UTHSCSA Faculty Profiles v1.0

Musi, M.D., Nicolas

School of Medicine
210 562-6140

I am a physician-scientist and received clinical training in Internal Medicine at the University of Miami-Jackson Memorial Medical Center. I then completed a clinical and research fellowship in Endocrinology and Metabolism at the Joslin Diabetes Center of Harvard Medical School in 2001, after which I joined the Harvard faculty. I was recruited to the University of Texas Health Science Center (UTHSCSA) in 2003 and currently I am a tenured Professor of Medicine (Division of Diabetes and Division of Geriatrics and Gerontology) and Director of the Barshop Institute for Longevity and Aging Studies.
My research program combines clinical research, animal, and cell culture approaches to tackle questions related to the molecular biology of insulin resistance and sarcopenia in diabetes and aging. Since joining the laboratory of Dr. Laurie Goodyear in 1998 as a postdoctoral fellow at the Joslin Diabetes Center, and then as an independent investigator, I have dedicated my career at identifying and characterizing potential molecular transducers of exercise through studies conducted in rodents and human subjects. My research in this area has been funded by the National Institute on Aging (NIA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the American Federation for Aging Research (AFAR), the American Diabetes Association (ADA) and the State of Texas. Currently, I am the principal investigator on an R01 grant from NIDDK aimed at understanding the role that inflammatory pathways have on mitochondrial function, glucose and lipid metabolism in older and diabetic subjects. Also, I am the PI on a newly awarded Claude D. Pepper Center Older Americans Independence Center. I was the recipient of a Paul B. Beeson Career Development Award in Aging Research, co-sponsored by the NIA and AFAR, to examine the role of inflammatory signaling pathways (NFB) and mitochondrial dysfunction in the pathogenesis of insulin resistance and sarcopenia in older adults. Also, I was the recipient of a Junior Faculty Award and a more recently a Translational Research Award from the ADA to study whether the AMPK-PCG1 signaling axis is involved in the age-related changes in mitochondrial function and lipid metabolism that occur in older adults.
In addition to my work on diabetes, exercise physiology and muscle biology described above, I have been heavily involved in conducting clinical trials. I was the Co-PI on a large (602 patients), multi-center (10 sites), randomized clinical trial that evaluated the effect of pioglitazone on diabetes and atherosclerosis progression in pre-diabetic individuals. Other clinical trials led by me have investigated the molecular, physiological and clinical effects of various interventions, including lifestyle (physical activity, dietary), nutraceutical (oligofructose, probiotics), and pharmacologic (metformin, acipimox, sevelamer, eritoran) in human subjects; these clinical studies have involved multiple collections of muscle, adipose tissue and blood for molecular and cellular function analyses.
I have served the scientific community as a reviewer for various NIH emphasis panels and for the ADA and the AFAR. Currently, I serve as Chair of the Clinical and Integrative Obesity and Diabetes (CIDO) study section of NIH.
As an educator, I mentor students, residents, and postdoctoral fellow. I am the PI on our T32 training grant on the Biology of Aging. Based upon my background as a physician-scientist and educator, I am fully qualified to serve as co-director of the Enrichment Program of the Diabetes Research Center.

1/2015 - Present Director, San Antonio OAIC and San Antonio OIAC UTHSCSA, San Antonio, TX
9/2013 - Present Director, Barshop Institute for Longevity and Aging Studies UTHSCSA, San Antonio, TX
9/2012 - Present Professor of Medicine UTHSCSA
1/2011 - Present Sam and Ann Barshop Endowed Chair in Translational/Clinical Research in Geriatrics UTHSCSA
7/2010 - Present Director, Center for Healthy Aging UTHSCSA, San Antonio, TX
7/2010 - Present Director, Geriatric Research, Education and Clinical Center South Texas Veterans Health Care System, San Antonio, TX
7/2010 - Present Associate Director for Translational Research Barshop Institute for Longevity and Aging Studies