Lynch, Jane LockwoodSchool of Medicine |
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I am an Associate Professor at the University of Texas Health Science Center at San Antonio. I been active with medical student and resident teaching for 20 years in both academic and private practice settings. I focus on mentoring and engaging medical students, residents and fellows in all aspects of pediatric endocrine and diabetes care with an active portfolio of clinical research projects at the University of Texas Health Science Center. I serve as the Fellowship Program Director of the Pediatric Endocrinology fellowship. Our 2010 ACGME site visit received a 5 year cycle and I received a Program Director commendation. I chair one of three Pediatric Scholarship Oversight Subcommittees and represent the Pediatric Endocrine Division at Scholarly Oversight and GME committee meetings. I have served as the Director of the Childrens Center at the Texas Diabetes Institute from 2005 to 12/2011. National activities include an appointment to the PREP Endocrinology Advisory Board of the American Academy of Pediatrics as one of eight authors for the National Pediatric Endocrine Board Review publication. This publication was successfully launched in 2008. I was elected to both the Academy of Pediatrics Executive Committee of Endocrinology Section and the Pediatric Endocrine Society National Education Committee in 2010. I am a Principal Investigator on the NIH sponsored TODAY study related to Type 2 Diabetes findings in adolescents. My role in this national study includes the responsibility of utilizing a novel safety tracker program to provide monitoring, tracking and guidance for the management of diabetes related hypertension and renal disease occurring at the thirteen sites for this study. |
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| 1/2005 - Present | Medical Staff Member | University Health System, San Antonio, TX |
| 1/2005 - Present | Associate Professor | University of Texas Health Science Center at San Antonio, Pediatrics, San Antonio, TX |
| 1/2005 - Present | Medical Staff Member | CHRISTUS Santa Rosa Childrens Hospital, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1990 | Clinical Fellowship | Pedi-Endocrine/Child Psychiatry Fellowship Award | Massachusetts General Hospital/ Harvard Medical School Boston , MA |
| 1989 | Clinical Fellowship | Genetics, Endocrinology and Metabolism | Oklahoma Health Sciences Center-Children''s Hospital of Oklahoma Oklahoma City , OK |
| 1987 | Residency | Pediatric Residency | University of Texas-Southwest-Childrens Medical Center Dallas , TX |
| 1985 | Internship | Pediatric Internship | Washington University- St. Louis Childrens Hospital St. Louis , MO |
| 1984 | MD | Medicine | Wright State University School of Medicine Dayton , OH |
| 1980 | BS | Microbiology (Honors Division) | Indiana University Bloomington , IN |
Chronic Endocrine Disease in Children- Dr. Lynch had an additional year of fellowship training to better address the behavioral and emotional aspects of chronic disease with an understanding of the impact on the family unit which included the first year didactics and consult liaison experience in the Massachusetts General Hospital Child Psychiatry Linda Pollen Award Program. Her interest in approaching complex medical issues with a focus on the family has led to her involvement in the funded Project Support Research Project at both her Texas Diabetes Institute and Santa Rosa Childrens Hospital setting. She has consulted with Winston School of San Antonio to revise the diabetes management guidelines for children with special needs. |
Diabetes- Dr. Lynch has expertise with prediabetes, T1 and T2 diabetes in children and adolescents. She was an Investigator in the seminal Diabetes Control and Complications Trial early in her career. She is actively investigating and collaborating to find new approaches to preventing and treating both Type 1 and Type 2 diabetes. The current studies address immune intervention, beta cell preservation and randomized medication trials which improve insulin sensitivity while minimizing weight gain. These studies are funded and approved by the UTHSCSA IRB. She is an Independent Investigator in research regarding the benefits and risks of continuous glucose monitoring to minimize both hyper and hypoglycemia events in children and adolescents. |
| Date | Description | Institution | # Students |
| 8/2005 - Present | Rotation Student Supervision | UT Health Science Center at San Antonio | |
| 8/2005 - Present | Rotation Student Supervision | UT Health Science Center at San Antonio | |
| 3/2005 - Present | Pediatric Endocrinology | The University of Texas Health Science Center | |
| Outpatient clinical instruction and mentoring of UTHSCSA and rotating MS3 and MS4 medical students for two or four week rotations where they are taught about Disorders of Thyroid, adrenal, growth and carbohydrate metabolism. The course includes weekly conference, lectures, and journal reviews with an elective rotation to the Austin Newborn Screening Program that Dr. Lynch developed in 2008. The course also includes a one hour insulin pump lecture with assessments developed as a Quality Improvement Project in 2009 by Dr. Lynch and Dr Pankratz. Dr. Lynch has also agreed to individual arrangements for research months and has overseen additional students who have volunteered to join the division during the Diabetes Camp Week. | |||
| 1/2005 - Present | Case Management Instruction | UT Health Science Center at San Antonio | 4 students |
| Case management conference for all students and residents of all levels on pediatric endocrinology, Fridays | |||
Journal Article |
| Arslanian S, Bacha F, Caprio S, Cuttler L, Goland R, Levitsky L, Lynch J, Nadeau K, Pyle L, Weinstock R, White NH. Determinants of Glycemic control in Youth with Type 2 diabetes at randomization in the TODAY study Pediatric Diabetes 2011 Sep;. |
| Lynch JL. Metformin monotherapy in youth with recent onset Type 2 Diabetes: Experience from the pre-randomization run in phase of the TODAY study Diabetes Care 2011 May;. |
| Orsi CM, Hale DE, Lynch JL. Pediatric obesity epidemiology Curr Opin Endocrinol Diabetes Obes 2011 Feb;18(1):14-22. |
| Banks WA, Morley JE, Lynch JL, Lynch KM, Mooradian AD. Insulin detemir is not transported across the blood-brain barrier Peptides 2010 Dec;31(12):2284-2288. |
| Lynch JL. The TODAY Study Group. Characteristics of Adolescents and Youth with Recent-Onset Type 2 Diabetes: the TODAY Cohort at Baseline Journal Clinical Endo and Metab 2010 Jun;. |
| Orsi CM, Pankratz L, Lynch JL. Neonatal Graves Disease: A Review of Diagnosis and Management Endo Trends 2010 May;17(2). |
| Pankratz L, Orsi CM, Slusser C, Lynch JL. Management of Neonatal Diabetes Mellitus in a 1-Month-Old Male: Use of Continuous Glucose Monitoring to Improve Patient Safety Practical Diabetology 2010 May;4(29):12-17. |
| Lynch JL. Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study Int J Obes 2010 Feb;34(2):217-226. |
| Lynch JL. Todays Pediatric Endocrinologists Must Also Be Health Care Advocates Review of Endocrinology 2008 Jan;. |
Abstract |
| Orsi CM Lynch JL Hale DE. Magnetic Resonance Spectroscopy quantification of NAFLD in Obese Adolescents on Vitamin D Therapy Houston, TX; 2012 Jun. (The Endocrine Society). |
| Orsi CM, Lynch JL, Hale DE. Degree of Fatty Liver in Obese, Hispanic Adolescents with Vitamin D Deficiency; 2010 Jun. (Endocrine Society). |
| Hamaker M, Fowler S, Farook V, Lynch JL, Comuzzie A, DeFronzo R, Hale DE, Duggirala R, Cersosimo E. Vascular Dysfunction and Microalbuminuria as Early Risk Indicators in Mexican American Children; 2010 Jun. (American Diabetes Association). |
| Arslanian S, Pyle L, Caprio S, Bacha F, Cutler L, Goland R, Levitsky L, Lynch J, Nadeau K, Winestock R, White N. Gender Differences in Baseline Fasting OGTT Derived Surrogate Estimates of Insulin Sensitivity and Secretion in TODAY; 2010 Jun. (American Diabetes Association). |
| Pankratz L, Orsi CM, Slusser C, Lynch JL. Use of Continuous Glucose Monitoring To Improve Patient Safety in the Transition from Insulin to Glyburide in an Infant Male with Neonatal Diabetes Mellitus; 2010 May. (Pediatric Academic Society). |
| Orsi CM, Matthew M, Kumar P, Chen J, Diaz N, Kraminski-Graham R, Darland C, Lynch JL, Cusi K. Exenatide Promotes Weight Loss and Improves Insulin Secretion, Subclinical Inflammation, and Hepatic Steatosis When Replaced for Pre-Meal Insulin in T2DM Patients; 2009 Jun. (American Diabetes Association). |
| Orsi CM, Mathew M, Chen J, Gastaldelli A, Darland C, Lynch JL, Cusi K. Effect of replacing pre-mail insulin for exenatide on body weight, insulin secretion and hepatic/muscle fat in well-controlled insulin-treated T2DM patients; 2009 Apr. (Texas AACE Annual Meeting). |
| Willey-Courand DB, Rayas, Maria S., Lynch JL. CFRD: A current review of screening, diagnosis, and treatment. 2009 Southern Regional Conference in New Orleans, LA; 2009 Feb. |
| Lynch JL, Hale DE, Blangero J, DeFronzo RA, Lehman D, Jenkinson CP, Comuzzie AG, Almasy L, Arya R, Duggirala R, Cersosimo E, Hunt KJ, Farook VS, Fowler SP, Schneider J, Puppala S. Increased Occurence of Childhood Obesity and Its Correlates and Their Genetic Architecture in Mexican American Children; 2009 Jan. (American Diabetes Association). |
| Farook V, Lynch JL, Schneider J, Fowler S, Puppala S, Mendoza-Orsi C, Hunt K, Curran J, Arya R, Almasy L, Comuzzie A, Jenkins C, Lehman D, DeFronze R, Blangero J, Hale DE, Duggirala R. Increased Prevalence of Elevated Hepatic ALT Enzyme Activity in Obesity and Related Conditions and Its Genetic Determinants in Mexican American Children; 2009 Jan. (American Diabetes Association). |
| Sosa E, Lynch JL, Hale DE, Resendez R, Puppala S, Schneidner J, Fowler S, Farook V, Arya R, Almasy L, Comuzzie A, Jenkins C, Lehman D, DeFronzo R, Blangero J, Duggirala R. Risk of Eating Disorders: Genetic Architecture and Correlation with Measures of Obesity in Mexican American Children; 2009 Jan. (American Diabetes Association). |
| Farook VS, Fowler SP, Schneider J, Puppala S, Hunt KJ, Bradshaw B, Cersosimo E, Arya R, Almasy L, Comuzzie AG, Jenkinson CP, MacCluer JW, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R. Complex Genetic Relationships among Obesity Phenotypes, Resting Energy Expenditure, and Physical Fitness in Mexican American Children; 2008 Jun. (Diabetic Dyslipidemia (ADA)). |
| Puppala S, Schneider J, Fowler SP, Farook VS, Hunt KJ, Bradshaw B, Cersosimo E, Arya R, Almasy L, Comuzzie AG, Jenkinson CP, MacCluer JW, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R. Increased Prevalence of Type 2 Diabetes Related Phenotypes and Their Genetic Determinants in Mexican American Children; 2008 Jun. (Diabetic Dyslipidemia (ADA)). |
| Duggirala R, Fowler SP, Schneider J, Puppala S, Farook VS, Hunt KJ, Arya R, Bradshaw B, Almasy L, Commuzzie AG, Lynch JL, Jenkinson CP, Maccluer JW, Defronzo RA, Blangero J, Hale DE. The Metabolic Syndrome in Mexican American Children: Preliminary Findings from the San Antonio Family Assessment of Metabolic Risk Indicators in Youth (SAFARI) Study (Poster Publication): American Diabetes Association; 2007 Jun. (Diabetes; vol. 56, no. A489). |
| Swamy A, Patel S, Wajcberg E, Defronzo R, Lynch JL, Cersosimo E, Hale DE. Dyslipidemia is a strong predictor of vascular dysfunction in Hispanic Children at risk for cardiovascular disease (poster publication): American Diabetes Association; 2007 Jun. (Diabetic Dyslipidemia 886-P (ADA)). |
Electronic/Web Publication |
| Lynch JL. 2010 PREP Endocrinology 2010 Jan. |
| Lynch JL. Current Diabetes related research at the Texas Diabetes Institute Children''s Center 2009 May. Available from: http://www.uhsemail.com/oempro/The-Insulin/2009-issue-2/2009_02_2.html . |
| Lynch JL. Diabetes Strikes Younger and Younger - USA Today (Interview) News / Health 2007: http://www.usatoday.com/news/health/2007-11-12-diabetes-children_N.htm?csp=34&loc=interstitialskip; 2007 Nov. |
Federal |
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| Funding Agency | NIH / Southwest Fdn for Biomedical Research |
| Title | The Metabolic Syndrome in Mexican American Children |
| Status | Complete |
| Period | 3/2006 - 2/2011 |
| Role | Co-Investigator |
| Grant Detail | (SAFARI Study 128266) To identify the early markers of the dysmetabolic syndrome in the progeny of participants in three long-standing longitudinal studies of diabetes and diabetes risk and to search for related genetic markers. ($252,047 Annual) |
Private |
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| Funding Agency | Baptist Health Foundation of San Antonio |
| Title | Diabetes Risk Reduction Via Community-Based Telemedicine (Proj DiRReCT) |
| Status | Active |
| Period | 2/2009 - 1/2012 |
| Role | Co-Investigator |
| Grant Detail | (Project ID# 128166)To survey the prevalence of diabetes risk in a school-based cohort of children and then to provide an intervention for those children who are at risk of overweight. Half of the children are in a local program and the other half take part in a telemedicine program. |
| Funding Agency | Lester & Liesel Baker Foundation |
| Title | Byetta Youth with Non-Alcoholic Fatty Liver Disease |
| Status | Complete |
| Period | 4/2009 - 7/2011 |
| Role | Principal Investigator |
| Grant Detail | (Project ID: 128470)This study assesses Children who do not have diabetes but have been diagnosed with vitamin D deficiency and fatty liver. The MRS noninvasively a measure of fat found in the liver is assessed at baseline and again in six months following aggressive normalization of Vitamin D levels. |
| Funding Agency | Tercica, Inc. - TOGA |
| Title | IGF-1 Treatment of Growth Failure in ADHD |
| Status | Complete |
| Period | 12/2006 - 7/2011 |
| Role | Co-Investigator |
| Grant Detail | (PGID# 123886) TOGA Clinical Trial - reimbursement is based on the number of patients enrolled. |
State |
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| Funding Agency | National Institute of Health - GWU |
| Title | TODAY2 |
| Status | Active |
| Period | 3/2011 - 2/2013 |
| Role | Principal Investigator |
| Grant Detail | (Project ID: 152190) Observational Study of T2 Diabetes Children who have completed the TODAY Study with medical therapy and annual studies completed by a three person study staff over the upcoming 2 years while the TODAY study data is analyzed. This study will then be further extended by final design which is under development and incorporating preliminary TODAY outcome data. |
| Funding Agency | National Institute of Health - GWU |
| Title | Treatment Options for Type 2 Diabetes in Adolescents and Youth - STOPP T2D |
| Status | Active |
| Period | 3/2012 - 2/2013 |
| Role | Principal Investigator |
| Grant Detail | (Project ID# 152190) To investigate the effectiveness of randomized interventions to treat Type 2 diabetes in children and adolescents and to follow the specific associated characteristics of the cohorts body composition, psychological, medical outcomes following their diagnosis for up to 7 years. This study has required a study staff of 5 persons in addition to physician collaboration and represents one of fourteen national sites. |
| Funding Agency | National Institute of Health - GWU |
| Title | TODAY Genetics |
| Status | Active |
| Period | 12/2008 - 2/2013 |
| Role | Principal Investigator |
| Grant Detail | (Project ID: 127929) Cost reimbursable based on # of patients enrolled. We anticipate enrolling about 150 participants to investigate the underlying Genetic patterns seen among different regional, gender, ethnic children diagnosed with T2 Diabetes in childhood or adolescence. |
| Funding Agency | National Institute of Health - USF |
| Title | Type 1 Diabetes TrialNet - Major Affiliates |
| Status | Active |
| Period | 9/2008 - 6/2012 |
| Role | Co-Investigator |
| Grant Detail | (PGID# 128288) Cost recoverable contract. |
| Funding Agency | National Institute of Health - GWU |
| Title | Statistics Center for Pediatric Type 2 Diabetes Therapy - Studies to Treat or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) |
| Status | Complete |
| Period | 4/2010 - 3/2012 |
| Role | Principal Investigator |
| Grant Detail | (Project ID: 132035) Centralized reading and blinded study of the echocardiogram baseline findings of participants in the TODAY study. This is a funded grant with all fourteen sites participating. This data will be used as a baseline for the TODAY2 study as well as compared to existing similar data in a matched cohort of T1 DM patients |
| Funding Agency | National Institute of Health - GWU |
| Title | Study to Treat or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) |
| Status | Complete |
| Period | 3/2010 - 2/2011 |
| Role | Co-Investigator |
| Grant Detail | (HEALTHY # 130504) To investigate the effectiveness of various interventions to prevent type 2 diabetes in children and adolescents and to follow changes in physical and biochemical parameters over 5 years. |
| Funding Agency | Eli Lilly |
| Title | Safety and Efficacy of Exenatide as Monotherapy and Adjunctive Therapy to Oral Antidiabetic Agents in Adolescents with Type 2 Diabetes. |
| Status | Active |
| Period | 12/2008 - Present |
| Role | Principal Investigator |
| Grant Detail | (Project ID: 128049)Double blind randomized trial of incretin therapy for children ages 10-17 with Type 2 diabetes. This medication has potential ability to preserve beta cell function as well as improve insulin sensitivity with weight loss and minimal risk for hypoglycemia. |