Journal Article |
| Norton L
Chen X
Fourcaudot M
Acharya NK
DeFronzo RA
Heikkinen S. The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells Nucleic Acids Research 2014 Dec;42(22).
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| Merovci A, Solis-Herrera C, Daniele G, Eldor R, Fiorentino TV, Tripathy D, Xiong J, Perez Z, Norton L, Abdul-Ghani MA, DeFronzo RA, Abdul-Ghani M. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production J Clin Invest 2014 Feb;124(2):509-514.
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| Tsintzas K, Norton L, Chokkalingam K, Nizamani N, Cooper S, Stephens F, Billeter R, Bennett A. Independent and combined effects of acute physiological hyperglycaemia and hyperinsulinaemia on metabolic gene expression in human skeletal muscle Clinical Science 2013 Jun;.
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| Abdul-Ghani MA, Norton L, DeFronzo RA. Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus Current Diabetes Reports 2012 Jun;.
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| Doiron B, Hu W, Norton L, Defronzo RA. Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels Diabetologia 2012 Mar;.
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| Doiron B, Hu W, Norton L, DeFronzo RA. Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased palsma glucagon levels Diabetologia 2012 Mar;55(3):719-728.
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| Kanat M, Mari A, Norton L, Winnier D, DeFronzo RA, Jenkinson C, Abdul-Ghani MA. Distinct b-cell defects in impaired fasting glucose and impaired glucose tolerance Diabetes 2012 Feb;61(2):447-453.
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| Kanat M, Mari A, Norton L, Winnier D, DeFronzo RA, Jenkinson CP and Abdul-Ghani MA. Distinct Beta Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance Diabetes 2012 Feb;.
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| Kanat M, Mari A, Norton L, Winnier D, Defronzo RA, Jenkinson C, Abdul-Ghani MA, Winnier DA. Distinct ?-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance Diabetes 2012 Feb;61(2):447-453.
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| Kanat M, Norton L, Winnier D, Jenkinson C, Defronzo RA, Abdul-Ghani MA, DeFronzo, M.D. RA. Impaired early- but not late-phase insulin secretion in subjects with impaired fasting glucose Acta Diabetol 2011 Sep;48(3):209-217.
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| Norton L, Fourcaudot M, Abdul-Ghani MA, Winnier D, Mehta FF, Jenkinson CP, Defronzo RA. Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism Diabetologia 2011 Sep;54(12):3132-3142.
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| Abdul-Ghani MA, Norton L, DeFronzo RA, DeFronzo, M.D. RA. Role of Sodium-Glucose Cotransporter 2 (SGLT 2) Inhibitors in the Treatment of Type 2 Diabetes Endocr Rev 2011 Aug;32(4):515-531.
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Review Article |
| Abdul-Ghani MA, Norton L, DeFronzo RA. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia Diabetes Obes Metab 2012 Jan;14:5-14.
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Federal |
| Funding Agency |
NIH |
| Title |
The role of glucose mediated glucose uptake in the pathogenesis of IFG and IGT (NIH R01DK09755401) |
| Status |
Active |
| Period |
9/2012 - 9/2017 |
| Role |
Co-Investigator |
| Grant Detail |
|
| Funding Agency |
NIH/NIA |
| Title |
K01 Career Development Award |
| Status |
Active |
| Period |
5/2014 - 5/2017 |
| Role |
Principal Investigator |
| Grant Detail |
Single-nucleotide polymorphisms (SNP) within the transcription factor 7-like 2 (TCF7L2) gene have been consistently associated with an elevated risk for type 2 diabetes (T2DM) in multiple populations throughout the world, but the mechanisms by which TCF7L2 affects the pathways important for the development of T2DM are still poorly understood. Addressing this question is of major importance, primarily because functional investigations into T2DM candidate genes will reveal novel molecular pathways that affect important physiological processes that are highly disturbed in T2DM. In several human studies, carriers of the T-allele for the "at-risk" SNP (rs7903146) have impaired hepatic glucose production (HGP) and hepatic insulin sensitivity. Preliminary findings from the laboratory of Dr Norton demonstrating that silencing of TCF7L2 markedly up- regulates HGP in vitro, strongly support a role for TCF7L2 in the pathways of HGP. The aim of this proposal is to establish the functional role of the T2DM candidate gene TCF7L2 in HGP in vivo, and to investigate the molecular mechanisms by which TCF7L2 affects the pathways of glucose metabolism in the liver. A combination of integrative physiology and genomics approaches will be used to address the central hypothesis that TCF7L2 is a major regulator of HGP in vivo and that transcriptional control of key metabolic genes by TCF7L2 in the liver is the underlying mechanism of this regulation. The major training component of this proposal is the acquisition, refinement and application of new skills, with focus on two areas: (i) integrated physiology, and (ii) functional genomics and bioinformatics. These thematic areas were selected because at the present time knowledge about these areas is extremely valuable to conduct cutting-edge diabetes research, and these areas are cohesive and highly integrated with the scientific goals of this project. In addition, the scientific objectives of this proposal will be coupled with an intensive c |
Private |
| Funding Agency |
Metabolic Solutions Devlopment Agency |
| Title |
Efficacy and mechanism of action of anti-diabetic drug MSDC-0602 |
| Status |
Active |
| Period |
2/2013 - Present |
| Role |
Co-Investigator |
| Grant Detail |
|
| Funding Agency |
|
| Title |
Sodium Coupled Glucose Transporter (SGLT) Expression in the Human Diabetic Kidney |
| Status |
Active |
| Period |
3/2010 - Present |
| Role |
Co-Principal Investigator |
| Grant Detail |
|
