. (Epilepsia; vol. 49, no. S7).

Yaltho, TC, Gullapalli, BS, Mayes BN, Cavazos JE, Szabo CA. One-Year Outcome of Resective Epilepsy Surgery; 2007 Jan. (Epilepsia; vol. 48, no. S6).

Gullanpalli BS, Cavazos JE, Yaltho TC, Mayes BN, Szabo CA. Epileptic Auras and the Outcome of Temporal Lobectomy; 2007 Jan. (Epilepsia; vol. 48, no. S6).

Szabo CA, Vollmer DG, Cavazos JE, Mayes BN. Electrocortical Mapping of the Occipital Lobe with Subdural Electrodes: Results in Four Patients; 2002 Jan. (Epilepsia; vol. 43, no. S7).

Editorial

Cavazos JE. Antiepileptic Drugs: Lessons from Bench to Bedside Revista Conocimento 2008 Jan;85:32-35.

Electronic/Web Publication

Cavazos JE, Spitz, MC. Seizures and Epilepsy, Overview and Classification. eMedicine from WebMD 2010 Jan. Available from: http://emedicine.medscape.com/article/1184846-overview .

Cavazos JE, Spitz MC, Maa EH. Status Epilepticus 2009 Jan.

Cavazos JE, Spitz, M. Seizures and Epilepsy, Overview and Classification Available at: http://emedicine.medscape.com/article/1184846-overview (In 2009: 50,470 unique webpage views; In; 2009 Jan.

Cavazos JE, Spitz, MC. Juvenile Myoclonic Epilepsy Available at: http://emedicine.medscape.com/article/1185061-overview (In 2009: 24,733 unique webpage views: In; 2009 Jan.

Year	Degree	Discipline	Institution
1997	Clinical Fellowship	Clinical Neurophysiology / Epilepsy	Duke University Durham , NC
1996	Residency	Neurology (Chief Resident)	Duke University Durham , NC
1993	PhD	Neuroscience	University of Wisconsin at Madison Madison , WI
1993	Internship	Internal Medicine	University of Wisconsin - Madison Madison , WI
1987	MD	Medicine (Cum Laude)	Instituto Tecnologico y de Estudios Superiores de Monterrey Monterrey, Nuevo Leon , Mexico

Federal
Funding Agency	NIH-NINDS
Title	BK Channel B4 Subunit in the Dentate Gyrus and Seizures
Status	Active
Period	4/2007 - 3/2012
Role	Co-Investigator
Grant Detail	The major goal of this project is to examine the role of the B4 subunit of BK channels in the dentate gyrus hyperexcitability shown by the knock-out mutation of BK Beta4 mice.
Funding Agency
Title	VA Merit Review - Seizure-induced Synaptic Reorganization in CA1 Projection to Subiculum
Status	Active
Period	7/2008 - 6/2011
Role	Principal Investigator
Grant Detail	This VA Merit Review grant provides direct cost supporting a study of the lamellar organization of the hippocampus in a rodent animal model model of epilepsy. In addition to the direct cost, the 25% salary support for the investigator is provided.

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