UTHSCSA Faculty Profiles v1.0

Lehman, Donna M

School of Medicine
(210) 567-6714

Associate Professor in the Division of Clinical Epidemiology, Department of Medicine with a secondary appointment in the Department of Epidemiology and Biostatistics. The current focus of my lab is to identify genes that are involved in the pathogenesis of type 2 diabetes and related metabolic traits among the Mexican American population using large cohort studies. We are using whole genome high-throughput methodology to screen the human genome and have identified multiple loci harboring genetic variants affecting risk for diabetes. Our goal now is to explore their functional effects in the etiology of disease. We have developed a new methodology in my lab for this purpose which is the application of induced pluripotent stem (iPS) cell technology to complex disease genetics. This technology will help us to explore biological effects of genetic variation on a whole-genome scale in multiple disease-relevant cell types. In addition to standard DNA sequence variation, we are examining the extent and effect of genome-wide structural variation on gene expression and disease. My research program also includes studies examining the mechanisms of effects of diabetic and lipid lowering medications on risk and progression of prostate cancer among diabetic men.

5/2012 - Present Adjunct Associate Professor UTSA, Biology, San Antonio, TX
9/2008 - Present Associate Professor UT Health Science Center San Antonio, Medicine, San Antonio, TX