Journal Article |
| Nair HB, Perla RP, Kirma NB, Krishnegowda NK, Ganapathy M, Rajhans R, Nair SS, Saikumar P, Vadlamudi RK, Tekmal RR. Estrogen receptor-beta mediates the protective effects of aromatase induction in the MMTV-Her-2/neu x aromatase double transgenic mice Horm Cancer 2012 Apr;3(1-2):26-36.
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| Roy, S.S., Chakravarty, D., Cortez, V., Keya, D., Bandhopadhyay, A., Ahn, JM, Raj, V,Tekmal R.R., Sun, L-Z., and Vadlamudi, R.K. Significance of PELP1 in ER-Nagative Breast Cancer Metastasis Molecular Cancer Research 2011 Oct;10:25-33.
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| Zhang QG, Han D, Wang RM, Dong Y, Yang F, Vadlamudi RK, Brann DW. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection Proc Natl Acad Sci U S A 2011 Aug;108(35):E617-624.
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| Nair HB, Kirma NB, Ganapathy M, Vadlamudi RK, Tekmal RR. Estrogen receptor- activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy Steroids 2011 Jul;76(8):792-796.
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| Gonugunta VK, Nair BC, Rajhans R, Sareddy GR, Nair SS, Vadlamudi RK. Regulation of rDNA transcription by proto-oncogene PELP1 PLoS One 2011 Jun;6(6):21095-21095.
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| Chakravarty D, Roy SS, Babu CR, Dandamudi R, Curiel TJ, Vivas-Mejia P,
Lopez-Berestein G, Sood AK, Vadlamudi RK. Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis Clin Cancer Res 2011 Mar;17(8):2250-2259.
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| Nair, S.S., Nair, B-C, Cortez, V., Chakravarty, D., Metzger, E., Schle, R., Bran, D.W., Tekmal R.R., and Vadlamudi, R.K. PELP1 is a reader of Histone H3 methylation that facilitates ER traget gene activation by regulating KDM1 specificity EMBO Report 2010 Jun;11:438-444.
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| Chakravarty D, Nair SS, Santhamma B, Nair BC, Wang L, Bandyopadhyay A, Agyin JK, Brann D, Sun LZ, Yeh IT, Lee FY, Tekmal RR, Kumar R, Vadlamudi RK. Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cells Cancer Res 2010 May;70(10):4092-4101.
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| Vadlamudi RK, Rajhans R, Chakravarty D, Nair BC, Nair SS, Evans DB, Chen S, Tekmal RR. Regulation of aromatase induction by nuclear receptor coregulator PELP1 J Steroid Biochem Mol Biol 2010 Feb;118(4-5):211-218.
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| Lin PY, Sun L, Thibodeaux SR, Ludwig SM, Vadlamudi RK, Hurez VJ, Bahar R, Kious MJ, Livi CB, Wall SR, Chen L, Zhang B, Shin T, Curiel TJ. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses J Immunol 2010 Jan;185(5):2747-2753.
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| Popov VM, Zhou1 J, Shirley LW, Quong J, Yeow W, Wright JA, Wu K, Rui H, Vadlamudi RK, Jiang J, Kumar R, Chenguang Wang C, and Pestell, RG. The Cell Fate Determination Factor DACH1 is expressed in Estrogen Receptor α (ERα) positive breast cancer and represses ERα signaling Cancer Research 2009 Jul;:in-press.
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| Rayala SK, Zhang H, Holm C, Vadlamudi RK, and Kumar R. Extracellular coactivator signaling confers insensitivity to tamoxifen Clinical Cancer Research 2009 Jan;15(4123).
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| Quan-Guang Zhang, Limor Raz, Ruimin Wang, Dong Han, Liesl De Sevilla, Fang Yang, Ratna Vadlamudi, and Darrell Brann. Estrogen Attenuates Ischemic Oxidative Damage via an ER-Mediated Inhibition of NADPH Oxidase Activation Journal of Neuroscience 2009 Jan;.
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| Kayahara M, Ohanian J, Ohanian V, Berry A, Vadlamudi RK, Ray DW. MNAR functionally interacts with both N- and C-terminal GR domains to modulate transactivation Am J Physiol Endocrinol Metab 2008 Aug;295:E1047-print.
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| Dimple C, Nair SS, Rajhans R, Pitcheswara PR, Liu J, Balasenthil S, Le XF, Burow ME, Auersperg N, Tekmal RR, Broaddus RR, Vadlamudi RK. Role of PELP1/MNAR signaling in ovarian tumorigenesis Cancer Research 2008 Jun;68(12):4902-4909.
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| Nagpal JK, Nair S, Chakravarty D, Rajhans R, Pothana S, Brann DW, Tekmal RR, Vadlamudi RK. Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway Molecular Cancer Research 2008 May;6(5):851-861.
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| Rajhans R, Nair HB, Nair SS, Cortez V, Ikuko K, Kirma NB, Zhou D, Holden AE, Brann DW, Chen S, Tekmal RR, Vadlamudi RK. Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells Molecular Endocrinology 2008 Mar;22(3):649-664.
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| Nagpal JK, Nair SS, Chakravarty D, Rajhans R, Saikumar P, Brann DW, Tekmal RR, and Vadlamudi RK. Growth Factor Regulation of ER-coregulator PELP1 Functions via PKA Pathway Molecular Cancer Research 2008 Jan;6(5):851-861.
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| Ohshiro K, Rayala SK, Kondo S, Gaur A, Vadlamudi RK, El-Naggar AK, Kumar R. Identifying the estrogen receptor coactivator PELP1 in autophagosomes Cancer Res 2007 Sep;67(17):8164-8171.
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Abstract |
| Gonugunta VK, Cortez V, Rethman C, Nair BC, Sareddy GR, Vadlamudi RK. Regulation of mTOR signaling by protooncogene PELP1; 2011 Dec. (Cancer Research; vol. 71).
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| Sareddy GR, nair BC, Krishnan SR, Gonugunta VK, Vadlamudi RK. The role of Ser991 PELP1 phosphorylation in therapy resistance and metastasis of breast cancer; 2011 Dec. (Cancer Research; vol. 71).
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| Valerie A. Cortez, Takayoshi Suzuki, Naoki Miyat, Anil K. Sood, and Ratna K. Vadlamudi. Therapeutic significance of ER{alpha}--PELP1 axis in blocking endocrine therapy resistance; 2011 Jul. (Cancer Research; vol. 71).
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| Ratna K. Vadlamudi andSudipa Saha Roy. Significance and therapeutic potential of PELP1 axis in ER-negative breast cancer; 2011 Jul. (Cancer Research; vol. 71).
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| Ratna K. Vadlamudi, Monica Mann, Valerie A. Cortez. PELP1 is a novel reader of chromatin modifications: Implications in cancer progression; 2011 Jul. (Cancer Res; vol. 71).
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| Vadlamudi RK. Significance of ER-Coregulator-Src Axis in Hormonal Resistance; 2011 Apr. (Cancer Research; vol. 70, no. 02).
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| V Cortez, M Mann, R Challa, SR Tekmal, T Suzuki, N Miyata, and RK. Vadlamudi. PELP1-KDM1 Axis: A Novel Therapeutic Target for Blocking Local Estrogen Synthesis; 2011 Apr. (Cancer Research; vol. 70).
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| SahaRoy, S, Rao M, Sun L, Tekmal R.R., Vadlamudi, RK. Proto-Oncogene PELP1 Promotes Matastasis through miR-200 Dependent Pathway; 2011 Jan. (Cancer Research; vol. 71, no. 24s).
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| Binoj Chandrasekharan Nair, Mary Morales, Hareesh Babu Bhaskaran Nair, Sreeram Vallabhaneni, Rong Li, Rajeshwar Rao Tekmal, and Ratna K. Vadlamudi. Roscovitine modulates ER{alpha}/ER{beta} ratio: A novel means to target hormonal therapy resistance; 2011 Jan. (Cancer Research; vol. 70).
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| Valerie Cortez, Sujit S. Nair, Seshidar Rao Tekmal, and Ratna K. Vadlamudi. Targeting ER-KDM1 axis to sensitize therapy resistant breast cancer cells to hormonal therapy; 2011 Jan. (Cancer research; vol. 70).
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| De K, Liu Z, Tekmal RR, Li R, Vadlamudi RK, Sun L. Role of Aromatase and its inhibitor in breast cancer-induced tumorigenesis and bone metastasis; 2010 Dec. (Poster presentation at the 33rd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, Dec. 8-12, 2010).
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| VM Popov, J Zhou, LA Shirley, K Wu, RK Vadlamudi, R Kumar, J Jiang, J Quong, H Rui, WS Yeow, C Wang, RG Pestell. Expression of DACH1 in Estrogen Receptor Positive Breast Cancer and DACH1-Mediated Repression of ER Signaling; 2009 Jun. (Annual Meeting (ENDO) 2009).
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| Chakravarty D, Nair S, Nair CB, Wang L, Bandyopadhyay A, Agyin JK, Francis L, Sun L-Z, Yeh I-T, Tekmal RR, Vadlamudi RK. Therapeutic potential of blocking ER non-genomic actions on ER-positive metastasis; 2009 Apr. (American Association for Cancer Research Annual Meeting: Proceedings: April 18-22, Denver, CO, AACR; vol. 2009, no. 2387).
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| Popov VM, Zhou J, Shirley A, Wu K, Vadlamudi RK, Kumar R, Jiang J, Quong J, Rui H, Yeow W, Wang C, Pestell RG. The cell fate determination factor DACH1 is expressed in estrogen receptor α positive breast cancer and represses ERα signaling; 2009 Apr. (Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; vol. 2009, no. 613).
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| Nair SS, Nair BC, Chakravarty D, Tekmal RR, Vadlamudi RK. Regulation of histone H3 methylation by ER coregulator PELP1: A novel paradigm in coregulator function; 2009 Apr. (Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; vol. 2009, no. 3848).
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| Chandrasekharan NB, Nair SS, Chakravarty D, Yew RP, Tekmal RR, Vadlamudi RK. Modulation of hormone therapy resistance by CDK2-PELP1 axis; 2009 Jan. (Cancer Research; vol. 69, no. 211S).
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| Chakravarty D, Nair BC, Nair SS, Tekmal RR, Vadlamudi RK. Potential role of estrogen receptor coregulator in mitosis; 2009 Jan. (Cancer Research; vol. 69, no. 311S).
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| Nair S, Nair BC, Chakravarty D, Tekmal RR, vadlamudi RK. Role of PELP1 in Epigenetic modifications at ER target genes; 2008 Nov. (Proceedings of Annual symposium on Advances in Cell Signaling, Cancer Prevention and Therapy).
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| Vadlamudi RK. Role of ER- coregulator PELP1 in local aromatase induction in breast cancer; 2008 Oct. (Proceedings of Ninth International Aromatase Conference, Shanghai, China; vol. 2008, no. 2.2).
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| Chakravarty D, Nair BC, Nair SS, Vadlamudi RK. The Nuclear Receptor Coregulator PELP1: A Novel Regulator of G2/M Progression: Cold Spring Harbor Laboratory; 2008 Aug. (Nuclear Receptors: Bench to Bedside).
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| Chakravarty D, Santhamma B, Nair BC, Rajib R, Nair S, Agyin S, Tekmal RR, and Vadlamudi RK. PELP1/MNAR couples estrogen signaling to cytoskeleton through ILK axis; 2008 Apr. (AACR Meeting Abstracts; vol. 2008, no. 5451).
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| Nair BC, Nair S, Chakravarty D, Rajhans R, Cortez V, Tekmal RR and Vadlamudi RK. PELP1/MNAR: A novel CDKs substrate and regulator of pRb/E2F pathway; 2008 Apr. (99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA; vol. 2008, no. 4222).
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| Zhou J, Popov V, Shirley L, Wu K, Rui H, Vadlamudi RK, Pestell R and Wang C. DACH1 regulation of estrogen receptor alpha through PELP1 in breast cancer; 2008 Apr. (99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA; vol. 2008, no. 71).
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| Popov V, Zhou J, Shirley LA, Wu K, Rui H, Vadlamudi RK, Wang C, Pestell RG. DACH1 regulation of estrogen receptor alpha through PELP1 in breast cancer; 2008 Jan. (Abcam meeting 2008).
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| Chakravarty D, Nair BC, Rajhans, Rajib, Cortez V, Nair SS, Tekmal RR, deGraffenried LA, Sun L, Vadlamudi RK. Significance of PELP1/MNAR-mediated ER-nongenotropic actions in cytoskeleton; 2007 Dec. (Breast cancer research and treatment; vol. 106, no. S29).
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| Chandrasekharan NB, Nair SS, Chakravarty D, Rajhans R, Cortez V, Yew RP, Tekmal R, Vadlamudi RK. Identification of proline-, glutamic acid-, leucine, rich protein (PELP1) as a novel CDK4 substrate and characterizing its role in breast cancer cell proliferation; 2007 Dec. (Breast cancer research and treatment; vol. 106, no. S124).
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| Vadlamudi RK Manavathi B Balasenthil B Yang Z Sahin AA Kumar R. Altered localization of ER-coregulator PELP1 promotes estrogen hypersensitivity and tamoxifen resistance; 2005 Jan. (Proceedings of Era of Hope, DOD Breast Cancer Meeting).
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Review Article |
| Mann M, Krishnan S, Vadlamudi RK. Emerging significance of estrogen cancer coregulator signaling in breast cancer Minerva Ginecol 2012 Feb;64(1):75-88.
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| Brann D, Raz L, Wang R, Vadlamudi R, Zhang Q. Oestrogen signalling and neuroprotection in cerebral ischaemia J Neuroendocrinol 2012 Jan;24(1):34-41.
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| Saha Roy S, Vadlamudi RK. Role of estrogen receptor signaling in breast cancer metastasis Int J Breast Cancer 2011 Dec;2012:654698-654698.
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| Scott E, Zhang QG, Wang R, Vadlamudi R, Brann D. Estrogen neuroprotection and the critical period hypothesis Front Neuroendocrinol 2011 Nov;In.
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| Mann M, Cortez V, Vadlamudi RK. Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy Cancers (Basel) 2011 Mar;3(3):1691-1707.
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| Cortez V, Nair BC, Chakravarty D, Vadlamudi RK. Integrin-linked kinase 1: role in hormonal cancer progression Front Biosci (Schol Ed) 2011 Jan;3:788-796.
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| Cortez V, Mann M, Brann DW, Vadlamudi RK. Extranuclear signaling by estrogen: role in breast cancer progression and metastasis Minerva Ginecol 2010 Dec;62(6):573-583.
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| Nair BC, Vadlamudi RK. ZD6474 coerces breast cancer for an apoptotic journey Cancer Biol Ther 2010 Apr;9(8):604-606.
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| Chakravarty D, Tekmal RR, Vadlamudi RK. PELP1: A novel therapeutic target for hormonal cancers IUBMB Life 2010 Mar;62(3):162-169.
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| Chandrasekharan Nair B and Vadlamudi RK. Regulation of hormonal therapy resistance by cell cycle machinery Gene Therapy and Molecular Biology 2008 Dec;12:395-404.
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| Brann DW, Zhang QG, Wang RM, Mahesh VB, Vadlamudi RK. PELP1-a novel estrogen receptor-interacting protein Mol Cell Endocrinol 2008 Aug;290:2-7.
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| Vadlamudi RK., Kumar R. PELP1 Targeted Proteins Database 1 2008 Jul;21627(10.29):10.297-tpdb.1.
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| Raz L, Khan MM, Mahesh VB, Vadlamudi RK, Brann DW. Rapid estrogen signaling in the brain Neurosignals 2008 Feb;16(2-3):140-153.
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