UTHSCSA Faculty Profiles v1.0

Hart, Matthew J.

Graduate School of Biomedical Sciences
Molecular Medicine
(210) 562-6006

Dr. Matthew J. Hart is an Assistant Professor/Research in the Department of Molecular Medicine, and is a member of the Barshop Instutute and the Cancer Therapy and Research Center (CTRC). Dr. Harts research is focused on the study of protein translation and its involvement in pathological conditions such as cancer, aging and neurodenerative diseases. Dr. Harts research goals include the study of Rag GTPases, the identification of regulatory proteins for Rag GTPases and the studying the involvement of these regulatory proteins in controlling the mTOR signaling pathway. It is anticipated that the identification of Rag GTPase regulatory proteins will provide important insights into mTOR regulation and potential points for therapeutic intervention. Dr. Harts goals also include making available to the UTHSCSA community automated high throughput screening for biochemical and cell-based small molecule, siRNA and miRNA screens. In collaboration with Doug Frantz at UTSA and Bruce Nicholson at UTHSCSA, we established the Center for Innovation in Drug Discovery (CIDD) which is a joint-venture between The University of Texas at San Antonio, The University of Texas Health Science Center and the Southwest Research Institute to provide capabilities and core services in support of biomedical research related to drug discovery. Dr. Hart goals for the CIDD include providing the following services: assay optimization, cell-based and biochemical-based screens of unique small molecule and natural product libraries and siRNA/ miRNA libraries in HTS format, consultation in all aspects of drug discovery and the evaluation and purchase of equipment, small molecule libraries and RNA based libraries necessary to perform automated high through biochemical and cell-based assays. In addition Dr. Hart is and will continue to reach out to the research community in San Antonio to evaluate their research and discuss the potential for translating their research into high throughput screens for the identification of potential therapeutics. Dr. Hart has also developed his own high throughput screens for the targeting of protein translation in aging and cancer. Dr. Hart is currently running cell based assays targeting mTOR and eIF4E dependent protein translation. In addition Dr. Hart has developed a biochemical screen targeting a kinase called Mnk1 which is involved in the regulation of eIF4E and represents an important therapeutic target for the development of anti-cancer therapeutics. Dr. Hart has a broad background in biochemistry, signal transduction and high throughput screening both in academic and pharmaceutical settings

10/2010 - Present Assistant Professor/Research The University of Texas Health Science Center, Molecular Medicine, San Antonio, TX