UTHSCSA Faculty Profiles v1.0

Hart, Matthew J.

Graduate School of Biomedical Sciences
(210) 567-3796

Dr. Matthew J. Hart is an Assistant Professor/Research in the Department of Biochemistry, and is a member of the Barshop Instutute and the Cancer Therapy and Research Center (CTRC). Dr. Hart serves as the Director of the High Throughput Screening Facility (HTSF), one of two major core facilities that comprise the Center for Innovative Drug Discovery (CIDD), a joint venture between UTHSCSA and UTSA established by Drs. Bruce Nicholson (UTHSCSA) and Doug Frantz. (UTSA). Dr. Hart works directly with Dr. Stan McHardy (Director of the Medicinal Chemistry facility at UTSA) to grow translational capabilities in drug discovery in South Texas and beyond.

As Director of the HTSF, Dr. Hart provides the following services: assay optimization, cell-based and biochemical-based screens of unique small molecule and natural product libraries in HTS format, consultation in all aspects of drug discovery and the evaluation and purchase of equipment and small molecule libraries necessary to perform automated high through biochemical and cell-based assays. In addition Dr. Hart is, and will continue to, reach out to the research community in San Antonio to evaluate their research and discuss the potential for translating their research into high throughput screens for the identification of potential therapeutics. In addition to being the Director of the CIDD small molecule HTS Facility, in November 2016, Dr. Hart will also assume the role of Director of the Greehey Children Cancer Research Institute siRNA/miRNA/CRISPR screening facility, where the focus is the use of genetic tolls to identify targets and signaling events that play a role in cancer development.

Dr. Hart has a broad background in biochemistry, signal transduction and high throughput screening both in academic and pharmaceutical settings. His own research, beyond his role as HTSF Director, has focused on the study of protein translation and its involvement in pathological conditions such as cancer, aging and neurodegenerative diseases. Specifically, he has been involved in the study of Rag GTPases, the identification of regulatory proteins for Rag GTPases and studying the involvement of these regulatory proteins in controlling the mTOR signaling pathway. The identification of Rag GTPase regulatory proteins will provide important insights into mTOR regulation and potential points for therapeutic intervention.

6/2011 - Present Assistant Professor/Research and DIRECTOR, HTS Facility of CIDD UTHSCSA, Biochemistry, Biochemistry