Journal Article |
| Takamura A, Sato Y, Watabe D, Okamoto Y, Nakata T, Kawarabayashi T, Oddo S, Laferla FM, Shoji M, Matsubara E. Sortilin is required for toxic action of A oligomers (AOs): Extracellular AOs trigger apoptosis, and intraneuronal AOs impair degradation pathways Life Sci 2012 May;.
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| S. Majumder, A. Caccamo, D.X. Medina, A.D. Benavides, M.A. Javors, E. Kraig, R. Strong, A. Richardson, and S. Oddo. Life-long rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and NMDA signaling Aging Cell 2012 Apr;11(2):326-335.
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| Cotella D, Hernandez Enriquez B, Wu X, Li R, Pan Z, Leveille J, Link C, Oddo S, and Sesti F. Toxic role of K channel oxidation in mammalian brain (in press) J Neurosci 2012 Mar;32`(12):4133-4144.
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| Oddo S. The role of mTOR signaling in Alzheimer disease Front Biosci (Schol Ed) 2012 Jan;4:941-952.
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| Walker MP, LaFerla FM, Oddo S, Brewer GJ. Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer''s disease Age 2012 Jan;.
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| Caccamo A, Majumder S, Oddo S. Cognitive decline typical of FTLD in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43 The American Journal of Pathology 2012 Jan;180(1):293-302.
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| Majumder S, Richardson A, Strong R, Oddo S. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits PLoS ONE 2011 Sep;6(9).
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| Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX. BACE1 Elevation is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimers Disease: Differential A Antibody Labeling of Early-Onset Axon Terminal Pathology Neurotox Res 2011 Jul;.
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| Bianchi FT, Camera P, Ala U, Imperiale D, Migheli A, Boda E, Tempia F, Berto G, Bosio Y, Oddo S, Laferla FM, Taraglio S, Dotti CG, Di Cunto F. The Collagen Chaperone HSP47 Is a New Interactor of APP that Affects the Levels of Extracellular Beta-Amyloid Peptides PLoS One 2011 Jul;6(7):22370-22370.
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| Medina DX, Caccamo A, Oddo S. Methylene blue reduces A levels and rescues early cognitive deficit by increasing proteasome activity Brain Pathol 2011 Mar;21(2):140-149.
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| Caccamo A, Maldonado MA, Majumder S, Medina DX, Holbein W, Magr A, Oddo S. Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism J Biol Chem 2011 Mar;286(11):8924-8932.
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| Caccamo A, Maldonado MA, Bokov AF, Majumder S, Oddo S. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimers disease Proc Natl Acad Sci U S A 2010 Dec;107(52):22687-22692.
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| Caccamo A, Magr A, Oddo S. Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to A oligomers accumulation Mol Neurodegener 2010 Nov;5:51-51.
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| Nakashima AS, Oddo S, LaFerla FM, Dyck RH. Experience-dependent regulation of vesicular zinc in male and female 3xTg-AD mice Neurobiol Aging 2010 Apr;31(4):605-613.
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| Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments J Biol Chem 2010 Apr;285(17):13107-13120.
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| Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD Proc Natl Acad Sci U S A 2010 Feb;107(7):3081-3086.
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| Caccamo A, Majumder S, Deng JJ, Bai Y, Thornton FB, Oddo S. Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability J Biol Chem 2009 Oct;284(40):27416-27424.
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| Oddo S, Caccamo A, Cheng D, LaFerla FM. Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology Brain Pathol 2009 Jul;19(3):421-430.
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| Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study Neurochem Int 2009 May;.
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| Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimers disease J Neurosci Res 2009 May;87(6):1462-1473.
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| McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. Inhibition of soluble TNF signaling in a mouse model of Alzheimers disease prevents pre-plaque amyloid-associated neuropathology Neurobiol Dis 2009 Apr;34(1):163-177.
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| Bourasset F, Mlissa O, Tremblay C, Julien C, Do TM, Oddo S, LaFerla F, Calon F. Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimers disease Neuropharmacology 2009 Mar;56(4):808-813.
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| Nuntagij P, Oddo S, LaFerla FM, Kotchabhakdi N, Ottersen OP, Torp R. Amyloid deposits show complexity and intimate spatial relationship with dendrosomatic plasma membranes: an electron microscopic 3D reconstruction analysis in 3xTg-AD mice and aged canine J Alzheimers Dis 2009 Feb;16(2):315-323.
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| Gulinello M, Gertner M, Mendoza G, Schoenfeld BP, Oddo S, LaFerla F, Choi CH, McBride SM, Faber DS. Validation of a 2-day water maze protocol in mice Behav Brain Res 2009 Jan;196(2):220-227.
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| Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice Am J Pathol 2008 Dec;173(6):1768-1782.
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| Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs DH, LaFerla FM. Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology J Neurosci 2008 Nov;28(47):12163-12175.
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| Rodrguez JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, LaFerla FM, Oddo S, Verkhratsky A. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimers disease PLoS One 2008 Aug;3(8):2935-2935.
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| Oddo S. The ubiquitin-proteasome system in Alzheimers disease J Cell Mol Med 2008 Apr;12(2):363-373.
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| Lopez JR, Lyckman A, Oddo S, LaFerla FM, Querfurth HW, Shtifman A. Increased intraneuronal resting [Ca2+] in adult Alzheimers disease mice J Neurochem 2008 Apr;105(1):262-271.
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| McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice Brain Res 2008 Feb;.
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| Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, LaFerla FM, Jin LW. Congo red and thioflavin-T analogs detect Abeta oligomers J Neurochem 2008 Jan;104(2):457-468.
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| Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ. Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice J Neurosci 2007 Nov;27(48):13357-13365.
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| Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, Richardson JC, Yan SD, Hanger DP, Allan SM, Sutherland C. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimers disease progression J Neurochem 2007 Nov;103(3):1132-1144.
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| Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. Neural stem cells improve memory in an inducible mouse model of neuronal loss J Neurosci 2007 Oct;27(44):11925-11933.
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| Clinton LK, Billings LM, Green KN, Caccamo A, Ngo J, Oddo S, McGaugh JL, LaFerla FM. Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice Neurobiol Dis 2007 Oct;28(1):76-82.
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| Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice J Neurochem 2007 Aug;102(4):1053-1063.
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| LaFerla FM, Green KN, Oddo S. Intracellular amyloid-beta in Alzheimers disease Nat Rev Neurosci 2007 Jul;8(7):499-509.
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Book Chapter |
| Oddo S. Animal models of Alzheimers disease: Plaques, tangles and memory decline. In: Roberto Dominici and Ida Biunno (editors). A multidisciplinary approach to dissect the Alzheimer Pathology. 2008. p. 79-82.
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Abstract |
| Caccamo, A., Oddo, S. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits Vancouver, British Columbia, Canada; 2012 Jul. (Alzheimers Association International Conference).
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| Oddo S. The role of mTOR in Alzheimers disease: Lessons from animal models Vancouver, British Columbia, Canada; 2012 Jul. (Alzheimers Association International Conference).
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| Wisely, E. and Oddo, S. The beta2 adrenergic receptors link Abeta accumulation to mTOR hyperactivity and cognitive decline Santa Barbara, CA; 2012 Jun. (American Federation for Aging Research).
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| Oddo S. The role of mTOR in Alzheimers disease: Lessons from animal models Baltimore, Maryland; 2012 Mar. (American Society for Neurochemistry).
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| Caccamo, A., Majumder, S., Magri, A., Oddo, S. Molecular Interplay between mTOR, A and tau: Effects on cognitive impairments Barcelona, Spain; 2011 Jul. (The 10th international conference on Alzheimers and Parkinsons diseases).
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| Medina, D., Caccamo, A., Majumder, S., Magri, A., Oddo, S. Modeling TDP-43 proteinopathies in mice Barcelona, Spain; 2011 Jul. (The 10th international conference on Alzheimers and Parkinsons diseases).
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| Caccamo, A., Medina D., Majumder S., Magri A., Oddo, S. Modeling TDP-43 proteinopathies in mice Taos, NM; 2011 May. (Keystone Symposia: Neurodegenerative diseases: The molecular and Cellular Basis for Neurodegeneration).
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| Hernandez-Enriquez, B., Cotella, D., Wu, X., Li, R., Pan, Z., Oddo, S., Sesti, F. Oxidation of K channels contribute to neuropathy in Alzheimers disease Washington, DC; 2011 Jan. (Society for Neuroscience. On line).
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| Oddo, S., Caccamo, A., Majumder S. Age-dependent cognitive decline typical of FTLD in transgenic mice expressing the 25-kDA C-terminal fragment of TDP-43 Washington, DC; 2011 Jan. (Society for Neuroscience. On line).
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| Caccamo, A., Majumder, S., Medina D.X., Magri, A., Oddo, S. TDP-43 C-terminal fragments play a critical role in the disease pathogenesis: Lessons from cellular and animal models of TDP-43 proteinopathies Indianapolis, Indiana; 2010 Dec. (The 7th international conference on frontotemporal dementias).
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| Caccamo, A., Majumber, S., Oddo, S. Rapamycin rescues TDP-43 mislocalization and the associated low molecular weight neurofilament instability Honolulu, HI; 2010 Jul. (International Conference on Alzheimers Disease).
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| Oddo S. Molecular interplay between mTOR, Abeta, and tau: Effects on Cognitive impairments: Honolulu, HI; 2010 May. (International Conference on Alzheimers Disease).
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| Romano, A., Cassano, T., Gaetani, S., Laconca, L., Macheda, T., Righetti, L., Cianci, S., Morgese, M.G., Mastrantonio, T., Oddo, S., LaFerla, F.M., Cuomo, V. Social memory impairment in a triple-transgenic mouse model of Alzheimers disease is accompanied by monoaminergic alterations Chicago, IL; 2009 Jan. (Society for Neuroscience. On line).
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| Medina, D.A., Caccamo, A., Majumber, S., Deng, J.J., Bai, Y., Thornton, F.B., Oddo, S. Rapamycin induces autophagy and reducesTDP-43 positive inclusions Chicago, IL; 2009 Jan. (Society for Neuroscience. On line).
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| Macklin, L. N., Cai, Y., Kanak, D.J., Ebersole, J., Corbin, A. E., Womack, A., Wendt, D., Oddo, S., LaFerla, F.M., Yan , X. X., Brewer, G.J., Struble, R., Rose, G. M., Strader, A.D., Patrylo, P. R. Impaired glucose tolerance precedes neuroanatomical identification of Abeta and hyperphosphorylated tau accumulation in the 3xTg model of Alzheimers disease Chicago, IL; 2009 Jan. (Society for Neuroscience. On line).
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| Roger, M., Bryleve, E., Chang, C., Buen, F., Harris, B., Rousselet, E., Seidah, N., Oddo, S., LaFerla, F.M., Spencer, T., Hickey, W., Change, T.Y. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in Alzheimer mice Chicago, IL; 2009 Jan. (Society for Neuroscience. On line).
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| Oddo, S., Caccamo, A., Thornton, F. B., Strong, R., Majumder, S. Rapamycin improves learning and memory in a transgenic model of Alzheimers disease Chicago, IL; 2009 Jan. (Society for Neuroscience. On line).
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| Coakley, M.F., Moloney, A.M., Oddo, S., LaFerla, F.M., O''Neill, C. Changes in Akt and IGF-1 receptor signalling relate to developing Abeta and tangle pathology in the triple transgenic model of Alzheimers disease Chicago, IL; 2008 Jul. (The 11th international conference on Alzheimers disease and related disorders).
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| Brewer, G.J., Kunz, E.A., Parihar, M.S., Oddo, S., LaFerla, F.M., Torricelli, J.R. 3xTg-AD mouse neurons show early oxidized redox state Chicago, IL; 2008 Jul. (The 11th international conference on Alzheimers disease and related disorders).
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| Liu, X., Guan, H., Klein, R.L., Oddo, S., LaFerla, F.M., Murphy, M.P., Hersh, L.B. Peripherally overexpessed neprilysin in muscle reduces brain amyloid in a transgenic mouse model of AD Chicago, IL; 2008 Jul. (The 11th international conference on Alzheimers disease and related disorders).
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| Oddo, S., Caccamo, A., Tseng, B., Cheng, D., Vasilevko, V., Cribbs, D.H., LaFerla, F.M. Blocking Abeta42 accumulation delays the onset and progression of Tau pathology and cognitive decline via CHIP: A mechanistic link between Aβ and Tau pathology Chicago, IL; 2008 Jul. (The 11th international conference on Alzheimers disease and related disorders).
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