UTHSCSA Faculty Profiles v1.0

Shireman, Paula K.

School of Medicine
(210) 567-5715

I am an academic vascular surgeon and clinical/translational science researcher, serving as the Scientific Advisor for Clinical Trials Xpress, the University of Texas System clinical trials office. I am a tenured Professor in the Departments of Surgery and Microbiology, Immunology and Molecular Genetics. I hold the Dielmann Chair in Surgery endowment. In my clinical role, I perform open and endovascular procedures as well as train residents and medical students. I am the principal investigator for grants from the National Institutes of Health and the Veterans Administration. Our translational and outcomes research incorporates medical, graduate and postdoctoral student training. I collaborate with investigators at the San Antonio Military Health System to determine the long-term outcomes of Service Members with extremity vascular injuries to improve battlefield treatments and transitions of care between the Department of Defense and Veterans Administration. Our group focuses on frailty and social risk factors effect on surgical outcomes utilizing surgical quality databases as well as PCORnet Clinical Data Research Networks. Our translational research has focused on macrophage biology, angiogenesis, stem cells, tissue regeneration and microRNAs. I am co-Principal Investigator on our NIH Clinical Translational Science Award responsible for strategic partnership with our CTSA affiliated institutions, biostatistics, study design and biomedical informatics cores, and evaluation of all CTSA programs. I have initiated a centralized clinical trials office for the University of Texas System, Clinical Trials Xpress, which utilizes a centralized IRB, master clinical trial agreements and single, centrally-negotiated clinical trial budget and shared Medicare coverage analysis to improve efficiency and decrease the regulatory burden of clinical trials. I have extensive experience in team building, research and administration. I was asked to present on two panels for the Institute of Medicine regarding sharing clinical trial data. I incorporated Lean Six Sigma methods into research administration and we have streamlined processes and increased efficiency. Vice Dean duties have included being responsible for 5 research centers/institutes, research faculty recruitments/retentions, integrating research and educational activities along the South Texas Border in conjunction with the Regional Academic Health Center in Harlingen and Edinburg during their transition to becoming an independent medical school.
As my career has progressed, I realize the importance of health care reform and programmatic sustainability to improve quality of care and outcomes. I am a student in the Executive MBA program at the McCombs School of Business in UT Austin to increase my knowledge of the business side of medicine. I work with faculty from the McCombs School of Business in modeling risk and quantifying uncertainty; I am convinced that medicine needs to adapt many strategies that are routine in other business sectors. Our team studies the effect of frailty on surgical outcomes, as well as the facilitation of alternative care pathways to improve patient-centered care for geriatric patients. We are poised to use the CTSAs and PCORI Clinical Data Research Network (CDRN) to answer complex questions of social risk factors, frailty and functional status to improve risk adjustment and identify at risk patients to develop improved clinical care pathways.
1. Strategies for Responsible Sharing of Clinical Trial Data, Institute of Medicine Workshop, Shireman presentation in SESSION 2: Strategies and Practical Approaches for Incentivizing Responsible Sharing of Clinical Trial Data: Perspectives of Investigators and Leaders of Academic Medical Centers, http://iom.nationalacademies.org/Activities/Research/SharingClinicalTrialData/2014-MAY-05/Videos/Session%202/11-Shireman-Video.aspx, May 5, 2014

2. Strategies for Responsible Sharing of Clinical Trial Data, Institute of Medicine Workshop, May 5, 2014, Shireman presentation in SESSION 3: Strategies and Practical Approaches for Responsible Sharing of Clinical Trial Data: Governance and Infrastructure, http://iom.nationalacademies.org/Activities/Research/SharingClinicalTrialData/2014-MAY-05/Videos/Session%203/23-Shireman-Video.aspx

6/2016 - Present Scientific Advisor Clinical Trials Xpress, University of Texas System, University of Texas System
9/2015 - Present Professor with Tenure (secondary appointment) Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX
9/2010 - Present Professor with Tenure Department of Surgery, University of Texas Health Science Center, San Antonio, TX
2/2004 - Present Faculty Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX
10/1999 - Present Staff Physician Audie L. Murphy VA Hospital, San Antonio, TX
10/1999 - Present Staff Physician University Hospital, San Antonio, TX