UTHSCSA - Faculty Profiles

Search All | Profile | Publications | Grants | Faculty Index

Tomlinson, Gail E.

School of Medicine
Pediatrics
(210) 562-9116
tomlinsong@uthscsa.edu

I am an academic pediatric oncologist and translational investigator. I currently direct the Division of Pediatric Hematology-Oncology. Within our Division we have initiated an ACGME-approved Fellowship Program in Pediatric Hematology-Oncology which received a commendation from the ACGME and continued accreditation for 10 years. I am also currently serving as Interim Director of the Greehey Childrens Cancer Research Institute, where we have recently established enhanced infrastructure for cancer genetics and genomic analyses for childhood cancer.

My own research interests pertain to the genetic predisposition to cancer including the genetics and biology pediatric liver tumors as well as other rare tumors and syndromes. I am the Lead P.I. for our CPRIT Multi-Investigator grant, "Genetics and Biology of Liver Tumorigenesis in Children" with collaborating investigators at Baylor College of Medicine and UT Southwestern. Our group has also begun a study of predisposition factors for leukemia which may be unique in Hispanic children of South Texas.

I also have a long-standing interest in familial cancer, particularly familial breast cancer, and the application of cancer predisposition to cancer risk assessment, early detection, and prevention in children and adults. Our recently funded CPRIT Prevention Project will establish infrastructure for comprehensive cancer genetic risk assessment at sites throughout San Antonio as well as at our regional campuses in Harlingen and Laredo.

Appointments Education Expertise Publications Grants

9/2012 - Present	Section Chief, Hematology/Oncology	Childrens Hospital of San Antonio
5/2008 - Present	Interim Director	Greehey Childrens Cancer Research Institute, Pediatrics, San Antonio, TX
1/2007 - Present	Professor with Tenure and Division Chief, Hematology/Oncology	University of Texas Health Science Center at San Antonio, Pediatrics, San Antonio, TX

Hepatoblastoma

- Much of my current research involves the study of genetic and developmental origins of the childhood liver tumor, hepatoblastoma. This tumor type typically occurs between birth and four years of age and histologically resembles elements characteristic of the fetal and embryonal liver. Several years ago, we described a new chromosomal translocation, t(1;4) which we later determined to be part of a family of translocations seen in approximately 20% of cases of hepatoblastoma. We have mapped the regions of the translocation breakpoint using oligonucleotide array comparative genomic hybridization. The breakpoint on chromosome 1 is in the vicinity of the NOTCH2 gene. We had been simultaneously studying genes involved in normal growth and development of the childhood liver and thus NOTCH2 became an excellent candidate gene due to both the known role of NOTCH2 development, as well as its genomic location. We recently demonstrated that our translocation involves a complex pericentric rearrangement in which NOTCH2 is transposed from the 1p pericentric region to the 1q pericentric region. I have an R21 grant which examines genome-wide copy number changes as well as the translocation involving the NOTCH2 gene in hepatoblastoma with possible clinical correlations. I am also leading a multi-institutional research (MIRA) initiative funded by the Cancer Prevention and Research Institute of Texas (CPRIT) to thoroughly explore the genomics of childhood liver tumors.

Hereditary breast cancer

- I have a long-standing research focus on hereditary breast cancer. At UTSW, I initiated a Familial Breast Cancer Registry of over 2000 breast cancer-prone families. This Registry formed the basis of participation in multiple multi-center studies in the genetic epidemiology of breast cancer, currently with an emphasis on genetic modifiers in breast cancer development in BRCA1/2 carriers and also on outcomes after BRCA1/2 testing. I have recently extended my interest in hereditary cancer by establishing a program for providing genetic risk assessment, counseling and testing at sites in South Texas, including San Antonio and the Rio Grande Valley. I am now also focusing my research interest in breast cancer towards the genetics of late effects after breast cancer treatment. I hope to develop this focus into a multi-institutional late effects registry for breast cancer survivors. As our risk assessment efforts currently are targeted towards the underserved Hispanic population in South Texas, I am initiating a study of risks associated with a specific genetic alteration in Hispanic women.

Other Rare Pediatric Tumors

- Although I have focused primarily on hepatic tumorigenesis, we have extended our studies of biologic factors contributing to the unique age of onset of other pediatric tumors. These tumors of interest have included rhabdoid tumor of the kidney, a highly malignant tumor of infancy. I am also currently investigating the genomics of highly lethal tumors including mesothelioma. These occur more typically occur in adults, but occasionally occur in children. The primary goal of these studies is to identify primary driver events.

Population-specific aspects of childhood cancer.

- We recently conducted a study of variations in the cytochrome P450 genes in children with acute lymphoblastic leukemia with emphasis on comparing genetic risk factors in Caucasian, Hispanic, and African-American children with acute leukemia. We found that Hispanic children with leukemia had a unique genetic profile of enzymes involved in xenobiotic metabolism. I am currently working to expand this observation to study a larger population of Hispanic children in Texas as a multi-institutional project. I am working with the Department of Biostatistics and Epidemiology to establish a multi-institutional registry of childhood cancer patients for the purpose of performing studies in genetic epidemiology of childhood cancer.

von Hippel-Lindau disease

- I recently completed an NIH-funded study involving von Hippel-Lindau disease. We compared serum levels of VEGF and VEGFR in mutation and non-mutation carriers. In the course of this study, my group established a von Hippel-Lindau Registry for which we collected and banked serum and DNA which will become the basis for continuing with a larger von Hippel-Lindau study.

Journal Article

Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson GE. Childrens Oncology Group 2013 blueprint for research: Rare tumors Pediatric Blood and Cancer 2013 Jun;60(6):1061-1021.

Sanchez-Diaz PC, Hsiao TH, Chang JC, Yue D, Tan MC, Chen HI, Tomlinson GE, Huang Y, Chen Y, Hung JY. De-Regulated MicroRNAs in Pediatric Cancer Stem Cells Target Pathways Involved in Cell Proliferation, Cell Cycle and Development PLoS One 2013 Apr;8(4):61622-61622.

Hsiao TH Chen HI Lu JY Lin PY Keller C Comerford S Tomlinson GE Chen Y. Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma Translational Cancer Research 2013 Feb;2(1):6-17.

Sugalski AJ, Davis M, Prasannan L, Saldivar VA, Hung JY, Tomlinson GE. Mesothelioma in a Seven-Year Old Child: Clinical, Histologic and Genetic Features Pediatric Blood and Cancer 2013 Jan;60(1):146-148.

Musselman JR Georgieff MK Ross JA Tomlinson GE Feusner J Krailo M Spector LG. Maternal pregnancy events and exposures and risk of hepatoblastoma: A Childrens Oncology Group (COG) study Cancer Epidemiol 2013 Jan;epub:1-3.

Iman JS Plyer JR Bansal H Prajapati S Bansal S Rebeles J Chen HI Chang YF Panneerdoss S Zoghi B Buddavarapu KC Broaddus R Hornsby P Tomlinson G Dome J Vadlamudi RK Pertsemlidis A Chen Y Rao MK. Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization PLos One 2012 Dec;7(12).

Bansal H, Seifert T, Bachier C, Rao M, Tomlinson G, Iyer SP, Bansal S, Tomlinson GE. The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic agent TRAIL by regulating the antiapoptotic protein Bcl-xL J Biol Chem 2012 Sep;287(39):32875-32880.

Ding YC, McGuffog L, Healey S, Friedman E, Laitman Y, Shimon-Paluch S, Kaufman B, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark Askmalm M, Melin B, Domchek SM, Nathanson KL, Rebbeck TR, Jakubowska A, Lubinski J, Jaworska K, Durda K, Gronwald J, Huzarski T, Cybulski C, Byrski T, Osorio A, Ramony Cajal T, Stavropoulou AV, Bentez J, Hamann U, Rookus MA, Aalfs CM, de Lange J, Meijers-Heijboer HE, Oosterwijk JC, van Asperen CJ, Gomez-Garcia EB, Hoogerbrugge N, Jager A, van der Luijt RB, Easton DF, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Izatt L, Eeles RA, Tomlinson GE, and 111 additional authors. A non-synonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers Cancer Epidemiol Biomarkers Prev 2012 Aug;21(8):1362-1370.

Puumala SE, Ross JA, Feusner JH, Tomlinson GE, Malogolowkin MH, Krailo MD, Spector LG. Parental infertility, infertility treatment and hepatoblastoma: a report from the Childrens Oncology Group Hum Reprod 2012 Jun;27(6):1649-1656.

Finkelman BS, Rubinstein WS, Friedman S, Friebel TM, Dubitsky S, Schonberger NS, Shoretz R, Singer CF, Blum JL, Tung N, Olopade OI, Weitzel JN, Lynch HT, Snyder C, Garber JE, Schildkraut J, Daly MB, Isaacs C, Pichert G, Neuhausen SL, Couch FJ, Vant Veer L, Eeles R, Bancroft E, Evans DG, Ganz PA, Tomlinson GE, Narod SA, Matloff E, Domchek S, Rebbeck TR. Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers J Clin Oncol 2012 Apr;30(12):1321-1328.

Lin S, Yang J, Elkahloun AG, Bandyopadhyay AM, Wang L, Cornell JE, Yeh I, Agyin JK, Tomlinson GE, Sun L. Attenuation of TGF-beta signaling suppresses premature senescence in a p21 -dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells Molecular Biology of the Cell 2012 Jan;23:1569-1581.

Mulligan AM, Couch FJ, Barrowdale D, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Robson M, Sherman M, Spurdle AB, Wappenschmidt B, Lee A, McGuffog L, Healey S, Sinilnikova OM, Janavicius R, Hansen TV, Nielsen FC, Ejlertsen B, Osorio A, Munoz-Repeto I, Duran M, Godino J, Pertesi M, Benitez J, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Cattaneo E, Bonanni B, Viel A, Pasini B, Papi L, Ottini L, Savarese A, Bernard L, Radice P, Hamann U, Verheus M, Meijers-Heijboer HE, Wijnen J, Gomez Garcia EB, Nelen MR, Kets CM, Seynaeve C, Tilanus-Linthorst MM, van der Luijt RB, van Os T, Rookus M, Frost D, Jones JL, Evans DG, Lalloo F, Eeles R, Izatt L, Adlard J, Davidson R, Cook J, Donaldson A, Dorkins H, Gregory H, Eason J, Houghton C, Barwell J, Side LE, McCann E, Murray A, Peock S, Godwin A, Schmutzler RK, Rhiem K, Engel C, Meindl A, Ruehl I, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Kast K, Preisler-Adams S, Varon-Mateeva R, Schoenbuchner I, Fiebig B, Heinritz W, Schafer D, Gevensleben H, Caux-Moncoutier V, Fassy-Colcombet M, Cornelis F, Mazoyer S, Leone M, Boutry-Kryza N, Hardouin A, Berthet P, Muller D, Fricker JP, Mortemousque I, Pujol P, Coupier I, Lebrun M, Kientz C, Longy M, Sevenet N, Stoppa-Lyonnet D, Isaacs C, Caldes T, de Al Hoya M, Heikkinen T, Aittomaki K, Blanco I, Lazaro C, Barkardottir RB, Soucy P, Dumont M, Simard J, Montagna M, Tognazzo S, D''Andrea E, Fox S, Yan M, Rebbeck TR, Olopade OI, Weitzel JN, Lynch HT, Ganz PA, Tomlinson GE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet M, Bhatia J, Kauff N, Singer CF, Tea MK, Gschwantler-Kaulich D, Fink-Retter A, Mai PL, Greene MH, Imyanitov E, O''Malley FP, Ozcelik H, Glendon G, Toland AE, Gerdes AM, Thomassen M, Kruse TA, Birk Jensen U, Skytte AB, Caligo MA, Soller M, Henriksson K, von Wachenfeldt A, Arver B, Stenmark-Askmalm M, Karlsson P, Ding YC, Neuhausen SL, Beattie M, Pharoah PD, Moysich KB, Nathanson KL, Karlan BY, Gross J, John EM, Daly MB, Buys SM, Southey MC, Hopper JL, Terry MB, Chung W, Miron AF, Goldgar D, Chenevix-Trench G, Easton DF, Andrulis IL, Antoniou AC, Family Registry BC, Collaborators GS, Network OC. Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 Breast Cancer Res 2011 Nov;13(6):110-110.

Neklason DW, Done MW, Sargent NR, Schwartz AG, Anton-Culver H, Griffin CA, Ahnen DJ, Schildkraut JM, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Burt RW. Activating mutation in MET oncogene in familial colorectal cancer BMC Cancer 2011 Oct;11(1):424-424.

Rebbeck TR, Mitra N, Domchek SM, Wan F, Klingner T, Tran TV, Singer CF, Tea MK, Blum JL, Tung N, Olopade OI, Weitzel JN, Lynch HT, Snyder C, Garber JE, Antoniou AC, Peock S, Evans DG, Paterson J, Kennedy JM, Donaldson A, Dorkins H, Easton DF, Rubinstein WS, Daly MB, Isaacs C, Nevanlinna H, Couch FJ, Andrulis IL, Friedman E, Laitman Y, Ganz PA, Tomlinson GE, Neuhausen SL, Narod SA, Phelan CM, Greenberg R, Nathanson KL. Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1 Interacting Genes Cancer Res 2011 Sep;71:5792-5802.

Beuten J, Gelfond JAL, Piwkham D, Pollock BH, Winick NJ, Collier A, Tomlinson GE. Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1) Carcinogenesis 2011 Sep;32(9):5792-5805.

Litten J, Chen T, Schultz R, Herman K, Comstock J, Schiffman J, Tomlinson GE, Rakheja D. Activated NOTCH2 is overexpressed in hepatoblastomas: an immunohistochemical study Pediatr Dev Pathol 2011 Sep;14(5):378-383.

Neuhausen SL, Brummel S, Ding YC, Steele L, Nathanson KL, Domchek SM, Rebbeck TR, Singer CF, Pfeiler G, Lynch HT, Garber JE, Couch FJ, Weitzel JN, Godwin AK, Narod SA, Ganz PA, Daly MB, Isaacs C, Olopade OI, Tomlinson GE, Rubinstein WS, Tung N, Blum JL, Gillen DL. Genetic Variation in IGF2 and HTRA1 and Breast Cancer Risk Among BRCA1 and BRCA2 Carriers Cancer Epidemiol Biomarkers Prev 2011 Aug;20(8):1690-1702.

Swinney RM, Beuten J, Collier A, Chen T, Winick N, Pollock BH, Tomlinson GE. Polymorphisms in CYP1A1 and Ethnic-Specific Susceptibility to Acute Lymphoblastic Leukemia in Children Cancer Epidemiol Biomarkers Prev 2011 Jul;20(7):1537-1542.

Ziogas A, Horick NK, Kinney AY, Lowery JT, Domchek SM, Isaacs C, Griffin CA, Moorman PG, Edwards KL, Hill DA, Berg JS, Tomlinson GE, Anton-Culver H, Strong LC, Kasten CH, Finkelstein DM, Plon SE. Clinically relevant changes in family history of cancer over time JAMA 2011 Jul;306(2):172-178.

Piwkham D, Gelfond JA, Rerkamnuaychoke B, Pakakasama S, Rebel VI, Pollock BH, Winick N, Collier A, Tomlinson G, Beuten J. Multi-Locus Association of Genetic Variants in MLL, CREBBP, EP300 and TOP2A with Childhood Acute Lymphoblastic Leukemia in Hispanics from Texas Cancer Epidemiol Biomarkers Prev 2011 Jun;20(6):1204-1212.

Spurdle AB, Marquart L, McGuffog L, Healey S, Sinilnikova O, Wan F, Chen X, Beesley J, Singer CF, Dressler AC, Gschwantler-Kaulich D, Blum JL, Tung N, Weitzel J, Lynch H, Garber J, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Conroy D, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Selkirk CG, Daly M, Isaacs C, Stoppa-Lyonnet D, Sinilnikova OM, Buecher B, Belotti M, Mazoyer S, Barjhoux L, Verny-Pierre C, Lasset C, Dreyfus H, Pujol P, Collonge-Rame MA, Rookus MA, Verhoef S, Kriege M, Hoogerbrugge N, Ausems MG, van Os TA, Wijnen J, Devilee P, Meijers-Heijboer HE, Blok MJ, Heikkinen T, Nevanlinna H, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Durocher F, Couch FJ, Lindor NM, Wang X, Thomassen M, Domchek S, Nathanson K, Caligo M, Jernstrm H, Liljegren A, Ehrencrona H, Karlsson P, Ganz PA, Olopade OI, Tomlinson G, Neuhausen S, Antoniou AC, Chenevix-Trench G, Rebbeck TR, Tomlinson GE. Common Genetic Variation at BARD1 Is Not Associated with Breast Cancer Risk in BRCA1 or BRCA2 Mutation Carriers Cancer Epidemiol Biomarkers Prev 2011 May;20(5):1032-1038.

Plon SE, Wheeler DA, Strong LC, Tomlinson GE, Pirics M, Meng Q, Cheung HC, Begin PR, Muzny DM, Lewis L, Biegel JA, Gibbs RA. Identification of genetic susceptibility to childhood cancer through analysis of genes in parallel Cancer Genet 2011 Jan;204(1):19-25.

Minnix JA, Robinson JD, Lam CY, Carter BL, Foreman JE, Vandenbergh DJ, Tomlinson GE, Wetter DW, Cinciripini PM. The serotonin transporter gene and startle response during nicotine deprivation Biol Psychol 2011 Jan;86(1):1-8.

Antoniou AC, Beesley J, McGuffog L, Sinilnikova OM, Healey S, Neuhausen SL, Ding YC, Rebbeck TR, Weitzel JN, Lynch HT, Isaacs C, Ganz PA, Tomlinson GE, et al. Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction Cancer Res 2010 Dec;70(23):9742-54.

Domchek SM, Friebel TM, Garber JE, Isaacs C, Matloff E, Eeles R, Evans DG, Rubinstein W, Singer CF, Rubin S, Lynch HT, Daly MD, Weitzel J, Ganz PA, Pichert G, Olopade OI, Tomlinson GE, Tung N, Blum JL, Couch F, Rebbeck TR. Occult Ovarian Cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers Breast Cancer Res Treat 2010 Nov;124(1):195-203.

Bansal H, Bansal S, Rao M, Foley KP, Sang J, Proia DA, Blackman RK, Ying W, Barsoum J, Baer MR, Kelly K, Swords R, Tomlinson GE, Battiwalla M, Giles FJ, Lee KP, Padmanabhan S. Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias Blood 2010 Nov;116(22):4591-4599.

Domchek SM, Friebel TM, Singer CF, Evans DG, Lynch HT, Isaacs D, Garber JE, Neuhausen SL, Mattloff E, Eles R, Pichert G, Van Tveer L, Tung N, Weitzel JN, Couch FJ, Rubinstein WS, Ganz PA, Daly MB, Olopade OI, Tomlinson GE, Schildkraut J, Blum JL, Rebbeck TR. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality JAMA 2010 Sep;304(9):967-975.

Chen TT, Rakheja D, Hung JY, Hornsby PJ, Tabaczewski P, Malogolowkin M, Feusner J, Miskevich F, Schultz R, Tomlinson GE. Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor Pediatr Blood Cancer 2009 Dec;53(6):1040-1047.

Neuhausen S, Brummel S, Ding Y, Singer C, Pfeiler G, Lynch H, Nathanson K, Rebbeck T, Garber J, Couch F, Weitzel J, Narod S, Ganz P, Daly M, Godwin A, Isaacs C, Olopade O, Tomlinson G, Rubinstein W, Tung N, Blum J, Gillen D, Tomlinson GE. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers Breast Cancer Res 2009 Oct;11(5).

Rebbeck TR, Mitra N, Domchek SM, Wan F, Chuai S, Friebel TM, Panossian S, Spurdle A, Chenevix-Trench G; kConFab, Singer CF, Pfeiler G, Neuhausen SL, Lynch HT, Garber JE, Weitzel JN, Isaacs C, Couch F, Narod SA, Rubinstein WS, Tomlinson GE, Ganz PA, Olopade OI, Tung N, Blum JL, Greenberg R, Nathanson KL, Daly MB. Modification of ovarian cancer risk by BRCA1/2 interacting genes in a multicenter cohort of BRCA1/2 mutation carriers Cancer Research 2009 Jul;15:69(14):5801-5810.

Trobaugh-Lotrario AD, Tomlinson GE, Finegold MJ, Gore L, Feusner JH,. Small cell undifferentiated variant of hepatoblastoma: Adverse molecular and clinical features similar to rhabdoid tumors Pediatric Blood and Cancer 2009 Mar;52(3):328-334.

Neklason DW, Kerber RA, Nilson DB, Anton-Culver H, Schwartz AG, Griffin CA, Lowery JT, Schildkraut JM, Evans JP, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Finkelstein DM, Nadkarni PM, Kasten CH, Mineau GP, Burt RW. Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis Cancer Res 2008 Nov;68(21):8993-8997.

Litten JB, Tomlinson GE. Liver tumors in children Oncologist 2008 Jul;13(7):812-820.

Rakheja D, Cunningham J, Mitui M, Tomlinson GE, Weinberg AG. A subset of cranial fasciitis is associated with dysregulation of the Wnt/b-catenin pathway Modern Pathology 2008 Jun;21:1330-1336.

Patterson AR, Davis H, Shelby K, McCoy J, Robinson LD, Rao SK, Banerji P, Tomlinson GE. Successful strategies for increasing African American participation in cancer genetic studies: hopeful signs for equalizing the benefits of genetic medicine Community Genet 2008 Apr;11(4):208-214.

Antoniou, AC, Spurdle A, Sinilnikova OM, Healey S, Pooley KA, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Hofmann W, Sutter C, Niederacher D, Deissler H, Caldes T, Kampjarvi K, Nevanlinna H, Simard J, Beesley J, Chen X, the Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Neuhausen SL, Rebbeck TR, Wagner T, Lynch HT, Isaacs C, Weitzel J, Ganz PA, Daly MB, Tomlinson GE, Olopade OI, Blum JL, Couch FJ, Peterlongo P, Manoukian S, Barile M, Radice P, Szabo CI, Pereira LH, Greene MH, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrults IL, Ozcelik H, OCGN, Eeles R, Gerdes AM, Caligo MA, Laitmran Y, Kaufman B, Milgram R, Friedman E, The Swedish BRCA1 and BRCA2 Study Collaborators, Domchek SM. Common Breast Cancer-Predisposition Alleles are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers Am J Hum Genet 2008 Mar;82:937-948.

Gao B, Xie XJ, Huang C, Shames DS, Chen TT, Lewis CM, Bian A, Zhang B, Olopade OI, Garber JE, Euhus DM, Tomlinson GE, Minna JD. RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers Cancer Res 2008 Jan;68(1):22-25.

Malogolowkin M, Cotton CA, Green D, Breslow N, Perlman E, Miser J, Ritchey M, Thomas P, Grundy P, DAngio G, Beckwith JB, Shamberger R, Haase G, Donaldson M, Weetman R, Coppes M, Shearer P, Coccia P, Kletzel M, Macklis R, Tomlinson GE, Huff V, Newbury R, Weeks D. Treatment of Wilms tumor relapsing after initial treatment with vincristine, actinomycin D and doxorubicin: A report from the National Wilms Tumor Study Group Pediatric Blood and Cancer 2008 Jan;50:236-241.

Friebel TM, Domchek SM, Neuhausen SL, Wagner T, Evans DG, Isaacs C, Garber JE, Daly MB, Eeles R, Matloff E, Tomlinson G, Lynch HT, Tung N, Blum JL, Weitzel J, Rubinstein WS, Ganz PA, Couch F, Rebbeck TR, Tomlinson GE. Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers Clin Breast Cancer 2007 Dec;7(11):875-882.

Antoniou AC, Sinilnikova OM, Simard J, Leone M, Dumont M, Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M, Lasset C, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson GE, Olopade LI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Gorski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Murray A, Rogers M, Daly PA, Dorkins H, EMBRACE, Schmutzler RK, Bersmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, Spurdle AB, Chen X, Waddell N, Cloonan N, kConFab, Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Vreeswijk MPG, Greene MH, Prindiville SA, Osorio A, Benitez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlina H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF, Chenevix-Trench G. RAD51 135G>C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies Am J. Hum. Genet 2007 Dec;81(6):1186-1200.

Parmigiani G, Friebel T, Iverson ES, Chen S, Finkelstein D, Anton-Culver H, Ziogas A, Weber BL, Eisen A, Malone KE, Daling JR, Hsu L, Ostrander E, Peterson LE, Schildkraut JM, Isaacs C, Peshkin BN, Corio C, Leondaridis L, Tomlinson GE, Amos CI, Strong LC, Berry DA, Weitzel JN, Sand S, Dutson D, Kerber R, Euhus DE. Validity of models for prediction of BRCA1 and BRCA2 mutations Annals of Internal Medicine 2007 Oct;147:441-450.

Robinson JD, Lam CY, Minnix JA, Wetter DW, Tomlinson GE, Minna JD, Chen TT, Cinciripini PM. The DRD2 TaqI-B polymorphism and its relationship to smoking abstinence and withdrawal symptoms Pharmacogenomics J 2007 Aug;7(4):266-274.

Weitzel JN, Lagos VI, Herzog JS, Judkins T, Henderickson B, Ho JS, Ricker CN, Lowstuter KJ, Blazer K, Tomlinson GE, Scholl T. Evidence for Common Ancestral Origin of a Recurring BRCA1 Genomic Rearrangement Identified in High-Risk Hispanic Families Cancer Epidemiology, Biomarkers and Prevention 2007 Aug;16(8):1615-1620.

Couch FJ, Sinilnioka O, Vierkant RA, Pankratz VS, Fredericksen ZS, Stoppa-Lyonnet D, Coupier I, Hughes D, Hardouin A, Berthet P, Peock S, Cook M, Baynes C, Hodgson S, Morrison PJ, Porteous ME, Jakubowska A, Lubinski J, Gronwald J, Spurdle AB, kConFab, Schmutler R, Versmold B, Engel C, Meindl A, Sutter C, Horst J, Schaefer D, Offit K, Kirchhoff T, Andrulis IL, Ilyushik E, Glendon G, Devilee P, Vreeswijk MP, Vasen HF, Borg A, Backenhorn K, Struewing JP, Greene MH, Neuhausen SL, Rebbeck TR, Nathanson K, Domchek S, Wagner T, Garber JE, Szabo C, Zikan M, Foretova L, Olson JE, Sellers TA, Lindor N, Nevanlinna H, Tommiska J, Aittomki K, Hamann U, Rashid MU, Torres D, Simard J, Durocher F, Guenard F, Lynch HT, Isaacs C, Wietzel J, Olopade OI, Narod S, Daly MB, Godwin AK, Tomlinson G, Easton DF, Chenevix-Trench G, Antoniou AC. AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Cancer Epidemiology, Biomarkers and Prevention 2007 Jul;16(7):1416-1421.

Book Chapter

Tomlinson GE, Katzenstein H. Malignant Liver Tumors. In: Rudolph C, Rudolph A, Lister G, First L, Gershon A. Rudolphs Pediatrics, 22nd Edition. New York, NY: McGraw-Hill Press; 2011.

Pollock BH, Tomlinson GE. Preventing Cancer in Adulthood: Advice for the Pediatrician. In: Pizzo P and Poplack DE. Principles of Pediatric Oncology; 6th edition. Philadelphia: Lippincott, Williams and Wilkins; 2010.

Tomlinson GE and Kim HB. Hepatoblastoma and Other Liver Tumors. In: Orkin SH, Fisher DE, Look TA, Lux SA, Ginsburg D, Nathan DG. Oncology of Infancy and Childhood Cancer. Philadelphia, PA: Saunders/Elsevier; 2009. p. 721-741.

Abstract

Beuten J, Piwkham D, Gelfond JAL, Collier III A, Pakakasama S, Pollock BH, Tomlinson GE. Association analysis of candidate genes in childhood acute lymphoblastic leukemia; 2010 Nov. (Cancer Prevention and Research Institute of Texas Innovations in Cancer Prevention and Research Conference).

Beuten J, Piwkham D, Gelfond JAL, Collier III A, Pakakasama S, Pollock BH, Tomlinson GE. Association analysis of candidate genes in childhood acute lymphoblastic leukemia Washington, DC; 2010 Nov. (60th Annual American Society of Human Genetics Meeting).

Beuten J, Piwkham D, Gelfond JA, Pakakasama S, Tomlinson GE. Association analysis of candidate genes in childhood acute lymphoblastic leukemia. (POSTER) San Antonio, TX: Greehey Childrens Cancer Research Institute; 2010 Sep. (GCCRI retreat).

Sanchez-Diaz, P, Chen, T, Meyers, R, Malogolowkin, MH, Hung JY, Tomlinson GE. Preclinical studies of sorafenib, bortezomib and a gamma-secretase inhibitor in aggressive hepatoblastoma. (POSTER) Chicago, IL: ASCO; 2010 Jun. (ASCO 2010 Annual Meeting).

Beuten J, Piwkham D, Gelfond JA, Pakakasama S, Tomlinson GE. Association analysis of candidate genes in childhood acute lymphoblastic leukemia. (POSTER) San Antonio, TX: Department of Pediatrics, UTHSCSA; 2010 May. (Pediatric Research Day).

Aguilar C, Perez Prado, Luz, Thomas, Martha, Langevin AR, Shah S, Pollock BH, Tomlinson GE. Pilot Study of the Genetic Epidemiology of Childhood Cancer: A Profile of Patients (POSTER) San Antonio, TX: Department of Pediatrics, UTHSCSA; 2010 May. (Pediatrics Research Day).

Romeo, Anne, Sanchez-Diaz, Patricia, Haskins WE, Tomlinson GE, Hung JY. Ubiquitin carboxy-terminal esterase L1 (UCHL1) in stem-like cancer cells of (POSTER) San Antonio, TX: Department of Pediatrics, UTHSCSA; 2010 May. (Pediatric Research Day).

Sanchez-Diaz, Patricia, Chen, Tina, Meyers, R, Malogolowkin, MH, Hung JY, Tomlinson GE. Preclinical studies of sorafenib, bortezomib and a gamma-secretase inhibitor in aggressive hepatoblastoma. (POSTER) San Antonio, TX: Department of Pediatrics, UTHSCSA; 2010 May. (Pediatric Research Day).

Piwkham D, Gelfond JA, Rerkamnuaychoke B, Pakakasama S, Tomlinson GE, Beuten J. Association of FPGS and MLL variants with childhood acute lymphoblastic leukemia in different ethnicities. (POSTER) Honolulu, Hawaii; 2009 Oct. (59th Annual Meeting of the American Society of Human Genetics).

Beuten J, Piwkham D, Gelfond J, Rerkamnuaychoke B, Pakakasama S, Tomlinson GE. Association of FPGS and MLL variants with childhood acute lymphoblastic leukemia in different ethnicities. (POSTER) Honolulu, Hawaii; 2009 Oct. (59th Annual Meeting of the American Society of Human Genetics).

Piwkham D, Gelfond JA, Rerkamnuaychoke B, Pakakasama S, Tomlinson GE, Beuten J. Association of FPGS and MLL variants with acute lymphoblastic leukemia in different ethnicities. (POSTER) Banff, Alberta, Canada; 2009 Jun. (Cohorts and Consortia from Biotechnology to Populations).

Piwkham, Duangjai, Gelfond, JAL, Pakakasama, Samart, Tomlinson GE, Beuten J. Association of FPGs and MLL variants with childhood acute lymphoblastic leukemia in different ethnicities. (POSTER) San Antonio, TX; 2009 May. (Pediatrics Research Day).

Aguilar C, Anbalagan, Naveen, Thomas, Martha, Langevin AR, Shah S, Pollock BH, Tomlinson GE. Pilot Study Genetic Epidemiology of Childhood Cancer in South Texas (POSTER) San Antonio, TX: Department of Pediatrics, UTHSCSA; 2009 May. (Pediatric Research Day).

Banerji P, Robinson L, Beitsch PD, Tomlinson GE. BRCA1, BRCA2, and CDKN2A Germ-like Mutations in American Patients with Breast Cancer and Melanoma. (POSTER); 2008 Nov. (National Society of Genetics Counselors).

Plon SE, Wheeler DE, Pirics M, Lewis L, Muzny DM, Meng Q, Erez A, Strong L, Tomlinson GE, Gibbs RA. Parallel sequence analysis identifies mutations that result in genetic susceptibility to childhood cancer. (Temporary Abstract Number #4608): San Diego, CA; 2008 Apr. (2008 AACR Annual Meeting).

Chang M, Hung J, Tomlinson GE. MicroRNAs in stem-like cells in pediatric cancers. (POSTER) New Orleans, LA; 2008 Feb. (Southern Society of Pediatric Research Annual Meeting).

Litten JB, Rakheja D, Schultz RA, Kamrudin SA, Chen T, Bartov G, Tomlinson GE. Immunohistochemical Investigation of NOTCH2 and JAGGED1 suggest that aberrant protein expression is important in the pathogenesis of hepatoblastoma; 2007 Oct. (2007 Texas Society of Medical Oncology Membership Meeting).

Review Article

Tomlinson GE, Kappler R. Genetics and Epigenetics of Hepatoblastoma Pediatric Blood and Cancer 2012 Nov;59(5):785-792.

Tomlinson GE. Cytogenetics of Hepatoblastoma Frontiers in Bioscience 2012 Jan;E4:1287-1292.

Federal
Funding Agency	NIH
Title	Correlative genetic markers in childhood hepatoblastoma
Status	Active
Period	9/2008 - 8/2012
Role	Principal Investigator
Grant Detail	This project will determine the clinical correlation of copy number changes detected by genome-wide array-based comparative genomic hybridization techniques.
Funding Agency	NIH/Massachusetts General Hospital
Title	Cancer Genetics Network
Status	Active
Period	5/2006 - 4/2011
Role	Principal Investigator
Grant Detail	This grant provides infrastructure for follow-up for approximately 1100 families at high risk of cancer previously recruited at either UTSW or UTHSCSA.
Funding Agency	NIH
Title	Pharmacogenetics, Emotional Reactivity and Smoking
Status	Active
Period	7/2005 - 4/2011
Role	Co-Principal Investigator
Grant Detail	This is a sub-contract with the Univeristy of Texas M.D. Anderson Cancer Center, Dr. Paul Cinciripini. Dr. Tomlinson is responsible for all genotype analysis as a correlative study to outcomes for smoking cessation.
Funding Agency	NIH
Title	Childrens Oncology Group Chairman Grant. Supplement for Hepatoblastoma Laboratory Facility
Status	Active
Period	7/2004 - 2/2011
Role	Co-Investigator
Grant Detail	Lab Director and Study Chair of Hepatoblastoma Biology Study and Tissue Bank. (Status: on-going)
Private
Funding Agency	St. Baldricks Foundation
Title	Infrastructure for Genetic Epidemiology of Pediatric Cancer in South Texas
Status	Active
Period	12/2012 - 11/2013
Role	Principal Investigator
Grant Detail	There is much evidence suggesting that cancers do not occur at equal frequency in all ethnic groups. The incidence of acute leukemia is substantially higher in persons of Hispanic background. Moreover, children of Hispanic background have been shown to have a worse outcome than children of non-Hispanic background. Recently several key studies from the Childrens Oncology Group as well as others have demonstrated that genetic factors, either constitutional or acquired, are associated with a poorer outcome in Hispanic children. Differences in cancer incidence and outcome in other diagnoses including germ cell tumors and bone tumors may also vary by ethnicity. This project will provide means for studying the effect on leukemia risk and outcome of some of the unique properties of the population of South Texas.
Funding Agency	St. Baldricks Foundation
Title	Genetic determinants of L-asparaginase associated pancreatitis in ALL
Status	Active
Period	7/2012 - 6/2013
Role	Principal Investigator
Grant Detail
Funding Agency	St Baldricks Foundation
Title	Summer Research Student Fellowship
Status	Active
Period	3/2011 - 3/2013
Role	Principal Investigator
Grant Detail
Funding Agency	Hyundai Hope on Wheels
Title	Research Infrastructure in Childhood Cancer Studies in South Texas: Genetic Studies in Hispanic Children with Leukemia.
Status	Active
Period	11/2010 - 11/2012
Role	Principal Investigator
Grant Detail	Genetic Studies in Hispanic Children with Leukemia
State
Funding Agency	Cancer Prevention and Research Institute of Texas
Title	Cancer Genetic Risk Assessment, Counseling and Screening of High-risk Individuals in Greater San Antonio and South Texas: Education and Implementation
Status	Active
Period	3/2012 - 2/2015
Role	Principal Investigator
Grant Detail	When determining ones risk of cancer, a family history of cancer can be a strong clue and health-care providers can often determine who is at high risk of cancer simply based on family history. For some individuals, a genetic test can determine if a person carries a genetic tendency to develop cancer. For those individuals at highest risk, many interventions have been tested and proven to decrease the risk of cancer or to detect cancer at an early stage. Using several different methods we will identify individuals at high-risk of cancer because of a family history. We will use a short questionnaire for women undergoing mammography and in primary care clinics to identify individuals who may be at risk of breast, colon, or other types of cancers. Those individuals who have a positive family history will be contacted by a specialist who will gather additional information to determine if a formal genetic evaluation is needed. For individuals at highest risk, we will recommend appropriate screening procedures which, depending on the type of risk, may include mammography, MRI scan, or colonoscopy. We will provide funds for those unable to pay for such screening tests. In South Texas there are few professional resources to work with families that may have an increased risk of cancer and need additional screening services. This project will fill this gap by providing specialists in the area of cancer genetic risk and counseling. In addition, this project will provide education to physicians-in-training as well as established clinicians, so that our medical community will collectively achieve a higher level of understanding of cancer risks and appropriate interventions to reduce risk. This program will service the greater San Antonio area at the University of Texas Health Science Center at San Antonio and through our primary community partner, the CHRISTUS Santa Rosa Health System. In addition, our services will extend to Laredo and Harlingen, sites of our regional campus
Funding Agency	Cancer Prevention and Research Institute of Texas
Title	Genetics and Biology of Liver Tumorigenesis in Children - Renewal
Status	Active
Period	9/2012 - 8/2013
Role	Principal Investigator
Grant Detail
Funding Agency	Cancer Prevention Research Institute of Texas
Title	Genetics and Biology of Liver Tumorigenesis in Children. Multi-Investigator Grant
Status	Active
Period	9/2010 - 2/2013
Role	Principal Investigator
Grant Detail	The focus of this proposal is on hepatoblastoma, the most common tumor of the liver in young children. We will utilize a very unique resource of specimens collected over the past 15 years by the NCI-sponsored Childrens Oncology Group in which pediatric hospitals from across the country have contributed clinical information along with blood and tumor tissues. We will determine the unique genetic signature of this pediatric tumor type and its variants. An overall goal is also to identify markers of highly aggressive tumor behavior that could aid in the development of future specifically targeted and less toxic therapies.

Year	Degree	Discipline	Institution
1992	Postdoctoral Fellowship	Pediatrics-Hematology/Oncology	University of Texas Southwestern Medical Center Dallas , TX
1989	Postdoctoral Fellowship	Pediatrics-Hematology/Oncology	University of Texas M.D. Anderson Cancer Center Houston , TX
1987	Residency	Pediatrics	Children''s Hospital National Medical Center Washington , DC
1984	MD	Medicine	George Washington University Medical School Washington , DC
1982	PhD	Biochemistry	Duke University Durham , NC
1974	BS	Biology (Summa Cum Laude)	Dickinson College Carlisle , PA

Faculty

FAQ

Suggestions