UTHSCSA Faculty Profiles v1.0

Salmon, Adam

Graduate School of Biomedical Sciences
Barshop Institute

I am currently a faculty of the Department of Molecular Medicine (MMED) and the Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas. I also hold affiliation with the South Texas Veterans Health Care System (STVHCS) affiliate of the Veterans Affairs administration. My long-term goals are to develop and maintain excellence in my research program, to mentor, train and educate young researchers and teachers and serve the scientific communities locally, nationally and internationally. In my four years as an independent scientific investigator, I have made significant impact in each of research, training and service which are summarized here. RESEARCH:My research expertise is in the basic biology of aging, with a focus on the impact that mechanisms of aging have on metabolic function (and vice versa). The research in my lab is focused on two primary interrelated fields: mechanistic target of rapamycin (mTOR) signaling and oxidative stress. The regulation of mTOR has been shown to profoundly impact lifespan across several invertebrate and vertebrate species. Inhibition of mTOR using the compound rapamycin can increase mouse lifespan even when administered late in life and has also been shown effective in combating several age-related diseases and pathologies. My lab is addressing whether this pathway could similar be utilized to improve lifespan and healthspan in primates in the eventual goal of clinical translation of these findings. Further, we wish to understand how to best derive the benefits of pharmaceutical inhibition of mTOR while reducing the potential side-effects. One of the risks of rapamycin treatment is metabolic dysfunction; my lab uses rodent and non-human primate models to address whether alternative treatments can eliminate this potential side effect. The second major focus of the lab is the role of oxidative stress in metabolic dysfunction. While obesity is a primary risk factor for diabetes, the mechanisms responsible are still largely unknown. We view oxidative stress, and mitochondria dysfunction, as potential targets in this pathway. My lab uses rodent and in vitro models to test this hypothesis with a long-term goal of pharmaceutical translation.

At this point in my career, I have published 49 journal articles, reviews and book chapters. Of these, I am 1st/Co-1st author on 17 and Corresponding author on an additional 17. The journals in which these have been published have included broad-range journals such as Science, PNAS, FASEB, aging-targeted including Aging Cell, Aging (Albany NY), Journals of Gerontology, and oxidative stress-targeted including Free Radical Biology and Medicine. As of writing, these manuscripts have generated 2864 independent citations, an h-index of 22 and an i10 index of 33 (https://scholar.google.com/citations?user=43MXg5QAAAAJ&hl=en). I currently have 2 additional manuscripts under revision and 6 in preparation. I have delivered 35 scientific presentations (oral) at different levels of conferences, meetings and seminars including local, national and international. As a Principle Investigator or Co-investigator, I have successfully obtained 9 grants from NIH, Department of Veterans Affairs, private foundations including the American Heart Association, the American Federation for Aging Research, and the San Antonio Area Foundation, as well as local University grants. TEACHING:I have been involved in teaching throughout both my training as well as now as a faculty member. At UTHSCSA, I have been actively engaged in both course-based and non course-based teaching. For the last three years (2014-16), I have taught lectures each Spring on nutritional regulation of aging in the Biology of Aging training course CSBL 6048. Over this period, I have also taught lectures on the basic biology of aging each spring to 1st year students in the UTSA-UTHSCSA Facilitated Acceptance to Medical School (FAME) program in UTSA course BIO 4953. I also have taught in the same capacity to both 1

9/2016 - Present Assistant Professor UTHSCSA, Molecular Medicine, San Antonio, TX
6/2012 - Present Research Health Scientist South Texas Veterans Healthcare System, Geriatric, Research, Education and Clinical Center (GRECC), San Antonio, TX