Clark, Robert A.School of Medicine |
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| 9/2012 - Present | Professor | UTHSCSA, Medicine, San Antonio, TX |
| 8/2006 - Present | Assistant Vice President for Clinical Research and Director, Institute for Integration of Medicine and Science | University of Texas Health Science Center at San Antonio, San Antonio, TX |
| 9/1994 - Present | Professor | University of Texas Health Science Center at San Antonio, Physiology, San Antonio, TX |
| 7/1994 - Present | Attending Physician | University Hospital, University Health System, San Antonio, TX |
| 7/1994 - Present | Staff Physician | South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1973 | Residency | Chief Resident in Medicine | Harborview Medical Center Seattle , WA |
| 1972 | Postdoctoral Fellowship | Infectious Diseases | Laboratory of Clinical Investigation, NIAID, NIH Bethesda , MD |
| 1969 | Residency | Resident in Medicine | Columbia Presbyterian Medical Center New York , NY |
| 1968 | Internship | Medicine | University of Washington Hospital Seattle , WA |
| 1967 | MD | Medicine (Alpha Omega Alpha) | Columbia University, College of Physicians and Surgeons New York , NY |
| 1963 | AB | Mathematics (Magna Cum Laude) | Syracuse University Syracuse , NY |
Biology of Aging- Basic research on biochemical and cellular pathways involved in the aging process. |
Calcium-Binding Proteins- Basic research on structure, function, and regulation of endoplasmic reticulum calcium-binding proteins. |
Infectious Diseases- Clinical infectious diseases. |
Inflammation- Basic research on mechanisms of the acute inflammatory response. |
Internal Medicine- Clinical general internal medicine. |
Neurodegenerative Disorders- Basic research on the biochemical and cellular pathways involved in neurodegenerative disorders, especially Parkinson''s disease. |
Reactive Oxygen Species- Basic research on the mechanisms of generation of reactive oxygen species and their role in antimicrobial function, tissue injury, degenerative diseases, and aging. |
| Date | Description | Institution | # Students |
| 9/2012 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
| 7/1994 - Present | Clin Infectious Disease | The University of Texas Health Science Center | 4 students |
Journal Article |
| He W, Jimenez F, Martinez H, Harper NL, Manoharan MS, Carillo A, Ingale P, Liu Y, Ahuja SS, Clark RA, Rather CG, Ramirez DA, Andrews CP, Jacobs RL, Ahuja SK. Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in patients allergic to house dust mites and pollen J Allergy Clin Immunol 2015 Sep;136(3):658-666. |
| Gornalusse G, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan M, Avadhanam N, Murthy KK, Martinez H, Molano Murillo AM, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich L, Karim SA, Martin JN, Deeks SJ, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndungu T, Hunt PW, He W, Ahuja SK. Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor Proc Natl Acad Sci (USA) 2015 Aug;112(34):E4762-E4771. |
| Okulicz JF, Le TD, Agan BK, Camargo JF, Landrum ML, Wright E, Dolan ML, Ganesan A, Ferguson TM, Smith DM, Richman DD, Little SL, Clark RA, He W, Ahuja SK. Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals JAMA Internal Med 2015 Jan;175(1):88-99. |
| de Figueiredo ASP, Salmon A, Bruno F, Jimenez F, Martinez HG, Halade GV, Ahuja SS, Clark RA, DeFronzo RA, Abboud HE, El Jamali A. Nox2 mediates skeletal muscle insulin resistance induced by a high-fat diet J Biol Chem 2015 Jan;290(21):13427-13439. |
| Li G, Chen C, Liang S, Ballard C, Biju KC, Reddick RL, Clark RA, Li S. Hematopoietic knockdown of PPAR? reduces atherosclerosis in LDLR-/- mice (in press) Gene Therapy 2015 Jan;. |
| Valente AJ, Yoshida T, Clark RA, Delafontaine P, Siebenlist U, Chandrasekar B. Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling Free Radic Biol Med 2013 Jul;60:125-135. |
| Le TD, Wright EJ, Smith DM, He W, Catano G, Okulicz JF, Young JA, Clark RA, Richman DD, Little SJ, Ahuja SK. Enhanced CD4+ T-Cell Recovery with Earlier HIV-1 Antiretroviral Therapy N Engl J Med 2013 Jan;368(3):218-230. |
| Biju KC, Santacruz R, Chen C, Zhou Q, Yao J, Rohrabaugh SL, Clark RA, Roberts JL, Phillips KA, Imam SZ, Li S. Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson''s disease Neurosci Letters 2013 Jan;535:24-29. |
| Imam SZ, Trickler W, Kimura S, Binienda ZK, Paule MG, Sikker W, Li S, Clark RA, Ali SF. Neuroprotective efficacy of a new brain-penetrating c-Abl inhibitor in a murine Parkinsons disease model PLoS ONE 2013 Jan;8(5). |
| Valente AJ, Yoshida T, Murthy SN, Sakamuri SS, Katsuyama M, Clark RA, Delafontaine P, Chandrasekar B. Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18 Am J Physiol Heart Circ Physiol 2012 Aug;303(3):H282-H296. |
| Musset B, Clark RA, DeCoursey TE, Petheo GL, Geiszt M, Chen Y, Cornell JE, Eddy CA, Brzyski RG, El Jamali A. NOX5 in human spermatozoa: expression, function, and regulation J Biol Chem 2012 Mar;287(12):9376-9388. |
| Valente AJ, Clark RA, Siddesha JM, Siebenlist U, Chandrasekar B. CIKS (Act1 or TRAF3IP2) mediates angiotensin-II-induced interleukin-18 expression and Nox2-dependent cardiomyocyte hypertrophy J Molec Cellular Cardiol 2012 Jan;53(1):113-124. |
| Ramsuran V, Kulkarni H, He W, Mlisana K, Wright EJ, Werner L, Castiblanco J, Dhanda R, Le T, Dolan MJ, Guan W, Weiss RA, Clark RA, Karim SS, Ahuja SK, Ndungu T. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women Clin Infect Dis 2011 May;52(10):1248-1256. |
| Li G, Biju KC, Xu X, Zhou Q, Chen C, Valente AJ, He W, Reddick RL, Freeman GL, Ahuja SS, Clark RA, Li S. Macrophage LXRa gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR(-/-) mice Gene Therapy 2011 Mar;18(8):835-841. |
| Catano G, Chykarenko ZA, Mangano A, Anaya JM, He W, Smith A, Bologna R, Sen L, Clark RA, Lloyd A, Shostakovich-Koretskaya L, Ahuja SK. Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates J Infect Dis 2011 Jan;203(2):263-272. |
| Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains M, Roberts JL, Kahle PJ, Clark RA, Li S. Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinsons disease J Neurosci 2011 Jan;31(1):157-163. |
Editorial |
| Clark RA. Hv1 H channel sustains neutrophil Nox2 activity, yet suppresses HOCl formation (in press) J Leuk Biol 2015 Jan;. |
Federal |
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| Funding Agency | Veterans Health Administration |
| Title | Analysis of Olfactory Dysfunction for Early Diagnosis of Parkinsons Disease |
| Status | Active |
| Period | 4/2016 - 3/2020 |
| Role | Principal Investigator |
| Grant Detail | This project will define the basis for olfactory dysfunction in early Parkinsons disease in a genetic murine model employing expertise in olfaction, neurodegeneration, oxidative stress, neurobehavioral testing, and advanced imaging technologies. |
| Funding Agency | Department of Veterans Affairs |
| Title | Macrophage-Mediated Gene Delivery of Neurotrophic Factors for Parkinsons Disease |
| Status | Active |
| Period | 10/2011 - 9/2019 |
| Role | Co-Investigator |
| Grant Detail | Using a chronic MPTP mouse model and regulatable glial-derived neurotrophic factor (GDNF)-expressing lentivectors, this project explores the efficacy and safety of hematopoietic stem cell-based macrophage-mediated GDNF gene therapy as a potential approach to Parkinsons disease. |
| Funding Agency | NIH/NIA |
| Title | Training Grant on the Biology of Aging (Program Director - Nicolas Musi) |
| Status | Active |
| Period | 5/1998 - 4/2018 |
| Role | Contributor |
| Grant Detail | This grant supports training for post-doctoral fellows in the basic biology of aging. |
| Funding Agency | NIH/NCATS |
| Title | Institute for Integration of Medicine & Science (IIMS): A Partnership to Improve Health (TL1 component of the Clinical and Translational Science Award) |
| Status | Active |
| Period | 5/2013 - 4/2018 |
| Role | Principal Investigator |
| Grant Detail | This institutional research training award represents the TL1 component of the Clinical and Translational Science Award. The goal is to support the research training of promising graduate students working in areas of translational science. I serve as the overall PI of the CTSA. My effort on the TL1 program is covered within the UL1 award. |
| Funding Agency | NIH/NCATS |
| Title | Institute for Integration of Medicine & Science (IIMS): A Partnership to Improve Health (KL2 Mentored Career Development component of the Clinical and Translational Science Award) |
| Status | Active |
| Period | 5/2013 - 4/2018 |
| Role | Principal Investigator |
| Grant Detail | This institutional research career development award represents the KL2 component of the Clinical and Translational Science Award. The goal is to support the career development of promising young clinical and translational investigators. I serve as the overall PI of the CTSA. My effort on the KL2 program is covered within the UL1 award. |
| Funding Agency | NIH/NCATS |
| Title | Institute for Integration of Medicine & Science: A Partnership to Improve Health (Clinical and Translational Science Award) |
| Status | Active |
| Period | 5/2013 - 4/2018 |
| Role | Principal Investigator |
| Grant Detail | This Clinical and Translational Science Award (CTSA) provides a broad range of infrastructure support across the institution and its CTSA partners. This UL1 component provides all CTSA support except for the KL2 Career Development Award and TL1 Training Award, which are listed separately. I served as the NIH Contact PI and Director of the IIMS. Note that this 2013-2018 CTSA comprises a new award (with a different grant number) from the 2008-2013 CTSA, due to a change in the NIH sponsoring center from NCRR to NCATS. Also note that due to NIH delays the period from 05/2013 to 09/2013 was funded by an extension of the prior award, but for consistency those funds are included in the first year amount reported here. |
| Funding Agency | Veterans Health Administration |
| Title | Center for Personalized Medicine |
| Status | Active |
| Period | 4/2014 - 3/2018 |
| Role | Co-Principal Investigator |
| Grant Detail | This Program Project Grant (Program Director - Sunil K. Ahuja) supports three thematic projects and a core for carrying out research on the pathogenesis of HIV/AIDS, with an emphasis on host genetic and epigenetic determinants of susceptibility, disease progression, and response to therapy. |
| Funding Agency | NIH/NHLBI |
| Title | Pathobiology of Occlusive Vascular Disease (Program Director - Linda McManus) |
| Status | Active |
| Period | 9/2007 - 8/2017 |
| Role | Contributor |
| Grant Detail | This NIH training grant supports postdoctoral training in the area of occlusive cardiovascular disease, inflammation, and degenerative disorders of cardiovascular tissues. |
| Funding Agency | NIH/NHLBI |
| Title | NOXA1 in NADPH Oxidase-Mediated Vascular Pathology (Sub-award from University of North Carolina; main grant PI - Marschall Runge) |
| Status | Complete |
| Period | 5/2012 - 4/2015 |
| Role | Principal Investigator |
| Grant Detail | This grant explores the role of NADPH oxidases of the NOX family in atherosclerosis using murine models. The primary focus is on NOXA1, a co-factor of the NOX1 isoform. The work to be done under the sub-award is directed characterizing the transcriptional regulation of NOXA1 in vascular smooth muscle cells. |
| Funding Agency | NIH/NCATS |
| Title | Institute for Integration of Medicine & Science (Administrative Supplement to the Clinical and Translational Science Award) |
| Status | Complete |
| Period | 9/2014 - 3/2015 |
| Role | Principal Investigator |
| Grant Detail | This administrative supplement to the CTSA supported the development and implementation of Good Clinical Practice (GCP) training for faculty and staff involved in clinical trials and related human subjects research. I serve as the overall PI of the CTSA. |
| Funding Agency | Department of Veterans Affairs |
| Title | Redox Regulation of Phagocyte NOX2 in Inflammation and Aging |
| Status | Complete |
| Period | 7/2010 - 6/2014 |
| Role | Principal Investigator |
| Grant Detail | The goals of this project are to characterize the molecular signaling pathways by which hydrogen peroxide activates superoxide generation by phagocyte NOX2 and assess the aberrant regulation of this pathway associated with aging. |
| Funding Agency | NIH/NIDDK |
| Title | Role of NADPH Oxidase in Insulin Resistance (PI - Amina El Jamali) |
| Status | Complete |
| Period | 8/2011 - 5/2014 |
| Role | Consultant |
| Grant Detail | This was a Mentored Research Scientist Development Award for Amina El Jamali. The goal of the research project is to characterize the role of NOX-derived reactive oxygen species in muscle cell insulin resistance. I served as the Career Development Mentor. |
Private |
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| Funding Agency | William & Ella Owens Medical Research Foundation |
| Title | Methylene Bliue: A Novel Disease-Modifying Drug for Early Intervention in Parkinsons Disease |
| Status | Active |
| Period | 1/2016 - 12/2016 |
| Role | Principal Investigator |
| Grant Detail | This project assesses the potential therapeutic benefits of methylene blue in murine models of Parkinsons disease, employing genetic, neurobehavioral, and advanced imaging technologies. |