| Date |
Description |
Institution |
# Students |
| 9/2012 - Present |
Post-Doctoral Student Supervision |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2012 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2012 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 7/2012 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 1/2012 - Present |
Post-Doctoral Student Supervision |
The University of Texas Health Science Center at San Antonio |
|
|
| 1/2012 - Present |
Masters'' Thesis Directed |
Binzhou Medical University |
|
|
| 1/2012 - Present |
Ph.D. Dissertations Directed |
The University of Texas Health Science Center at San Antonio |
|
|
| 9/2011 - Present |
Undergraduate Student Supervision |
The University of Texas Health Science Center at San Antonio |
|
|
| 10/2010 - Present |
Post-Doctoral Student Supervision |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2010 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2010 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 7/2010 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 1/2010 - Present |
Ph.D. Dissertations Directed |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2009 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2009 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2008 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2008 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2008 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
| 8/2007 - Present |
Membership on Supervising Committee |
The University of Texas Health Science Center at San Antonio |
|
|
Journal Article |
| Zhang J, Zhang N, Liu M, Li XM, Zhou L, Liu J, Musi N, DeFronzo M, Cunningham JM, Zhou Z, Lu XY, Liu F. Disruption of Grb10 in the pancreas enhances [Beta]-cell proliferation and protects mice from streptozotocin-induced [Beta]-cell apoptosis Diabetes 2012 Dec;61(12):3189-3198.
|
| Guo M, Huang TY, Garza JC, Lu XY. Selective deletion of the leptin receptor in the adult hippocampus induces depression-related behaviors International Journal of Neuropsychopharmacology 2012 Aug;.
|
| Garza JC, Guo M, Zhang W, Lu XY. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3[Beta]/[Beta]-catenin signaling Mol Psychiatry 2012 Jan;17(8):790-808.
|
| Guo M, Lu Y, Garza JC, Li Y, Chua SC, Zhang W, Lu B, Lu XY. Forebrain glutamateric neurons mediate leptin action on depression-like behaviors and synaptic depression Transl Psychiatry 2012 Jan;2.
|
| Liu J, Guo M, Zhang D, Cheng SY, Liu M, Ding J, Scherer P, Liu F, Lu XY. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity Proc Natl Acad Sci USA 2012 Jan;109(30):12248-12253.
|
| Liu J, Guo M, Zhang D, Cheng SY, Liu M, Ding J, Scherer P, Liu F, Lu XY. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity Proc Natl Acad Sci USA 2012 Jan;109(30):12248-12253.
|
| Yu T, Guo M, Garza JC, Rendon, S, Sun XL, Zhang W, Lu XY. Cognitive and neural correlates of depression-like behavior in socially defeated mice: An animal model of depression with cognitive dysfunction International Journal of Neuropsychopharmacology 2011 Jan;14:303-317.
|
| Liu J, Perez SM, Zhang W, Lodge DJ, Lu XY. Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala Mol Psychiatry 2011 Jan;16(10):1024-1038.
|
| Zhang D, Guo M, Zhang W, Lu XY. Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38MAPK/GSK-3[Beta]/[Beta]-catenin signaling cascade J Biol Chem 2011 Jan;286(52):44913-44920.
|
| Liu, J, Garza, JC, Bronner, J, Kim, CS, Zhang, W, Lu, XY. Acute administration of leptin produces anxiolytic-like effects: A comparison with fluoxetine Psychopharmacology 2010 Jan;207(4):535-545.
|
| Ryu KY, Fujiki N, Kazantzis M, Garza JC, Bouley DM, Stahl A, Lu XY, Nishino S, Kopito RR. Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice Neuropathology and Applied Neurobiology 2010 Jan;36(4):285-299.
|
| Garza J, Kim CS, Liu J, Zhang W, Lu XY. AAV-mediated knockdown of MC4R in the paraventricular nucleus of the hypothalamus promotes high-fat-diet-induced hyperphagia and obesity Journal of Endocrinology 2008 Mar;197(3):471-482.
|
| Garza JC, Zhang W, Lu XY. Leptin stimulates adult hippocampal neurogenesis in vivo and in vitro Journal of Biological Chemistry 2008 Mar;283(26):18238-18247.
|
| Ryu KY, Garza JC, Lu XY, Barsh GS, Kopito RR. Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene Proc Natl Acad Sci USA 2008 Jan;105(10):4016-4021.
|
Abstract |
| Liu J, Zhang W, Lu XY. Anxiolytic effects of leptin in the ventral tegmental area; 2009 Oct. (Society for Neuroscience 2009-S-16740).
|
| Garza JC, Yu T, Ramos F, Liu F, Zhang W, Lu XY. Effects of Grb10 on adult hippocampal neurogenesis and hippocampal dependent learning and memory; 2009 Jan. (Society for Neuroscience Abstracts; vol. 34).
|
| Garza JC, Guo M, Zhang W, Lu XY. Opposing effects of chronic stress and leptin on adult hippocampal neurogenesis; 2009 Jan. (Federation of American Society for Experimental Biology; vol. 25).
|
| Liu J, Li W, Garza JC, Zhang W, Lu XY. Melanocortin signaling in the medial amygdala is involved in emotional stress-induced anorexia and anxiety behavior; 2008 Nov. (Society for Neuroscience Program 479.4).
|
| Garza JC, Guo M, Zhang W, Lu XY. Leptin increases adult hippocampal neurogenesis in vivo and in vitro; 2008 Jan. (Society for Neuroscience Abstracts; vol. 33).
|
| Truong H, Garza JC, Lu XY. Role of leptin in social withdrawal and anhedonia; 2008 Jan. (Society for Neuroscience Abstracts; vol. 33).
|
| Garza JC, Kim CS, Liu J, Zhang W, Lu XY. RNAi-mediated silencing of the melanocortin-4 receptor in the hypothalamic paraventricular nucleus increases food intake and body weight; 2007 Nov. (Society for Neuroscience Program 524.5).
|
| Liu J, Garza J, Truong H, Lu XY. Central melanocortin signaling mediates behavioral responses to acute emotional stress; 2007 Nov. (Society for Neuroscience Program 734.4).
|
Review Article |
| Stunkard AJ, Lu XY. Rapid changes in night eating: Considering mechanisms Eating and Weight Disorders 2010 Jan;15(1-2):e2-e8.
|
Federal |
| Funding Agency |
NIH/NIMH |
| Title |
Characterization of leptins antidepressant activity |
| Status |
Active |
| Period |
12/2012 - 7/2017 |
| Role |
Principal Investigator |
| Grant Detail |
The goals of this renewal project are to determine the key components of glutamate neurotransmission that are responsive to leptin signaling and responsible for the antidepressive effects of leptin. The role of remodeling of hippocampal dendritic spines, sites of glutamatergic synapses, in the antidepressive effects of leptin will be investigated. These studies will generate novel insights into molecular and cellular mechanisms into leptin action in the limbic system and lead to the development of novel therapies for depression. |
| Funding Agency |
NIH/NIMH |
| Title |
Adiponectin regulation of the mesolimbic dopamine system |
| Status |
Active |
| Period |
2/2012 - 1/2014 |
| Role |
Principal Investigator |
| Grant Detail |
The major goals of this project are to examine how the adipocyte hormone, adiponectin, regulates the mesolimbic dopamine pathway to provide insight into dopamine-related processes in psychiatric illnesses associated with metabolic syndrome such as obesity and diabetes. |
| Funding Agency |
NARSAD |
| Title |
The role of adiponectin in depression and anxiety |
| Status |
Active |
| Period |
9/2010 - 9/2013 |
| Role |
Principal Investigator |
| Grant Detail |
The goal of this project is to investigate the effects of adiponectin on anxiety- and depression-related behaviors and hippocampal neurogenesis. |
| Funding Agency |
NIH |
| Title |
Characterization of leptins antidepressant activity |
| Status |
Complete |
| Period |
12/2006 - 9/2012 |
| Role |
Principal Investigator |
| Grant Detail |
The goal of this project is to elucidate the neural mechanisms underlying the antidepressant-like effects of leptin. The role of hippocampal leptin receptor signaling in adult neurogenesis and mood-related behaviors, its impact on chronic stress-induced behavioral and cellular changes and its functional interactions with the serotonergic system will be investigated. |
| Funding Agency |
NIH/NIMH |
| Title |
Melanocortin system, stress and HPA axis |
| Status |
Complete |
| Period |
6/2006 - 5/2012 |
| Role |
Principal Investigator |
| Grant Detail |
|
| Funding Agency |
NIH |
| Title |
Neural regulation of vasopressin release |
| Status |
Complete |
| Period |
8/2006 - 7/2011 |
| Role |
Co-Investigator |
| Grant Detail |
|
State |
| Funding Agency |
Institute for Integration of Medicine and Science, UTHSCSA |
| Title |
Alterations in leptin receptor signaling in major depression |
| Status |
Active |
| Period |
9/2012 - 8/2013 |
| Role |
Principal Investigator |
| Grant Detail |
The goal of this project is to examine the alterations in expression levels of leptin receptors in the hippocampus and prefrontal cortex in depressed patients and identify the target genes of leptin signaling that may contribute to the pathogenesis of major depression. |
