Escalante, AgustinSchool of Medicine |
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I joined the Department of Medicine in 1992 as an assistant professor, received Tenure in 2000, and was promoted to professor in 2003. During this time, I have studied the genetic and environmental determinants of the rheumatoid arthritis (RA) phenotype, basing most of my observations on a multi-ethnic RA cohort that my colleagues and I assembled in San Antonio. I have also examined ethnic disparities among patients with rheumatic diseases, and have considerable experience in the cross-cultural adaptation of research instruments. I have published my research in peer review journals, and have received RO1 and K24 grants from the NIH, as well as grants from the Health Care Financing Administration (now Center for Medicare and Medicaid Services), the Arthritis Foundation and the Robert Wood Johnson Foundation. I am a past Harold Amos scholar. I have served on advisory and grant review committees for the NIH, the American College of Rheumatology, the Arthritis Foundation, and several universities. I am former associate editor of Arthritis & Rheumatism, and current associate editor of Arthritis Care and Research. As a board certified rheumatologist, I have provided ongoing care to rheumatic disease patients at the Brady-Green clinic (now University Health Center Downtown) since 1992. I grew up in Mexico City, where I completed my undergraduate education and attended medical school. I did my residency at the Baylor College of Medicine in Houston, and my fellowship at the University of Southern California in Los Angeles. |
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| 9/2011 - Present | Professor and Chief, Division of Rheumatology and Clinical Immunology | The University of Texas Health Science Center at San Antonio, Medicine, San Antonio, TX |
| 1/2003 - Present | Professor of Medicine with Tenure | University of Texas Health Science Center at San Antonio, Medicine, San Antonio, TX |
| 1/1992 - Present | Attending Physician | University Hospital, San Antonio, TX |
| 1/1992 - Present | Attending Physician | University Health Center Downtown, San Antonio, TX |
| 1/1992 - Present | Attending Physician | Audie L. Murphy Memorial VA Hospital, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1999 | Postdoctoral Fellowship | Clinical Research | Robert Wood Johnson Foundation, Harold Amos Scholar/UTHSCSA San Antonio , TX |
| 1996 | Clinical Fellowship | Health Services Research | Association of American Medical Colleges/UTHSCSA San Antonio , TX |
| 1989 | Clinical Fellowship | Rheumatology | University of Southern California Los Angeles , CA |
| 1986 | Residency | Internal Medicine | Baylor College of Medicine Houston , TX |
| 1983 | MD | Medicine | Universidad Nacional Autonoma de Mexico Mexico City , Mexico |
| 1976 | BS | Bio./Chem. | Colegio Franco Espanol Mexico City , Mexico |
| 1973 | AB | Sec. School | Escuela Secundaria Ramon Lopez Velarde Mexico City , Mexico |
Data analysis- Statistical analysis of clinical research data, with special interest in longitudinal data analysis. Expertise with Stata statistical analysis software. |
Diagnosis and treatment of rheumatic diseases- ABIM certification in rheumatology, nearly 30 years of experience in the diagnosis and treatment of rheumatic diseases, with special interest in rheumatoid arthritis. |
Health Disparities- Epidemiology of rheumatic diseases and utilization of health services for arthritis in the U.S. Hispanic population |
Rheumatoid arthritis phenotype- Genetic and environmental determinants of the RA phenotype, including joint inflammation and damage, extra-articular features, disease outcome and comorbidity. |
| Date | Description | Institution | # Students |
| 1/2006 - Present | Intro to Clinical Medicine | The University of Texas Health Science Center | |
| Lecture about rheumatoid arthritis | |||
| 1/2004 - Present | Patient Orient Clin Res Method-2 | The University of Texas Health Science Center | 8 students |
| Causation and bias. Lecture about inferring causation from observational studies, and strategies to minimize bias in research. | |||
| 1/2003 - Present | Post-Doctoral Student Supervision | Rheumatology Fellow, UTHSCSA | |
| 1/2003 - Present | Post-Doctoral Student Supervision | University of Texas Health Science Center, San Antonio, Texas | |
| 1/2001 - Present | Post-Doctoral Student Supervision | Postdoctoral research fellow, UTHSCSA | |
| 1/2001 - Present | Rheumatology Clinic | University Health Center Downtown | |
| Medical School, PHY 1-6, MSIV | |||
| 1/2001 - Present | Rheumatology Consult Attending | Audie. L. Murphy Memorial VA Hospital, San Antonio, Texas | |
| Medical School, PGY 1-6, MSIV | |||
| 1/2000 - Present | Introduction to Clinical Medicine- "Systemic Lupus Eryhtematosus" | 200 students | |
| Medical School Year II Students | |||
| 1/2000 - Present | Introduction to Clinical Medicine - "Rheumatoid Arthritis" | 200 students | |
| Medical School Year II Students | |||
| 1/1999 - Present | Post-Doctoral Student Supervision | University of Texas Health Science Center at San Antonio, Texas | |
| 1/1994 - Present | Introductin to Physical Diagnosis | 2 students | |
| Year 1 Medical Students | |||
| 2/1992 - Present | Rheumatology Consult Attending | University Hospital, San Antonio, Texas | |
| Medical School, PGY 1-6, MSIV | |||
| 1/1992 - Present | Rheumatology Journal Club | 4 students | |
| Medical School PHY-4-6 | |||
Abstract |
| Restrepo JF, Del Rincon I, Escalante A. Joint Damage Associated with Loss of Body Mass in Rheumatoid Arthritis; 2015 Oct. (Arthritis & Rheumatology; vol. 67, no. 10 Su). |
| Arya R, Del Rincon I, Restrepo JF, Farook VS, Jenkinson CP, Duggirala R, Escalante A. Cumulative Association of Genetic Variants with Rheumatoid Joint Damage Progression in Mexican Americans and European Americans; 2015 Oct. (Arthritis & Rheumatism; vol. 67, no. 10 Su). |
| Molina E, Del Rincon I, Restrepo JF, Battafarano DF, Escalante A. Treatment Delays and Worse Outcomes Associated with Lower Socioeconomic Status in Rheumatoid Arthritis; 2014 Oct. (Arthritis & Rheumatism; vol. 66, no. 10 Su). |
| Restrepo JF, Del Rincon I, Battafarano DF, Molina E, Escalante A. Use of Hydroxychloroquine Associated with Improved Lipid Profile in Rheumatoid Arthritis Patients; 2014 Oct. (Arthritis & Rheumatism; vol. 66, no. 10 Su). |
| Arya R, Del Rincon I, Farook VS, Restrepo JF, Winnier, DA, Fourcadot MJ, Battafarano DF, Kumar S, de Almeida MAA, Curran JE, Jenkinson CP, Blangero J, Duggirala R, Escalante A. Genetic Variants Influencing Joint Damage in Mexican Americans and European Americans with Rheumatoid Arthritis; 2014 Oct. (Arthritis & Rheumatism; vol. 66, no. 10 Su). |
| Molina, E, Restrepo, JF, Del Rincon I, Battafarano DF, Escalante A. Factors Associated with Recording of Rheumatoid Arthritis on Death Certificate; 2014 Oct. (Arthritis & Rheumatism; vol. 66, no. 10 Su). |
| Restrepo JF, Del Rincon I, Haas RW, Battafarano DF, Escalante A. A Novel Index to Identify Interstitial Lung Disease in Rheumatoid Arthritis Patients; 2013 Oct. (Arthritis & Rheumatism; vol. 65, no. 10 Su). |
| Del Rincon I, Haas RW, Restrepo JF, Battafarano DF, O'Leary DH, Molina E, Escalante A. Carotid Atherosclerosis As a Predictor Of Mortality In Rheumatoid Arthritis; 2013 Oct. (Arthritis & Rheumatism; vol. 65, no. 10 Su). |
| Escalante A, Haas RW, Battafarano DF, Del Rincon I. Prediction of mortality in rheumatoid arthritis using a serum cytokine profile; 2012 Oct. (Arthritis & Rheumatism; vol. 64, no. 10 Su). |
| Restrepo JF, Del Rincon I, Haas RW, Battafarano DF, Escalante A. Joint damage progression in rheumatoid arthritis: role of the HLA-DRB1 shared epitope and anti-CCP; 2012 Oct. (Arthritis & Rheumatism; vol. 64, no. 10 Su). |
| Del Rincon I, Haas RW, O'Leary DH, Polak JF, Battafarano DF, Escalante A. Serum cytokines associated with carotid atherosclerosis in rheumatoid arthritis; 2012 Oct. (Arthritis & Rheumatism; vol. 64, no. 10 Su). |
| Restrepo JF, Del Rincon I, Haas RW, Battafarano DF, Escalante A. The serum cytokine profile of interstitial lung disease in rheumatoid arthritis; 2012 Oct. (Arthritis & Rheumatism; vol. 64, no. 10 Su). |
| Restrepo JF, del Rincon I, Zuniga-Montes LR, Pogosian S, Escalante A. Gene-environment interaction determines interstitial lung disease in rheumatoid arthritis; 2010 Oct. (Arthritis & Rheumatism; vol. 60, no. 10 Su). |
Book Chapter |
| Escalante A. Rheumatoid Arthritis. In: Goldman MB, Troisi R, Rexrode KM. Women & Health. London: Elsevier-Academic Press; 2013. p. 771-784. |
Journal Article |
| Arya R, Del Rincon I, Farook VS, Restrepo JF, Winnier DA, Fourcaudot MJ, Battafarano DF, Kumar S, de Almeida MAA, Curran JE, Jenkinson CP, Blangero J, Duggirala R, and Escalante A. Genetic Variants Influencing Joint Damage in Mexican Americans and European Americans with Rheumatoid Arthritis Genetic Epidemiology 2015 Dec;39(8):678-688. |
| Molina E, Del Rincon I, Restrepo JF, Battafarano DF, Escalante A. Mortality in Rheumatoid Arthritis (RA): factors associated with recording RA on death certificates BMC Musculoskeletal Disorders 2015 Oct;16(277):1-6. |
| Restrepo JF, Del Rincon I, Battafarano DF, Haas RW, Doria M, Escalante A. Clinical and Laboratory Factors Associated with Interstitial Lung Disease in Rheumatoid Arthritis Clinical Rheumatology 2015 Sep;34(9):1529-1536. |
| Molina E, Del Rincon I, Restrepo JF, Battafarano DF, Escalante A. Association of socioeconomic status with treatment delays, disease activity, joint damage and disability in rheumatoid arthritis Arthritis Care & Research 2015 Jul;67(7):940-946. |
| Del Rincon I, Polak JF, O`Leary DH, Battafarano DF, Erikson JM, Restrepo JF, Molina E, Escalante A. Systemic Inflammation and Cardiovascular Risk Factors Predict Rapid Progression of Atherosclerosis in Rheumatoid Arthritis Annals of the Rheumatic Diseases 2015 Jun;74(6):1118-1123. |
| Molina E, Haas RW, Del Rincon I, Battafarano DF, Restrepo JF, Escalante A. Does the "Hispanic Paradox" apply to rheumatoid arthritis? Survival data from a multi-ethnic cohort Arthritis Care and Research 2014 Jul;66(7):972-979. |
| Del Rincon I, Haas R, Battafarano D, Restrepo JF, Erikson JM, Escalante A. Glucocorticoid Dose Thresholds Associated with All-cause and Cardiovascular Mortality in Rheumatoid Arthritis Arthritis and Rheumatology 2014 Feb;66(2):264-272. |
Federal |
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| Funding Agency | NIH (NIAMS) |
| Title | The Safety and Effectiveness of the VaricElla zosteR VaccinE (VERVE) in Anti-TNF Users |
| Status | Active |
| Period | 3/2016 - 2/2018 |
| Role | Principal Investigator |
| Grant Detail | Clinical trial of the immunogenicity of the varicell-zoster vaccines (Zostavax) in patients with inflammatory arthritis who are receiving biologic therapy |
| Funding Agency | NIH/NHLBI |
| Title | Effect of Chronic Inflammation on Atherosclerosis Outcomes in Rheumatoid Arthritis |
| Status | Active |
| Period | 3/2008 - 3/2016 |
| Role | Co-Investigator |
| Grant Detail | The major goal of this research is to examine candidate genes for association with atherosclerosis and cardiovascular outcomes in rheumatoid arthritis |
| Funding Agency | NIH/NICHD |
| Title | The Disablement Process in Rheumatoid Arthritis-Competitive Renewal |
| Status | Complete |
| Period | 8/2007 - 7/2015 |
| Role | Principal Investigator |
| Grant Detail | The aim to this grant is to identify genetic and environmental determinants of joint damage in RA, and to evaluate the role of those determinants in the disablement process in rheumatoid arthritis |