Aguiar, Ricardo C.School of Medicine |
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| 9/2010 - Present | Associate Professor in Medicine | University of Texas Health Science Center at San Antonio, Medicine, San Antonio, TX |
| 8/2005 - Present | Assistant Professor in Biochemistry | University of Texas Health Science Center at San Antonio, Biochemistry, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1998 | Postdoctoral Fellowship | Lymphoma Biology | Harvard Medical School Boston , MA |
| 1996 | Postdoctoral Fellowship | Leukemia Biology | Centre for Adult Leukaemia, Hammersmith Hospital, University of London London , UK |
| 1994 | PhD | Leukemia Biology (Magna Cum Laude) | University of Sao Paulo, School of Medicine Sao Paulo , Brazil |
| 1992 | Clinical Fellowship | Hematology & Oncology | Hospital das Clinicas, School of Medicine, University of Sao Paulo Sao Paulo , Brazil |
| 1990 | Residency | Internal Medicine | Hospital das Clinicas, School of Medicine, University of Sao Paulo Sao Paulo , Brazil |
| 1988 | MD | Medicine | Federal University of Paraiba Paraiba , Brazil |
Hematological Malignancies- I have clinical and basic research training in hematology malignancies, with particular emphasis in lymphomas and leukemias. I have been working in this area since completing my fellowship training and obtaining my PhD degree, in 1994. The research program in my lab is centered on these disorders, and we have extensive track record of publications, funding and teaching in this field. |
Molecular and Cellular Biology- Molecular and cellular biology are centerpieces of the research projects in my laboratory. We have outstanding training on these areas (University of London and Harvard Medical School) and utilize state of the art molecular and cellular approaches to the study of cancer. |
Translational Research- Most of our research endeavors in my group are aimed at bringing laboratorial findings to the clinical practice translational research. We have extensive demonstrated standing in this field, including numerous publications and funded research projects. In addition, most of our teaching activity to the graduate students, clinical fellows, and faculty, highlights the relevance of translational research in contemporary cancer biology. |
| Date | Description | Institution | # Students |
| 1/2012 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
| 1/2012 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
| 10/2011 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
| 9/2011 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
| 2/2011 - Present | Individual Instruction | UTHSCSA | |
| 12/2010 - Present | Individual Instruction | UTHSCSA | |
| 4/2010 - Present | Post-Doctoral Student Supervision | UTHSCSA | |
Journal Article |
| Kim SW, Ramasamy K, Bouamar H, Lin AP, Jiang D, Aguiar RC. MicroRNAs miR-125a and miR-125b constitutively activate the NF-kB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) Proc Natl Acad Sci U S A 2012 May;109(20):7865-7870. |
| Kim SW, Rai D, Aguiar RC. Gene-set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma Clinical Cancer Research 2011 Nov;17(21):6723-6732. |
| Lyu MA, Sung B, Cheung LH, Marks JW, Aggarwal BB, Aguiar RCT, Rosenblum MG. The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6receptor in diffuse large B-cell lymphoma Biochemical Pharmacology 2010 Nov;80(9):1335-1342. |
| Lyu M, Rai D, Ahn KS, Sung B, Cheung LH, Marks JW, Aggarwal BB, Aguiar RCT, Gandhi V,Rosenblum MG. The rGel/BLyS fusion toxin inhibits tumor growth in severe combined immunodeficiency mice bearing diffuse large B cell lymphoma Neoplasia 2010 May;12(5):366-375. |
| Qin Y, Yao L, King E, Buddavarapu K, Lenci R, Chocron S, Lechleiter J, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo R, Toledo S, Stiles C, Aguiar RC, Dahia PL. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma Nature Genetics 2010 Mar;42(3):229-233. |
| Rai D, Kim SW, Mckeller MR, Dahia PL, Aguiar RC. Targeting of SMAD5 links microRNA-155 to the TGFβ pathway and lymphomagenesis Proceedings of the National Academy of Sciences USA 2010 Feb;107(7):3111-3116. |
| McKeller MR, Robetorye RS, Dahia PL, Aguiar RC. Integrity of the CBL gene in mature B-cell malignancies Blood 2009 Nov;114(19):4321-4322. |
| Li C, Kim SW, Rai D, Bolla AR, Adhvaryu S, Kinney MC, Robetorye RS, Aguiar RC. Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma Blood 2009 Jun;113(26):6681-6690. |
| Kim SW, Rai D, McKeller MR, Aguiar RC. Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL Blood 2009 Jun;113(24):6153-6160. |
| Jung I & Aguiar RC. MicroRNA-155 expression and outcome in diffuse large B-cell lymphoma British Journal of Haematology 2009 Jan;141(1):138-140. |
| Chaubey A, Karanti S, Rai D, Oh T, Adhvaryu SG, Aguiar RC. MicroRNAs and deletion of the derivative chromosome 9 in chronic myeloid leukemia Leukemia 2009 Jan;23(1):186-188. |
| Rai D, Karanti S, Jung I, Dahia PL, Aguiar RC. Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma Cancer Genet Cytogenet 2008 Feb;181(1):8-15. |
Electronic/Web Publication |
| Li,C & Aguiar RC. Gene Expression Omnibus, accession# GSE15225 Non-coding RNA profiling by array 2009 Mar. |
| Li C & Aguiar RC. Gene Expression Omnibus, accession# GSE15177 Genome variation profiling by genome tiling array 2009 Mar. |
| Li C & Aguiar RC. Gene Expression Omnibus, accession# GPL8276 Human 41K miRNA CGH - spotted oligonucleotide 2009 Mar. |
Federal |
|
| Funding Agency | NIH/NCI |
| Title | microRNA-155 and Lymphoma |
| Status | Active |
| Period | 3/2010 - 12/2014 |
| Role | Principal Investigator |
| Grant Detail | Characterize the mechanism by which targeting of SMAD5 by microRNA-155 induces lymphomagenesis - roles of E2A and PAX5 |
Private |
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| Funding Agency | Voelcker Fund |
| Title | MicroRNA-155 targets the TGF-beta pathway in lymphoma |
| Status | Active |
| Period | 7/2009 - 6/2014 |
| Role | Principal Investigator |
| Grant Detail | Aim: Characterize the interaction microRNA-155 and the TGF-beta pathway. |
| Funding Agency | Concern Foudation |
| Title | Regulation of microRNA-155 expression in Lymphomas |
| Status | Complete |
| Period | 7/2008 - 6/2010 |
| Role | Principal Investigator |
| Grant Detail | Aim: Characterize the regulation of miR-155 in human lymphoma. |
State |
|
| Funding Agency | Cancer Prevention and Research Institute of Texas |
| Title | Rational Combinatorial Targeting of PDE4 and Associated Survival Pathways in B-cell |
| Status | Active |
| Period | 12/2010 - 11/2013 |
| Role | Principal Investigator |
| Grant Detail | |
| Funding Agency | CPRIT |
| Title | A next-generation sequencing strategy to identify chromosomal translocations targeting the immunoglobulin loci in B-cell malignancies |
| Status | Active |
| Period | 12/2011 - 11/2013 |
| Role | Principal Investigator |
| Grant Detail | |