Nijland, Mark J.M.School of Medicine |
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| 9/2011 - Present | Associate Professor with Tenure and Scientific Director, Center for Pregnancy and Newborn Research | UTHSCSA, Ob-Gyn, San Antonio, TX |
| 5/2005 - Present | Adjunct Associate Scientist | Southwest Foundation for Biomedical Research, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1995 | Postdoctoral Fellowship | Obstetrics and Gynecology | University of California School of Medicine Los Angeles , CA |
| 1992 | Postdoctoral Fellowship | Biomedical Sciences | University of California Riverside , CA |
| 1990 | Postdoctoral Fellowship | Biomedical Sciences | University of California Riverside , CA |
| 1989 | PhD | Thermoregulation | University of Witwatersrand Johannesburg , South Africa |
| 1985 | BS | Physiology (Hons) | University of Witwatersrand Johannesburg , South Africa |
| 1984 | BS | Zoology & Physiology | University of Witwatersrand Johannesburg , South Africa |
Animal Surgery- Fetal and adult survival surgery, primarily in sheep and non-human primates. Special interest in fetal instrumentation for functional assessment in utero. Catheterization, EEG, EKG, EMG implantation, telemetry in primates. |
Data Management Systems- Approaches: Implement and administer computer server systems (Unix/Linux/Windows Server); centralization of laboratory record keeping: database tracking of study protocols, analytical results, digital images and files, experiment participant history and characteristics; management of high throughput technology data output; data sharing. |
Fetal Cardiovascular Development- Approaches: proteomics, transcriptomics, genomics, PCR, Western blot, in vitro vascular function (smooth muscle and endothelial) |
Fetal Renal Development- Approaches: proteomics, transcriptomics, genomics, PCR, Western blot, proximal tubule cell culture, organ explant culture |
Large Animal Physiology- Approaches: smooth muscle function (myography), endothelial function (myography, cell culture), circulatory function (vascular instrumentation), renal function |
Software Engineering- Approaches: SQL Database design and implementation (MSSQL, Postres, MySQL, Oracle); high throughput technology data pipeline development and integration into LIMS; Web Application design and implementation (Python, PHP, Java, Javascript, C#); User Interface design and implementation (Spring, Faces, EXT, YUI); Desktop/Mobile device application design and implementation (Cocoa, C#, C++). |
| Date | Description | Institution | # Students |
| 7/2010 - Present | Individual Instruction | The University of Texas Health Science Center at San Antonio | |
| 6/2009 - Present | Introduction to Ob/Gyn | The University of Texas Health Science Center | 200 students |
| Co-Course Director - Co-Director of second year medical student didactic course (now known as INTD 2002) covering multiple topics in Womens health including obstetrics, gynecology, reproductive endocrinology and infertility, and basic science. | |||
| 4/2008 - Present | Individual Instruction | The University of Texas Health Science Center at San Antonio | |
| 2/2008 - Present | Individual Instruction | The University of Texas Health Science Center at San Antonio | |
| 9/2005 - Present | Department of OB/GYN Grand Rounds | Univ of Texas Health Science Center at San Antonio | 80 students |
| Lectures to OB/GYN faculty, Residents and Medical Students. | |||
Journal Article |
| Kamat A (corresponding author), Nijland MJ, McDonald TJ, Cox LA, Nathanielsz PW, Li C. Moderate Global Reduction in Maternal Nutrition Has Differential Stage of Gestation Specific Effects on {beta}1- and {beta}2-Adrenergic Receptors in the Fetal Baboon Liver Reprod Sci 2011 Apr;18(4):398-405. |
| Fan X, Turdi S, Ford SP, Hua Y, Nijland MJ, Zhu M, Nathanielsz PW, Ren J. Influence of gestational overfeeding on cardiac morphometry and hypertrophic protein markers in fetal sheep J Nutr Biochem 2011 Jan;22(1):30-37. |
| Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW, Ford SP. Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring J Anim Sci 2010 Nov;88(11):3546-3553. |
| Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW, Ford SP. Maternal obesity and high nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring J Anim Sci 2010 Jul;. |
| Long NM, Nijland MJ, Nathanielsz PW, Ford SP. The effect of early to mid-gestational nutrient restriction on female offspring fertility and hypothalamic-pituitary-adrenal axis response to stress J Anim Sci 2010 Jun;88(6):2029-2037. |
| Fan X, Turdi S, Ford SP, Hua Y, Nijland MJ, Zhu M, Nathanielsz PW, Ren J. Influence of gestational overfeeding on cardiac morphometry and hypertrophic protein markers in fetal sheep J Nutr Biochem 2010 Feb;. |
| Nijland MJ, Mitsuya K, Li C, Ford SP, McDonald TJ, Nathanielsz PW, Cox LA. Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability J Physiol 2010 Feb;. |
| Zrcher NR, Rodriguez JS, Jenkins SL, Keenan K, Bartlett TQ, McDonald TJ, Nathanielsz PW, Nijland MJ. Performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention J Neurosci Methods 2010 Feb;. |
| Loehle M, Schwab M, Kadner S, Maner KM, Gilbert JS, Brenna JT, Ford SP, Nathanielsz PW, Nijland MJ. Dose-response effects of betamethasone on maturation of the fetal sheep lung Am J Obstet Gynecol 2010 Feb;202(2):186-187. |
| Wang J, Ma H, Tong C, Zhang H, Lawlis GB, Li Y, Zang M, Ren J, Nijland MJ, Ford SP, Nathanielsz PW, Li J. Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart FASEB J 2010 Jan;. |
| Ford SP, Zhang L, Zhu M, Miller MM, Smith DT, Hess BW, Moss GE, Nathanielsz PW, Nijland MJ. Maternal obesity accelerates fetal pancreatic beta-cell but not alpha-cell development in sheep: prenatal consequences Am J Physiol Regul Integr Comp Physiol 2009 Sep;297(3):835-843. |
| Zhu MJ, Du M, Nijland MJ, Nathanielsz PW, Hess BW, Moss GE, Ford SP. Down-Regulation of Growth Signaling Pathways Linked to a Reduced Cotyledonary Vascularity in Placentomes of Over-Nourished, Obese Pregnant Ewes Placenta 2009 Mar;. |
| Dong F, Ford SP, Nijland MJ, Nathanielsz PW, Ren J. Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep J Nutr Biochem 2008 Jun;19(6):409-414. |
Book Chapter |
| Nijland MJ, Nathanielsz, PW. Developmental Programming of the Kidney. In: Newnham JP, Ross MG. Early Life Origins of Human Health and Disease. Basel, Switzerland: Karger; 2009. p. 133-141. |
Abstract |
| Nathanielsz PW. Prenatal betamethasone (BM) exposure decreases motivation and impairs simple and compound discrimination reversal learning in female juvenile baboon offspring (OFF); 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Kamat (nee Bhakta) A, Choi J., McDonald TJ, Nathanielsz PW, Nijland MJ, Li C. ontogeny and effects of moderate maternal nutrient reduction (MNR) on fetal baboon liver tyrosine hydroxylase (TH) and sympathetic nervous system 9SNS) innervation; 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Developmental expression of renin-angiotensin system 9RAS) and cell proliferation markers in nonhuman primate (NHP) kidney; 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Juvenile baboons exposed to clinical courses of betamethasone (BM) in fetal life show sex specific responses to challenges to the pituitary adrenal axis (PAA); 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Baboon fetal arterial endothelial cells (BFAEC) are more responsive to TNF-[alpha] but not lipopolysaccharide (LPS) than umbilical vein EC (BUVEC); 2010 Jan. (Reprod.Sci; vol. 17, no. 3). |
| Nathanielsz PW. Key principles of developmental programming of later life events: Observation in primate development; 2010 Jan. (Annual Meeting of American Society of Animal Science). |
| Oliviera PJ, Cox LA, Nijland MJ, Nathanielsz PW. Maternal nutrient restriction down regulates cardiac mitochondrial proliferation in male non-human primates at 0.5 gestation (G); 2009 Jan. (J Dev Origins Health Dis; vol. 1, no. 1). |
| Reyes-Castro L, Wimmer RD, Buatista CJ, Rodriguez-Gonzalez GL, Zambrano E, Nijland MJ, Nathanielsz PW, McDonald TJ. Maternal low protein diets during pregnancy and/or lactation impair male offspring motivation to work for reward; 2009 Jan. (J Dev Origins Health Dis; vol. 1, no. 1). |
| Ford SP, Ma Y, Long NM, George LA, Uthlaut AB, Nijland MJ, Nathanielsz PW. Maternal obesity and a high maternal nutritional plane result in initial fetal overgrowth followed by slowing of the fetal growth trajectory in later gestation; 2009 Jan. (J Dev Origins Health Dis; vol. 1, no. 1). |
| Cox, L.A., Glenn, J., Schlabritz-Lutsevich N, Nathanielsz PW, Nijland MJ. Sex effects of maternal nutrient restriction (MNR) on renal transcriptome expression in the 0.9 gestation (G) fetal baboon; 2008 Jan. (Reprod.Sci; vol. 15, no. 2). |
| VanHeesewijk, A.D., Nijhuis, J.G., Jenkins, S.L., Nathanielsz PW, Nijland MJ. Ovine fetal regional blood flow following prenatal dexamethasone (DEX) at 0.75 gestation (G); 2008 Jan. (Reprod.Sci; vol. 15, no. 2). |
Review Article |
| Gilbert JS, Nijland MJ. Sex differences in the developmental origins of hypertension and cardiorenal disease Am J Physiol Regul Integr Comp Physiol 2008 Dec;295(6):1941-1952. |
| Gilbert JS, Nijland MJ, Knoblich P. Placental ischemia and cardiovascular dysfunction in preeclampsia and beyond: making the connections Expert Rev Cardiovasc Ther 2008 Nov;6(10):1367-1377. |
| Nijland MJ, Ford SP, Nathanielsz PW. Prenatal origins of adult disease Curr Opin Obstet Gynecol 2008 Apr;20(2):132-138. |
| McDonald TJ, Nijland MJ, Nathanielsz PW. The insulin-like growth factor system and the fetal brain: Effects of poor maternal nutrition Rev Endocr Metab Disord 2007 Jun;8(2):71-84. |
Federal |
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| Funding Agency | NCRR |
| Title | Developmental Programming by Mismatch of Pre- and Postnatal Nutrition |
| Status | Active |
| Period | 9/2011 - 8/2016 |
| Role | Principal Investigator |
| Grant Detail | SPECIFIC AIMS. Developmental Programming (DP) is defined as a response to a specific challenge in a critical time window that alters normal development with resulting persistent effects on phenotype. Adult phenotype is determined by complex gene environment interactions. Human epidemiological and controlled animal studies indicate that the fetal and neonatal nutritional environment significantly alters phenotype by epigenetic mechanisms. In rodent studies maternal nutrient reduction (MNR) leading to offspring (OFF) nutrient reduction in pregnancy and lactation predisposes OFF to diabetes, obesity, cardiovascular and other chronic conditions due to adaptations in cell metabolism in developing tissues. MNR OFF develop a thrifty phenotype during fetal life enabling survival if nutrients are scarce in later life a predictive adaptive response. A mismatch of fetal nutrient reduction (FNR) and excess (or even normal) neonatal nutrition also predisposes OFF to chronic disease. Mechanisms producing similar outcomes in response to exposures are unknown We used NCRR funding in a completed R24 to develop baboon OFF cohorts of 1) control (CTR) baboons fed ad lib in pregnancy (P) and lactation (L) CTR/CTR (P diet first, L diet second) and 2) MNR baboons fed 70% global CTR diet, MNR/MNR. We refer to this completed R24 as our MNR R24. Fetal exposure to a 30% global reduction in maternal food intake represents a moderate exposure as shown by effects on fetal growth and metabolism. We were recently awarded a second R24 to develop OFF cohorts of healthy female baboons randomly selected and fed to develop dietary induced maternal obesity (MO) to which fetus and neonate are exposed (MO/MO). We refer to this new R24 as the MO R24. General Hypothesis: We hypothesize that mismatch between fetal and neonatal nutrition leads to OFF obesity and predisposes to adult disease. Specific Aim: To develop cohorts of male and female nonhuman primate (NHP) OFF exposed to nutrient mismatch in feta |
| Funding Agency | NIH |
| Title | Developmental Programming, Maternal Obesity and Overnutrition |
| Status | Active |
| Period | 3/2010 - 12/2014 |
| Role | Co-Principal Investigator |
| Grant Detail | Resource grant to develop a cohort of obese pregnant baboons and study offspring for affects to developmental programming |
| Funding Agency | NIH/NICHD |
| Title | Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanisms |
| Status | Active |
| Period | 9/2007 - 7/2012 |
| Role | Principal Investigator |
| Grant Detail | Overall PO1 goal is to study effects of global maternal nutrient restriction. Sub0potimal fetal organ growh and development are major problems associated with increased neonatal death and long term morbidity. |
| Funding Agency | NIH HD |
| Title | Effects of Prenatal Nutrition on Developmental Outcomes in the the Juvenile Baboon |
| Status | Active |
| Period | 7/2008 - 6/2010 |
| Role | Principal Investigator |
| Grant Detail | |