Journal Article |
| Vadlamudi RK, Rajhans R, Chakravarty D, Chandrasekharan Nair B, Nair SS, Evans DB, Chen S, Tekmal RR. Regulation of aromatase induction by nuclear receptor coregulator PELP1 Journal of Steroid Biochemistry and Molecular Biology 2009 Sep;doi10(1016).
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| Popov VM, Zhou1 J, Shirley LW, Quong J, Yeow W, Wright JA, Wu K, Rui H, Vadlamudi RK, Jiang J, Kumar R, Chenguang Wang C, and Pestell, RG. The Cell Fate Determination Factor DACH1 is expressed in Estrogen Receptor α (ERα) positive breast cancer and represses ERα signaling Cancer Research 2009 Jul;:in-press.
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| Rayala SK, Zhang H, Holm C, Vadlamudi RK, and Kumar R. Extracellular coactivator signaling confers insensitivity to tamoxifen Clinical Cancer Research 2009 Jan;15(4123).
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| Quan-Guang Zhang, Limor Raz, Ruimin Wang, Dong Han, Liesl De Sevilla, Fang Yang, Ratna Vadlamudi, and Darrell Brann. Estrogen Attenuates Ischemic Oxidative Damage via an ER-Mediated Inhibition of NADPH Oxidase Activation Journal of Neuroscience 2009 Jan;.
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| Kayahara M, Ohanian J, Ohanian V, Berry A, Vadlamudi RK, Ray DW. MNAR functionally interacts with both N- and C-terminal GR domains to modulate transactivation Am J Physiol Endocrinol Metab 2008 Aug;295:E1047-print.
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| Dimple C, Nair SS, Rajhans R, Pitcheswara PR, Liu J, Balasenthil S, Le XF, Burow ME, Auersperg N, Tekmal RR, Broaddus RR, Vadlamudi RK. Role of PELP1/MNAR signaling in ovarian tumorigenesis Cancer Research 2008 Jun;68(12):4902-4909.
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| Nagpal JK, Nair S, Chakravarty D, Rajhans R, Pothana S, Brann DW, Tekmal RR, Vadlamudi RK. Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway Molecular Cancer Research 2008 May;6(5):851-861.
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| Rajhans R, Nair HB, Nair SS, Cortez V, Ikuko K, Kirma NB, Zhou D, Holden AE, Brann DW, Chen S, Tekmal RR, Vadlamudi RK. Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells Molecular Endocrinology 2008 Mar;22(3):649-664.
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| Nagpal JK, Nair SS, Chakravarty D, Rajhans R, Saikumar P, Brann DW, Tekmal RR, and Vadlamudi RK. Growth Factor Regulation of ER-coregulator PELP1 Functions via PKA Pathway Molecular Cancer Research 2008 Jan;6(5):851-861.
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| Ohshiro K, Rayala SK, Kondo S, Gaur A, Vadlamudi RK, El-Naggar AK, Kumar R. Identifying the estrogen receptor coactivator PELP1 in autophagosomes Cancer Res 2007 Sep;67(17):8164-8171.
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| Rajhans R, Nair SS, Holden AH, Kumar R, Tekmal RR, Vadlamudi RK. Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor Cancer Research 2007 Jun;67(11):5505-5512.
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| Gururaj AE, Peng S, Vadlamudi RK, Kumar R. Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through PELP1 Molecular Endocrinology 2007 May;21.
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| Nair SS, Guo Z, Mueller JM, Koochekpour S, Qiu Y, Tekmal RR, Schule R, Kung HJ, Kumar R, Vadlamudi RK. PELP1/MNAR enhances androgen receptor functions through LIM-only coactivator FHL2 Mol Endocrinol 2007 Jan;21:613-624.
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| Singh RR, Gururaj AE, Vadlamudi RK and Kumar R. 9-cis-retinoic acid upregulates expression of transcriptional coregulator PELP1, a novel coactivator of RXRalpha pathway J. Biol. Chem 2006 Jun;I281(22):15394-14404.
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| Rayala SK, den Hollander P, Balasenthil S, Molli PR, Bean AJ, Vadlamudi RK, Wang RA, and Kumar R. HRS, an Endosomal Trafficking Component, Interacts with PELPI and activates MAPK J Bio Chem 2006 Jan;281(7).
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| Rayala SK, Mascarenhas J Vadlamudi RK and Kumar R. Altered localization of a co-activator sensitizes breast cancer cells to TNF-induced apoptosis Mol Cancer Therapeutics 2006 Jan;5(2):230-237.
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| Zhu Y, Sullivan1 LL, Nair SS, Williams CC, Pandey AK, Marrero L, Vadlamudi RK, and Jones FE. Coregulation of Estrogen Receptor by ERBB4/HER4 Establishes a Growth Promoting Autocrine loop Cancer research 2006 Jan;66:7991-7998.
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| Khan MM, Hadman M, Wakade C, De Sevilla LM, Dhandapani KM, Mahesh VB, Vadlamudi RK, Brann DW. Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha- but not in gonadotropin-releasing hormone-positive neurons Endocrinology 2005 Dec;146(12):5215-5227.
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| Vadlamudi RK, Manavathi B, Balasenthil S, Nair SS, Yang Z, Sahin AA, Kumar R. Functional implications of altered subcellular localization of PELP1 in breast cancer cells Cancer Res 2005 Sep;65(17):7724-7732.
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| Manavathi B, Nair SS, Wang RA, Kumar R, Vadlamudi RK. Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation Cancer Res 2005 Jul;65(13):5571-5577.
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| Vadlamudi RK, Balasenthil S, Sahin AA, Kies M, Weber RS, Kumar R, El-Naggar AK. Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expression in salivary duct adenocarcinoma: potential therapeutic targets Hum Pathol 2005 Jun;36(6):670-675.
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| Vadlamudi RK, Manavathi B, Singh RR, Nguyen D, Li F, Kumar R. An essential role of Pak1 phosphorylation of SHARP in Notch signaling Oncogene 2005 Jun;24(28):4591-4596.
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| Vadlamudi RK, Barnes CJ, Rayala S, Li F, Balasenthil S, Marcus S, Goodson HV, Sahin AA, Kumar R. P21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B Mol Cell Biol 2005 May;25(9):3726-3736.
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| Yang Z, Vadlamudi RK, Kumar R. Dynein light chain 1 phosphorylation controls macropinocytosis J Biol Chem 2005 Jan;280(1):654-659.
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| Vadlamudi RK, Balasenthil S, Broaddus RR, Gustafsson JA, Kumar R. Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors J Clin Endocrinol Metab 2004 Dec;89(12):6130-6138.
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| Gururaj A, Barnes CJ, Vadlamudi RK, Kumar R. Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase Oncogene 2004 Oct;23(49):8118-8127.
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| Nair SS, Mishra SK, Yang Z, Balasenthil S, Kumar R, Vadlamudi RK. Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells Cancer Res 2004 Sep;64(18):6416-6423.
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| Talukder AH, Gururaj A, Mishra SK, Vadlamudi RK, Kumar R. Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator Mol Cell Biol 2004 Aug;24(15):6581-6591.
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| Bagheri-Yarmand R, Talukder AH, Wang RA, Vadlamudi RK, Kumar R. Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis Development 2004 Jul;131(14):3469-3479.
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| Mishra SK, Talukder AH, Gururaj AE, Yang Z, Singh RR, Mahoney MG, Franc C, Vadlamudi RK, Kumar R. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway J Biol Chem 2004 Jul;279(31):32709-32715.
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| Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den Hollander P, Kumar R. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes Cancer Cell 2004 Jun;5(6):575-585.
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| Mishra SK, Balasenthil S, Nguyen D, Vadlamudi RK. Cloning and functional characterization of PELP1/MNAR promoter Gene 2004 Apr;330:115-122.
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| Barnes CJ, Vadlamudi RK, Kumar R. Novel estrogen receptor coregulators and signaling molecules in human diseases Cell Mol Life Sci 2004 Feb;61(3):281-291.
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| Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R. P41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate EMBO Rep 2004 Feb;5(2):154-160.
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| Balasenthil S, Sahin AA, Barnes CJ, Wang RA, Pestell RG, Vadlamudi RK, Kumar R. P21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells J Biol Chem 2004 Jan;279(2):1422-1428.
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Book Chapter |
| Vadlamudi RK. Nuclear receptor coregulators:Emerging drug targets for treatment of women cancers. In: David K Wong (ed). Tumor Research Advances. 2007. p. 87-102.
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| Vadlamudi RK and Kumar R. P21-activated Kinase: An emerging therapeutic target. In: Edited By Rakesh Kumar. Molecular targeting and signal transduction. 2004. p. 77-88.
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Abstract |
| VM Popov, J Zhou, LA Shirley, K Wu, RK Vadlamudi, R Kumar, J Jiang, J Quong, H Rui, WS Yeow, C Wang, RG Pestell. Expression of DACH1 in Estrogen Receptor Positive Breast Cancer and DACH1-Mediated Repression of ER Signaling; 2009 Jun. (Annual Meeting (ENDO) 2009).
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| Chakravarty D, Nair S, Nair CB, Wang L, Bandyopadhyay AM, Agyin JK, Francis L, Sun L, Yeh I, Tekmal RR, Vadlamudi RK. Therapeutic potential of blocking ER non-genomic actions on ER-positive metastasis; 2009 Apr. (American Association for Cancer Research Annual Meeting: Proceedings: April 18-22, Denver, CO, AACR; vol. 2009, no. 2387).
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| Nair SS, Nair BC, Chakravarty D, Tekmal RR, Vadlamudi RK. Regulation of histone H3 methylation by ER coregulator PELP1: A novel paradigm in coregulator function; 2009 Apr. (Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; vol. 2009, no. 3848).
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| Popov VM, Zhou J, Shirley A, Wu K, Vadlamudi RK, Kumar R, Jiang J, Quong J, Rui H, Yeow W, Wang C, Pestell RG. The cell fate determination factor DACH1 is expressed in estrogen receptor α positive breast cancer and represses ERα signaling; 2009 Apr. (Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; vol. 2009, no. 613).
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| Chandrasekharan NB, Nair SS, Chakravarty D, Yew RP, Tekmal RR, Vadlamudi RK. Modulation of hormone therapy resistance by CDK2-PELP1 axis; 2009 Jan. (Cancer Research; vol. 69, no. 211S).
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| Chakravarty D, Nair BC, Nair SS, Tekmal RR, Vadlamudi RK. Potential role of estrogen receptor coregulator in mitosis; 2009 Jan. (Cancer Research; vol. 69, no. 311S).
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| Rajhans R, Cortez V, Nair SS, Tekmal RR, Kumar R, Vadlamudi RK. Novel mouse model for studying role of ER-nongenomic actions in breast cancer; 2009 Jan. (Cancer Research; vol. 69, no. 96S).
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| Nair S, Nair BC, Chakravarty D, Tekmal RR, vadlamudi RK. Role of PELP1 in Epigenetic modifications at ER target genes; 2008 Nov. (Proceedings of Annual symposium on Advances in Cell Signaling, Cancer Prevention and Therapy).
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| Vadlamudi RK. Role of ER- coregulator PELP1 in local aromatase induction in breast cancer; 2008 Oct. (Proceedings of Ninth International Aromatase Conference, Shanghai, China; vol. 2008, no. 2.2).
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| Chakravarty D, Nair BC, Nair SS, Vadlamudi RK. The Nuclear Receptor Coregulator PELP1: A Novel Regulator of G2/M Progression: Cold Spring Harbor Laboratory; 2008 Aug. (Nuclear Receptors: Bench to Bedside).
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| Zhou J, Popov V, Shirley L, Wu K, Rui H, Vadlamudi RK, Pestell R and Wang C. DACH1 regulation of estrogen receptor alpha through PELP1 in breast cancer; 2008 Apr. (99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA; vol. 2008, no. 71).
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| Chakravarty D, Santhamma B, Nair BC, Rajib R, Nair S, Agyin S, Tekmal RR, and Vadlamudi RK. PELP1/MNAR couples estrogen signaling to cytoskeleton through ILK axis; 2008 Apr. (AACR Meeting Abstracts; vol. 2008, no. 5451).
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| Nair BC, Nair S, Chakravarty D, Rajhans R, Cortez V, Tekmal RR and Vadlamudi RK. PELP1/MNAR: A novel CDKs substrate and regulator of pRb/E2F pathway; 2008 Apr. (99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA; vol. 2008, no. 4222).
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| Popov V, Zhou J, Shirley LA, Wu K, Rui H, Vadlamudi RK, Wang C, Pestell RG. DACH1 regulation of estrogen receptor alpha through PELP1 in breast cancer; 2008 Jan. (Abcam meeting 2008).
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| Chakravarty D, Nair BC, Rajhans, Rajib, Cortez V, Nair SS, Tekmal RR, deGraffenried LA, Sun L, Vadlamudi RK. Significance of PELP1/MNAR-mediated ER-nongenotropic actions in cytoskeleton; 2007 Dec. (Breast cancer research and treatment; vol. 106, no. S29).
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| Chandrasekharan NB, Nair SS, Chakravarty D, Rajhans R, Cortez V, Yew RP, Tekmal R, Vadlamudi RK. Identification of proline-, glutamic acid-, leucine, rich protein (PELP1) as a novel CDK4 substrate and characterizing its role in breast cancer cell proliferation; 2007 Dec. (Breast cancer research and treatment; vol. 106, no. S124).
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| Rajhans R, Nair H, Kirma N, Ikuko K, Shiuan C, Tekmal RR, and Vadlamudi RK. PELP1/MNAR deregulation promotes local estrogen synthesis in breast cancer cells; 2007 Apr. (AACR Meeting Abstracts; vol. 2007, no. 2520).
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| Nair H, Perla R, Liu Y, Rajhans R, Nair S, Kirma N, Pothana S, Vadlamudi Rk, and Tekmal R. Estrogen receptor β overexpression leads to decreased mammary tumorigenesis in Aromatase x HER2/neu double transgenic mice; 2007 Apr. (AACR Meeting Abstracts; vol. 2007, no. 4332).
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| Chakravarty D, Nair SS, Seetharaman Balasenthil, Liu J, Tekmal RR, Ausperg N, Burrow M, Broaddus R, Vadlamudi RK. PELP1/MNAR in ovarian cancer: implications in tumorigenesis; 2007 Jan. (American Association For Cancer Research, Annual Meeting 2007; vol. 4449).
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| Shirley, L.A., Popov, V., Zhou, J., Wu, K., Tran, T.H., Rui, H., Vadlamudi, R.K., Kumar, R.,
Wang, C., Pestell, R.G. The cell fate determination factor DACH1 represses estrogen; 2007 Jan. (Proceedings of Academic Surgical congress, Huntington Beach, CA).
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| Rajhans R, Nair SS, De La Pena MO, Alan H, Kumar R, Rajeshwar TR, Vadlamudi RK. The role of PELP1/MNAR in progression and metastasis of breast cancer; 2006 Dec. (Breast cancer research and treatment; vol. 100, no. S13).
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| Nair SS, Guo Z, Mueller JM, Koochekpour S, Qiu Y, Tekmal RR, Schule R, Kung, H, Kumar R, Vadlamudi RK. PELP1 enhances androgen receptor functions through LIM-only coactivator FHL2; 2006 Nov. (Proceedings of Annual symposium on Adbvances in Cell Signaling, Cancer Prevention and Therapy).
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| Vadlamudi RK ,Rajib R, Nair H, Kirma N, Chen S, Kumar R, Tekmal RR. Potentiation of E2-ER autocrine signaling loop by ER coregulator PELP1/MNAR; 2006 Sep. (Proceedings of 8th International Aromatase Conference, Baltimore, USA; vol. 2006).
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| Nair HB, Perla R, Kirma NB, Rajhans R, Vadlamudi RK, and Tekmal RR. HER2/neu-induced mammary tumorigenesis is reduced in Aromatase x HER2/neu double transgenic mice; 2006 Apr. (AACR Meeting Abstracts; vol. 2006, no. 693).
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| Singh RR Vadlamudi RK Kumar R. 9-cis-retinoic acid upregulates expression of transcriptional coregulator PELP1, a novel coactivator of RXRα; 2006 Jan. (Proc Amer Assoc Cancer Res; vol. 47, no. 1741).
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| Nair HB, Perla RP, Liu YG, Kirma N, Rajhans R, Chen S, Pothana S, Vadlamudi RK, Tekmal RR. Estrogen receptor plays an important role in mammary tumorigenesis in aromatase x HER2/neu double transgenic mice; 2006 Jan. (Breast cancer research and treatment; vol. 100, no. S248).
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| Nagpal J, Nair S, Saikumar P, Kumar R, Tekmal RR, Kumar R and Vadlamudi RK. Growth factor regulation of PELP-1/MNAR functions: Role of PKA-dependent phosphorylation; 2006 Jan. (Proc. Am. Assn. Cancer Res; vol. 47, no. 2933).
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| Rajhans R, Nair S, Tekmal RR, Kumar R and Vadlamudi RK. Cellular transformation and oncogenesis by PELP-1/MNAR, a major broad coactivator in mammalian cells; 2006 Jan. (Proc. Assn. Cancer Res; vol. 47, no. 4215).
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| Nair SS, Rajhans R, Nagpal JK, Guider, J, Kumar,R, Vadlamudi RK. PELP1/MNAR Interacts with BCAS2: Potential Role in ER-mediated Splicing; 2006 Jan. (Proc. Am. Assn. Cancer Res; vol. 47, no. 2930).
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| Nair S Seetharaman B Mueller J M Koochekpour S Schle R Kumar R Vadlamudi R K. PELP1/MNAR Modulates LIM-only coactivator FHL2 Transactivation Functions; 2005 Jan. (Proceedings of 96th AACR Annual Meeting).
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| Vadlamudi RK Manavathi B Balasenthil B Yang Z Sahin AA Kumar R. Altered localization of ER-coregulator PELP1 promotes estrogen hypersensitivity and tamoxifen resistance; 2005 Jan. (Proceedings of Era of Hope, DOD Breast Cancer Meeting).
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| Nair SS, Seetharaman B, Mueller J, Shule R, Kumar R, Vadlamudi RK. PELP1/MNAR Modulates LIM-only coactivator FHL2 Transactivation Functions 2005; 2005 Jan. (Proceedings of 96th AACR Annual Meeting).
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| Williams MD Vadlamudi RK Sahin AA Kies MS Kumar R and El-Naggar AK. Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expressed in salivary duct adenocarcinoma: Potential therapeutic targets; 2005 Jan. (Laboratory Investigation; vol. 85, no. 218A).
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| Barnes C, Gururaj AE, Vadlamudi RK, Kumar R. Phosphoglucomutase 1 regulation by the signaling kinase Pak1: AACR; 2004 Jan. (Proceedings of AACR 95th Annual Meeting).
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| Vadlamudi RK, Balasenthil S, Kries M, Kumar R,
El-Naggar AK. PELP1/MNAR co-activator and the hormonal receptor expression in salivary duct adenocarcinoma; 2004 Jan. (Proceedings of 6th international conference on Head and Neck Cancer).
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| Balasenthil S Gururaj AE Yang Z Broaddus R Vadlamudi RK and Kumar R. Modulation of hormonal responsiveness by the status and subcellular localization of ER and MTA family members; 2004 Jan. (Proceedings of AACR 95th Annual Meeting; vol. A2867).
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| Sandip M Balasenthil S Yang Z Vadlamudi RK. PELP1/MNAR modulate ER genomic functions via Histone H1 interactions; 2004 Jan. (Proc Amer Assoc Cancer Res; vol. 43, no. 1480).
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| Manavathi B, Wang R, Kumar R, Vadlamudi RK. PELP1 is essential in growth factor regulation of STAT3 activation; 2004 Jan. (Molecular Biology of the Cell; vol. 15, no. 126A).
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Review Article |
| Chandrasekharan Nair B and Vadlamudi RK. Regulation of hormonal therapy resistance by cell cycle machinery Gene Therapy and Molecular Biology 2008 Dec;12:395-404.
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| Brann DW, Zhang QG, Wang RM, Mahesh VB, Vadlamudi RK. PELP1-a novel estrogen receptor-interacting protein Mol Cell Endocrinol 2008 Aug;290:2-7.
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| Vadlamudi RK., Kumar R. PELP1 Targeted Proteins Database 1 2008 Jul;21627(10.29):10.297-tpdb.1.
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| Raz L, Khan MM, Mahesh VB, Vadlamudi RK, Brann DW. Rapid estrogen signaling in the brain Neurosignals 2008 Feb;16(2-3):140-153.
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| Vadlamudi RK, Kumar R. Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR Nucl Recept Signal 2007 May;5:004-004.
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| Nair SS, Vadlamudi RK. Emerging significance of ER-coregulator PELP1/MNAR in cancer Histology and Histopathology 2007 Jan;22(91-96):1-7.
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| Vadlamudi RK, Gururaj A, Rayala SK and Kumar R. Novel Mechanisms of Resistance to Endocrine Therapy - Genomic and non-genomic considerations Clinical Cancer Research 2006 Jan;12(3):1001s-1007s.
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| Rajib R and Vadlamudi RK. Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR Clin. Exp. Metastasis 2006 Jan;23:1-7.
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| Kumar R, Gururaj AE, Vadlamudi RK, Rayala SK. The clinical relevance of steroid hormone receptor corepressors Clin Cancer Res 2005 Apr;11(8):2822-2831.
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| Vadlamudi RK, Kumar R. P21-activated kinases in human cancer Cancer Metastasis Rev 2003 Dec;22(4):385-393.
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