Abstract |
| Grant C, Cai S, Grkovic T, O'Keefe B, Cichewicz R, Risinger AL, Mooberry SL. New approaches for target identification of natural products; 2018 Jul. (Presented at American Society of Pharmacognosy Conference).
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| Kaul R, Risinger AL, Mooberry SL. Eribulin disrupts TGF-Beta mediated signaling in triple negative breast cancer cells; 2018 Apr. (Presented at AACR Annual Meeting).
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| Shaffer CV, Risinger AL, Beutler JA, Mooberry SL. Characteristics of triple negative breast cancer cells that result in sensitivity to englerin A; 2018 Apr. (Presented at the American Association for Cancer Research Annual Meeting).
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| Shaffer CV, Robles AJ, Risinger AL, Mooberry SL. Differential efficacies of DNA damaging agents in basal-like TNBC subtypes; 2017 Dec. (Presented at San Antonio Breast Cancer Symposium).
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| Kaul R, Risinger AL, Mooberry SL. Eribulin differentially disrupts TGF-Beta signaling pathway in BT-549 and HCC1937 breast cancer cell lines; 2017 Dec. (Presented at San Antonio Breast Cancer Symposium).
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| Shaffer CV, Cai S, Risinger AL, Du L, O'Keefe BR, Beutler JA, Cichewicz RH, Mooberry SL. Plant derived compounds with selective acitivites against triple negative breast cancer subtypes; 2017 Dec. (Presented at the Cancer Therapy and Research Center Symposium).
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| Shaffer CV, Risinger AL, Beutler JA, Beech DJ, Mooberry SL. Mechanism of action of englerin a in BT-549 triple negative breast cancer cells; 2017 Jul. (Presented at American Society of Pharmacognosy Conference).
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| Kaul R, Risinger AL, Mooberry SL. Eribuulin rapidly impairs TGF-Beta signaling; 2017 Apr. (Presented at AACR Annual Meeting).
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| Risinger AL, Dybdal-Hargreaves N, Kaul R, Clark AD, Mooberry SL. Establishing an experimental paradigm to study the interphase effects of microtubule targeting agents; 2017 Apr. (Presented at AACR Annual Meeting).
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| Kaul R, Risinger AL, Mooberry SL. Eribulin impairs TGF-Beta type I receptor localization and signaling in BT-549 cells; 2016 Dec. (Presented at San Antonio Breast Cancer Symposium).
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| Shaffer CV, Cai S, Perez A, Risinger AL, Du L, O'Keefe BR, Cichewicz RH, Mooberry SL. Extracts derived from fungi and plants demonstrate specificity for subtypes of triple negative breast cancer; 2015 Dec. (Presented at San Antonio Breast Cancer Symposium).
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| Shaffer CV, Du L, Dai W, Risinger AL, Sarkar P, Cichewicz RH, Mooberry SL. Great Lakes-derived fungal extracts yield compounds targeting pediatric cancer; 2015 Jul. (Presented at American Society of Pharmacognosy).
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Editorial |
| Mooberry SL, Kingston DGI, Smith AB III, Swanson SM, Wani MC. Special Issue in Honor of Professor Susan Band Horwitz J Nat Prod 2018 Jan;81:449-450.
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Journal Article |
| Pavana RK, Shah K, Gentile T, Dybdal-Hargreaves NF, Risinger AL, Mooberry SL, Hamel E, Gangjee A. Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents Bioorg Med Chem 2018 Sep;.
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| Xiang W, Choudhary S, Hamel E, Mooberry SL, Gangjee A. Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent Bioorg Med Chem 2018 Apr;.
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| Ola ARB, Risinger AL, Du L, Zammiello CL, Peng J, Cichewicz RH, Mooberry SL. Taccalonolide microtubule stabilizers generated using semisynthesis define the effects of mono acyloxy moieties at C-7 or C-15 and disubstitutions at C-7 and C-25 J Nat Prod 2018 Jan;.
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| Dybdal-Hargreaves NF, Risinger AL, Mooberry SL. Regulation of E-cadherin localization by microtubule targeting agents: rapdi promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin Oncotarget 2018 Jan;9:5545-5561.
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| Deyambatlaa RKV, Choudharya S, Ihnatb M, Hamel E, Mooberry SL, Gangjee A. Design, synthesis and preclinical evaluation of 5-methyl-n4-arl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential Bioorg Med Chem 2018 Jan;28:3085-3093.
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| Jans PE, Mfuh, AM, Arman HD, Shaffer CV, Larionov OV, Mooberry SL. Cytotoxicity and mechanism of action of the marine-derived fungal metabolite trichodermamide B and synthetic analogues J Nat Prod 2017 Jan;80:676-683.
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| Danielsson D, Sun DX, Chen X-Y, Risinger AL, Mooberry SL, Sorensen EJ. A controlled annulation of the taccalonolide epoxy lactone onto the molecular framework of trans-androsterone Org Lett 2017 Jan;9:4892-4895.
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| Robles AJ, McCowen S, Cai S, Glassman M, Ruiz F, Cichewicz RH, McHardy SF, Mooberry SL. Structure-activity relationships of new natural product-based diaryloxazoles with selective activity against androgen receptor-positive breast cancer cells J Med Chem 2017 Jan;60:9275-9289.
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| Mooberry SL. Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells Bioorg Med Chem Lett 2017 Jan;:3423-3430.
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| Dybdal-Hargreaves NF, Risinger AL, Mooberry SL. Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130CAS/Src inhibition by eribulin Oncotarget 2017 Jan;9(5):5545-5561.
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| Gupton JT, Yeudall S, Telang N, Hoerrner M, Huff E, Crawford E, Lounsbury K, Kimmel M, Curry W, Harrison A, Juekun W, Shimozono A, Ortolani J, Lescalleet K, Patteson J, Moore-Stoll V, Rohena CC, Mooberry SL, Obaidullah AJ, Kellogg GE, Sikorski JA. Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities Bioorg Med Chem 2017 Jan;25:3206-3214.
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| Risinger AL, Li J, Du L, Benavides R, Robles AJ, Cichewicz RH, Kuhn JG, Mooberry SL. Pharmacokinetic analysis and in vivo antitumor efficacy of taccalonolides AF and AJ J Nat Prod 2017 Jan;80(2):409-414.
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| Shaffer CV, Cai S, Peng J, Robles AJ, Hartley RM, Powell DR, Du L, Cichewicz RH, Mooberry SL. Texas native plants yield compounds with cytotoxic activities against prostate cancer cells J Nat Prod 2016 Jan;.
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| Cai S, Risinger AL, Nair SS, Peng J, Anderson TJ, Du L, Powell DR, Mooberry SL, Cichewicz RH. Identification of compounds with efficacy against malaria parasites from common North American plants J Nat Prod 2016 Jan;79(3):490-498.
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| Robles AJ, Cai S, Cichewicz RH, Mooberry SL. Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer Breast Cancer Res Treat 2016 Jan;157:475-488.
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| Rohena CC, Telang NS, Da C, Risinger AL, Sikorski JA, Kellogg GE, Gupton JT, Mooberry SL. Biological characterization of an improved pyrrole-based colchicine site agent identified through structure-based design Mol Pharmacol 2016 Jan;89(2):287-296.
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| Deyambatla RK, Namjoshi OA, Choudhary S, Hamel E, Shaffer CV, Rohena CC, Mooberry SL, Gangjee A. Design, synthesis, and preclinical evaluation of 4-substituted-5-methyl-furo[2,3-d]pyrimidines as microtubule targeting agents that are effective against multidrug resistant cancer cells J Med Chem 2016 Jan;59:5752-5765.
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| Rohena CC, Risinger AL, Devambatla RK, Dybdal-Hargreaves NF, Kaul R, Choudhary S, Gangjee A, Mooberry SL. Janus compounds, 5-chloro-N4-methyl-Nr-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, cause both microtubule depolymerizing and stabilizing effects Molecules 2016 Jan;21.
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| Mourshid SS, Badr JM, Risinger AL, Mooberry SL, Youssef DT. Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species Z Naturforsch C 2016 Jan;71:387-392.
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| Robles AJ, Du L, Cichewicz RH, Mooberry SL. Maximiscin induces DNA damage, activates DNA damage response pathways, and has selective cytotoxic activity against a subtype of triple-negative breast cancer J Nat Prod 2016 Jan;79:1822-1827.
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| Robles AJ, Peng J, Hartley RM, Lee B, Mooberry SL. Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities J Nat Prod 2015 Jan;78:388-395.
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| Risinger AL, Dybdal-Hargreaves NF, Mooberry SL. Breast cancer cell lines exhibit differential sensitivites to microtubule-targeting drugs independent of doubling time Anticancer Res 2015 Jan;35(11):5845-5850.
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| Youssef DT, Shaala LA, Mohamed GA, Ibrahim SR, Banjar ZM, Badr JM, McPhail KL, Risinger AL, Mooberry SL. 2,3-Seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens Nat Prod Res 2015 Jan;29:703-709.
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| Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents Bioorg Med Chem 2015 Jan;23(10):2408-2423.
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| Du L, Robles AJ, King JB, Powell DR, Miller AN, Mooberry SL, Cichewicz RH. Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity Agnew Chem Int Ed Eng 2014 Jan;53:804-809.
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| Li J, Risinger AL, Mooberry SL. Taccalonolide microtubule stabilizers Bioorganic & Medicinal Chemistry 2014 Jan;22(18):5091-5096.
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| Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents Bioorg Med Chem 2014 Jan;22:3753-3772.
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| Risinger AL, Riffle SM, Lopus M, Jordan MA, Wilson L, Mooberry SL. The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation Mol Cancer 2014 Jan;13.
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| Peng J, Risinger AL, Li J, Mooberry SL. Synthetic reactions with rare taccalonolides reveal the value of C-22,23 epoxidation for microtubule stabilizing potency J Med Chem 2014 Jan;57:6141-6149.
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| Du L, Robles AJ, King JB, Mooberry SL, Cichewicz RH. Cytotoxic dimerica epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum J Nat Prod 2014 Jan;77:1459-1466.
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| Kittiwisuta S, Rohena CC, Chatakula P, Wattanapiromsakula C, Yuenyongsawada S, Mooberry SL, Plubrukarna A. Cellular effects of heteronemin and 12-oxoheteronemin Nat Prod Comm 2014 Jan;9:359-360.
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| Shaala L, Youssef D, Ibrahim S, Mohamed G, Badr J, Risinger AL, Mooberry SL. Didemnaketals F and G, new bioactive spiroketals from a Red Sea ascidian Didemnum species Marine Drugs 2014 Jan;12:5021-5034.
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Review Article |
| Dybdal-Hargreaves NF, Risinger AL, Mooberry SL. Eribulin Mesylate: mechanism of action of a unique microtubule-targeting agent Clinical Cancer Research 2015 Apr;21:2445-2452.
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| Rohena CC, Mooberry SL. Recent progress witih microtubule stabilizers: new compounds, binding modes and cellular activities Natural Product Reports 2014 Jan;31:335-355.
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| Li J, Risinger AL, Mooberry SL. Microtubule stabilizers Bioorganic & Medicinal Chemistry 2014 Jan;22:5091-5096.
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