| Date |
Description |
Institution |
# Students |
| 9/2009 - Present |
Post-Doctoral Student Supervision |
The University of Texas Health Science Center, San Antonio TX |
|
|
| 6/2009 - Present |
Introduction to Clinical Laboratory Sciences |
The University of Texas Health Science Center |
18 students |
| Lectured on recent advances in natural products for cancer management |
| 3/2009 - Present |
Cancer Biology Core II |
The University of Texas Health Science Center |
11 students |
| Lectured on GU malignancies with special reference to prostate cancer and treatment strategies |
| 3/2009 - Present |
Ph.D. Dissertations Directed |
The University of Texas Health Science Center, San Antonio TX |
|
|
| 8/2008 - Present |
Post-Doctoral Student Supervision |
The University of Texas Health Science Center, San Antonio, TX |
|
|
| 6/2008 - Present |
Cancer Biology Core II |
The University of Texas Health Science Center |
3 students |
| Lectured on molecular events associated with prostate cancer development, detection methods and preventive strategies |
| 4/2008 - Present |
Individual Instruction |
The University of Texas Health Science Center, San Antonio, TX |
|
|
| 6/2007 - Present |
Lecutred to Urology residents |
The University of Texas Health Science Center San Antonio TX |
12 students |
|
| 5/2007 - Present |
Individual Instruction |
The University of Texas Health Science Center, San Antonio, TX |
|
|
| 1/2007 - Present |
Individual Instruction |
The University of Texas Health Science Center, San Antonio, TX |
|
|
| 7/2006 - Present |
Individual Instruction |
The University of Texas Health Science Center, San Antonio, TX |
|
|
| 6/2006 - Present |
Lecture to Residents of Urology |
The University of Texas Health Science Center, San Antonio TX |
12 students |
|
Journal Article |
| Sri Balasubashini, M., Kunnumakkara, A. B., Bhaskaran, S. B., Kulkarni, K. H., Xu, H., Hu, M., Aggarwal, B. A., Ghosh, R. and Kumar A. P. Butanol fraction containing berberine or related compound from NexrutineR inhibits NFkB signaling and induces apoptosis in prostate cancer cells Prostate 2009 Jan;69:494-504.
|
| Ganapathy M, Ghosh R, Xie J, Zhang X, Bedolla R, Schoolfield J, Yeh I, Troyer DA, Olumi AF, Kumar P. Involvement of FLIP in 2-methoxyestradiol induced tumor regression in transgenic adenocarcinoma of mouse prostate (TRAMP) model Clin Cancer Res 2009 Jan;15:1601-1611.
|
| Yeh I, Reddick RL, Kumar P. Malignancy arising in seminal vesicles in the transgenic adenocarcinoma of mouse prostate (TRAMP) model The Prostate 2009 Jan;69:755-760.
|
| Kumar P, Schoolfield J, Yeh I, Ghosh R. Loss of NADPH Quinone Oxidoreductase (NQO1) in the prostate and enhanced serum levels of cytokine-induced neutrophil chemoattractant-2alpha(CINC-2alpha) in hormone stimulated Noble rats: potential role in PIN development Translational Oncology 2009 Jan;2:65-72.
|
| Ghosh R
Ganapathy M
Alworth WL
Chan DC
Kumar AP. Combination of 2-methoxyestradiol (2-ME(2)) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells J Steroid Biochem Mol Biol 2009 Jan;113(1-2):25-35.
|
| Ghosh, R., Ganapathy, M., Sribalasubashini, M., Graham, H., Rivas, P., Jianping, X., Robson, C and Kumar AP. Targeting cell survival and apoptotic signaling pathways for prostate cancer management Anticancer Research 2008 Jan;28(5C):3362-3362.
|
| Kumar AP, Bhaskaran S, Ganapathy M, Crosby K, Davis MD, Kochunov P, Schoolfield J, Yeh IT, Troyer DA, Ghosh R, Yeh I. Akt/cAMP-Responsive Element Binding Protein/Cyclin D1 Network: A Novel Target for Prostate Cancer Inhibition in Transgenic Adenocarcinoma of Mouse Prostate Model Mediated by Nexrutine, a Phellodendron Amurense Bark Extract Clin Cancer Res 2007 Jan;13(9):2784-2794.
|
| Ghosh, R., Garcia, GE., Crosby, K., Inoue, H., Thompson, IM., Troyer, DA and Kumar, AP. Regulation of Cox-2 by Cyclic-AMP response element binding protein in prostate cancer: potential role for Nexrutine Neoplasia 2007 Jan;9(11):893-899.
|
| Garcia GE, Wisniewski HG, Lucia MS, Arevalo N, Slaga TJ, Kraft SL, Strange R, Kumar AP. 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6 Clin Cancer Res 2006 Jan;12(3 Pt):980-988.
|
| Ghosh R, Nadiminty N, Fitzpatrick JE, Alworth WL, Slaga TJ, Kumar AP. Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity J Biol Chem 2005 Jan;280(7):5812-5819.
|
| Kumar AP, Garcia GE, Ghosh R, Rajnarayanan R, Alworth WL, Slaga TJ. Curcumin derivatives: potential for prostate cancer management Toxicological Pathology 2004 Jan;32:132-167.
|
Abstract |
| Kumar, AP
Ghosh, R
Ganapathy, M
Sribalasubashini, M
Graham, H
Rivas, P
Jianping, X
Robson, C. Targeting cell survival and apoptotic signaling pathways for prostate cancer management; 2009 Jan. (Anticancer Reserch).
|
| Kumar, Ph.D. AP. Prostaglandin signaling: target for pancreatic cancer; 2009 Jan. (Presented at Cell Signaling meeting South Padre Island November 2009).
|
| Manonmani Ganapathy
Jianping Xie
Heather Graham
Aria F Olumi
Rita Ghosh
Addanki P. Kumar. Androgen medicated FLIP expression in androgen-sensitive prostatic cancer cell LNCaP as a novel target for 2-Methoxyestradiol (2-Me2) induced apoptosis. 2009 Proceedings of 100th Annual Meeting of American Association for Cancer Research; 2009 Jan. (Proceedings of American Association for Cancer Research).
|
| Rita Ghosh
Rumu Bose
Addanki P. Kumar. E2F2 in eugenol-induced inhibitory activities in malignant melanoma. 2009 Proceedings of 100th Annual Meeting of the American Association for Cancer Research; 2009 Jan. (Proceedings of American Association for Cancer Research).
|
| CPT Craig H. Robson
Manonmani Ganapathy
Gregory P. Swanson
Niko Papanikolaou
Paul Rivas
Martha A. Hanes
Yeh I-Tien
Rita Ghosh
Addanki P. Kumar. Phellodendoron amurense bark extract as an adjuvant for prostate cancer radio-therapy. 2009 Proceedings of 100th Annual Meeting of the American Association for Cancer Research; 2009 Jan. (Proceedings of American Association for Cancer Research).
|
| Kumar, AP
Muralimanohara SriBalasubhasini,
Paul Rivas,
Kunnumakarra, AB,
Aggarwal, BA,
Rita Ghosh. Butanol fraction of Nexrutine targets NFkB pathway in prostate cancer cells. 2008 Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Jan. (Proceedings of American Association for Cancer Research).
|
| Kumar, Ph.D. AP. Phellodendron amurense Bark Extract Enhances Radiosensitivity by inhibition of NF-kappa B in; 2008 Jan. (Presented at American Urological Association Annual Meeting).
|
| Kumar, AP
Manonmani Ganapathy,
Paul Rivas,
Rita Ghosh,
Xiaoping Zhang,
Aria F Olumi,. Transcriptional regulation of FLIP as a target in prostate cancer. 2008 Proceedings of the 99th Annual Meeting of the American Associatin for Cancer Research; 2008 Jan. (Proceedings of Amercian Association for Cancer Research).
|
| Yeh I, Reddick RL, Kumar AP. Malignancy arising in seminal vesicles in the transgenic adenocarcinoma of mouse prostate (TRAMP) model; 2007 Jan. (American Society of Investigative Pathology).
|
| Kumar, AP
Rumu Bose,
Florastina Payton
Manonmani Ganapathy
William Alworth
Rita Ghosh. Catechols Modulate Proliferation and Apoptosis in Malignant Melanoma Cells; 2007 Jan. (4th International Melanoma Congress New York).
|
| Kumar, AP
Ganapathy, M
Xiaoping Zhang,
Aria F Olumi,
Rita Ghosh,. Antiproliferative activity of 2-methoxyestradiol in prostate cancer cells through induction of apoptosis. 2007 Proceedings of the 98th Annual Meeting of the American Association for Cancer Research; 2007 Jan. (Proceedings of American Association for Cancer Research).
|
| Kumar AP, Lucia MS, Garcia GE, Arevalo n, Chan DE, Kyprianou N, Kraft SL, Wisniewski HG, Ghosh R. 2-Methoxyestradiol induced prevention of prostate tumors: enhancing its efficacy. 2005 Proceedings of the 96th Annual Meeting of the American Association for Cancer Research; 2005 Jan. (Proceedings fo American Association for Cancer Research).
|
| Kumar AP, Garcia GE, Arevalo N, Lucia MS, Wisniewski HG, Slaga TJ, Ghosh R. Preventing the development of prostate tumors in preclinical models: Role of NFkB and TNFa - stimulated gene 6 (TSG-6) in 2-Methoxyestradiol (2-ME) induced apoptosis and invasion; 2004 Jan. (Proceedings of Third Annual AACR International conference Frontiers in Cancer Prevention Research).
|
Review Article |
| Brand, T. C., C-Hagino, E. D., Kumar, A. P., Ghosh, R., Leach, R. L. and Thompson, I. M. Chemoprevention of prostate cancer Hematol Oncol Clin N Am 2006 Jan;20:831-843.
|
Federal |
| Funding Agency |
National Cancer Institute |
| Title |
SIRT1 as a Resveratrol target in PTEN knockout Prostrate Cancer Model |
| Status |
Active |
| Period |
4/2009 - Present |
| Role |
Principal Investigator |
| Grant Detail |
The goal of this proposal is to test a life-span increasing, cost-effective and non toxic dietary supplement in a preclinical model of PCA targeting Novel SIRT1 signaling (associated with increasing life span) for prostate cancer prevention. |
| Funding Agency |
National Institute of Health |
| Title |
Targeting FLIP for Prostate Cancer |
| Status |
Active |
| Period |
7/2008 - Present |
| Role |
Principal Investigator |
| Grant Detail |
Understanding The Mechanism of Development of AIPCA: Role of FLIP |
| Funding Agency |
SACI |
| Title |
CTRC Pilot project |
| Status |
Active |
| Period |
3/2007 - Present |
| Role |
Principal Investigator |
| Grant Detail |
Primary goal is to develop Nexrutine a herbal extract as an adjuvant for prostate cancer therapy |
| Funding Agency |
Institue of Integration of Medicine and Science |
| Title |
Translational Technology Resource Supplement Funds |
| Status |
Active |
| Period |
10/2009 - Present |
| Role |
Principal Investigator |
| Grant Detail |
The goal of this supplemental funding is to develop a combination of markers for predicting prostate cancer recurrence |
| Funding Agency |
NIH |
| Title |
Eugenol and 2-methoxyestradiol: combination approach to prostate cancer prevention. |
| Status |
Active |
| Period |
7/2009 - Present |
| Role |
Principal Investigator |
| Grant Detail |
The goal of this grant application is to test the potential of eugenol in combination with 2-methoxyestradiol to inhibit prostate tumor development in preclinical animal model |
| Funding Agency |
Department of Defense |
| Title |
Antioxidant prophylaxis in the prevention of prostatic intraepithelial neoplasia |
| Status |
Complete |
| Period |
2/2004 - 2/2009 |
| Role |
Principal Investigator |
| Grant Detail |
The major goal of this grant is to develop a combination of antioxidants for prevention of PIN. |
| Funding Agency |
SACI PIlot |
| Title |
CTRC Pilot project |
| Status |
Complete |
| Period |
1/2007 - 12/2007 |
| Role |
Co-Investigator |
| Grant Detail |
The goal of this project is to understand the role of metastasis suppressor gene TSG-6 in prostate cancer development |
Private |
| Funding Agency |
American Cancer Society |
| Title |
2-Methoxyestradiol in prostate cancer management: mechanism of action |
| Status |
Active |
| Period |
7/2004 - Present |
| Role |
Principal Investigator |
| Grant Detail |
Selected by the American Cancer Society as its top grants out of 128 grants funded this cycle and was cited in the ACS press release. The goal of this grant is to understand the mechanism of action of 2-methoxyestradiol (2-ME) to develop as a preventive agent for PCA. |
State |
| Funding Agency |
Integrative Health and Chronic Diseases (IHCD) Program (Slaga, TJ PI). |
| Title |
Nutritional Compounds-Induced Modulation of Signaling for Prostate |
| Status |
Active |
| Period |
4/2007 - 3/2009 |
| Role |
Co-Investigator |
| Grant Detail |
Test the ability of nutriional compounds to modulate signaling pathways |
|
| Funding Agency |
CTRC Pilot project |
| Title |
CTRC Pilot project |
| Status |
Active |
| Period |
7/2008 - Present |
| Role |
Principal Investigator |
| Grant Detail |
Nexrutine for Pancreatic Cancer |
