UTHSCSA Faculty Profiles v1.0

Lehman, Donna M

School of Medicine
(210) 567-6714

Associate Professor with tenure in the Departments of Medicine/Cardiology and Cellular & Structural Biology with a cross appointment in the Department of Epidemiology and Biostatistics. A major focus of my lab has been to identify genes that are involved in the pathogenesis of type 2 diabetes and related metabolic traits among the Mexican American population using large cohort studies. We are using whole genome high-throughput methodology to screen the human genome and have identified multiple loci harboring genetic variants affecting risk for diabetes and obesity. Our goal now is to explore their functional effects in the etiology of disease. We have developed a new methodology in my lab for this purpose which is the application of induced pluripotent stem (iPS) cell technology to complex disease genetics. This technology will help us to explore biological effects of genetic variation in human disease-relevant cell types. In addition to standard DNA sequence variation, we are examining the extent and effect of genome-wide structural variation on gene expression and disease. My research program also includes studies on prevention of prostate cancer and its progression among diabetic men. Although the incidence of prostate cancer appears lower for men with diabetes, the severity may be higher. We are examining the mechanisms of effects of diabetic and lipid lowering medications on this risk.

5/2012 - Present Adjunct Associate Professor UTSA, Biology, San Antonio, TX
9/2008 - Present Associate Professor UT Health Science Center San Antonio, Medicine, San Antonio, TX