Nijland, Mark J.M.School of Medicine |
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| 9/2011 - Present | Associate Professor with Tenure and Scientific Director, Center for Pregnancy and Newborn Research | UTHSCSA, Ob-Gyn, San Antonio, TX |
| 5/2005 - Present | Adjunct Associate Scientist | Southwest Foundation for Biomedical Research, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1995 | Postdoctoral Fellowship | Obstetrics and Gynecology | University of California School of Medicine Los Angeles , CA |
| 1992 | Postdoctoral Fellowship | Biomedical Sciences | University of California Riverside , CA |
| 1990 | Postdoctoral Fellowship | Biomedical Sciences | University of California Riverside , CA |
| 1989 | PhD | Thermoregulation | University of Witwatersrand Johannesburg , South Africa |
| 1985 | BS | Physiology (Hons) | University of Witwatersrand Johannesburg , South Africa |
| 1984 | BS | Zoology & Physiology | University of Witwatersrand Johannesburg , South Africa |
Animal Surgery- Fetal and adult survival surgery, primarily in sheep and non-human primates. Special interest in fetal instrumentation for functional assessment in utero. Catheterization, EEG, EKG, EMG implantation, telemetry in primates. |
Data Management Systems- Approaches: Implement and administer computer server systems (Unix/Linux/Windows Server); centralization of laboratory record keeping: database tracking of study protocols, analytical results, digital images and files, experiment participant history and characteristics; management of high throughput technology data output; data sharing. |
Fetal Cardiovascular Development- Approaches: proteomics, transcriptomics, genomics, PCR, Western blot, in vitro vascular function (smooth muscle and endothelial) |
Fetal Renal Development- Approaches: proteomics, transcriptomics, genomics, PCR, Western blot, proximal tubule cell culture, organ explant culture |
Large Animal Physiology- Approaches: smooth muscle function (myography), endothelial function (myography, cell culture), circulatory function (vascular instrumentation), renal function |
Software Engineering- Approaches: SQL Database design and implementation (MSSQL, Postres, MySQL, Oracle); high throughput technology data pipeline development and integration into LIMS; Web Application design and implementation (Python, PHP, Java, Javascript, C#); User Interface design and implementation (Spring, Faces, EXT, YUI); Desktop/Mobile device application design and implementation (Cocoa, C#, C++). |
| Date | Description | Institution | # Students |
| 7/2010 - Present | Individual Instruction | The University of Texas Health Science Center at San Antonio | |
| 6/2009 - Present | Introduction to Ob/Gyn | The University of Texas Health Science Center | 200 students |
| Co-Course Director - Co-Director of second year medical student didactic course (now known as INTD 2002) covering multiple topics in Womens health including obstetrics, gynecology, reproductive endocrinology and infertility, and basic science. | |||
| 4/2008 - Present | Individual Instruction | The University of Texas Health Science Center at San Antonio | |
| 2/2008 - Present | Individual Instruction | The University of Texas Health Science Center at San Antonio | |
| 9/2005 - Present | Department of OB/GYN Grand Rounds | Univ of Texas Health Science Center at San Antonio | 80 students |
| Lectures to OB/GYN faculty, Residents and Medical Students. | |||
Journal Article |
| Abushebab M, Damerril E, Shen T, Joseph F, Gynis L, Nijland MJ, Nathanielsz PW, Kamat (nee Bhakta) A, Jansson T, Gupta M. Liver mTOR inhibition causes IGFBP-1 hyperphosphorlyation in fetal growth restriction Endocrinology 2014 Jan;. |
| Tchoukalova YD, Krishnapuram R, White UA, Burk D, Fang X, Nijland MJ, Nathanielsz PW. Fetal baboon sex-specific outcomes in adipocyte differentiation at 0.9 gestation in response to moderate maternal nutrient reduction Int J Obes (Lond) 2013 Jun;. |
| Li C, McDonald TJ, Wu G, Nijland MJ, Nathanielsz PW. Intrauterine growth restriction alters term fetal baboon hypothalamic appetitive peptide balance J Endocrinol 2013 Apr;217(3):275-282. |
| Cox LA, Glenn JP, Spradling KD, Nijland MJ, Garcia R, Nathanielsz PW, Ford SP. A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome J Physiol 2012 Jun;590:2873-2884. |
| Rodriguez JS, Zrcher NR, Keenan KE, Bartlett TQ, Nathanielsz PW, Nijland MJ. Prenatal betamethasone exposure has sex specific effects in reversal learning and attention in juvenile baboons Am J Obstet Gynecol 2011 Jun;204(6):545-545. |
| Kamat A (corresponding author), Nijland MJ, McDonald TJ, Cox LA, Nathanielsz PW, Li C. Moderate Global Reduction in Maternal Nutrition Has Differential Stage of Gestation Specific Effects on {beta}1- and {beta}2-Adrenergic Receptors in the Fetal Baboon Liver Reprod Sci 2011 Apr;18(4):398-405. |
| Kamat A, Nijland MJ, McDonald TJ, Cox LA, Nathanielsz PW, Li C. Moderate global reduction in maternal nutrition has differential stage of gestation specific effects on {beta}1- and {beta}2-adrenergic receptors in the fetal baboon liver Reprod Sci 2011 Apr;18(4):398-405. |
| Ma Y, Zhu MJ, Uthlaut AB, Nijland MJ, Nathanielsz PW, Hess BW, Ford SP. Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes Placenta 2011 Mar;32(3):255-263. |
| Rodriguez JS, Zrcher NR, Bartlett TQ, Nathanielsz PW, Nijland MJ. CANTAB delayed matching to sample task performance in juvenile baboons J Neurosci Methods 2011 Mar;196(2):258-263. |
| Fan X, Turdi S, Ford SP, Hua Y, Nijland MJ, Zhu M, Nathanielsz PW, Ren J. Influence of gestational overfeeding on cardiac morphometry and hypertrophic protein markers in fetal sheep J Nutr Biochem 2011 Jan;22(1):30-37. |
| Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW, Ford SP. Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring J Anim Sci 2010 Nov;88(11):3546-3553. |
| Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW, Ford SP. Maternal obesity and high nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring J Anim Sci 2010 Jul;. |
| Long NM, Nijland MJ, Nathanielsz PW, Ford SP. The effect of early to mid-gestational nutrient restriction on female offspring fertility and hypothalamic-pituitary-adrenal axis response to stress J Anim Sci 2010 Jun;88(6):2029-2037. |
| Fan X, Turdi S, Ford SP, Hua Y, Nijland MJ, Zhu M, Nathanielsz PW, Ren J. Influence of gestational overfeeding on cardiac morphometry and hypertrophic protein markers in fetal sheep J Nutr Biochem 2010 Feb;. |
| Nijland MJ, Mitsuya K, Li C, Ford SP, McDonald TJ, Nathanielsz PW, Cox LA. Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability J Physiol 2010 Feb;. |
| Loehle M, Schwab M, Kadner S, Maner KM, Gilbert JS, Brenna JT, Ford SP, Nathanielsz PW, Nijland MJ. Dose-response effects of betamethasone on maturation of the fetal sheep lung Am J Obstet Gynecol 2010 Feb;202(2):186-187. |
| Zrcher NR, Rodriguez JS, Jenkins SL, Keenan K, Bartlett TQ, McDonald TJ, Nathanielsz PW, Nijland MJ. Performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention J Neurosci Methods 2010 Feb;. |
| Wang J, Ma H, Tong C, Zhang H, Lawlis GB, Li Y, Zang M, Ren J, Nijland MJ, Ford SP, Nathanielsz PW, Li J. Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart FASEB J 2010 Jan;. |
| Ford SP, Zhang L, Zhu M, Miller MM, Smith DT, Hess BW, Moss GE, Nathanielsz PW, Nijland MJ. Maternal obesity accelerates fetal pancreatic beta-cell but not alpha-cell development in sheep: prenatal consequences Am J Physiol Regul Integr Comp Physiol 2009 Sep;297(3):835-843. |
Abstract |
| Li C, Xie D, McDonald TJ, Nathanielsz PW, Nijland MJ. Increased nitrotyrosine (NT) expression in the frtonal cortex of IUGR fetal baboons in late gestation indicates that unlike in adults, fetal nutrient restriction promotes a pro-inflammatory state in the brain; 2013 Mar. (Reprod Sci; vol. 20, no. 3 Sup). |
| Cun Li, Dongbin Xie, Mark J Nijland, Thomas J McDonald and Peter W Nathanielsz. Intrauterine Growth Restriction (IUGR) In Baboon Pregnancy Alters Key Regulatory Factors In Fetal Pancreatic Proliferation And Differentiation; 2013 Mar. (Reprod Sci; vol. 20, no. Sup 3). |
| McDonald TJ, Antonow-Schlorke I, Schwab M, Li C, Nijland MJ, Wu G, Nathanielsz PW. Maternal nutrient restriction (MNR) in the baboon impairs neuronal migration to the frontal cortex (FC) accompanied by upregulation of glutaminergic NMDA receptors (NMDAR) at 0.5 gestation (G) and down regulation by 0.9G: potential role of circulating am; 2013 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Nijland MJ, Xie D, McDonald TJ, Nathanielsz PW, Li C. IUGR in fetal baboons at 0.8 gestation (G) results in increased fetal kidney 11-betahyroxysteroid hydrogenase (B-HSD)-1 and 11BHSD-2; potential implications for dysfunctional fetal renal mineralocorticoid receptor (MR) activity and development in IUGR; 2013 Mar. (Reprod Sci; vol. 20, no. 3 sup). |
| Cun Li, Dongbin Xie, Thomas J McDonald, Peter W Nathanielsz and Mark J Nijland. Effects Of IUGR On Fetal Baboon Kidney Multi-Drug Resistance Protein 1 (MDRP 1) At 0.9 Gestation (G); Potential Implications For Fetal Renal Mineralocorticoid Development And Function; 2013 Mar. (Reprod Sci; vol. 20, no. Sup 3). |
| Thomas J McDonald, Cun Li, Dean A Myers, Dongbin Xie, Mark J Nijland and Peter W Nathanielsz. Down-regulated Leptin Receptor (ObRb) Peptide Expression in the Fetal Hypothalamic Paraventricular Nucleus (PVN) and Adrenal Cortex Explains the Observed Hypothalamo-Pituitary-Adrenal Axis (HPAA) Up-regulation in Fetal Baboon Intrauterine Growth Restrict; 2013 Mar. (Reprod Sci; vol. 20, no. 3 Sup). |
| Cun Li, Dongbin Xie, Mark J Nijland, Thomas J McDonald and Peter W Nathanielsz. IUGR In Fetal Baboons At 0.9 Gestation (G) Increases Fetal Pancreatic 11-Betahydroxysteroid Dehydrogenase (11hsd) 1 And Decreases 11hsd2. Implications For Later Life Failure Of Insulin Secretion; 2013 Mar. (Reprod Sci; vol. 20, no. Sup 3). |
| Abushehab M, Shen T, Gyenis L, Rosario F, Nijland MJ, Nathanielsz PW, Kamat (nee Bhakta) A, Jansson T, Gupta M. Decreased mTOR activity, and increased CK2 activity and IGFBP-1 phosphorylation in the liver of IUGR baboon fetuses; 2013 Jan. (Reprod Sci; vol. 20, no. Suppl). |
| Xie L, Cun Li, Nijland MJ, Nathanielsz PW, McDonald TJ. Maternal Nutrient Restriction (MNR): Effects On Mitochondrial Ribosomal Protein Subunit (MRPS) Expression In Late Gestation (G) Fetal Baboon Frontal Cortex (FC) And Heart; 2012 Mar. (Reproductive Sciences Supplement; vol. 19). |
| Li C, Nijland MJ, Nathanielsz PW, McDonald TJ. Contrasting effects of maternal nutrient restriction (MNR) on fetal baboon frontal cortex (FC) glycogen storage at 0.5 vs 0.9 of gestation (G); 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Pereira SP, Oliveira PJ, Nathanielsz PW, Nijland MJ. Effects of maternal nutrition restriction (MNR) on fetal cardiac mitochondrial transcripts at 0.9G in nonhuman-primates (NHP); 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Li C, Nijland MJ, Nathanielsz PW, McDonald TJ. Maternal nutrient restriction (MNR) effects on glial fibrillary acidic protein (GFAP), the main intermediate filament protein in astrocytes; 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Cun Li, Zhen-Ju S, McDonald TJ, Nathanielsz PW, Nijland MJ, Cox LA, Kamat A. Effects Of Maternal Nutrient Restriction (MNR) On Hepatocyte Nuclear Factor 4 Alpha (HNF4) Expression In Fetal Baboon Liver At Term; 2012 Mar. (Reproductive Sciences Supplement; vol. 19). |
| Cox LA, Glenn J, Spradlig KD, Nijland MJ, Garcia R, Nathanielsz PW, Ford SP. Elucidation of microRNA-gene networks in the fetal sheep heart; 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Rupprecht S, Mueller J, Franke S, Rakers F, Frauendorf V, Schubert H, Nijland MJ, Nathanielsz PW. Maternal Mental Stress During Early and Midgestation Accelerates Maturation of Fetal Sheep Resistance Vessel Function; 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Pereira SP, Oliveira PJ, Nathanielsz PW, Nijland MJ. Sex differences in fetal non-human primate (NHP) heart mitochrondrial transcripts at 0.9 gestation (G); 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Li C, Shu Z-J, McDonald TJ, Nathanielsz PW, Nijland MJ, Cox LA, Kamat (nee Bhakta) A. Effects of maternal nutrient restriction (MNR) on hepatocyte nuclear factor 4 alpha (HNF4a) expression in fetal baboon liver at term; 2012 Mar. (Society for Gynecologic Investigation (SGI) Annual Meeting). |
| Pereira SP, Oliveira PJ, Cox LA, Nathanielsz PW, Nijland MJ. Maternal nutrient restriction down regulated cardiac mitochondrial proliferation in male non-human primates (NHP) at 0.5 gestation (G); 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Pereira SP, Oliveira PJ, Cox LA, Nathanielsz PW, Nijland MJ. Gender-specific effects of 30 global maternal nutrient restriction (MNR) on non-human primate renal mitochondrial transcripts at 0.9 gestation (G); 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| McDonald TJ, Antonow-Schlorke I, Schwab M, Cun Li, Nijland MJ, Wu G, Nathanielsz PW. Maternal Nutrient Restriction (MNR) In The Baboon Impairs Neuronal Migration To The Frontal Cortex (FC) Accompanied By Upregulation Of Glutaminergic NMDA Receptors (NMDAR) At 0.5 Gestation (G) And Down Regulation By 0.9G: Potential Role Of Circulating Am; 2012 Mar. (Reproductive Sciences Supplement; vol. 19). |
| Rupprecht S, Mueller J, Franke S, Schubert H, Nijland MJ, Nathanielsz PW, Schwab M. Functional Development of Fetal Sheep Vascular Resistance Vessels; 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Pereira SP, Oliveira PJ, Nathanielsz PW, Nijland MJ. Maternal nutrition restriction (MNR) in non-human primates (NHP) down-regulates mitochondrial oxidative phosphorylation transcripts at 0.5G; 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Kavitha, JV, Nathanielsz PW, McDonald TJ, Wu, G, Powell TL, Nijland MJ, Jansson T. Down regulation of placental amino acid and glucose tranporters in response to maternal nutrient restriction (MNR) in the baboon; 2012 Mar. (Reprod Sci; vol. 19, no. Suppl). |
| Cun Li, Nijland MJ, Nathanielsz PW McDonald TJ. Contrasting Effects Of Maternal Nutrient Restriction (MNR) On Fetal Baboon Frontal Cortex (FC) Glycogen Storage At 0.5 Vs 0.9 Of Gestation (G); 2012 Mar. (Reproductive Sciences Supplement; vol. 19). |
| Nathanielsz PW, Nijland MJ, McDonald TJ, Cun Li. Maternal Obesity (MO) And Maternal Nutrient Excess (MNE) In Baboon Pregnancy Stimulate Pancreatic Islet β-Cell Insulin (INS) Content But Decrease IGF-II; Potential Role Of Amino Acids (AA); 2012 Mar. (Reproductive Sciences Supplement; vol. 19). |
| Cun Li, Nijland MJ, Nathanielsz TJ, McDonald TJ. Maternal Nutrient Restriction (MNR) Effects On Glial Fibrillary Acidic Protein (GFAP), The Main Intermediate Filament Protein In Astrocytes; 2012 Mar. (Reproductive Sciences Supplement; vol. 19). |
| Maloyan A, Gelfond J, Nijland MJ, Nathanielsz PW, Myatt L. Commonalities in cardiac miRNA expression in baboon fetuses born to over- and under-nourished mothers; 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Du M, Yan X, Nijland MJ, McDonald TJ, Nathanielsz PW. Maternal nutrient restriction (MNR) during pregnancy redirects fetal baboon skeletal muscle (SM) miRNA expression profile to promote a mesenchymal, adipose cell phenotype; 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Nathanielsz PW, Nijland MJ, McDonald TJ, Li C. Maternal obesity (MO) and maternal nutrient excess (MNE) in baboon pregnancy stimulate pancreatic islet β-cell insulin (INS) content but decrease IGF-II; potential role of amino acids (AA); 2012 Mar. (Reprod Sci; vol. 19, no. 3 Sup). |
| Nathanielsz PW, Nijland MJ, McDonald TJ, Cun Li. Maternal Obesity (MO) And Maternal Nutrient Excess (MNE) In Baboon Pregnancy Stimulate Pancreatic Islet ?-Cell Insulin (INS) Content But Decrease IGF-II; Potential Role Of Amino Acids (AA); 2012 Mar. (Reproductive Sciences Supplement; vol. 19). |
| Nathanielsz PW, Choi J, Nijland MJ, Cun Li. Fetal Vitamin B12 Is Similarly Decreased In Baboon Pregnancy In Both Maternal Nutrient Restriction (MNR) And Maternal Obesity Combined With Maternal Nutrient Excess (MO/MNE). However Changes In Placental B12 Transcobalamin Receptor (TNC2R) Immunoreac; 2011 Sep. (Developmental Origins of Health and Disease (DoHaD)). |
| Jaehyek Choi, Thomas J McDonald, Anthony G Comuzzie, Vicki Mattern, Susan L Jenkins, Mark J Nijland, Cun Li, and Peter W Nathanielsz. Pre-Pubertal Baboon Offspring Of Mothers Exposed To Moderate Maternal Nutrient Restriction (MNR) In Pregnancy and Lactation Show Peripheral Insulin Resistance; 2011 Sep. (Developmental Origins of Health and Disease (DOHaD)). |
| Cun Li, Lynn Xie, Thomas J McDonald, Mark J Nijland, and Peter W Nathanielsz. Effects Of Maternal Obesity (OB) Due To Maternal Nutrient Excess (MNE) On The Insulin-Like Growth Factor (IGF) System In The Baboon Placenta At 0.9 Gestation (G); 2011 Mar. (Reproductive Sciences Supplement; vol. 18, no. 3). |
| Cun Li, Lynn Y Xie, Jaehyek Choi, Thomas J McDonald, Mark J Nijland, Laura A Cox and Peter W Nathanielsz. Fetal Baboon Pituitary Leptin And Leptin Receptor (Ob-R) Are Both Down Regulated By Maternal Nutrient Excess (MNE); 2011 Mar. (Reproductive Sciences Supplement; vol. 18, no. 3). |
| Cun Li, Jaehyek Choi, Lynn Y Xie, Thomas J McDonald, Mark J Nijland and Peter W Nathanielsz. Does Fetal Pituitary Leptin (Ob) Regulate Pituitary Function? Changes In Ob And Leptin Receptor (Ob-R) In The Fetal Baboon Pituitary Gland At Term In The Presence Of Moderate Maternal Nutrient Reduction (MNR); 2011 Mar. (Reproductive Sciences Supplement; vol. 18, no. 3). |
| Choi J, Nijland MJ, McDonald TJ, Jenkins SL, Nakamura M, Nathanielsz PW, Cun Li. Juvenile Baboons Exposed to Clinical Courses of Betamethasone ([beta]M) in Fetal Life Show Sex Specific Responses to Challenges to the Pituitary Adrenal Axis (PAA); 2010 Mar. (Reproductive Sciences Supplement; vol. 17, no. 3). |
| Kamat A, Choi J, McDonald, TJ, Nathanielsz PW, Nijland MJ and Cun Li. Ontogeny And Effects Of Moderate Maternal Nutrient Reduction (MNR) On Fetal Baboon Liver Tyrosine Hydroxylase (TH) And Sympathetic Nervous System (SNS) Innervation; 2010 Mar. (Reproductive Sciences Supplement; vol. 17, no. 3). |
| Kamat (nee Bhakta) A, Choi J., McDonald TJ, Nathanielsz PW, Nijland MJ, Li C. ontogeny and effects of moderate maternal nutrient reduction (MNR) on fetal baboon liver tyrosine hydroxylase (TH) and sympathetic nervous system 9SNS) innervation; 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Juvenile baboons exposed to clinical courses of betamethasone (BM) in fetal life show sex specific responses to challenges to the pituitary adrenal axis (PAA); 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Developmental expression of renin-angiotensin system 9RAS) and cell proliferation markers in nonhuman primate (NHP) kidney; 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Key principles of developmental programming of later life events: Observation in primate development; 2010 Jan. (Annual Meeting of American Society of Animal Science). |
| Nathanielsz PW. Prenatal betamethasone (BM) exposure decreases motivation and impairs simple and compound discrimination reversal learning in female juvenile baboon offspring (OFF); 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Baboon fetal arterial endothelial cells (BFAEC) are more responsive to TNF-[alpha] but not lipopolysaccharide (LPS) than umbilical vein EC (BUVEC); 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
Editorial |
| Regnault TR, Nijland MJ, Budge H, Morrison JL. Basic experimental and clinical advances in the mechanisms underlying abnormal pregnancy outcomes J Pregnancy 2013 Feb;2013:327638-327638. |
Federal |
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| Funding Agency | NCRR |
| Title | Developmental Programming by Mismatch of Pre- and Postnatal Nutrition |
| Status | Active |
| Period | 9/2011 - 8/2016 |
| Role | Principal Investigator |
| Grant Detail | SPECIFIC AIMS. Developmental Programming (DP) is defined as a response to a specific challenge in a critical time window that alters normal development with resulting persistent effects on phenotype. Adult phenotype is determined by complex gene environment interactions. Human epidemiological and controlled animal studies indicate that the fetal and neonatal nutritional environment significantly alters phenotype by epigenetic mechanisms. In rodent studies maternal nutrient reduction (MNR) leading to offspring (OFF) nutrient reduction in pregnancy and lactation predisposes OFF to diabetes, obesity, cardiovascular and other chronic conditions due to adaptations in cell metabolism in developing tissues. MNR OFF develop a thrifty phenotype during fetal life enabling survival if nutrients are scarce in later life a predictive adaptive response. A mismatch of fetal nutrient reduction (FNR) and excess (or even normal) neonatal nutrition also predisposes OFF to chronic disease. Mechanisms producing similar outcomes in response to exposures are unknown We used NCRR funding in a completed R24 to develop baboon OFF cohorts of 1) control (CTR) baboons fed ad lib in pregnancy (P) and lactation (L) CTR/CTR (P diet first, L diet second) and 2) MNR baboons fed 70% global CTR diet, MNR/MNR. We refer to this completed R24 as our MNR R24. Fetal exposure to a 30% global reduction in maternal food intake represents a moderate exposure as shown by effects on fetal growth and metabolism. We were recently awarded a second R24 to develop OFF cohorts of healthy female baboons randomly selected and fed to develop dietary induced maternal obesity (MO) to which fetus and neonate are exposed (MO/MO). We refer to this new R24 as the MO R24. General Hypothesis: We hypothesize that mismatch between fetal and neonatal nutrition leads to OFF obesity and predisposes to adult disease. Specific Aim: To develop cohorts of male and female nonhuman primate (NHP) OFF exposed to nutrient mismatch in feta |
| Funding Agency | NIH |
| Title | Developmental Programming, Maternal Obesity and Overnutrition |
| Status | Active |
| Period | 3/2010 - 12/2014 |
| Role | Co-Principal Investigator |
| Grant Detail | Resource grant to develop a cohort of obese pregnant baboons and study offspring for affects to developmental programming |
| Funding Agency | NIH/NICHD |
| Title | Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanisms |
| Status | Active |
| Period | 9/2007 - 7/2012 |
| Role | Principal Investigator |
| Grant Detail | Overall PO1 goal is to study effects of global maternal nutrient restriction. Sub0potimal fetal organ growh and development are major problems associated with increased neonatal death and long term morbidity. |