Henry, Michael ADental School |
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| 9/2005 - Present | Professor w/tenure | University of Texas Health Science Center San Antonio, Endodontics, San Antonio, TX |
| Year | Degree | Discipline | Institution |
| 1992 | Postdoctoral Fellowship | Department of Neurological Surgery | University of Washington Seattle , WA |
| 1992 | Postdoctoral Training | Individual Award from the NIDR | University of Washington Seattle , WA |
| 1991 | PhD | Biological Structure | University of Washington School of Medicine Seattle , WA |
| 1987 | Residency | Univ. of Florida, College of Dentistry Gainesville , FL |
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| 1987 | Postdoctoral Fellowship | Dental Occlusion and Orofacial Pain | University of Florida Gainesville , FL |
| 1985 | Postdoctoral Fellowship | Department of Neurological Surgery | University of Washington, School of Medicine Seattle , WA |
| 1983 | DDS | University of Washington, School of Dentistry Seattle , WA |
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| 1982 | Internship | Department of Neurological Surgery | University of Washington Seattle , WA |
| 1978 | BS | Zoology (Cum Laude) | Washington State University Pullman , WA |
Neuroanatomy, electron/confocal microscopy, pain- 1)The normal organization of the trigeminal brainstem nuclear complex and its response and reorganization following injury with emphasis on central nervous system plasticity. 2)The neuroanatomical basis for pain transmission and modulation within the trigeminal nucleus. 3)The correlation of basic research findings with the pathophysiology of orofacial pain patients and the development of new treatments for these patients. 4)Sodium channel localization within the normal and injured rat trigeminal system; contribution to neuropathic pain states. 5)Sodium channel and thermoreceptor localization within normal and diseased human teeth. 6) Human trigeminal pulpal pain mechanisms. 7) Regeneration of the human dental pulp with post-natal, dentally-derived stem cells. 8) Gial-neuro-immune-vascular interactions in neuropathic and inflammatory trigeminal pain states in humans and rats. |
| Date | Description | Institution | # Students |
| 1/2010 - Present | Individual Instruction | University of Texas Health Science Center at San Antonio | |
| 1/2010 - Present | Individual Instruction | University of Texas Health Science Center at San Antonio | |
| 1/2010 - Present | Individual Instruction | University of Texas Health Science Center at San Antonio | |
| 1/2009 - Present | Individual Instruction | University of Texas Health Science Center at San Antonio | |
| 1/2008 - Present | Post-Doctoral Student Supervision | University of Texas Health Science Center at San Antonio | |
| 1/2008 - Present | Pre-Doctoral Student Supervision | University of Texas Health Science Center at San Antonio | |
Journal Article |
| Diogenes A, Ferraz CC, Akopian AN, Henry MA, Hargreaves KM. LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons J Dent Res 2011 Mar;90(6):759-764. |
| Henry MA, Trevino E.N, Patwardhan A.N, Perry G.M, Dybal-Hargreaves N, Hargreaves KM, Diogenes AR. Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet rich plasma scaffold in human root tips Journal of Endodontics 2011 Jan;37(8):1109-1115. |
| Lovelace T.W, Henry MA, Hargreaves K, Diogenes AR. Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedures Journal of Endodontics 2011 Jan;37(2):133-138. |
| Ferraz C.C, Henry MA, Hargreaves K, Diogenes AR. Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors Journal of Endodontics 2011 Jan;37(1):45-48. |
| Lovelace T.W., Diogenes AR, Henry MA, Hargreaves KM. Evaluation of clinically deliverred SCAP cells in regenerative endodontic procedures J Endo 2010 Mar;36:554-554. |
| Jeske NA, Patwardhan AM, Ruparel NB, Akopian AN, Shapiro MS, Henry MA. A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1 Pain 2009 Dec;146(3):301-307. |
| Fehrenbacher JC, Sun XX, Locke EE, Henry MA, Hargreaves KM. Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue Pain 2009 Aug;144(3):253-261. |
| Jeske NA, Patwardhan AM, Henry MA, Milam SB. Fibronectin stimulates TRPV1 translocation in primary sensory neurons J Neurochem 2009 Feb;108(3):591-600. |
| Fehrenbacher JC, Sun XX, Locke EE, Henry MA, Hargreaves K. Capsaicin-evoked iCGRP release from human dental pulp: A model system for the study of periperhal neuropeptide secretion in normal health tissue Pain 2009 Jan;144:253-261. |
| Jeske NA, Diogenes AR, Ruparel N.B., Fehrenbacher JC, Henry MA, Akopian AN, Hargreaves K. A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 Pain 2008 Sep;138(3):604-616. |
| Khan AA, Diogenes A, Jeske NA, Henry MA, Akopian A, Hargreaves KM. Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin Neuroscience 2008 Aug;155(2):503-509. |
| Hargreaves KM, Giesler T, Wang Y, Henry MA. Regeneration potential of the young permanent tooth: What does the future hold? J Endod 2008 Jan;34:S51-S56. |
Abstract |
| Por ED., Belugin S., Chaudry S., Berg KA., Akopian AN., Henry MA., Gomez R., Jeske NA. AKAP150 Mediates TRPV1 sensitivity to phosphatidylinositol-4, 5-bisphosphate; 2011 Jan. (UTHSCSA Center for Biomedical Neuroscience Annual Meeting). |
| Bose R.S, Diogenes AR, Henry MA, Khaing Z, Schmidt C, Hargreaves KM. Comparison of two different scaffolds used in the regeneration of the pulp-dentin complex; 2011 Jan. (Journal of Endodontics; vol. 37, no. 3). |
| Loyd D, Sun X, Henry MA, Hargreaves KM. Serotonin enhances CGRP release from female human trigeminal nociceptors; 2011 Jan. (Journal of Pain; vol. 12, no. 4). |
| Quang P.N, Martin D.E, Ishikawa B, Althumairy R, Henry MA, Teixeira FB, Hargreaves KM, Diogenes AR. Understanding regenerative endodontic treatments: scaffolds; 2011 Jan. (TC23, American Association of Endodontists 2011 Annual Meeting). |
| McNamara RP Henry MA Schindler WG Hargreaves KM. Biocompatability of Accelerated Mineral Trioxide Aggregate in a Rat Model; 2010 Mar. (J Endod; vol. 36, no. 3). |
| Shiloah Y, Diogenes AR, Henry MA, Hargreaves KM. Anatomical characterization of stem cell markers within human dental pulp; 2010 Mar. (J Endo, Abstract #OR20; vol. 36). |
| Ruparel S.B., Helesic G, Patil M, Henry MA, Hargreaves KM, Green D. Expression of cytochrome P450 isoforms in rat nociceptive neurons; 2010 Jan. (2010 IASP 13th World Congress on Pain, Montreal, Canada, Abstract #313). |
| Henry MA, Loyd, D.R, Helesic G, Hargreaves KM. Serotonin enhances capsaicin- sensitive trigeminal nociceptor function via serotonin receptor colocalization with TRPV1 in rat trigeminal sensory neurons; 2010 Jan. (2010 ISAP 13th World Congress on Pain, Montreal Canada, Abstract #313). |
| Subhani M, Perry G, Luo S, Levinson S.R., Hargreaves KM, Henry MA. Neurovascular relationships in normal and painful human dental pulp; 2010 Jan. (J Dent, Special Issue A, Abstract #994; vol. 89). |
| Henry MA, Adicks J, Gonzales C. Over-expression of transient receptor potential channels in oral cancer; 2010 Jan. (J Dent, Special Issue A, Abstract #1308). |
| Patil M.J, Belugin S, Henry MA, Hargreaves KM, Akopian AN. Regulation of prolactin system in sensory neurons by estrogen and testosterone; 2010 Jan. (Poster #78.17, Society for Neuroscience 2010). |
| Por, ED., Gomez, R., Henry, MA., Shapiro, MS., Jeske NA. Inflammation induces feed-forward sensitization of TRPV1 through AKAP150; 2010 Jan. (Society for Neuroscience Annual Meeting, San Diego, CA). |
| Popp M.T, Gomez R, Henry MA, Jeske NA. Collagen mediated hyperalgesia; 2010 Jan. (J Dent, Special Issue A, Abstract #1437; vol. 89). |
| Moridinia M, Gomez R, Ruparel NB, Henry MA, Jeske NA. Biochemical characterization of the ECM protein fibronectin following peripheral inflammation; 2009 Jan. (J Dent Res, Special Issue A, Abstract #2688; vol. 88). |
| Henry MA, Luo S, Perry GM, Levinson SR. VEGF and Flk-1 expressions increase following infraorbital nerve injury; 2009 Jan. (J Dent Res, Special Issue A, Anstract #2747; vol. 88). |
| Fehrenbacher JC, Locke EE, Sun XX, Henry MA, Hargreaves KM. Effects of estrogens on human nociceptor sensitivity: Society for Neuroscience; 2009 Jan. (2009 abstract viewer and itinerary planner (online), Washington D.C). |
| Henry MA. Effects of estrogen on human nociceptor sensitivity; 2009 Jan. (Society of Nueroscience, Poster #268.23). |
| Fehrenbacher JC. Effects of estrogens on human nociceptor sensitivity: Society for Neroscience; 2009 Jan. (National Institute for Drug Abuse Frontiers in Addiction Research Mini-Convention). |
| Perry GM, Luo S, Levinson SR, Henry MA. Sodium channel Nav1.6 expression in painful and non-painful human teeth; 2009 Jan. (J Dent Res, Special Issue A, Abstract #1430; vol. 88). |
| Henry MA, Luo S, Foley BD, Rzasa RS, Johnson LR, Levinson SR. Sodium channel expression and localization at demyelinated sites in painful human dental pulp; 2009 Jan. (Journal of Pain; vol. 10, no. 7). |
| Millar GC, Luo S, Perry GM, Hargreaves KM, Henry MA. Immunohistochemical characterization of TRPV1 staining in human dental pulp; 2009 Jan. (J Dent Res, Special Issue A, Abstract #1429; vol. 88). |
| Luo S, Perry GM, Levinson SR, Henry MA. Schwann cell proliferation precedes macrophage infiltration following infraorbital nerve injury; 2009 Jan. (J Dent Res, Special Issue A, Abstratct #2746; vol. 88). |
| Trevino EG, Henry MA, Patwardhan AM, Perry, GM, Sun, X, Helesic, G, Locke, E, Hargreaves KM. The effect of different irrigants on SCAP in human roots; 2009 Jan. (J Dent Res, Special Issue A, Abstract #1603; vol. 88). |
| Trevino EG, Henry MA, Patwardhan AM, Perry GM, Sun X, Helesic G, Locke E, Hargreaves KM. The effect of different irrigation solutions on the survival of stem cells of the apical papilla (SCAP) in a PRP scaffold in human root tips; 2009 Jan. (J Endod, Abstract #OR; vol. 35, no. 428). |
| Diogenes AR, Akopian AN, Henry MA, Perry GM, Hargreaves KM. A mechanism for abscess-related pain: How bacteria directly sensitizes trigeminal nociceptors; 2009 Jan. (J Endod, Abstract #OR24; vol. 35, no. 432). |
| Jeske NA, Patwardhan AM, Akopian AN, Scotland PE, Henry MA. A-Kinase anchoring protein 150 mediates protein kinase C-directed phosphorylation and sensitization of TRPV1; 2008 Jan. (IASP 12th World Congress on Pain, Dublin, Scotland, Abstract #PW295). |
| Geisler TM, Wang Y, Perry GM, Henry MA, Sun X, Locke E, Hargreaves KM. Regenerative endodontics: growth factors control the phenotype of human dental pulp stem/progenitor cells; 2008 Jan. (J Endod; vol. 34, no. 341). |
| Scotland PE, Diogenes AR, Jeske NA, Patwardhan AM, Henry MA, Hargreaves KM, Akopian AN. Prolactin sensitizes TRPV1 and produces hyperalgesia in male rats; 2008 Jan. (Soc Neurosci Abstr, poster #265; vol. 265, no. 17). |
| Jeske NA, Patwardhan AM, Akopian AN, Henry MA. A-kinase anchoring protein mediates protein kinase C-directed phosphorylation and sensitization of TRPV1; 2008 Jan. (Soc Neurosci Abstr, Poster #628.4). |
| Scotland PE, Helesic G, Perry G, Henry MA, Hargreaves KM, Akopian AN. Colocalization of prolactin and TRPV1 in inflamed rat hindpaw skin; 2008 Jan. (IASP 12th World Congress on Pain, Dublin, Scotland, Anstract #PT163). |
| Maggio A, Vela J, Perry GM, Henry MA, Hargreaves KM. B1 adrenergic receptor expression on human dental pulp neurons; 2008 Jan. (J. Dent. Res., Special Issue A, Abstract #0493). |
| Luff KC, Khan A, Perry GM, Henry MA, Hargreaves KM. Tumor necrosis factor receptor I expression in inflamed human pulps; 2008 Jan. (J Dent Res, Special Issue A, Abstract #0484). |
| Luo S, Perry GM, Helesic G, Levinson SR, Henry MA. Increased expression of sodium channel Nav1.7 in painful human teeth; 2008 Jan. (J Dent Res, Special Issue A, Abstract # 0497). |
| Wood AA, Perry GM, Henry MA. Nerve density in normal and carious/non-painful human dental pulp; 2008 Jan. (J Dent Res, Special Issue A, Abstract #0490). |
| Bruggeman JJ, Perry GM, Levinson SR, Henry MA. Nav1.6 sodium channel expression in rat model for trigeminal neuralgia; 2008 Jan. (J Dent Res, Special Issue A, Anstract #0491). |
| Perry GM, Johnson LR, Levinson SR, Henry MA. Glial and immune cell responses following rat infraorbital nerve lesion; 2008 Jan. (J Dent Res, Special Issue A, Abstract #1228; vol. 87). |
Federal |
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| Funding Agency | NIH-NINDS |
| Title | Role of Oxidized Linoleic Acid Metabolites in Pain |
| Status | Active |
| Period | 9/2010 - 8/2015 |
| Role | Co-Investigator |
| Grant Detail | This R01 utilizes molecular, electrophysiologic anatomical, biochemical and behavior methods to evaluae the role of endogenous TRPV1 agonists (OLAMS) in inflammatory pain. |
| Funding Agency | NIH- NIDCR |
| Title | Prolactin Regulation of Trigeminal Nociceptors |
| Status | Active |
| Period | 8/2007 - 5/2013 |
| Role | Co-Investigator |
| Grant Detail | This series of studies utilizes molecular neuroscience, anatomical and behavior methods to test the hypothesis that prolactin (sex related hormone) regulates the activity of nociceptive sensory neurons of male and female rat trigeminal ganglia. |
| Funding Agency | NINDS |
| Title | Estrogen Modulation of Human Nociceptors- R01 |
| Status | Active |
| Period | 2/2008 - 1/2013 |
| Role | Co-Investigator |
| Grant Detail | |
| Funding Agency | NIDCR |
| Title | Regeneration of Pulp-Dentin Development in Immature Teeth with Necrosis |
| Status | Active |
| Period | 7/2010 - 6/2011 |
| Role | Co-Investigator |
| Grant Detail | |