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Sharma, Ramaswamy

Graduate School of Biomedical Sciences
Cellular & Structural Biology
(210) 567-3845
sharmar3@uthscsa.edu

Assistant Professor/Research of Cell Systems & Anatomy

Appointments Education Expertise Teaching Publications Grants

3/2018 - Present	IBMS Graduate Faculty	University of Texas Health Science Center at San Antonio, San Antonio, TX
9/2012 - Present	Assistant Professor/Research	University of Texas Health Science Center at San Antonio, Cellular & Structural Biology, San Antonio, TX

Date	Description	Institution	# Students
8/2018 - Present	Intro to Research	The University of Texas Health Science Center
Course Director
12/2017 - Present	Masters' Thesis Directed	UTHSCSA

12/2017 - Present	Ph.D. Dissertations Directed	UTHSCSA

12/2017 - Present	Masters' Thesis Directed	UTHSCSA

10/2017 - Present	CSBL5060 Advanced Histology
Course Director
9/2017 - Present	Masters' Thesis Directed	UTHSCSA

3/2016 - Present	Circulation	The University of Texas Health Science Center	220 students

2/2016 - Present	Respiratory Health	The University of Texas Health Science Center	220 students

1/2016 - Present	Hematology	The University of Texas Health Science Center	220 students

1/2016 - Present	Musculoskeletal & Dermatology	The University of Texas Health Science Center	220 students

10/2015 - Present	Attack and Defense	The University of Texas Health Science Center	220 students

8/2015 - Present	Molecules to Medicine	The University of Texas Health Science Center	220 students

8/2015 - Present	Digestive health & Nutrition	The University of Texas Health Science Center	220 students

8/2015 - Present	Endocrine & Female Reproductive	The University of Texas Health Science Center	220 students

3/2015 - Present	Renal & Male Reproductive	The University of Texas Health Science Center	220 students

9/2014 - Present	Fundamentals of Biomedical Sciences	The University of Texas Health Science Center

7/2014 - Present	Dental Histology	The University of Texas Health Science Center	111 students
Co-Course Director

Abstract

Parker A, Bendele M, Fajardo R, Guda T, Herman B and Sharma R. Caspase-2 maintains bone homeostasis by regulating osteoclast numbers and function University of Texas HSC at San Antonio, TX; 2018 Aug. (2018 Voelcker Biomedical Research Academy Scholars Symposium).

Sharma R, Bendele M, Guda T and Herman B. Caspase-2 maintains bone homeostasis by regulating osteoclast number and function Santa Barbara, CA; 2018 Jun. (31st Paul F. Glenn/AFAR Conference on the Biology of Aging).

Mattila MN, Bhattacharya A, Herman B and Sharma R. Caspase-2 maintains bone homeostasis by regulating osteoclast number and function San Antonio, TX; 2018 May. (21st Annual Department of Medicine Research Day).

Mattila MN, Bhattacharya A, Herman B and Sharma R. Caspase-2 maintains bone homeostasis by regulating osteoclast number and function University of Texas HSC at San Antonio, TX; 2018 May. (2018 Mikiten Research Symposium).

Hanson ER, Sharma R, Jackson J and King TS. Bringing lab up to speed: A redesign of histopathology teaching laboratories using a modified Team-Based Learning (TBL) format Jackson, MS; 2018 Apr. (Southern Group on Educational Affairs (SGEA) Regional Meeting).

Tschumi C, Sharma R, Beckstead MJ. D2 autoreceptor signaling is depressed by neurotensin released from discrete inputs to midbrain dopamine neurons Experimental Biology, San Deigo, CA; 2018 Apr. (Faseb J; vol. 32_1, no. 680.7).

Mattila MN, Bhattacharya A, Herman B and Sharma R. Caspase-2 maintains bone homeostasis by regulating osteoclast number and function. University of Texas HSC at San Antonio, TX University of Texas HSC at San Antonio. San Antonio, TX; 2018 Mar. (36th Annual School of Dentistry?s Dental Science Symposium).

King T, Sharma R and Nelson E. Connecting the dots: Morphing-based animation of cervical pathology for medical students Commons Learning Center, Austin, TX: The Shine Academy of Health Science Education (UT System),; 2018 Feb. (Innovations in Interprofessional Health Science Education Annual Conference).

Mota A, Hildreth K, Reddick R, Sharma R and Walter C. Subcellular localization of Ape1/Ref1 in C3HeB/FeJ liver tumor cells San Antonio, TX: University of Texas HSC at San Antonio; 2017 Aug. (Summer High School CURE Cancer Research Training Program).

Tschumi C, Sharma R, Beckstead, MJ. D2 autoreceptor signaling is depressed by neurotensin released from discrete inputs to midbrain dopamine neurons University of Texas HSC at San Antonio, TX; 2017 Apr. (5th Annual Physiology Graduate Student Symposium).

Hager AM, Dominguez-Lopez S, Sharma R, Wickman K, Beckstead MJ. Cocaine effects on dopamine neurons in mice are reduced by deletion of GIRK2 channels specifically in dopamine neurons and with cocaine self-administration San Antonio, TX: Addiction Research Treatment and Training Center of Excellence; 2017 Mar. (Behavior, Biology and Chemistry: Translational Research in Addiction).

Dominguez Lopez S, Sharpe AL, Sharma R, Wickman K and Beckstead MJ. Selective deletion of GIRK2 channels in dopamine neurons decreases cocaine sensitivity and increases cocaine self-administration in mice San Antonio, TX: UTHSCSA; 2016 May. (Center for Biomedical Neuroscience Retreat).

Stoveken B, Widjaja C, Sharma R and Lechleiter JD. Regulation of the Integrated Stress Response by the PERK Juxtamembrane Domain Memphis, TN: St. Jude's Hospital; 2016 Mar. (St. Jude's Hospital Symposia).

Dominguez Lopez S, Sharpe AL, Sharma R, Wickman K and Beckstead MJ. Selective deletion of GIRK 2 channels in dopamine neurons decreases cocaine sensitivity and increases cocaine self-administration in mice San Antonio, TX: UTHSCSA; 2016 Mar. (Behavior, Biology and Chemistry: Translational Research in Addiction,).

Stoveken B, Sharma R, Lechleiter JD. Evidence for cytosolic domain influence on PERK oligomerization San Deigo, CA; 2015 Dec. (American Society for Cell Biology).

Stoveken B, Sharma R, Lechleiter JD. Elements in the Cytosolic Domain of PERK Regulate its Oligomerization Mayan Ranch, Bandera, Texas; 2015 Oct. (Barshop Symposium on Aging).

Branch SY, Chen C, Sharma R, Lechleiter JD, Li S and Beckstead, MJ. Dopaminergic neurons exhibit age-dependent decline in electrophysiological parameters in the MitoPark model of Parkinson`s disease; 2015 May. (CSB Retreat).

Sharma R, Horn D, Woodruff K, Jiang JX, Fajardo R, and Abboud-Werner,S. . sCSF-1 Maintains Cortical Bone Thickness During Aging Houston, TX: American Society for Bone and Mineral Research; 2014 Sep. (J.Bone Miner Res; vol. 29, no. Supp1).

Sharma R, Vanegas D, Victor D, Zhang Y, Lopez-Cruzan M, Woodruff K, Horn D, Fajardo RJ, Harris SE, Werner SL, Herman BA. A critical role for Caspase-2 in regulating osteoclast numbers in male age-related osteoporosis Minneapolis, MN; 2012 Oct. (J Bone Miner Res; vol. 27, no. Supp1).

Sharma R, Tye CE, Arun A, McDonald D and Bartlett JD. Assessment of Dental Fluorosis in Mmp20 Heterozygous Mice San Deigo, CA: IADR; 2011 Mar. (International Association of Dental Research (IADR)).

Victor D.A., Vanegas D., Woodruff K., Lopez-Cruzan M., Sharma R., Abboud-Werner S.L., Herman B.A. The Role of Caspase-2 in Osteoblast-Osteoclast Interactions San Antonio, TX; 2010 Sep. (Medical Student Training in Aging Research (MSTAR) Meeting).

Skobe, Z., Dobeck, J., Tye, C.E., Sharma R, Perze-Moreno, M., Stokes, N., Reynolds, A., Fuchs, E., Bartlett, J.D. p120 catenin is necessary for cadherin switching in ameloblasts; 2010 Jan. (American Association for Dental Research (AADR)).

Sharma R, Skobe, Z., Tannous, B.A., Bartlett, J.D. Low pH enhances ameloblast sensitivity to fluoride-mediated cell stress; 2009 Jan. (International Association for Biological and Medical Research (IABMR)).

Sharma R. Fluoride exposure significantly reduces protein secretion in cultured LS8 cells; 2008 Jan. (American Association for Dental Research).

Tsuchiya, M., Sharma R, Tye, C.E., Bartlett, J.D. Stress-related genes are upregulated in maturation stage ameloblasts; 2008 Jan. (International Association for Dental Research (IADR)).

Tsuchiya, M., Tye, C.E, Sharma R, Smith, C.E., Bartlett, J.D. XBP-1 may contribute to the expansion of the ER in the secretory stage of ameloblasts; 2008 Jan. (International Association for Dental Research (IADR)).

Sharma R, Gow, A. Minor role for caspase-12 in animal models of neurodegenerative disease; 2006 Jan. (J Neurochem; vol. 96, no. Supp1).

Gow, A., Sharma R, Tseng, J., Zhong, L. Minor roles for Atf3 and caspase-12 in neurodegenerative disease; 2005 Jan. (Society for Neuroscience).

Sharma R, Gow, A. Caspase-12 and Neurodegeneration; 2004 Jan. (J Neurochem; vol. 90, no. Supp1).

Gow, A., Southwood, C., Jiang, W., Sharma R, Wang, L., Garbern, J. The role of signaling by the unfolded protein response in neurodegenerative disease; 2003 Jan. (J Neurochem; vol. 85, no. Supp1).

Book Chapter

Sharma R., Tsuchiya M., Tannous B.A., Bartlett, J.D. Measurement of fluoride-induced endoplasmic reticulum stress. In: Conn, Michael P. Methods in Enzymology: UPR and Cellular Stress. San Diego, CA: Academic Press (Elsevier); 2011. p. 111-125.

Bartlett, J.D., Tye, C.E., Abrazinski, T.A., Antone, J., Lopez,G.F, Sharma R. Degradation of enamel matrix proteins. In: Goldberg, M. Amelogenins: Multifaceted Proteins for Dental & Bone Formation & Repair. 2010. p. 99-105.

Sharma R, Bartlett, J.D. A stress-based mechanism to explain dental fluorosis. In: Sasano T., Suzuki, O. Interface Oral Health Science. 2010. p. 421-423.

Journal Article

Reiter J, Tan DX and Sharma R. Historical Perspective and Evaluation of the Mechanisms by which Melatonin Mediates Seasonal Reproduction in Mammals Melatonin-Research 2018 Nov;.

Werner SL, Sharma R, Woodruff K, Horn D, Harris S, Gorin Y, Lee D_Y, Block K, Gu S, Fajardo R, Habib S and Jiang J. CSF-1 in Osteocytes Inhibits Nox4-mediated Oxidative Stress and Promotes Normal Bone Homeostasis The Journal of Bone and Mineral Research Plus 2018 Sep;.

King T, Sharma R, Jackson J and Fiebelkorn K. Clinical case-based image portfolios in medical histopathology Anatomical Sciences Education 2018 Apr;.

Branch SY, Chen C, Sharma R, Lechleiter JD, Li S, Beckstead MJ. Dopaminergic neurons exhibit an age-dependent decline in electrophysiological parameters in the MitoPark mouse model of Parkinsons disease Journal of Neuroscience 2016 Apr;36(14):4026-4037.

Lopez-Cruzan M, Sharma R, Tiwari M, Karbach S, Holstein D, Martin C, Lechleiter JD, Herman B. Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment Cell Death and Discovery 2016 Jan;.

Choveau F, Zhang J, Bierbower S, Sharma R, Shapiro MS. The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K Current Amplitudes by Controlling Channel Trafficking PLoS One 2015 Dec;10(12).

Paiva B, Azpilikueta A, Puig M, Ocio EM, Sharma R, Oyajobi BO, Labiano S, San-Segundo L, Rodriguez A, Aires-Mejia I, Rodriguez I, Escalante F, de Coca AG, Barez A, San Miguel JF, Melero I. PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma Leukemia 2015 Oct;29(10):2110-2113.

Sharma R, Williams PJ, Gupta A, Mccluskey B, Bhaskaran S, Munoz S, Oyajobi, BO. A Dominant-negative F-box?deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice Oncotarget 2015 Aug;6(25):21589-21602.

Callaway DA, Riquelme MA, Sharma R, Lopez-Cruzan M, Herman BA, Jiang JX. Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress Bone 2015 Jul;76:40-48.

Shah AR, Cornejo A, Guda T, Sahar DE, Stephenson SM, Chang S, Krishnegowda NK, Sharma R, Wang HT. Differentiated adipose-derived stem cell cocultures for bone regeneration in polymer scaffolds in vivo J Craniofac Surg 2014 Jul;25(4):1504-1509.

Branch S, Sharma R, Beckstead M.J. Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons Journal of Neuroscience 2014 Jul;34(26):9310-9318.

Sharma R, Callaway D, Vanegas D, Bendele M, Lopez-Cruzan M, Horn D, Guda T, Fajardo R, Abboud-Werner S, Herman B. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts PLoS One 2014 Apr;9(4):1-11.

Cornejo A, Sahar DE, Stephenson SM, Chang S, Nguyen S, Guda T, Wenke JC, Vasquez, A, Michalek JE, Sharma R, Krishnegowda NK, Wang HT. Effect of Adipose Tissue-Derived Osteogenic and Endothelial Cells on Bone Allograft Osteogenesis and Vascularization in Critical-Sized Calvarial Defects Tissue Eng Part A 2012 May;18(15-16):1-10.

Poche RA, Sharma R, Garcia MD, Wada AM, Nolte MJ, Udan RS, Paik J-H, DePinho RA, Bartlett JD, Dickinson ME. Transcription factor FoxO1 is essential for enamel biomineralization PLoS one 2012 Jan;7(1).

Sharma R, Tye CE, Arun A, Macdonald D, Chatterjee A, Abrazinski T, Everett ET, Whitford GM, Bartlett JD. Assessment of dental fluorosis in Mmp20+/- mice J Dent Res 2011 Jun;90(6):788-792.

Tye CE, Sharma R, Smith CE, Bartlett JD. Altered ion-responsive gene expression in Mmp20- Null Mice J Dent Res 2010 Oct;90(6):788-792.

Sharma R, Tsuchiya M, Skobe Z, Tannous BA, Bartlett JD. The acid test of fluoride: how pH modulates toxicity PLoS one 2010 May;5(5):10895-10895.

Tsuchiya M, Sharma R, Tye CE, Sugiyama T, Bartlett JD. Transforming growth factor-beta1 expression is up-regulated in maturation-stage enamel organ and may induce ameloblast apoptosis Eur J Oral Sci 2009 Apr;117(2):105-112.

Tsuchiya M, Tye CE, Sharma R, Smith CE, Bartlett JD. XBP1 may determine the size of the ameloblast endoplasmic reticulum J Dent Res 2008 Nov;87(11):1058-1062.

Sharma R, Tsuchiya M, Bartlett JD. Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion Environ Health Perspect 2008 Sep;116(9):1142-1146.

Sharma R, Jiang H, Zhong L, Tseng J, Gow A. Minimal role for activating transcription factor 3 in the oligodendrocyte unfolded protein response in vivo J Neurochem 2007 Sep;102(5):1703-1712.

Sharma R, Gow A. Minimal role for caspase 12 in the unfolded protein response in oligodendrocytes in vivo J Neurochem 2007 May;101(4):889-897.

Gow A, Sharma R. The unfolded protein response in protein aggregating diseases Neuromolecular Med 2003 Jan;4(1-2):73-94.

Federal
Funding Agency	Nathan Shock Center of Excellence Pilot Grant
Title	Targeting Caspase-2 for augmenting bone strength during aging
Status	Active
Period	7/2017 - 6/2018
Role	Principal Investigator
Grant Detail
Private
Funding Agency	William & Ella Owens Medical Research Foundation
Title	Targeting Caspase-2 for augmenting bone strength
Status	Active
Period	3/2017 - 6/2018
Role	Principal Investigator
Grant Detail	The aim of this grant is to determine if enhanced bone mass in Caspase-2 overexpressing mice correlates to increased mechanical strength.
Funding Agency	San Antonio Area Foundation Biomedical Research Grant
Title	Targeting Casp2_FoxO1 axis to prevent diabetes and diabetes-induced bone loss.
Status	Active
Period	4/2017 - 4/2018
Role	Principal Investigator
Grant Detail	The aim of this grant is to determine if Casp2 regulates glucose metabolism by modulationg FoxO1 and osteocalcin.
State
Funding Agency	UT Shine Academy of Health Science Education
Title	A three-dimensional model of pterygopalatine fossa for anatomy education
Status	Active
Period	1/2018 - 12/2018
Role	Principal Investigator
Grant Detail	The pterygopalatine fossa (PPF) is a complicated anatomical space that can neither be visualized clearly during cadaveric dissections nor can its multiple communicating channels be conceptually appreciated in two-dimensional textbook figures. Knowledge of the PPF is important not only for dental and medical students but also for residents specializing in radiology, ophthalmology, neurosurgery and ENT. Previous attempts to build a negative space model of only the PPF resulted in incomplete display of the boundaries of the fossa. More importantly, such models do not directly reflect the passage of the neurovascular structures through the PPF. Therefore, we propose the development of a 3D model of a half skull for completely visualizing the PPF and evaluating its spatial relationship with its communicating channels. The 3D model will be accompanied by a pictorial instructional manual that describes relevant information regarding each structure in relation to its interaction with other structures. Outcomes will be evaluated by analyzing student performance on examinations pre- and post- model introduction and by a student satisfaction survey based on Likert scales. Successful outcomes will allow us to disseminate the 3D model to universities within and outside the UT system using MedEd Portal, thereby enhancing anatomy education and promoting information retention.
Funding Agency	UT System Shine Academy Small Grants
Title	Connecting the dots: Morphing-based animation of cervical pathology for medical students.
Status	Active
Period	1/2017 - 12/2017
Role	Principal Investigator
Grant Detail	The aims of this grant are to develop an animated video initiated with a series of digitized microscopic images of the normal exocervix morphing through eversion and development of the transformation zone (squamous metaplasia). The 3-D animations will continue through dysplastic and neoplastic development. The video will include colposcopic images of the transformation zone, demonstrating the gross appearance of dysplastic and neoplastic alterations in the cervical surface.

Year	Degree	Discipline	Institution
2008	Postdoctoral Fellowship	Dental Research	Harvard School of Dental Medicine / Forsyth Institute Boston , MA
2006	PhD	Molecular Neuroscience	Wayne State University Detroit , MI
2001	DPL	Software Engineering (Honors)	Aptech Computer Education
1999	Certificate	Mid-Range Computer Programming	Pentasoft Mumbai , India
1995	MS	Microbiology & Immunology	University of Mumbai Mumbai , India
1993	BS	Biochemistry & Chemistry	University of Mumbai Mumbai , India
1992	BS	Microbiology	University of Mumbai Mumbai , India

Faculty

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Sharma, Ramaswamy

Aging

Apoptosis

Bone development and osteoporosis

Dental enamel development and fluorosis

Mesenchymal stem cells

Neurodegeneration and stroke

Oxidative stress and ER stress

Abstract

Book Chapter

Journal Article

Federal

Private

State