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Cornell, John E

School of Medicine
Epidemiology & Biostatis
(210) 567-0874
cornell@uthscsa.edu

Appointments Education Expertise Teaching Publications Grants

7/2007 - Present

Professor

UT Health Science Center at San Antonio, Epidemiology & Biostatis, San Antonio, TX

Journal Article

Coletta DK, Balas B, Chavez AO, Baig M, Abdul-Ghani M, Kashyap SR, Folli F, Tripathy D, Mandarino LJ, Cornell JE, Defronzo RA, Jenkinson CP. Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo Am J Physiol Endocrinol Metab 2008 May;294(5):910-917.

Mortensen EM, Pugh MJ, Copeland LA, Restrepo MI, Cornell JE, Anzueto AR, Pugh JA. Impact of statins and ACE inhibitors on mortality for patients hospitalized with pneumonia European Respiratory Journal 2008 Mar;31(3):611-617.

Markland AD, Gerety MB, Goode PS, Kraus SR, Cornell JE, Hazuda HP. Uninary incontinence in community-dewelling older Mexican American and European American women [Epub ahead of print] Arch Gerontol Geriatr 2008 Feb;.

Han E-S, Muller FL, Perez V, Qi W, Liang H, Xi L, Doyle E, Hicly M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson AG. The In Vivo Gene Expression Signature of Oxidative Stress APS Physiological Genomics 2008 Jan;34:112-126.

Mortensen EM, Restrepo MI, Copeland LA, Pugh JA, Anzueto A, Cornell JE, Pugh MJ. Impact of previous statin and angiotensin II receptor blocker use on mortality in patients hospitalized with sepsis Pharmacotherapy 2007 Dec;27(12):1619-1626.

Leykum LK, Pugh J, Lawrence V, Parchman M, Nol PH, Cornell J, McDaniel RR. Organizational interventions employing principles of complexity science have improved outcomes for patients with Type II diabetes Implementation Science 2007 Aug;2.

Nair PN, McArdle L, Cornell JE, Cohn SL, Stallings RL. High resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene Cancer Genetics and Cytogenetics, In Press 2007 Apr;174(2):100-110.

Chamberlain CK, Cornell JE, Saunders MJ, Hatch JP, Shinkai RS, Yeh CK. Intra-oral tactile sensation and aging in a community-based population Aging Clin Exp Res 2007 Apr;19(2):85-90.

Adams SG, Smith PK, Allan PF, Anzueto A, Pugh JA, Cornell JE. Systematic review of the chronic care model in chronic obstructive pulmonary disease prevention and management Arch Intern Med 2007 Mar;167(6):551-561.

Leykum LK, El-Serag, HB, Cornell JE, Papadopoulos K. Screening for hepatocellular carcinoma among veterans with hepatitis c on disease stage, treatment received, and survival Clin Gastroenterol Hepatol 2007 Mar;5(4):508-512.

Cornell JE, Pugh JA, Williams JW Jr, Kazis LE, Lee A, Parchman ML, Zeber JE, Montogemery KA, Noel PH. Multimorbidity clusters: Clustering binary data from a large administrative medical database Applied Multivariate Research 2007 Jan;12(3):163-182.

Noel PH, Parchman ML, Williams JW, Cornell JE, Shuko L, Zeber JE, Kazis LE, Lee AF, Pugh JA. The challenges of multimorbidity from the patient perspective Journal of General Internal Medicine 2007 Jan;22:419-424.

Chamberlain CK, Cornell JE, Saunders MJ, Hatch JP, Shinkai RS, Yeh C. Intra-oral tactile sensation and aging in a community-based population Aging: Clinical and Experimental Research, In Press 2006 Dec;.

Angel LF, Levine DJ, Restrepo MI, Johnson S, Sako E, Carpenter A, Calhoon J, Cornell JE, Adams SG, Chisholm GB, Nespral J, Roberson A, Levine SM. Impact of a Novel Donor Management Protocol on Lung Donation and Recipient Outcomes American Journal of Respiratory and Critical Care Medicine 2006 Sep;174(6):710-716.

Angel LF, Levine DJ, Restrepo MI, Johnson S, Sako E, Carpenter A, Calhoon J, Cornell JE, Adams SG, Chisholm GB, Nespral J, Roberson A, Levine SM, Calhoon JH. Impact of a lung transplantation donor-management protocol on lung donation and recipient outcomes Am J Respir Crit Care Med 2006 Sep;174(6):710-716.

Bandyopadhyay A, Agyin JK, Wang L, Tang Y, Lei X, Story BM, Cornell JE, Pollock BH, Mundy GR, Sun LZ. Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor Cancer Res 2006 Jul;66(13):6714-6721.

Lawrence VA, Cornell JE, Smetana GW. Strategies to reduce postoperative pulmonary complications after noncardiothoracic surgery: systematic review for the American College of Physicians Ann Intern Med 2006 Apr;144(8):596-608.

Smetana GW, Lawrence VA, Cornell JE. Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians Ann Intern Med 2006 Apr;144(8):581-595.

Bandyopadhyay A, Agyin JK, Wang L, Tang Y, Lei X, Story BM, Cornell JE, Pollock BH, Mundy GR, Sun L-Z. Inhibition of pulmonary and skeletal metastasis by a TGFβ Type I receptor kinase inhibitor Cancer Res 2006 Jan;66(13):6714-6721.

Pugh MJ, Hanlon JT, Zeber JE, Bierman A, Cornell J, Berlowitz DR. Assessing potentially inappropriate prescribing in the elderly VA population using the HEDIS 2006 quality measure Journal of Managed Care Pharmacy 2006 Jan;12(7):537-545.

Cody JD, Semrud-Clikeman M, Hardies LJ, Lancaster J, Ghidoni PD, Schaub RL, Thompson NM, Wells L, Love TM, Cornell JE, Fox PT, Leach RJ, Kaye CI, Hale DE. Growth hormone benefits children with 18q deletions American Journal of Medical Genetics 2005 Jan;137A:9-15.

Wen L, Badgett R, Cornell JE. How to weigh benefits and harm in considering therapeutic options: The NNT and alternatives Journal of Health System Pharmacists 2005 Jan;.

Chang J, Remmen HV, Ward WF, Regnier RE, Richardson A,Cornell JE. Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics Journal of Proteome Research 2004 Nov;3(6):1210-1218.

Lawrence VA, Hazuda HP, Cornell JE, Pederson T, Bradshaw PT, Mulrow CD, Page CP. Functional independence after major abdominal surgery in the elderly J Am Coll Surg 2004 Nov;199(5):762-772.

Nol PH, Williams JW Jr., Unutzer J, Worchel J, Lee S, Cornell J, Katon W, Harpole L, Hunkeler E. Depression and comorbid illness in elderly primary care patients: Impact on multiple domains of health status and well-being Annals of Family Medicine 2004 Nov;2(6):555-562.

Mortensen EM, Cornell JE, Whittle J. Racial variations in processes of care for patients with community-acquired pneumonia BMC Health Serv Res 2004 Aug;4(1):20-20.

Escalante A., del Rincon I, Cornell J.E. Latent variable approach to the measurement of physical disability in rheumatoid arthritis Arthritis and Rheumatism 2004 Jun;51(3):399-407.

Williams JW Jr, Katon W, Lin EH, Noel P, Worchel J, Cornell J, Harpole L, Fultz BA, Hunkeler E, Mika V, Unutzer J, IMPACT Investigators. The effectiveness of depression care management on diabetes-related outcomes in older patients Annals of Internal Medicine 2004 Jun;140(12):1015-1024.

Zaccagni H, Fried J, Cornell JE, Padilla P, Brey RL. Soluble adhesion molecule levels, neuropsychiatric lupus and lupus-related damage Frontiers in Bioscience 2004 May;9:1654-1659.

Shinkai RS, Hatch JP, Cornell JE, Yeh CK. Intraoral tactile sensitivity in adults with diabetes Diabetes Care 2004 Apr;27(4):869-873.

Williams JW Jr., Stellato CP, Cornell JE, Barrett JE. The 13- and 20-item Hopkins Symptom Checklist Depression Scale: Psychometric properties in primary care patients with minor depression or dysthymia Intl J Psych in Med 2004 Jan;34(1):37-50.

Shinkai R, Hatch JJ, Cornell JE, Yeh C. Intra-oral tactile sensitivity in adults with Diabetes Diab Care 2004 Jan;27(4):869-873.

Lawrence VA, Silverstein JH, Cornell JE, Pederson T, Noveck H, Carson JL. Higher Hb level is associated with better early functional recovery after hip fracture repair Transfusion 2003 Dec;43(12):1717-1722.

Abstract

Lawrence VA, Cornell JE, Hazuda HP. Perioperative depression and elders recovery after major open abdominal surgery; 2008 Apr. (Journal of General Internal Medicine; vol. 23, no. S2).

Lawrence VA, Cornell JE, Hazuda HP. Elders use of diverse adaptive strategies improves recovery after major abdominal surgery; 2008 Jan. (American Geriatrics Society).

Cynthia L. Blanco, John E. Cornell, Rajam S. Ramamurthy, Alice K. Gong. Two Year Follow-Up Study From: The Effect of Early and Higher Protein Supplementation on Prevention of Hyperkalemia in Extremely Low Birth Weight (ELBW) Infants; 2008 Jan. (Pediatric Research).

Blanco CL. The Effect of Early and Higher Protein Supplementation on Prevention of Hyperkalemia in ELBW Infants; 2007 May. (Pediatric Research).

Lawrence VA, Hazuda HP, Cornell JE. How elders help themselves recover from major surgery. (Poster presentation at Society of General Internal Medicine National Meeting); 2007 Apr.

Lawrence VA, Hazuda HP, Cornell JE. How elders help themselves recover from major abdominal surgery; 2007 Jan. (Society of General Internal Medicine).

Adams SG, Smith PK, Cornell JE, Anzueto AR, Pugh JA. Systematic review of disease management in chronic obstructive pulmonary disease; 2005 Oct. (CHEST; vol. 128, no. 4).

Smetana GW, Lawrence VA, Cornell JE. Preoperative pulmonary risk stratification for noncardiopulmonary surgery: A systematic review. (Presented at VA Health Services Research & Development National Meeting 2005 & Society of General Internal Medicine); 2005 Jan. (J Gen Intern Med; vol. 20, no. Supp1).

Smetana GW, Lawrence VA, Cornell JE. Preoperative Pulmonary Risk Stratification for Noncardiopulmonry Surgery: A Systematic Review; 2005 Jan. (Journal of General Internal Medicine; vol. 20, no. supp1).

Lawrence VA, Cornell JE, Smetana GW. Prevention of Postoperative Pulmonary Complications: A Systematic Review; 2005 Jan. (Journal of General Internal Medicine; vol. 20, no. supp1).

Lawrence VA, Cornell JE, Smetana GW. Prevention of postoperative pulmonary complications: A systematic review; 2005 Jan. (J Gen Intern Med; vol. 20, no. Supp1).

Lawrence VA, Cornell JE, Hazuda HP. Improving elders recovery after major abdominal surgery. (Presented at the Society of General Internal Medicine (SGIM) National Meeting 2005); 2005 Jan. (J Gen Intern Med; vol. 20, no. Supp1).

Lawrence VA, Cornell JE, Hazuda HP. Improving Elders'' Recovery after Major Abdominal Surgery; 2005 Jan. (Journal of General Internal Medicine; vol. 20, no. supp1).

Lawrence VA, Hazuda HP, Cornell JE. Shared information improves elders recovery after major abdominal surgery; 2005 Jan. (International Society of Decision Making).

Review Article

Adams SG, Smith PK, Allan PF, Anzueto AR, Pugh JA, Cornell JE. Systematic review of the Chronic Care Model in chronic obstructive pulmonary disease prevention and management Arch Intern Med 2007 Mar;167:551-561.

Editorial

Cornell JE, Mulrow CD, Localio AR. Diagnostic test accuracy and clinical decision making Ann Intern Med 2008 Dec;149(12):904-906.

Cornell JE, Laine C. The Science and Art of Deduction: Complex Systematic Overiews (in press for May 20 issue) Annals of Internal Medicine 2008 May;.

Mulrow CD, Cornell JE, Lucalio R. Rosiglitizone: A Thunder Storm from Scarce and Fragile Data Annals of Internal Medicine 2007 Oct;147(8):585-587.

Cornell JE, Lawrence VA. How to report statistics in medicine. Philadelphia: American College of Physicians 2006 Evidence-based Medicine 2007 Jan;12(3):90-91.

Cornell JE, Lawrence VA. How to report statistics in medicine. Philadelphia: American College of Physicians 2006 ACP Journal Club 2007 Jan;141(1).

Other

Cornell JE, Lawrence VA. How to Report Statistics in Medicine.(Book review) Evidence-Based Medicine 2007 Jun;12:90-91.

Federal
Funding Agency	VA HSR&D
Title	Verdict, an HSR&D Research Award Enhancement Program
Status	Active
Period	4/1998 - Present
Role	Contributor
Grant Detail	To improve the health of vetrans by researching methods to optimize the performance of clinical microsytems
Funding Agency	VA
Title	Geriatric Research, Education, and Clinical Center (GRECC)
Status	Active
Period	9/1989 - Present
Role	Co-Investigator
Grant Detail	To give visibility to the study of geriatrics or diseases of the elderly, and the study of the aging process-gerontology. As the name implies, GRECCs support a multi-disciplinary approach to research, education, and clinical care at each center.
Funding Agency	NIH/NCRR
Title	CTSA
Status	Active
Period	5/2008 - 4/2013
Role	Co-Investigator
Grant Detail	Institute for Integration of Medicine & Science: A Partnership to Improve Health Major goals: Our mission is to achieve optimal integration of clinical and translational research, education, training, and career development across all UTHSCSA schools and among our partner organizations in the South Texas region. IIMS will focus existing and newly developing resources and intellectual capital on advancing the discipline of clinical and translational research for the improvement of human health. Meaningful bidirectional community participation has promoted buy-in from all stakeholders and will remain a key principle as IIMS continues to evolve. IIMS partners have brought together major talent and a broad array of resources to create synergies that add value to all participating organizations, residents of our region and the CTSA network. Key function working groups have developed many innovative approaches to providing optimal support for IIMS investigators and programs. Distinctive features of IIMS include: 1) thriving partnerships with key public and private organizations (academic, health care, public health, military), 2) major investments in research resources and infrastructure, 3) the largest cadre of military health care and biomedical research operations in the US, 4) one of the worlds largest primate research colonies, 5) a 46,000 square mile service area populated by predominantly Hispanic residents comprising some of the countrys poorest people, plagued by high rates of health disparities, providing an opportunity, challenge and obligation for us to make a significant impact on human health.
Funding Agency	Veterans Affairs Health Services Research & Development
Title	Long-term Outcomes in Burned OEF/OIF Veterans (LOBO)
Status	Active
Period	8/2007 - 7/2012
Role	Co-Investigator
Grant Detail	To prospectively compare the rate of improvement in functioning for survivors of combat burns, combat nonburn trauma, and civilian burns at discharge, 1, 2, 3, and 4 years after injury. We will also compare the two military cohorts on 4-year DoD/VA healthcare utilization.
Funding Agency	NIH
Title	Diabetes: Implant Integration, Success, and Benefit
Status	Active
Period	12/2006 - 12/2011
Role	Co-Investigator
Grant Detail	This study will be a cohort study of poor glycemic control in type 2 Diabetes patients will shows that it is directly related correlation to short-term impairments and delays in implant integration, but does not impair longer-term implant integration, Type 2 diabetes patients have dental implant success and complications rates independent of glycemic control with functional loading delayed to accommodate impairments in integration, and implant support of dental prostheses for edentulous type 2 diabetes patients provides clinically meaningful improvements in oral health-related quality of life.
Funding Agency	NIH
Title	Impact of Statins and ACE inhibitors on outcomes for Peumonia and Sepsis
Status	Active
Period	10/2007 - 11/2011
Role	Co-Investigator
Grant Detail	To determine the association between the outpatient use of statins and ACE inhibitors and clinical outcomes such as 30-day mortality and length of stay, to determine the association between the inpatient continuation of these medications and clinical outcomes for patients hospitalized with CAP and sepsis, and to examine the impact of medication dosage upon 30-day mortality for patients hospitalized with CAP and sepsis.
Funding Agency	VA/HSR&D
Title	Inappropriate Drug Use for Seniors: Should VA Adopt New HEDIS Measures?
Status	Active
Period	7/2007 - 6/2011
Role	Co-Investigator
Grant Detail	Recently, the National Committee on Quality Assurance developed measures to identify potentially inappropriate prescribing in the elderly (PIPE). These measures (2006, 2007 HEDIS PIPE) are controversial and not strongly linked to patient outcomes. Because of methodological problems with prior studies this study will assess the link between HEDIS PIPE exposure and patient outcomes in cohorts of older veterans with incident exposure to drugs included in these measures.
Funding Agency	NIDCR
Title	Detection and Significance of Antifungal Resistance in Oropharyngeal Candidiasis
Status	Active
Period	5/2006 - 6/2011
Role	Co-Principal Investigator
Grant Detail	This grant is developing improved techniques to identify antifungal resistance.
Funding Agency	NIH/NHLBI
Title	Master of Science Degree in Clinical Investigations (Renewal)
Status	Active
Period	9/2005 - 8/2010
Role	Co-Investigator
Grant Detail	The primary goal of our M.S. degree in Clinical Investigation is to provide an innovative training program in clinical research to train young scientist, physicians, dentists, nurses and allied health professionals for successful careers in clinical investigations.
Funding Agency	NIH/NCI
Title	Targeting Transforming Growth Factor Beta for Cancer Therapy
Status	Active
Period	8/2008 - 7/2009
Role	Co-Investigator
Grant Detail	Major goals: to determine gene expression profiles in breast cancer cell lines and the isogenic human mammary epithelial cell lines developed in your lab. I will help you analyzing microarray data to identify gene transcripts that are significantly altered between control and experimental cells.
Funding Agency	NIH/NIA
Title	Mitochondrial Proteomics of Aging
Status	Active
Period	9/2004 - 7/2009
Role	Co-Principal Investigator
Grant Detail	The aim of this grant is to test the hypothesis that age-related changes in the expression and/or post-translational modificaiton of the mitochondria proteome are responsible for the changes in mitochondria function that occur with increasing age and that play a role in aging.
Funding Agency	VA HSR&D
Title	Systematic Review and Tracking Databases for CPG Implementation.
Status	Active
Period	7/2003 - 6/2008
Role	Co-Investigator
Grant Detail	To systematically identify, track, categorize, and synthesize research on strategies of implementing medical evidence in clinical practice.
Funding Agency	NIH/NIA
Title	Elder Surgery: Functional Recovery Following Beta-Blockade
Status	Active
Period	9/2002 - 8/2007
Role	Co-Investigator
Grant Detail	Randomized trial to determine the effect of anesthetic-coupled beta blockade and postoperative long-term functional recovery in elders after major elective abdominal surgery.

Year	Degree	Discipline	Institution
1989	Postdoctoral Fellowship	Statistics	Baylor University Waco , TX
1987	Postdoctoral Fellowship	Behavioral Dentistry	SUNY-Buffalo Buffalo , NY
1985	Postdoctoral Fellowship	Cardiovascular and Renal Physiology	University of Mississippi Medical School Jackson , MS
1976	PhD	Experimental Psychology	University of Southern Mississippi Hattiesburg , MS
1973	MA	Psychology	University of Southern Mississippi Hattiesburg , MS
1971	BA	Religion	Millsaps College Jackson , MS

Date	Description	Institution	# Students
9/2006 - Present	Membership on Supervising Committee	UTSA

9/2004 - Present	Post-Doctoral Student Supervision	Audie L. Muphy Division, South Texas Veterans Health Care System

1/2003 - 5/2010	Patient Orient Cln Res Biostat-2	The University of Texas Health Science Center	15 students
Course Director - (MEDI 6061 - 2 SCH) Covered topics include Multivariable Regression Models, Survival Analysis, Mixed-effects models, and Methods of Meta-Analysis.
9/2002 - 12/2009	Patient Orient Clin Res Biostat	The University of Texas Health Science Center	15 students
Course Director - MEDI 5072 - 2 SCH) Covered topics include Probability Distributions, Sample Size Calculations, Hypothesis Testing, Odds Ratios and Logistic Regression.

Faculty

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Cornell, John E

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Psychometrics

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Abstract

Review Article

Editorial

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Federal