UTHSCSA Faculty Profiles v1.0

Rea, Shane Leslie

Graduate School of Biomedical Sciences
Barshop Institute
(210) 562-5092

As a PhD scientist I have trained and worked extensively in multiple disciplines including muscle development, subcellular vesicular trafficking, intermediary metabolism, worm genetics and aging. Currently I head a basic biology of aging research lab and the focus of my group is on understanding how biological systems can be altered to extend life- and health-span. Our model of choice is the nematode Caenorhabdidtis elegans, and in particular we focus on a class of long-lived mutants that have disruptions in their mitochondrial electron transport chain (ETC) ? the Mit mutants. There are several projects ongoing in my laboratory ? these involve Gas Chromoatography-Mass Spectrometry (GC-MS) based metabolic pathway mapping in long-lived versus short-lived ETC mutants; elucidation of the role of MAPKs in Mit mutant life extension; analysis of checkpoint signaling and its role in Mit mutant longevity. My group also makes use of mammalian cell models and the yeast Saccharomyces cerevisae. My group has published multiple papers, we are presently NIH funded, and I have been PI on multiple, competitively-funded grant applications. My laboratory has been a functional part of the Barshop Institute since Nov. 2007. Throughout my career I have mentored a combined total of over 40 students, post-docs and technicians.

11/2007 - Present Assistant Professor UTHSCSA, Barshop Institute for Longevity and Aging Studies, Physiology, San Antonio, TX