UTHSCSA Faculty Profiles v1.0
Norton, Luke
School of Medicine
Medicine
(210) 567-0739
nortonl@uthscsa.edu
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| 1/2014 - Present |
Assistant Professor/Research |
University of Texas Health Science Center at San Antonio, Medicine |
| 4/2010 - Present |
Instructor and Other |
University of Texas Health Science Center San Antonio (UTHSCSA), Medicine, San Antonio, TX |
| Year |
Degree |
Discipline |
Institution |
| 2007 |
PhD |
Biomedical Science (NA) |
University of Nottingham
Nottingham , England |
| 2003 |
BS |
Human Physiology (First class honours) |
University of Hertfordshire
Hatfield , England |
Molecular genetics of type 2 diabetes -
My area of interest lies with the fundamental molecular biology of type 2 diabetes and, more specifically, how genetic variation impacts an individual's risk for the development and progression of the disease. My main goals are to 1) find new genes that are associated with diabetes and 2) characterise the functional role of these genes as it pertains to the development of the diabetes. To this end I employ numerous experimental approaches ranging from in vivo human to detailed in vitro cell culture studies. |
| Date |
Description |
Institution |
# Students |
| 5/2013 - Present |
Membership on Supervising Committee |
UTHSCSA |
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| 5/2013 - Present |
Ph.D. Dissertations Directed |
UTHSCSA |
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Journal Article |
| Norton L
Chen X
Fourcaudot M
Acharya NK
DeFronzo RA
Heikkinen S. The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells Nucleic Acids Research 2014 Dec;42(22).
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| Merovci A, Solis-Herrera C, Daniele G, Eldor R, Fiorentino TV, Tripathy D, Xiong J, Perez Z, Norton L, Abdul-Ghani MA, DeFronzo RA, Abdul-Ghani M. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production J Clin Invest 2014 Feb;124(2):509-514.
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| Tsintzas K, Norton L, Chokkalingam K, Nizamani N, Cooper S, Stephens F, Billeter R, Bennett A. Independent and combined effects of acute physiological hyperglycaemia and hyperinsulinaemia on metabolic gene expression in human skeletal muscle Clinical Science 2013 Jun;.
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| Kanat M, Mari A, Norton L, Winnier D, DeFronzo RA, Jenkinson CP and Abdul-Ghani MA. Distinct Beta Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance Diabetes 2012 Feb;.
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Review Article |
| Abdul-Ghani MA, Norton L, DeFronzo RA. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia Diabetes Obes Metab 2012 Jan;14:5-14.
|
Federal |
| Funding Agency |
NIH |
| Title |
The role of glucose mediated glucose uptake in the pathogenesis of IFG and IGT (NIH R01DK09755401) |
| Status |
Active |
| Period |
9/2012 - 9/2017 |
| Role |
Co-Investigator |
| Grant Detail |
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| Funding Agency |
NIH/NIA |
| Title |
K01 Career Development Award |
| Status |
Active |
| Period |
5/2014 - 5/2017 |
| Role |
Principal Investigator |
| Grant Detail |
Single-nucleotide polymorphisms (SNP) within the transcription factor 7-like 2 (TCF7L2) gene have been consistently associated with an elevated risk for type 2 diabetes (T2DM) in multiple populations throughout the world, but the mechanisms by which TCF7L2 affects the pathways important for the development of T2DM are still poorly understood. Addressing this question is of major importance, primarily because functional investigations into T2DM candidate genes will reveal novel molecular pathways that affect important physiological processes that are highly disturbed in T2DM. In several human studies, carriers of the T-allele for the "at-risk" SNP (rs7903146) have impaired hepatic glucose production (HGP) and hepatic insulin sensitivity. Preliminary findings from the laboratory of Dr Norton demonstrating that silencing of TCF7L2 markedly up- regulates HGP in vitro, strongly support a role for TCF7L2 in the pathways of HGP. The aim of this proposal is to establish the functional role of the T2DM candidate gene TCF7L2 in HGP in vivo, and to investigate the molecular mechanisms by which TCF7L2 affects the pathways of glucose metabolism in the liver. A combination of integrative physiology and genomics approaches will be used to address the central hypothesis that TCF7L2 is a major regulator of HGP in vivo and that transcriptional control of key metabolic genes by TCF7L2 in the liver is the underlying mechanism of this regulation. The major training component of this proposal is the acquisition, refinement and application of new skills, with focus on two areas: (i) integrated physiology, and (ii) functional genomics and bioinformatics. These thematic areas were selected because at the present time knowledge about these areas is extremely valuable to conduct cutting-edge diabetes research, and these areas are cohesive and highly integrated with the scientific goals of this project. In addition, the scientific objectives of this proposal will be coupled with an intensive c |
Private |
| Funding Agency |
Metabolic Solutions Devlopment Agency |
| Title |
Efficacy and mechanism of action of anti-diabetic drug MSDC-0602 |
| Status |
Active |
| Period |
2/2013 - Present |
| Role |
Co-Investigator |
| Grant Detail |
|
| Funding Agency |
|
| Title |
Sodium Coupled Glucose Transporter (SGLT) Expression in the Human Diabetic Kidney |
| Status |
Active |
| Period |
3/2010 - Present |
| Role |
Co-Principal Investigator |
| Grant Detail |
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