UTHSCSA Faculty Profiles v1.0

Hart, Matthew J.

Graduate School of Biomedical Sciences
(210) 567-3796

Dr. Matthew J. Hart is an Assistant Professor/Research in the Department of Biochemistry, and is a member of the Barshop Instutute and the Cancer Therapy and Research Center (CTRC). Dr. Harts research is focused on the study of protein translation and its involvement in pathological conditions such as cancer, aging and neurodenerative diseases. Dr. Harts research goals include the study of Rag GTPases, the identification of regulatory proteins for Rag GTPases and the studying the involvement of these regulatory proteins in controlling the mTOR signaling pathway. It is anticipated that the identification of Rag GTPase regulatory proteins will provide important insights into mTOR regulation and potential points for therapeutic intervention. Dr. Harts goals also include making available to the UTHSCSA community automated high throughput screening for biochemical and cell-based small molecule, siRNA and miRNA screens. In collaboration with Doug Frantz and Stan McHardy at UTSA and Bruce Nicholson at UTHSCSA, we established the Center for Innovative Drug Discovery (CIDD) which provides capabilities and core services in support of biomedical research related to drug discovery. Dr. Hart goals for the CIDD include providing the following services: assay optimization, cell-based and biochemical-based screens of unique small molecule and natural product libraries in HTS format, consultation in all aspects of drug discovery and the evaluation and purchase of equipment and small molecule librariesnecessary to perform automated high through biochemical and cell-based assays. In addition Dr. Hart is and will continue to reach out to the research community in San Antonio to evaluate their research and discuss the potential for translating their research into high throughput screens for the identification of potential therapeutics. In addition to being the Director of the CIDD small molecule HTS Facility, Dr. Hart is also the Director go the siRNA/miRNA Greehey Children Cancer Research Institute screening facility where the focus is the use of genetic tolls to identify targets and signaling events that play a role in cancer development. Dr. Hart has a broad background in biochemistry, signal transduction and high throughput screening both in academic and pharmaceutical settings

6/2011 - Present Assistant Professor/Research and Director, HTS Facility of CIDD UTHSCSA, Biochemistry, Biochemistry